S M Ward
Affiliation: University of Nevada
Ward S, Baker S, de Faoite A, Sanders K. Propagation of slow waves requires IP3 receptors and mitochondrial Ca2+ uptake in canine colonic muscles. J Physiol. 2003;549:207-18 pubmed
..The data predict that partial loss of or disruptions to ICC networks observed in human motility disorders could lead to incomplete penetration of slow waves through GI organs and, thus, to defects in myogenic regulation. ..
Ward S, Bayguinov J, Won K, Grundy D, Berthoud H. Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J Comp Neurol. 2003;465:121-35 pubmed
..VR1-like fibers appear to be predominantly spinal in origin, but a few vagal VR1-like fibers exist in the stomach. ..
Ward S, Gershon M, Keef K, Bayguinov Y, Nelson C, Sanders K. Interstitial cells of Cajal and electrical activity in ganglionic and aganglionic colons of mice. Am J Physiol Gastrointest Liver Physiol. 2002;283:G445-56 pubmed
..The electrical activity and neural responses of the circular layer are significantly different in aganglionic segments of ls/ls mutants. ..
Ward S. Changes in electrical and mechanical activity during ontogeny of the canine proximal colon. Am J Physiol. 1996;271:G184-91 pubmed
..The gradient in resting membrane potential across the circular layer is absent at birth but develops within 2-3 wk after parturition...
Ward S, Harney S, Bayguinov J, McLaren G, Sanders K. Development of electrical rhythmicity in the murine gastrointestinal tract is specifically encoded in the tunica muscularis. J Physiol. 1997;505 ( Pt 1):241-58 pubmed
..The development of ICCs and electrical rhythmicity persists in vitro. ICCs appear to be necessary for the initiation of electrical rhythmicity. These findings provide further evidence for the pacemaker role of ICCs. ..
Ward S, Ordog T, Bayguinov J, Horowitz B, Epperson A, Shen L, et al
. Development of interstitial cells of Cajal and pacemaking in mice lacking enteric nerves. Gastroenterology. 1999;117:584-94 pubmed
..These data suggest that enteric neurons are not required for the development of functional ICC. The circular smooth muscle layer, which develops before ICC, may be the source of SCF required for ICC development. ..
Ward S, Beckett E, Wang X, Baker F, Khoyi M, Sanders K. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci. 2000;20:1393-403 pubmed
..These data suggest that IC-IM play a major role in receiving cholinergic excitatory inputs from the enteric nervous system in the murine fundus...
Ward S, Sanders K. Physiology and pathophysiology of the interstitial cell of Cajal: from bench to bedside. I. Functional development and plasticity of interstitial cells of Cajal networks. Am J Physiol Gastrointest Liver Physiol. 2001;281:G602-11 pubmed
..This article examines the role of ICC in GI motility, focusing on the functional development and maintenance of ICC networks in the GI tract and the phenotypic changes that can occur when the Kit signaling pathway is disrupted...