Dennis R Warner

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint Identification of novel CBP interacting proteins in embryonic orofacial tissue
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD Louisville, KY 40292, USA
    Biochem Biophys Res Commun 329:1010-7. 2005
  2. ncbi request reprint Functional analysis of CBP/p300 in embryonic orofacial mesenchymal cells
    D R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, University of Louisville School of Dentistry, Louisville, Kentucky 40292, USA
    J Cell Biochem 99:1374-9. 2006
  3. ncbi request reprint PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Biochim Biophys Acta 1773:814-20. 2007
  4. ncbi request reprint Cross-talk between the TGFbeta and Wnt signaling pathways in murine embryonic maxillary mesenchymal cells
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, 501 South Preston Street, Suite 301, Louisville, KY 40292, United States
    FEBS Lett 579:3539-46. 2005
  5. ncbi request reprint Functional interaction between Smad, CREB binding protein, and p68 RNA helicase
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 324:70-6. 2004
  6. ncbi request reprint Identification of novel Smad binding proteins
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 312:1185-90. 2003
  7. ncbi request reprint Interaction of Smads with collagen types I, III, and V
    Leslie R Ellis
    Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville Birth Defects Center, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 310:1117-23. 2003
  8. ncbi request reprint Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Int J Mol Med 16:251-6. 2005
  9. ncbi request reprint Intracellular dynamics of Smad-mediated TGFbeta signaling
    Robert M Greene
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, ULSD, Louisville, Kentucky, USA
    J Cell Physiol 197:261-71. 2003
  10. ncbi request reprint Novel interaction between nuclear coactivator CBP and the protein inhibitor of activated Stat1 (PIAS1)
    Xiaolong Yin
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Louisville, KY 40292, USA
    J Interferon Cytokine Res 25:321-7. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Identification of novel CBP interacting proteins in embryonic orofacial tissue
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD Louisville, KY 40292, USA
    Biochem Biophys Res Commun 329:1010-7. 2005
    ..The identification of these proteins as novel CBP-binding partners allows exploration of new mechanisms by which CBP regulates and integrates diverse cell signaling pathways...
  2. ncbi request reprint Functional analysis of CBP/p300 in embryonic orofacial mesenchymal cells
    D R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, University of Louisville School of Dentistry, Louisville, Kentucky 40292, USA
    J Cell Biochem 99:1374-9. 2006
    ....
  3. ncbi request reprint PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Biochim Biophys Acta 1773:814-20. 2007
    ..Taken together, these results demonstrate that PRDM16/MEL1 is a Smad binding protein that may be important for development of orofacial structures through modulation of the TGFbeta signaling pathway...
  4. ncbi request reprint Cross-talk between the TGFbeta and Wnt signaling pathways in murine embryonic maxillary mesenchymal cells
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, 501 South Preston Street, Suite 301, Louisville, KY 40292, United States
    FEBS Lett 579:3539-46. 2005
    ..These data demonstrate a functional interaction between the TGFbeta and Wnt signaling pathways and suggest that Wnt activation of the canonical pathway is an important mediator of MEMM cell growth...
  5. ncbi request reprint Functional interaction between Smad, CREB binding protein, and p68 RNA helicase
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 324:70-6. 2004
    ..This offers a means of enhancing TGFbeta-mediated cellular responses in developing orofacial tissue...
  6. ncbi request reprint Identification of novel Smad binding proteins
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 312:1185-90. 2003
    ..The identification of these proteins as Smad binding partners allows exploration of new mechanisms whereby TGFbeta signaling may be regulated, and reveals additional potential interactions with other signaling pathways...
  7. ncbi request reprint Interaction of Smads with collagen types I, III, and V
    Leslie R Ellis
    Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville Birth Defects Center, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 310:1117-23. 2003
    ..Moreover, TGFbeta is a potent regulator of collagen synthesis and turnover during mammalian orofacial development. These data thus suggest an important means of feedback regulation of the TGFbeta signaling cascade...
  8. ncbi request reprint Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Birth Defects Center, 501 S Preston Street, Suite 301, Louisville, KY 40292, USA
    Int J Mol Med 16:251-6. 2005
    ....
  9. ncbi request reprint Intracellular dynamics of Smad-mediated TGFbeta signaling
    Robert M Greene
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, ULSD, Louisville, Kentucky, USA
    J Cell Physiol 197:261-71. 2003
    ..Collectively, these data point to the presence of a functional Smad-mediated TGFbeta signaling system in cells of the developing murine palate...
  10. ncbi request reprint Novel interaction between nuclear coactivator CBP and the protein inhibitor of activated Stat1 (PIAS1)
    Xiaolong Yin
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Louisville, KY 40292, USA
    J Interferon Cytokine Res 25:321-7. 2005
    ....
  11. ncbi request reprint Identification of three novel Smad binding proteins involved in cell polarity
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville School of Dentistry, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    FEBS Lett 539:167-73. 2003
    ....
  12. pmc Gene expression changes in the secondary palate and mandible of Prdm16(-/-) mice
    Dennis R Warner
    Birth Defects Center, University of Louisville, 501 South Preston Street, Suite 350, Louisville, KY 40202, USA
    Cell Tissue Res 351:445-52. 2013
    ..These data suggest that one function of Prdm16 is the regulation of genes that play a role in the differentiation of mesenchymal cells into chondro-/osteocytes...
  13. pmc Expression of Wnts in the developing murine secondary palate
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, Kentucky 40292, USA
    Int J Dev Biol 53:1105-12. 2009
    ..The expression of 5 Wnt family members was found to be temporally regulated. Moreover, these Wnts had unique spatio-temporal patterns of expression which suggested possible roles in palatal ontogeny...
  14. ncbi request reprint Interaction between Smad 3 and Dishevelled in murine embryonic craniofacial mesenchymal cells
    D R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, Louisville, KY 40292, USA
    Orthod Craniofac Res 8:123-30. 2005
    ..To determine the in vivo interaction between Smad 3 and Dishevelled-1...
  15. doi request reprint Chromatin immunoprecipitation-promoter microarray identification of genes regulated by PRDM16 in murine embryonic palate mesenchymal cells
    Dennis R Warner
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville Birth Defects Center, University of Louisville, Louisville, KY 40292, USA
    Exp Biol Med (Maywood) 237:387-94. 2012
    ..These results suggest that PRDM16 may play a role in differentiation of mesenchymal cells in the embryonic secondary palate that contribute to the anterior, bony palate and posterior, muscular palate...
  16. pmc BMP signaling dynamics in embryonic orofacial tissue
    Partha Mukhopadhyay
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD, University of Louisville, Louisville, Kentucky 40292, USA
    J Cell Physiol 216:771-9. 2008
    ..Collectively, these data document the existence of a functional Smad-mediated BMP signaling system in cells of the developing murine orofacial region...
  17. pmc Developmental profiles of the murine palatal methylome
    Ratnam S Seelan
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, 501 S Preston Street, Louisville, KY 40202, USA
    Birth Defects Res A Clin Mol Teratol 97:171-86. 2013
    ..Identification of genes that are methylated during development of the secondary palate will contribute to a better understanding of the gene-environment link contributing to CP...
  18. pmc TGFβ-1 and Wnt-3a interact to induce unique gene expression profiles in murine embryonic palate mesenchymal cells
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, Louisville, KY 40292, USA
    Reprod Toxicol 31:128-33. 2011
    ..In the current study we tested the hypothesis that unique gene expression profiles are induced in murine embryonic palate mesenchymal cells as a result of this cross-talk between the TGFβ and Wnt signal transduction pathways...
  19. pmc Epigenetic regulation of Sox4 during palate development
    Ratnam S Seelan
    University of Louisville, Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, 501 S Preston St, Suite 350, Louisville, KY 40202, USA
    Epigenomics 5:131-46. 2013
    ..In this study, we have examined if the differential expression of Sox4 in the palate is due to changes in DNA methylation...
  20. pmc PRDM16 expression in the developing mouse embryo
    Kristin H Horn
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, 501 South Preston Street, Louisville, KY 40292, USA
    Acta Histochem 113:150-5. 2011
    ..The expression pattern is consistent with a role for PRDM16 in the development of multiple tissues. Collectively, these studies are the first to characterize the expression of the PRDM16 gene during early murine development...
  21. ncbi request reprint Nuclear convergence of the TGFbeta and cAMP signal transduction pathways in murine embryonic palate mesenchymal cells
    D R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville School of Dentistry, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Cell Signal 15:235-42. 2003
    ..This suggests cooperative regulation of genes with SBE-containing promoters by the cAMP and TGFbeta signalling pathways in the developing palate...
  22. ncbi request reprint Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue
    D R Warner
    University of Louisville Birth Defects Center, Kentucky 40292, USA
    In Vitro Cell Dev Biol Anim 38:48-53. 2002
    ..These studies lay the groundwork for further investigations into the role of CBP and p300 in cellular signaling during craniofacial development...
  23. doi request reprint Altered signal transduction in Folr1-/- mouse embryo fibroblasts
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, KY 40292, U S A
    Cell Biol Int 35:1253-9. 2011
    ..These results demonstrate that under conditions of reduced folate (Folr-/-) signalling, pathways crucial for proper development of the neural tube are significantly altered...
  24. pmc Mesenchymal cell remodeling during mouse secondary palate reorientation
    Jiu Zhen Jin
    Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville, Louisville, Kentucky
    Dev Dyn 239:2110-7. 2010
    ..Because palate elevation represents a classic example of embryonic tissue re-orientation, our findings here may also shed light on the process of tissue re-orientation in general...