Matthew J Wargo

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Homeostasis and catabolism of choline and glycine betaine: lessons from Pseudomonas aeruginosa
    Matthew J Wargo
    Department of Microbiology and Molecular Genetics and The Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, USA
    Appl Environ Microbiol 79:2112-20. 2013
  2. pmc Choline catabolism to glycine betaine contributes to Pseudomonas aeruginosa survival during murine lung infection
    Matthew J Wargo
    Department of Microbiology and Molecular Genetics and The Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, United States of America
    PLoS ONE 8:e56850. 2013
  3. pmc Characterization of the GbdR regulon in Pseudomonas aeruginosa
    Ken J Hampel
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA
    J Bacteriol 196:7-15. 2014
  4. pmc Bioengineered lysozyme reduces bacterial burden and inflammation in a murine model of mucoid Pseudomonas aeruginosa lung infection
    Charlotte C Teneback
    University of Vermont College of Medicine, Division of Pulmonary and Critical Care Medicine, Burlington, Vermont, USA
    Antimicrob Agents Chemother 57:5559-64. 2013
  5. pmc Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells
    Wendy A Neveu
    Division of Immunobiology, Department of Medicine, Vermont Lung Center, University of Vermont College of Medicine, Burlington, USA
    Am J Respir Cell Mol Biol 45:1133-41. 2011
  6. ncbi request reprint Detecting bacterial lung infections: in vivo evaluation of in vitro volatile fingerprints
    Jiangjiang Zhu
    School of Engineering, University of Vermont, Burlington, VT 05405, USA
    J Breath Res 7:016003. 2013
  7. pmc Hemolytic phospholipase C inhibition protects lung function during Pseudomonas aeruginosa infection
    Matthew J Wargo
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Crit Care Med 184:345-54. 2011
  8. pmc Cellular choline and glycine betaine pools impact osmoprotection and phospholipase C production in Pseudomonas aeruginosa
    Liam F Fitzsimmons
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA
    J Bacteriol 194:4718-26. 2012
  9. pmc Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    Jenna B Allard
    Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
    Eur J Immunol 39:776-88. 2009
  10. pmc Small-molecule inhibition of choline catabolism in Pseudomonas aeruginosa and other aerobic choline-catabolizing bacteria
    Liam F Fitzsimmons
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, 95 Carrigan Drive, 322 Stafford Hall, Burlington, VT 05405, USA
    Appl Environ Microbiol 77:4383-9. 2011

Collaborators

Detail Information

Publications15

  1. pmc Homeostasis and catabolism of choline and glycine betaine: lessons from Pseudomonas aeruginosa
    Matthew J Wargo
    Department of Microbiology and Molecular Genetics and The Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, USA
    Appl Environ Microbiol 79:2112-20. 2013
    ..aeruginosa associations with eukaryotes and other bacteria also makes this a powerful model to study the impact of choline and GB, and their associated regulatory and catabolic pathways, on host-microbe and microbe-microbe relationships...
  2. pmc Choline catabolism to glycine betaine contributes to Pseudomonas aeruginosa survival during murine lung infection
    Matthew J Wargo
    Department of Microbiology and Molecular Genetics and The Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, United States of America
    PLoS ONE 8:e56850. 2013
    ..aeruginosa survival in the mouse lung. While defective plcH induction can explain a portion of the betBA mutant phenotype, the exact mechanisms driving the betBA mutant survival defect remain unknown...
  3. pmc Characterization of the GbdR regulon in Pseudomonas aeruginosa
    Ken J Hampel
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA
    J Bacteriol 196:7-15. 2014
    ..Additionally, identification of two uncharacterized regulon members suggests roles for these proteins in response to choline metabolites. ..
  4. pmc Bioengineered lysozyme reduces bacterial burden and inflammation in a murine model of mucoid Pseudomonas aeruginosa lung infection
    Charlotte C Teneback
    University of Vermont College of Medicine, Division of Pulmonary and Critical Care Medicine, Burlington, Vermont, USA
    Antimicrob Agents Chemother 57:5559-64. 2013
    ..Thus, the charge-engineered lysozyme represents an interesting therapeutic candidate for P. aeruginosa lung infections. ..
  5. pmc Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells
    Wendy A Neveu
    Division of Immunobiology, Department of Medicine, Vermont Lung Center, University of Vermont College of Medicine, Burlington, USA
    Am J Respir Cell Mol Biol 45:1133-41. 2011
    ..Thus, β-glucans may constitute a common determinant of the fungal and plant-derived allergens responsible for some of the pathological features in allergic asthma...
  6. ncbi request reprint Detecting bacterial lung infections: in vivo evaluation of in vitro volatile fingerprints
    Jiangjiang Zhu
    School of Engineering, University of Vermont, Burlington, VT 05405, USA
    J Breath Res 7:016003. 2013
    ..aeruginosa PAO1, FRD1, and S. aureus RN450, and the first comparison of in vivo and in vitro volatile profiles from the same strains using the murine infection model...
  7. pmc Hemolytic phospholipase C inhibition protects lung function during Pseudomonas aeruginosa infection
    Matthew J Wargo
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Respir Crit Care Med 184:345-54. 2011
    ..Decreased lung function contributes significantly to morbidity and mortality during P. aeruginosa infection, and damage inflicted by P. aeruginosa virulence factors contributes to lung function decline...
  8. pmc Cellular choline and glycine betaine pools impact osmoprotection and phospholipase C production in Pseudomonas aeruginosa
    Liam F Fitzsimmons
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA
    J Bacteriol 194:4718-26. 2012
    ..These findings suggest that the levels of both pools are actively maintained and that perturbation of either pool impacts P. aeruginosa physiology...
  9. pmc Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
    Jenna B Allard
    Department of Medicine, Division of Pulmonary Disease and Critical Care, Vermont Lung Center, University of Vermont, Burlington, VT, USA
    Eur J Immunol 39:776-88. 2009
    ..Thus, different types of microbial products within the airway can alter the host's adaptive immune response and potentially impact the development of allergic airway disease to environmental fungal antigens...
  10. pmc Small-molecule inhibition of choline catabolism in Pseudomonas aeruginosa and other aerobic choline-catabolizing bacteria
    Liam F Fitzsimmons
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, 95 Carrigan Drive, 322 Stafford Hall, Burlington, VT 05405, USA
    Appl Environ Microbiol 77:4383-9. 2011
    ..We predict that chemical inhibitors of choline catabolism will be useful for studying this pathway in clinical and environmental isolates and could be a useful tool to study proteobacterial choline catabolism in situ...
  11. pmc Characterization of Pseudomonas aeruginosa growth on O-acylcarnitines and identification of a short-chain acylcarnitine hydrolase
    Jamie A Meadows
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT, USA
    Appl Environ Microbiol 79:3355-63. 2013
    ..These findings expand our knowledge of short-chain acylcarnitine catabolism and also point to remaining questions related to acylcarnitine transport and hydrolysis of medium- and long-chain acylcarnitines...
  12. pmc Identification of genes required for Pseudomonas aeruginosa carnitine catabolism
    Matthew J Wargo
    The Vermont Lung Center, Department of Medicine, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Microbiology 155:2411-9. 2009
    ..These results provide important insight into elements required for carnitine catabolism in P. aeruginosa and probably in other bacteria...
  13. doi request reprint Growth and laboratory maintenance of Pseudomonas aeruginosa
    Annette E Labauve
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA
    Curr Protoc Microbiol . 2012
    ..aeruginosa a common model organism to study Gram-negative opportunistic pathogens and basic microbiology. This unit describes the basic laboratory growth and maintenance of P. aeruginosa...
  14. pmc Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung
    Annette E Labauve
    Department of Microbiology and Molecular Genetics and The Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont, United States of America
    PLoS Pathog 10:e1003889. 2014
    ..aeruginosa. ..
  15. pmc Catabolism of host-derived compounds during extracellular bacterial infections
    Jamie A Meadows
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, 05405
    J Cell Biochem 115:217-23. 2014
    ..In the process, we point out key gaps in the field that will require new or newly adapted techniques...