Jerry Ware

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Platelet function beyond hemostasis and thrombosis
    Jerry Ware
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Curr Opin Hematol 20:451-6. 2013
  2. pmc Dysfunctional platelet membrane receptors: from humans to mice
    Jerry Ware
    The Room Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Thromb Haemost 92:478-85. 2004
  3. pmc Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation
    Jose A Guerrero
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Blood 114:5541-6. 2009
  4. pmc Platelet glycoprotein Ib-IX as a regulator of systemic inflammation
    Adam Corken
    From the Departments of Physiology and Biophysics A C, S R, J D, J W and Pathology S R P, University of Arkansas for Medical Sciences, Little Rock
    Arterioscler Thromb Vasc Biol 34:996-1001. 2014
  5. pmc Platelets: linking hemostasis and cancer
    Shashank Jain
    Department of Physiology and Biophysics, University of Arkansas for Medical Science, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 30:2362-7. 2010
  6. doi request reprint A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal
    Muthu Veeraputhiran
    Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Transfusion 51:1030-6. 2011
  7. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
  8. doi request reprint Give me an intron: any intron
    Jerry Ware
    University of Arkansas for Medical Sciences, AR, USA
    Blood 121:4251-2. 2013
  9. ncbi request reprint Mammalian septin function in hemostasis and beyond
    Constantino Martinez
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Exp Biol Med (Maywood) 229:1111-9. 2004
  10. pmc Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease
    Larry J Suva
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Pathol 172:430-9. 2008

Collaborators

Detail Information

Publications16

  1. pmc Platelet function beyond hemostasis and thrombosis
    Jerry Ware
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Curr Opin Hematol 20:451-6. 2013
    ..A consideration for some major health issues, such as inflammation, cancer, infection, and neuroscience, and how platelet function impacts the pathophysiology of each clinical situation is provided...
  2. pmc Dysfunctional platelet membrane receptors: from humans to mice
    Jerry Ware
    The Room Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Thromb Haemost 92:478-85. 2004
    ..Concluding remarks focus on the importance of understanding the power and limitations of various in vitro, ex vivo and in vivo models currently being used and the impact of the mouse strain on the described platelet phenotype...
  3. pmc Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation
    Jose A Guerrero
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Blood 114:5541-6. 2009
    ..Visualization of the receptor/ligand interaction and characterization of a severe antithrombotic phenotype provide a new understanding on the molecular basis of bleeding associated with the PT-VWD phenotype...
  4. pmc Platelet glycoprotein Ib-IX as a regulator of systemic inflammation
    Adam Corken
    From the Departments of Physiology and Biophysics A C, S R, J D, J W and Pathology S R P, University of Arkansas for Medical Sciences, Little Rock
    Arterioscler Thromb Vasc Biol 34:996-1001. 2014
    ..We examine the GP Ib-IX/von Willebrand factor axis in murine polymicrobial sepsis, as modeled by cecal ligation and puncture (CLP)...
  5. pmc Platelets: linking hemostasis and cancer
    Shashank Jain
    Department of Physiology and Biophysics, University of Arkansas for Medical Science, Little Rock, AR 72205, USA
    Arterioscler Thromb Vasc Biol 30:2362-7. 2010
    ..The studies provide a link between the well-studied paradigms of platelet hemostasis and tumorigenesis...
  6. doi request reprint A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal
    Muthu Veeraputhiran
    Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Transfusion 51:1030-6. 2011
    ..Washed or volume-reduced platelets (PLTs) are occasionally requested for patients with a history of allergic or anaphylactic transfusion reactions. However, conclusive data are not available as to which method is more suitable...
  7. pmc The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
  8. doi request reprint Give me an intron: any intron
    Jerry Ware
    University of Arkansas for Medical Sciences, AR, USA
    Blood 121:4251-2. 2013
    ..1)..
  9. ncbi request reprint Mammalian septin function in hemostasis and beyond
    Constantino Martinez
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Exp Biol Med (Maywood) 229:1111-9. 2004
    ..The mouse platelet provides an experimental framework to define septin function in hemostasis, with implications for neurobiology and beyond...
  10. pmc Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease
    Larry J Suva
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Pathol 172:430-9. 2008
    ..These studies provide new insights into the relationship between the regulation of megakaryocytopoiesis and bone mass...
  11. doi request reprint Fragmenting the platelet to reduce metastasis
    Jerry Ware
    University of Arkansas for Medical Sciences, AR, USA
    Blood 120:2779-80. 2012
    ..1) Their experiments outline an early-stage preclinical approach providing proof-of-principle for antiplatelet strategies that may ultimately lead to an improved prognosis for the cancer patient.(1)..
  12. ncbi request reprint The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion
    Kazunobu Kato
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Blood 102:1701-7. 2003
    ..These results illustrate the role of GP VI in postadhesion events leading to the development of platelet thrombi on collagen fibrils...
  13. pmc Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells
    Hidekazu Nishikii
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Exp Med 205:1917-27. 2008
    ..Thus, the regulation of metalloproteinases in culture could be useful for obtaining high-quality, efficacious ESPs as an alternative platelet source for transfusions...
  14. pmc GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk
    Sascha C Hughan
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, UK
    Arterioscler Thromb Vasc Biol 27:422-9. 2007
    ..The present study investigates the role of Src and Syk tyrosine kinases in signaling by G-protein coupled and platelet adhesion receptors...
  15. pmc The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    Wolfgang Bergmeier
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16900-5. 2006
    ..Thus, GPIbalpha contributes to arterial thrombosis by important adhesion mechanisms independent of the binding to VWF...
  16. ncbi request reprint Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model
    Christel Poujol
    UMR 5533 CNRS, Laboratoire d Hematologie, Hopital Cardiologique, Avenue de Magellan, 33604 Pessac, France
    Exp Hematol 30:352-60. 2002
    ..To study how giant platelets are produced in vivo, we used a model of GPIbalpha-deficient mice (GPIbalpha(null)) and mice rescued with the human GPIbalpha transgene (GPIbalpha(null;hTg))...

Research Grants22

  1. Characterization and Analysis of Platelet Septins
    Jerry Ware; Fiscal Year: 2004
    ..A platelet model to examine septin function exploits the fundamental importance of secretion for the platelet response at sites of vascular injury. ..
  2. Characterization and Analysis of Platelet Septins
    Jerry Ware; Fiscal Year: 2005
    ..A platelet model to examine septin function exploits the fundamental importance of secretion for the platelet response at sites of vascular injury. ..
  3. Characterization and Analysis of Platelet Septins
    Jerry Ware; Fiscal Year: 2004
    ..A platelet model to examine septin function exploits the fundamental importance of secretion for the platelet response at sites of vascular injury. ..
  4. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2006
    ..abstract_text> ..
  5. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2007
    ..abstract_text> ..
  6. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2009
    ..An understanding of how platelets function in the process will lead to better therapeutic strategies and improved health in the U.S. ..
  7. Characterization and Analysis of Platelet Septins
    Jerry Ware; Fiscal Year: 2003
    ..A platelet model to examine septin function exploits the fundamental importance of secretion for the platelet response at sites of vascular injury. ..
  8. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 1999
    ..These studies will generate basic information that can be applied to therapeutic strategies for pathological conditions affecting megakaryocytopoiesis and platelet production. ..
  9. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2000
    ..These studies will generate basic information that can be applied to therapeutic strategies for pathological conditions affecting megakaryocytopoiesis and platelet production. ..
  10. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2001
    ..These studies will generate basic information that can be applied to therapeutic strategies for pathological conditions affecting megakaryocytopoiesis and platelet production. ..
  11. Characterization and Analysis of Platelet Septins
    Jerry Ware; Fiscal Year: 2002
    ..A platelet model to examine septin function exploits the fundamental importance of secretion for the platelet response at sites of vascular injury. ..
  12. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2003
    ..abstract_text> ..
  13. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2010
    ..An understanding of how platelets function in the process will lead to better therapeutic strategies and improved health in the U.S. ..