Jerry Ware

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. ncbi Dysfunctional platelet membrane receptors: from humans to mice
    Jerry Ware
    The Room Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Thromb Haemost 92:478-85. 2004
  2. ncbi A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal
    Muthu Veeraputhiran
    Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Transfusion 51:1030-6. 2011
  3. ncbi The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
  4. ncbi The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion
    Kazunobu Kato
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Blood 102:1701-7. 2003
  5. ncbi Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model
    Christel Poujol
    UMR 5533 CNRS, Laboratoire d Hematologie, Hopital Cardiologique, Avenue de Magellan, 33604 Pessac, France
    Exp Hematol 30:352-60. 2002
  6. ncbi Mammalian septin function in hemostasis and beyond
    Constantino Martinez
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Exp Biol Med (Maywood) 229:1111-9. 2004
  7. ncbi The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    Wolfgang Bergmeier
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16900-5. 2006
  8. ncbi GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk
    Sascha C Hughan
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, UK
    Arterioscler Thromb Vasc Biol 27:422-9. 2007
  9. ncbi Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells
    Hidekazu Nishikii
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Exp Med 205:1917-27. 2008

Research Grants

  1. Characterization and Analysis of Platelet Septins
    Jerry Ware; Fiscal Year: 2005
  2. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2006
  3. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2007
  4. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2001
  5. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2003
  6. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2010

Collaborators

Detail Information

Publications9

  1. ncbi Dysfunctional platelet membrane receptors: from humans to mice
    Jerry Ware
    The Room Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Thromb Haemost 92:478-85. 2004
    ..Concluding remarks focus on the importance of understanding the power and limitations of various in vitro, ex vivo and in vivo models currently being used and the impact of the mouse strain on the described platelet phenotype...
  2. ncbi A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal
    Muthu Veeraputhiran
    Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Transfusion 51:1030-6. 2011
    ..Washed or volume-reduced platelets (PLTs) are occasionally requested for patients with a history of allergic or anaphylactic transfusion reactions. However, conclusive data are not available as to which method is more suitable...
  3. ncbi The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice
    Yann Cheli
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 111:1266-73. 2008
    ..9, P < .0001) that we designate Modifier of hemostasis (Mh). Our results indicate that one or more modifier genes in Mh control the extent to which in vivo platelet thrombus formation is disrupted by the absence of platelet GPVI...
  4. ncbi The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion
    Kazunobu Kato
    Roon Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Blood 102:1701-7. 2003
    ..These results illustrate the role of GP VI in postadhesion events leading to the development of platelet thrombi on collagen fibrils...
  5. ncbi Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model
    Christel Poujol
    UMR 5533 CNRS, Laboratoire d Hematologie, Hopital Cardiologique, Avenue de Magellan, 33604 Pessac, France
    Exp Hematol 30:352-60. 2002
    ..To study how giant platelets are produced in vivo, we used a model of GPIbalpha-deficient mice (GPIbalpha(null)) and mice rescued with the human GPIbalpha transgene (GPIbalpha(null;hTg))...
  6. ncbi Mammalian septin function in hemostasis and beyond
    Constantino Martinez
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Exp Biol Med (Maywood) 229:1111-9. 2004
    ..The mouse platelet provides an experimental framework to define septin function in hemostasis, with implications for neurobiology and beyond...
  7. ncbi The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    Wolfgang Bergmeier
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:16900-5. 2006
    ..Thus, GPIbalpha contributes to arterial thrombosis by important adhesion mechanisms independent of the binding to VWF...
  8. ncbi GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk
    Sascha C Hughan
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, UK
    Arterioscler Thromb Vasc Biol 27:422-9. 2007
    ..The present study investigates the role of Src and Syk tyrosine kinases in signaling by G-protein coupled and platelet adhesion receptors...
  9. ncbi Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells
    Hidekazu Nishikii
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Exp Med 205:1917-27. 2008
    ..Thus, the regulation of metalloproteinases in culture could be useful for obtaining high-quality, efficacious ESPs as an alternative platelet source for transfusions...

Research Grants22

  1. Characterization and Analysis of Platelet Septins
    Jerry Ware; Fiscal Year: 2005
    ..A platelet model to examine septin function exploits the fundamental importance of secretion for the platelet response at sites of vascular injury. ..
  2. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2006
    ..abstract_text> ..
  3. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2007
    ..abstract_text> ..
  4. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2001
    ..These studies will generate basic information that can be applied to therapeutic strategies for pathological conditions affecting megakaryocytopoiesis and platelet production. ..
  5. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2003
    ..abstract_text> ..
  6. TRANSGENIC ANALYSIS OF PLATELET RECEPTOR EXPRESSION
    Jerry Ware; Fiscal Year: 2010
    ..An understanding of how platelets function in the process will lead to better therapeutic strategies and improved health in the U.S. ..