Robert L Wardle

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Ca2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery
    Robert L Wardle
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Physiol 572:259-67. 2006
  2. ncbi request reprint Rho kinase is an effector underlying Ca2+-desensitizing hypoxic relaxation in porcine coronary artery
    Robert L Wardle
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Heart Circ Physiol 293:H23-9. 2007
  3. pmc Ca2+-independent hypoxic vasorelaxation in porcine coronary artery
    Min Gu
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    J Physiol 562:839-46. 2005
  4. ncbi request reprint N-acetylaspartate as a reservoir for glutamate
    Joseph F Clark
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0536, USA
    Med Hypotheses 67:506-12. 2006
  5. ncbi request reprint Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylation
    Christopher M Rembold
    Box 801395, Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Am J Physiol Cell Physiol 287:C594-602. 2004

Detail Information

Publications5

  1. pmc Ca2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery
    Robert L Wardle
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Physiol 572:259-67. 2006
    ..Moreover, no kinases, other then those inhibited by ML7 and Y27632, nor their associated phosphoproteins can be involved in Ca(2+)-desensitizing hypoxic relaxation...
  2. ncbi request reprint Rho kinase is an effector underlying Ca2+-desensitizing hypoxic relaxation in porcine coronary artery
    Robert L Wardle
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    Am J Physiol Heart Circ Physiol 293:H23-9. 2007
    ..Our evidence strongly implicates that hypoxia directly inhibits Rho kinase-dependent phosphorylation of MYPT1. This underlies the decreases in both p-MYPT1 and p-MRLC and thereby leads to the Ca(2+)-desensitizing hypoxic relaxation...
  3. pmc Ca2+-independent hypoxic vasorelaxation in porcine coronary artery
    Min Gu
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0576, USA
    J Physiol 562:839-46. 2005
    ..Importantly, these results unambiguously show that hypoxia-induced vasorelaxation can occur in permeabilized arteries where the Ca(2+) is clamped at a constant value...
  4. ncbi request reprint N-acetylaspartate as a reservoir for glutamate
    Joseph F Clark
    Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0536, USA
    Med Hypotheses 67:506-12. 2006
    ..Future studies to demonstrate the chemical, metabolic and pathological links between NAA and glutamate will support this hypothesis...
  5. ncbi request reprint Cooperative attachment of cross bridges predicts regulation of smooth muscle force by myosin phosphorylation
    Christopher M Rembold
    Box 801395, Cardiovascular Division, Univ of Virginia Health System, Charlottesville, VA 22908 1395, USA
    Am J Physiol Cell Physiol 287:C594-602. 2004
    ..This result suggests cooperative mechanisms analogous to skeletal muscle that will require testing...