Edus Warren

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc High-throughput sequencing of B- and T-lymphocyte antigen receptors in hematology
    Edus H Warren
    Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
    Blood 122:19-22. 2013
  2. pmc Dissecting graft-versus-leukemia from graft-versus-host-disease using novel strategies
    E H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Tissue Antigens 81:183-93. 2013
  3. pmc Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT
    Edus H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 120:2796-806. 2012
  4. pmc Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens
    Edus H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 115:3869-78. 2010
  5. ncbi request reprint The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen
    E H Warren
    Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 164:2807-14. 2000
  6. ncbi request reprint Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens
    E H Warren
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 59:293-303. 2002
  7. ncbi request reprint Minor histocompatibility antigens--targets of graft versus leukemia responses
    Stanley R Riddell
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    Int J Hematol 76:155-61. 2002
  8. ncbi request reprint T-cell therapy targeting minor histocompatibility Ags for the treatment of leukemia and renal-cell carcinoma
    E H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cytotherapy 4:441. 2002
  9. pmc The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL
    Anthony G Brickner
    Department of Medicine, Unviersity of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, PA, USA
    Blood 107:3779-86. 2006
  10. pmc C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients
    Scott S Tykodi
    Program in Immunology, Fred Hutchinson Cancer Research Center
    Clin Cancer Res 14:5260-9. 2008

Research Grants

Collaborators

Detail Information

Publications20

  1. pmc High-throughput sequencing of B- and T-lymphocyte antigen receptors in hematology
    Edus H Warren
    Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
    Blood 122:19-22. 2013
    ....
  2. pmc Dissecting graft-versus-leukemia from graft-versus-host-disease using novel strategies
    E H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Tissue Antigens 81:183-93. 2013
    ..Adoptive transfer of donor-derived T cells genetically modified for tumor-specific reactivity, in particular, has the potential to transform the practice of allogeneic HCT by selectively enhancing antitumor immunity without causing GVHD...
  3. pmc Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT
    Edus H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 120:2796-806. 2012
    ....
  4. pmc Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens
    Edus H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 115:3869-78. 2010
    ..This study has been registered at http://clinicaltrials.gov as NCT00107354...
  5. ncbi request reprint The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen
    E H Warren
    Program in Immunology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Immunol 164:2807-14. 2000
    ..Identification of this CTL-defined H-Y epitope should facilitate analysis of its contribution to graft/host interactions following sex-mismatched organ and bone marrow transplantation...
  6. ncbi request reprint Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens
    E H Warren
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 59:293-303. 2002
    ..Over the next years, refinement and annotation of the human genome sequence will undoubtedly increase the utility of linkage analysis as a tool for identifying minor histocompatibility antigen genes...
  7. ncbi request reprint Minor histocompatibility antigens--targets of graft versus leukemia responses
    Stanley R Riddell
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, USA
    Int J Hematol 76:155-61. 2002
    ..Studies of this approach are now in progress in acute leukemia and have provided important insights into potential obstacles of T cell therapy for relapsed leukemia after HCT...
  8. ncbi request reprint T-cell therapy targeting minor histocompatibility Ags for the treatment of leukemia and renal-cell carcinoma
    E H Warren
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Cytotherapy 4:441. 2002
  9. pmc The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL
    Anthony G Brickner
    Department of Medicine, Unviersity of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, PA, USA
    Blood 107:3779-86. 2006
    ..These studies suggest distinct roles for different PANE1 isoforms in resting compared with activated CD19(+) cells, and identify PANE1 as a potential therapeutic target in B-CLL...
  10. pmc C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients
    Scott S Tykodi
    Program in Immunology, Fred Hutchinson Cancer Research Center
    Clin Cancer Res 14:5260-9. 2008
    ..Cellular and molecular characterization of antigens recognized by tumor-reactive T cells isolated from responding patients could potentially provide insight into the mechanisms of tumor regression...
  11. ncbi request reprint A single minor histocompatibility antigen encoded by UGT2B17 and presented by human leukocyte antigen-A*2902 and -B*4403
    Seitaro Terakura
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Transplantation 83:1242-8. 2007
    ....
  12. ncbi request reprint An antigen produced by splicing of noncontiguous peptides in the reverse order
    Edus H Warren
    Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 313:1444-7. 2006
    ..The antigenic peptide could be produced in vitro by incubation of precursor peptides with highly purified 20S proteasomes. Cutting and splicing probably occur within the proteasome by transpeptidation...
  13. ncbi request reprint Adoptive transfer of allogeneic antigen-specific T cells
    Stanley R Riddell
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Biol Blood Marrow Transplant 12:9-12. 2006
    ..Here we discuss strategies for employing T cells specific for minor H antigens to augment the GVL effect...
  14. pmc A human minor histocompatibility antigen resulting from differential expression due to a gene deletion
    Makoto Murata
    D3 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Exp Med 197:1279-89. 2003
    ....
  15. ncbi request reprint A novel HLA-A*3303-restricted minor histocompatibility antigen encoded by an unconventional open reading frame of human TMSB4Y gene
    Hiroki Torikai
    Division of Immunology, Aichi Cancer Center Research Institute, Aichi Cancer Center Hospital, Nagoya, Japan
    J Immunol 173:7046-54. 2004
    ..This finding underscores the in vivo immunological relevance of minor histocompatibility Ags derived from unconventional open reading frame products...
  16. ncbi request reprint Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling
    Yoshiki Akatsuka
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Br J Haematol 123:671-5. 2003
    ..These data suggest that the increased risk of acute GVHD associated with recipient HA-8 disparity was not sufficient to change other clinical outcomes...
  17. pmc DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells
    Kellie V Rosinski
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Blood 111:4817-26. 2008
    ..This study is registered at http://clinicaltrials.gov as NCT00107354...
  18. pmc Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation
    Carolina Berger
    Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, Washington 98109, USA
    Blood 107:2294-302. 2006
    ..The potency of gene-modified T cells to elicit robust and durable immune responses imply this approach might be used for vaccination to elicit T-cell responses to viral or tumor antigens...
  19. ncbi request reprint Allogeneic hematopoietic cell transplantation for metastatic renal cell carcinoma after nonmyeloablative conditioning: toxicity, clinical response, and immunological response to minor histocompatibility antigens
    Scott S Tykodi
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Clin Cancer Res 10:7799-811. 2004
    ..This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma...
  20. ncbi request reprint The graft versus leukemia response after allogeneic hematopoietic stem cell transplantation
    Stanley R Riddell
    D3 100, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Blood Rev 17:153-62. 2003
    ..The challenge for the future is to continue to build on our understanding of the allogeneic graft versus tumor effect and develop strategies that can be incorporated into clinical practice to augment this effect without GVHD...

Research Grants5

  1. Allogeneic T Cell Responses Against Renal Cell Carcinoma
    Edus Warren; Fiscal Year: 2007
    ..3) Identify the genes encoding antigens recognized by RCC-reactive CD8+ T cell clones isolated from patients with metastatic RCC who exhibit tumor regression after nonmyeloablative HCT. ..