Noel A Warfel
Affiliation: University of Arizona
Warfel N, Sainz A, Song J, Kraft A. PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Mol Cancer Ther. 2016;15:1637-47 pubmed publisher
..Thus, inhibition of PIM kinases has the potential to oppose hypoxia-mediated therapeutic resistance and induce cell death in the hypoxic tumor microenvironment. Mol Cancer Ther; 15(7); 1637-47. ©2016 AACR. ..
Warfel N, Kraft A. PIM kinase (and Akt) biology and signaling in tumors. Pharmacol Ther. 2015;151:41-9 pubmed publisher
..This review focuses on the regulation of PIM kinases, their role in tumorigenesis, and the biological impact of their interaction with the Akt signaling pathway on the efficacy of cancer therapy. ..
Toth R, Warfel N. Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia. Antioxidants (Basel). 2017;6: pubmed publisher
..In this review, we discuss the distinct and overlapping roles of HIF-1 and Nrf2 in the cellular response to hypoxia, with a focus on how targeting Nrf2 could provide novel chemotherapeutic modalities for treating solid tumors. ..
Casillas A, Toth R, Sainz A, Singh N, Desai A, Kraft A, et al
. Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents. Clin Cancer Res. 2018;24:169-180 pubmed publisher
..i>Clin Cancer Res; 24(1); 169-80. ©2017 AACR. ..