Genomes and Genes
Affiliation: University of Arkansas for Medical Sciences
- Platelet function beyond hemostasis and thrombosisJerry Ware
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Curr Opin Hematol 20:451-6. 2013..A consideration for some major health issues, such as inflammation, cancer, infection, and neuroscience, and how platelet function impacts the pathophysiology of each clinical situation is provided...
- Dysfunctional platelet membrane receptors: from humans to miceJerry Ware
The Room Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
Thromb Haemost 92:478-85. 2004..Concluding remarks focus on the importance of understanding the power and limitations of various in vitro, ex vivo and in vivo models currently being used and the impact of the mouse strain on the described platelet phenotype...
- Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutationJose A Guerrero
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Blood 114:5541-6. 2009..Visualization of the receptor/ligand interaction and characterization of a severe antithrombotic phenotype provide a new understanding on the molecular basis of bleeding associated with the PT-VWD phenotype...
- Platelet glycoprotein Ib-IX as a regulator of systemic inflammationAdam Corken
From the Departments of Physiology and Biophysics A C, S R, J D, J W and Pathology S R P, University of Arkansas for Medical Sciences, Little Rock
Arterioscler Thromb Vasc Biol 34:996-1001. 2014..We examine the GP Ib-IX/von Willebrand factor axis in murine polymicrobial sepsis, as modeled by cecal ligation and puncture (CLP)...
- Platelets: linking hemostasis and cancerShashank Jain
Department of Physiology and Biophysics, University of Arkansas for Medical Science, Little Rock, AR 72205, USA
Arterioscler Thromb Vasc Biol 30:2362-7. 2010..The studies provide a link between the well-studied paradigms of platelet hemostasis and tumorigenesis...
- The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- miceYann Cheli
Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Blood 111:1266-73. 2008..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
- A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removalMuthu Veeraputhiran
Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Transfusion 51:1030-6. 2011..Washed or volume-reduced platelets (PLTs) are occasionally requested for patients with a history of allergic or anaphylactic transfusion reactions. However, conclusive data are not available as to which method is more suitable...
- Platelets at the interface of thrombosis, inflammation, and cancerAime T Franco
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR
Blood 126:582-8. 2015..Thus, the basic scientist studying platelet function can think beyond the traditional hemostasis and thrombosis paradigms, while the practicing hematologist must appreciate platelet relevance in a wide range of disease processes. ..
- Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand diseaseLarry J Suva
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Am J Pathol 172:430-9. 2008..These studies provide new insights into the relationship between the regulation of megakaryocytopoiesis and bone mass...
- Give me an intron: any intronJerry Ware
University of Arkansas for Medical Sciences, AR, USA
Blood 121:4251-2. 2013..1)..
- Mammalian septin function in hemostasis and beyondConstantino Martinez
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
Exp Biol Med (Maywood) 229:1111-9. 2004..The mouse platelet provides an experimental framework to define septin function in hemostasis, with implications for neurobiology and beyond...
- Fragmenting the platelet to reduce metastasisJerry Ware
University of Arkansas for Medical Sciences, AR, USA
Blood 120:2779-80. 2012..1) Their experiments outline an early-stage preclinical approach providing proof-of-principle for antiplatelet strategies that may ultimately lead to an improved prognosis for the cancer patient.(1)..
- The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletionKazunobu Kato
Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
Blood 102:1701-7. 2003..These results illustrate the role of GP VI in postadhesion events leading to the development of platelet thrombi on collagen fibrils...
- Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cellsHidekazu Nishikii
Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
J Exp Med 205:1917-27. 2008..Thus, the regulation of metalloproteinases in culture could be useful for obtaining high-quality, efficacious ESPs as an alternative platelet source for transfusions...
- GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and SykSascha C Hughan
Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, UK
Arterioscler Thromb Vasc Biol 27:422-9. 2007..The present study investigates the role of Src and Syk tyrosine kinases in signaling by G-protein coupled and platelet adhesion receptors...
- The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosisWolfgang Bergmeier
CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:16900-5. 2006..Thus, GPIbalpha contributes to arterial thrombosis by important adhesion mechanisms independent of the binding to VWF...
- Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic modelChristel Poujol
UMR 5533 CNRS, Laboratoire d Hematologie, Hopital Cardiologique, Avenue de Magellan, 33604 Pessac, France
Exp Hematol 30:352-60. 2002..To study how giant platelets are produced in vivo, we used a model of GPIbalpha-deficient mice (GPIbalpha(null)) and mice rescued with the human GPIbalpha transgene (GPIbalpha(null;hTg))...
- Characterization and Analysis of Platelet SeptinsJerry Ware; Fiscal Year: 2005..A platelet model to examine septin function exploits the fundamental importance of secretion for the platelet response at sites of vascular injury. ..