Research Topics
Genomes and Genes
| Dennis R WarnerSummaryAffiliation: University of Louisville Country: USA Publications
| Collaborators
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Detail Information
Publications
Identification of novel CBP interacting proteins in embryonic orofacial tissueXiaolong Yin
Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD Louisville, KY 40292, USA
Biochem Biophys Res Commun 329:1010-7. 2005..The identification of these proteins as novel CBP-binding partners allows exploration of new mechanisms by which CBP regulates and integrates diverse cell signaling pathways...- PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissueDennis R Warner
Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
Biochim Biophys Acta 1773:814-20. 2007..Taken together, these results demonstrate that PRDM16/MEL1 is a Smad binding protein that may be important for development of orofacial structures through modulation of the TGFbeta signaling pathway... - Functional analysis of CBP/p300 in embryonic orofacial mesenchymal cellsD R Warner
Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, University of Louisville School of Dentistry, Louisville, Kentucky 40292, USA
J Cell Biochem 99:1374-9. 2006.... - Identification of novel Smad binding proteinsDennis R Warner
Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
Biochem Biophys Res Commun 312:1185-90. 2003..The identification of these proteins as Smad binding partners allows exploration of new mechanisms whereby TGFbeta signaling may be regulated, and reveals additional potential interactions with other signaling pathways... - Functional interaction between Smad, CREB binding protein, and p68 RNA helicaseDennis R Warner
Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
Biochem Biophys Res Commun 324:70-6. 2004..This offers a means of enhancing TGFbeta-mediated cellular responses in developing orofacial tissue... - Cross-talk between the TGFbeta and Wnt signaling pathways in murine embryonic maxillary mesenchymal cellsDennis R Warner
University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, 501 South Preston Street, Suite 301, Louisville, KY 40292, United States
FEBS Lett 579:3539-46. 2005..These data demonstrate a functional interaction between the TGFbeta and Wnt signaling pathways and suggest that Wnt activation of the canonical pathway is an important mediator of MEMM cell growth... - Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53Xiaolong Yin
Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
Int J Mol Med 16:251-6. 2005.... - Intracellular dynamics of Smad-mediated TGFbeta signalingRobert M Greene
University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, ULSD, Louisville, Kentucky, USA
J Cell Physiol 197:261-71. 2003..Collectively, these data point to the presence of a functional Smad-mediated TGFbeta signaling system in cells of the developing murine palate... - Interaction of Smads with collagen types I, III, and VLeslie R Ellis
Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville Birth Defects Center, Louisville, KY 40292, USA
Biochem Biophys Res Commun 310:1117-23. 2003..Moreover, TGFbeta is a potent regulator of collagen synthesis and turnover during mammalian orofacial development. These data thus suggest an important means of feedback regulation of the TGFbeta signaling cascade... - Novel interaction between nuclear coactivator CBP and the protein inhibitor of activated Stat1 (PIAS1)Xiaolong Yin
University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Louisville, KY 40292, USA
J Interferon Cytokine Res 25:321-7. 2005.... - Identification of three novel Smad binding proteins involved in cell polarityDennis R Warner
University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville School of Dentistry, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
FEBS Lett 539:167-73. 2003.... - Expression of Wnts in the developing murine secondary palateDennis R Warner
University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Kentucky 40292, USA
Int J Dev Biol 53:1105-12. 2009..The expression of 5 Wnt family members was found to be temporally regulated. Moreover, these Wnts had unique spatio-temporal patterns of expression which suggested possible roles in palatal ontogeny... - Interaction between Smad 3 and Dishevelled in murine embryonic craniofacial mesenchymal cellsD R Warner
Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, Louisville, KY 40292, USA
Orthod Craniofac Res 8:123-30. 2005..CONCLUSION: Smad 3 binds all three known isoforms of Dishevelled and binds Dishevelled 1 in vivo. TGFbeta signaling modulates the interaction between Smad 3 and Dishevelled-1... - BMP signaling dynamics in embryonic orofacial tissuePartha Mukhopadhyay
Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, University of Louisville, Louisville, Kentucky 40292, USA
J Cell Physiol 216:771-9. 2008..Collectively, these data document the existence of a functional Smad-mediated BMP signaling system in cells of the developing murine orofacial region... - Chromatin immunoprecipitation-promoter microarray identification of genes regulated by PRDM16 in murine embryonic palate mesenchymal cellsDennis R Warner
Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, University of Louisville, Louisville, KY 40292, USA
Exp Biol Med (Maywood) 237:387-94. 2012..These results suggest that PRDM16 may play a role in differentiation of mesenchymal cells in the embryonic secondary palate that contribute to the anterior, bony palate and posterior, muscular palate... - TGF?-1 and Wnt-3a interact to induce unique gene expression profiles in murine embryonic palate mesenchymal cellsDennis R Warner
University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, Louisville, KY 40292, USA
Reprod Toxicol 31:128-33. 2011..In the current study we tested the hypothesis that unique gene expression profiles are induced in murine embryonic palate mesenchymal cells as a result of this cross-talk between the TGF? and Wnt signal transduction pathways... - PRDM16 expression in the developing mouse embryoKristin H Horn
University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, 501 South Preston Street, Louisville, KY 40292, USA
Acta Histochem 113:150-5. 2011..The expression pattern is consistent with a role for PRDM16 in the development of multiple tissues. Collectively, these studies are the first to characterize the expression of the PRDM16 gene during early murine development... - Nuclear convergence of the TGFbeta and cAMP signal transduction pathways in murine embryonic palate mesenchymal cellsD R Warner
University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville School of Dentistry, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
Cell Signal 15:235-42. 2003..This suggests cooperative regulation of genes with SBE-containing promoters by the cAMP and TGFbeta signalling pathways in the developing palate... - Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissueD R Warner
University of Louisville Birth Defects Center, Kentucky 40292, USA
In Vitro Cell Dev Biol Anim 38:48-53. 2002..These studies lay the groundwork for further investigations into the role of CBP and p300 in cellular signaling during craniofacial development... - Altered signal transduction in Folr1-/- mouse embryo fibroblastsDennis R Warner
University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, KY 40292, U S A
Cell Biol Int 35:1253-9. 2011..These results demonstrate that under conditions of reduced folate (Folr-/-) signalling, pathways crucial for proper development of the neural tube are significantly altered... - Mesenchymal cell remodeling during mouse secondary palate reorientationJiu Zhen Jin
Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville, Louisville, Kentucky
Dev Dyn 239:2110-7. 2010..Because palate elevation represents a classic example of embryonic tissue re-orientation, our findings here may also shed light on the process of tissue re-orientation in general...