D Warburton

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia
    Davaasambuu Enkhmaa
    The Lifespan Environmental Pollution Global Impact Center at The Saban Research Institute, Children s Hospital of Los Angeles, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    BMC Pregnancy Childbirth 14:146. 2014
  2. pmc MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal plasticity in normal murine mammary gland cells
    Gianluca Turcatel
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e31032. 2012
  3. pmc Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage
    Orquidea Garcia
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California, USA
    PLoS ONE 8:e71679. 2013
  4. ncbi request reprint Lung mesenchymal expression of Sox9 plays a critical role in tracheal development
    Gianluca Turcatel
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
    BMC Biol 11:117. 2013
  5. doi request reprint New ideas in lung regeneration: a personal view from Estoril
    David Warburton
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital, Los Angeles, CA, USA
    Expert Rev Respir Med 6:507-8. 2012
  6. doi request reprint TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?
    David Warburton
    Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Blvd MS35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 304:L83-5. 2013
  7. doi request reprint Modulating the alveolar milieu to enhance resolution of fibrotic lung injury
    Orquidea Garcia
    Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    Proc Am Thorac Soc 9:117-9. 2012
  8. pmc Cell-based therapies for lung disease
    Orquidea Garcia
    Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Br Med Bull 101:147-61. 2012
  9. pmc Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry
    David Warburton
    Developmental Biology Program, Childrens Hospital Los Angeles Research Institute and the Center for Craniofacial Molecular Biology, Keck School of Medicine and School of Dentistry, University of Southern California, USA
    Respir Res 4:5. 2003
  10. ncbi request reprint Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny?
    D Warburton
    Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    Am J Respir Crit Care Med 164:S59-62. 2001

Research Grants

  1. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  2. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2006
  3. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2005
  4. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  5. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2004
  6. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2004
  7. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2003
  8. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2003
  9. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2003
  10. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2002

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia
    Davaasambuu Enkhmaa
    The Lifespan Environmental Pollution Global Impact Center at The Saban Research Institute, Children s Hospital of Los Angeles, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    BMC Pregnancy Childbirth 14:146. 2014
    ..This study aimed to examine the association between spontaneous abortion and seasonal variation of air pollutants in Ulaanbaatar, Mongolia...
  2. pmc MIR-99a and MIR-99b modulate TGF-β induced epithelial to mesenchymal plasticity in normal murine mammary gland cells
    Gianluca Turcatel
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e31032. 2012
    ....
  3. pmc Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage
    Orquidea Garcia
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California, USA
    PLoS ONE 8:e71679. 2013
    ..Based on this data, we concluded that AFSC have the potential to inhibit the development or progression of fibrosis in a bleomycin injury model during both acute and chronic remodeling events. ..
  4. ncbi request reprint Lung mesenchymal expression of Sox9 plays a critical role in tracheal development
    Gianluca Turcatel
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine and Ostrow School of Dentistry, University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
    BMC Biol 11:117. 2013
    ..Sox9 is expressed in both distal lung epithelium and proximal lung mesenchyme. Here, we investigated the effect of lung mesenchyme-specific inducible deletion of Sox9 during murine lung development...
  5. doi request reprint New ideas in lung regeneration: a personal view from Estoril
    David Warburton
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital, Los Angeles, CA, USA
    Expert Rev Respir Med 6:507-8. 2012
    ..Thus, the major research themes focused on lung development, lung stem and progenitor cell populations, regenerative signaling mechanisms and tissue engineering and transplantation...
  6. doi request reprint TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?
    David Warburton
    Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Blvd MS35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 304:L83-5. 2013
    ....
  7. doi request reprint Modulating the alveolar milieu to enhance resolution of fibrotic lung injury
    Orquidea Garcia
    Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    Proc Am Thorac Soc 9:117-9. 2012
    ..Corrective therapy of the alveolar milieu may therefore prove to be beneficial in many presently serious and incurable lung diseases that likely begin and progress with injury to the alveolar epithelium...
  8. pmc Cell-based therapies for lung disease
    Orquidea Garcia
    Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Br Med Bull 101:147-61. 2012
    ..Alternatively when lung repair becomes impossible, replacement with tissue-engineered lung is an attractive emerging alternative using a decellularized matrix or bioengineered scaffold...
  9. pmc Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry
    David Warburton
    Developmental Biology Program, Childrens Hospital Los Angeles Research Institute and the Center for Craniofacial Molecular Biology, Keck School of Medicine and School of Dentistry, University of Southern California, USA
    Respir Res 4:5. 2003
    ....
  10. ncbi request reprint Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny?
    D Warburton
    Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    Am J Respir Crit Care Med 164:S59-62. 2001
    ..We speculate that genes in evo-devo functionally conserved signaling pathways such as FGF-FGF receptor-Sprouty may provide novel therapeutic targets to augment lung repair and induce lung regeneration...
  11. pmc The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors
    Susan Buckley
    Developmental Biology and Regenerative Medicine, Saban Research Institute, Childrens Hospital Los Angeles, California, USA
    Am J Respir Cell Mol Biol 45:1212-21. 2011
    ..Thus, the microenvironment created by AEC2 damage not only promotes autocrine repair but also can attract uncommitted stem cells, which further augment healing through cytokine secretion and differentiation...
  12. ncbi request reprint Commitment and differentiation of lung cell lineages
    D Warburton
    Department of Surgery, Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, University of Southern California Schools of Medicine and Dentistry 90027, USA
    Biochem Cell Biol 76:971-95. 1998
    ..The ideal agent or agents would therefore mimic the instructive role of lung mesenchyme, correctly inducing the temporospatial pattern of lung cell lineages necessary to restore pulmonary gas diffusing capacity...
  13. ncbi request reprint Molecular embryology of the lung: then, now, and in the future
    D Warburton
    Developmental Biology Program and Department of Surgery, Childrens Hospital Los Angeles Research Institute, Los Angeles, California 90027, USA
    Am J Physiol 276:L697-704. 1999
    ..A scientific rationale for developing new therapeutic approaches to urgent questions of human pulmonary health such as bronchopulmonary dysplasia is beginning to emerge from work in this field...
  14. ncbi request reprint Lung development and susceptibility to chronic obstructive pulmonary disease
    David Warburton
    Saban Research Institute Children s Hospital Los Angeles, 4650 Sunset Blvd 35, Los Angeles, CA 90027, USA
    Proc Am Thorac Soc 3:668-72. 2006
    ..The hope is that providing the correct exogenous signals can coax them into doing so...
  15. pmc Stem/progenitor cells in lung development, injury repair, and regeneration
    David Warburton
    Developmental Biology, Regenerative Medicine and Surgery Program, Saban Research Institute, Children s Hospital Los Angeles, 4661 Sunset Boulevard, Los Angeles CA 90027, USA
    Proc Am Thorac Soc 5:703-6. 2008
    ..Further work will be needed to translate stem/progenitor cell therapy for the lung...
  16. pmc The 2nd International Collaborative Symposium on Stem Cell Research
    David Warburton
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles and University of Southern California Keck School of Medicine, CA, USA
    Regen Med 4:129-31. 2009
    ....
  17. pmc Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity
    David Warburton
    Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Am J Pathol 167:921-2. 2005
  18. ncbi request reprint Molecular mechanisms of early lung specification and branching morphogenesis
    David Warburton
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
    Pediatr Res 57:26R-37R. 2005
    ....
  19. ncbi request reprint The molecular genetics of lung morphogenesis and injury repair
    David Warburton
    Developmental Biology Program, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    Paediatr Respir Rev 5:S283-7. 2004
    ..Novel therapy to activate lung stem/progenitor cells, ameliorate lung injury, augment lung repair and/or induce lung regeneration could be highly beneficial in both children and adults with intractable pulmonary insufficiency...
  20. pmc TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung
    H Chen
    Developmental Biology Program, Dept of Surgery, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Eur Respir J 32:285-95. 2008
    ....
  21. ncbi request reprint TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids
    W Shi
    Developmental Biology Program, Childrens Hospital Los Angeles and University of Southern California School of Medicine, Los Angeles 90027, California
    Am J Physiol 277:L1205-13. 1999
    ..This finding provides direct evidence that glucocorticoid signaling in the lung can use alternative pathways and can exert its effect without the presence of TGF-beta3...
  22. ncbi request reprint Gremlin negatively modulates BMP-4 induction of embryonic mouse lung branching morphogenesis
    W Shi
    Developmental Biology Program, Department of Surgery, Childrens Hospital Los Angeles Research Institute, Los Angeles, California 90027, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1030-9. 2001
    ..Therefore, our data support the hypothesis that Gremlin is a physiologically negative regulator of BMP-4 in lung branching morphogenesis...
  23. ncbi request reprint BMP4 signaling induces senescence and modulates the oncogenic phenotype of A549 lung adenocarcinoma cells
    S Buckley
    Developmental Biology, Children s Hospital Los Angeles Research Institute, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 286:L81-6. 2004
    ..Direct overexpression of Smad1 using adenoviral constructs resulted in cell death within 5 days. These studies suggest that BMP4 pathway signaling can induce senescence and thus negatively regulate the growth of A549 lung cancer cells...
  24. ncbi request reprint Inhibition of transforming growth factor-beta type II receptor signaling accelerates tooth formation in mouse first branchial arch explants
    Y Chai
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mech Dev 86:63-74. 1999
    ....
  25. ncbi request reprint Migration and gelatinases in cultured fetal, adult, and hyperoxic alveolar epithelial cells
    S Buckley
    Developmental Biology, Childrens Hospital Los Angeles Research Institute, Los Angeles, California 90027, USA
    Am J Physiol Lung Cell Mol Physiol 281:L427-34. 2001
    ....
  26. ncbi request reprint Smad7 is a TGF-beta-inducible attenuator of Smad2/3-mediated inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Mech Dev 93:71-81. 2000
    ..The optimization of TGF-beta signaling during early lung development therefore requires a finely-regulated competitive balance between both permissive and inhibitory members of the Smad family...
  27. ncbi request reprint Smad7 and Smad6 differentially modulate transforming growth factor beta -induced inhibition of embryonic lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 275:23992-7. 2000
    ....
  28. ncbi request reprint Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse
    R C Burns
    Division of Developmental Biology, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 265:61-74. 2004
    ..Thus, FGF10 signaling via FGFR2b appears to be critical in the extension of the epithelium into the mesenchyme during cecal development...
  29. ncbi request reprint A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway
    T J Fairbanks
    Developmental Biology Program, Children s Hospital Los Angeles, 4650 Sunset Boulevard, Smith Research Tower 804, Mail stop 100, Los Angeles, CA 90027, USA
    J Surg Res 120:201-9. 2004
    ..Fgf10 is known to serve a key role in budding morphogenesis; however, little is known about its role in the development of this transitional structure. Here we evaluate the effect of Fgf10/Fgfr2b invalidation on the developing cecum...
  30. ncbi request reprint Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar St, CSA 103, Los Angeles, California, 90033, USA
    Dev Biol 232:204-18. 2001
    ....
  31. ncbi request reprint Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, Department of Surgery, Childrens Hospital Los Angeles Research Institute, University of Southern California School of Dentistry, Los Angeles 90033, USA
    Am J Physiol 277:L412-22. 1999
    ....
  32. ncbi request reprint Novel mechanisms in murine nitrofen-induced pulmonary hypoplasia: FGF-10 rescue in culture
    J M Acosta
    Division of Pediatric Surgery and Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    Am J Physiol Lung Cell Mol Physiol 281:L250-7. 2001
    ..Exogenous FGF-10 not only stimulates FGF signaling, marked by increased mSpry2 expression, in both nitrofen-treated and control lungs but also substantially rescues nitrofen-induced lung hypoplasia in culture...
  33. doi request reprint TGF-beta signaling promotes survival and repair in rat alveolar epithelial type 2 cells during recovery after hyperoxic injury
    S Buckley
    Developmental Biology and Regenerative Medicine and Surgery Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 294:L739-48. 2008
    ....
  34. ncbi request reprint Abrogation of transforming growth factor-beta type II receptor stimulates embryonic mouse lung branching morphogenesis in culture
    J Zhao
    Department of Surgery, Pediatrics, and Cardiothoracic Surgery, Childrens Hospital, Los Angeles Research Institute, California, USA
    Dev Biol 180:242-57. 1996
    ....
  35. ncbi request reprint Abrogation of tumor necrosis factor-alpha converting enzyme inhibits embryonic lung morphogenesis in culture
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles 90033, USA
    Int J Dev Biol 45:623-31. 2001
    ....
  36. ncbi request reprint Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages
    C W Wuenschell
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, USA
    J Histochem Cytochem 44:113-23. 1996
    ..This transient expression in progenitor cells of gene products characteristic of diverse differentiated cell types may reflect an underlying mechanism of gene regulation...
  37. ncbi request reprint Nongenomic estrogen action in human lung myofibroblasts
    G Flores-Delgado
    Developmental Biology Program, University of Southern California, Los Angeles, California, 90027, USA
    Biochem Biophys Res Commun 283:661-7. 2001
    ....
  38. pmc Overexpression of transforming growth factor-beta1 in fetal monkey lung results in prenatal pulmonary fibrosis
    A F Tarantal
    Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases, California National Primate Research Center and Dept of Pediatrics, School of Medicine, University of California, Davis, CA, USA
    Eur Respir J 36:907-14. 2010
    ..Therefore, overexpression of TGF-β1 within developing fetal monkey lung results in severe and progressive fibrosis in lung parenchyma and pleural membrane, in addition to pulmonary hypoplasia...
  39. ncbi request reprint mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins
    D Tefft
    Center for Craniofacial Biology, Department of Surgery, and the Developmental Biology Program, The Childrens Hospital Los Angeles Research Institute, University of Southern California Schools of Dentistry and Medicine, 90023, USA
    Am J Physiol Lung Cell Mol Physiol 283:L700-6. 2002
    ..Our data demonstrate novel intracellular mechanisms mediating mSpry2 function as a negative regulator of uncontrolled FGF-induced MAP kinase signaling...
  40. ncbi request reprint Smad1 expression and function during mouse embryonic lung branching morphogenesis
    Cheng Chen
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1033-9. 2005
    ..Therefore, these data indicate that Smad1, acting as an intracellular BMP signaling pathway component, positively regulates early mouse embryonic lung branching morphogenesis...
  41. ncbi request reprint VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis
    Pierre Marie del Moral
    Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, Department of Pediatric Surgery, USC Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Dev Biol 290:177-88. 2006
    ..These results demonstrate that the VEGF pathway is involved in driving epithelial to endothelial crosstalk in embryonic mouse lung morphogenesis...
  42. ncbi request reprint Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture
    J Zhao
    Department of Surgery, Children s Hospital Los Angeles Research Institute, University of Southern California Schools of Dentistry and Medicine, Los Angeles 90033, USA
    Dev Biol 194:182-95. 1998
    ....
  43. ncbi request reprint In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling
    S Buckley
    Developmental Biology, Saban Research Institute, Children s Hospital of Los Angeles, Los Angeles, California 90027, USA
    Am J Physiol Lung Cell Mol Physiol 288:L569-75. 2005
    ..Thus inosine may deserve further evaluation for its potential to reduce hyperoxic damage to the pulmonary alveolar epithelium...
  44. pmc Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages
    Gianni Carraro
    Developmental Biology, Regenerative Medicine and Surgery Program, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine and School of Dentistry, Los Angeles, California 90027, USA
    Stem Cells 26:2902-11. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  45. ncbi request reprint A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function
    J Liu
    Developmental Biology Program, Division of Pediatric Surgery, Childrens Hospital Los Angeles, University of Southern California, Keek School of Medicine, 4650 Sunset Boulevard, Los Angeles, California 90027, USA
    Biochem Biophys Res Commun 273:1042-7. 2000
    ....
  46. pmc Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation
    Jianping Sun
    Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Pathol 172:571-82. 2008
    ..Therefore, our data suggest that deficiency of appropriate BMP signaling in lung epithelial cells results in prenatal lung malformation, neonatal atelectasis, and respiratory failure...
  47. ncbi request reprint Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, Saban Research Institute of Childrens Hospital Los Angeles, CA 90027, USA
    Dev Biol 299:52-62. 2006
    ..Our work unravels part of the complex interactions that govern normal lung development and may be pertinent to understanding the basis of respiratory defects in Apert syndrome...
  48. ncbi request reprint Dynamics of metalloproteinase-2 and -9, TGF-beta, and uPA activities during normoxic vs. hyperoxic alveolarization
    S Buckley
    Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, California 90027, USA
    Am J Physiol Lung Cell Mol Physiol 283:L747-54. 2002
    ..The developmental profile of neonatal lung was perturbed within a day of initiating oxygen treatment, suggesting that putative palliative treatments should be coadministered with oxygen therapy...
  49. ncbi request reprint Endothelial monocyte activating polypeptide II inhibits lung neovascularization and airway epithelial morphogenesis
    M A Schwarz
    Department of Pediatrics, Children s Hospital Research Institute, Los Angeles, CA 90027, USA
    Mech Dev 95:123-32. 2000
    ..These studies demonstrate that EMAP II negatively modulates lung neovascularization as well as leading to the arrest of lung airway epithelial morphogenesis and apoptosis...
  50. ncbi request reprint Renal differentiation of amniotic fluid stem cells
    L Perin
    Childrens Hospital Los Angeles, Saban Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Cell Prolif 40:936-48. 2007
    ..We show that these pluripotent cells can develop and differentiate into de novo kidney structures during organogenesis in vitro...
  51. ncbi request reprint Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    V Kaartinen
    Department of Pathology, Childrens Hospital of Los Angeles Research Institute, California 90027, USA
    Nat Genet 11:415-21. 1995
    ..This study demonstrates an essential function for TGF-beta 3 in the normal morphogenesis of palate and lung, and directly implicates this cytokine in mechanisms of epithelial-mesenchymal interaction...
  52. ncbi request reprint Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
    Dev Dyn 211:11-25. 1998
    ..We present an epigenetic model of information processing related to cell proliferation. The model is a dynamical network that uses continuous logic to learn its rules from changing conditions...
  53. ncbi request reprint Prenatal exposure to nitrofen induces Fryns phenotype in mice
    J M Acosta
    Division of Pediatric Surgery, Plastic Surgery, Childrens Hospital Los Angeles Research Institute, CA 90027, USA
    Ann Plast Surg 46:635-40. 2001
    ..The authors propose that prenatal exposure to nitrofen induces a Fryns phenotype in mice, and thus speculate that nitrofen may target similar molecular mechanisms to those that lead to Fryns syndrome...
  54. ncbi request reprint Current concepts on lung development
    D Warburton
    Childrens Hospital Los Angeles Research Institute, CA 90027, USA
    Curr Opin Pediatr 11:188-92. 1999
    ..These new contributions represent substantial advances toward a comprehensive molecular model of pulmonary development...
  55. ncbi request reprint Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung
    Pierre Marie del Moral
    Developmental Biology Program, Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 293:77-89. 2006
    ..Our work shows for the first time that FGF9 acts on the epithelium involving FGFR2b to control its proliferation but not its differentiation and contributes to the regulation of canonical Wnt signaling in the epithelium...
  56. pmc Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
    Suresh K Ramasamy
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 307:237-47. 2007
    ..Thus, our results indicate that FGF10 plays a pivotal role in maintaining epithelial progenitor cell proliferation as well as coordinating alveolar smooth muscle cell formation and vascular development...
  57. ncbi request reprint Bradykinin B1 receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts
    S B Phagoo
    Developmental Biology Program, Department of Surgery, Childrens Hospital Los Angeles Research Institute, Los Angeles, California 90027, USA
    J Pharmacol Exp Ther 298:77-85. 2001
    ..Thus, kinins may exert a pivotal role in maintaining and modulating feed-forward inflammatory processes in the lung...
  58. ncbi request reprint Bioactive transforming growth factor-beta in the lungs of extremely low birthweight neonates predicts the need for home oxygen supplementation
    C Lecart
    Division of Neonatology, Department of Pediatrics, Women s and Children s Hospital, LAC USC Medical Center, Los Angeles, CA 90033, USA
    Biol Neonate 77:217-23. 2000
    ..We conclude that abundant BA- TGF-beta is present in the lungs of preterm infants and speculate that it may be involved in inflammatory and repair processes encountered in acute and chronic lung disease...
  59. ncbi request reprint Laminin 2 attachment selects myofibroblasts from fetal mouse lung
    G Flores-Delgado
    Department of Pediatric Surgery, Children s Hospital Los Angeles Research Institute, University of Southern California Schools of Dentistry and Medicine, Los Angeles, CA 90033, USA
    Am J Physiol 275:L622-30. 1998
    ..These findings lead us to speculate that LN2 may play a key role in the cell biology of myofibroblasts during lung development...
  60. pmc Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha
    Wei Ding
    Developmental Biology Program, Saban Research Institute Childrens Hospital Los Angeles, 4650 Sunset Boulevard, MS 35, Los Angeles, CA 90027, USA
    Biochem Biophys Res Commun 375:460-4. 2008
    ..To our knowledge, this study is the first that reported the association of Spry2 with TNF-alpha signaling pathway...
  61. ncbi request reprint A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis
    Denise Tefft
    Developmental Biology Program, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 282:422-31. 2005
    ..Our results show that the protein tyrosine phosphatase Shp2 plays an essential role in modulating growth factor mediated tyrosine kinase receptor activation in early embryonic lung branching morphogenesis...
  62. ncbi request reprint Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice
    Jingsong Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, California 90033, USA
    Am J Physiol Lung Cell Mol Physiol 282:L585-93. 2002
    ..These results show that Smad3 contributes to bleomycin-induced lung injury and that Smad3 may serve as a novel target for potential therapeutic treatment of lung fibrosis...
  63. ncbi request reprint Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema
    Hui Chen
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Am J Physiol Lung Cell Mol Physiol 288:L683-91. 2005
    ..Therefore, these results indicate that Smad3 not only has a positive regulatory impact on neonatal lung alveolarization but also potentially plays a protective role against the occurrence of centrilobular emphysema later on in life...
  64. pmc When the lung is stretched, could it be thrombospondin via TGFbeta1 peptide activation?
    David Warburton
    Developmental Biology and Regenerative Medicine Program, Saban Reasearch Institute, Children s Hospital Los AAngeles, Keck School of Dentistry, University of Southern California, Los Angeles, CA 90027, USA
    J Physiol 584:365. 2007
  65. pmc TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
    Matt K Lee
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA 90033, USA
    EMBO J 26:3957-67. 2007
    ..Thus, TbetaRI, like the TGF-beta type II receptor, is a dual-specificity kinase. Recruitment of tyrosine kinase signalling pathways may account for aspects of TGF-beta biology that are independent of Smad signalling...
  66. doi request reprint The human gamma-glutamyltransferase gene family
    Nora Heisterkamp
    Division of Hematology Oncology, The Saban Research Institute of Childrens Hospital, Los Angeles, CA 90027, USA
    Hum Genet 123:321-32. 2008
    ..In view of the widespread clinical use of assays that measure gamma-glutamyl transfer activity, this would appear to be of significant interest...
  67. pmc TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
    Nian Ling Zhu
    University of Southern California, Keck School of Medicine, Department of Pediatrics, Division of Neonatal Medicine, Los Angeles, CA 90033, United States
    Gene 393:70-80. 2007
    ..These findings provide a mechanistic paradigm for interactions between mediators of inflammation and morphogenesis with relevant implications for normal lung development and pathogenesis of disease...
  68. ncbi request reprint Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells
    Wei Ding
    Developmental Biology Program, Childrens Hospital Los Angeles Saban Research Institute, Los Angeles, CA 90027, USA
    J Cell Physiol 212:796-806. 2007
    ..Together, the combined operation of transcriptional and post-translational mechanisms suggests that regulation of Spry2 is a crucial event and emphasizes the important role that Spry2 plays in controlling cell behaviors...
  69. ncbi request reprint Murine nitrofen-induced pulmonary hypoplasia does not involve induction of TGF-beta signaling
    Michael J Leinwand
    Division of Pediatric Surgery, Childrens Hospital Los Angeles Research Institute and Center for Craniofacial and Molecular Biology, University of Southern California Schools of Medicine and Dentistry, Los Angeles, CA, USA
    J Pediatr Surg 37:1123-7. 2002
    ..Therefore, abrogation of TGF-beta signaling might rescue the hypoplasia...
  70. ncbi request reprint Nongenomic estrogen action regulates tyrosine phosphatase activity and tuberin stability
    Guillermo Flores-Delgado
    Department of Surgery and the Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, University of Southern California, 4650, Sunset Blvd MS 35, 90027, USA
    Mol Cell Endocrinol 199:143-51. 2003
    ....
  71. pmc Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
    Development 138:1395-407. 2011
    ..Indeed, genetic activation of Notch partially rescues Eya1(-/-) lung epithelial defects. These findings uncover novel functions for Eya1 as a crucial regulator of the complex behavior of distal embryonic lung epithelium...
  72. ncbi request reprint Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins
    Wei Shi
    Developmental Biology Program, Department of Surgery, Children s Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 286:L293-300. 2004
    ..Thus overexpression of Smurf1 specifically promotes Smad1 and Smad5 ubiquitination and degradation in embryonic lung epithelium, thereby modulating the effects of BMP4 on embryonic lung growth...
  73. ncbi request reprint Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis
    Wei Ding
    Developmental Biology Program, Saban Research Institute, Childrens Hospital Los Angeles, and Department of Pediatric Surgery, University of Southern California Keck School of Medicine and School of Dentistry, 90027, USA
    Am J Physiol Lung Cell Mol Physiol 287:L52-9. 2004
    ..Homology analysis further showed that the core promoter region of the hSpry4 gene exhibits significant similarity to the 5'-flanking region of the mouse gene...
  74. pmc Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation
    Pierre Marie del Moral
    Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Methods Mol Biol 633:71-9. 2010
    ..g., epithelial and mesenchymal separation) and microbead studies...
  75. pmc Lung organogenesis
    David Warburton
    The Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, USA
    Curr Top Dev Biol 90:73-158. 2010
    ....
  76. ncbi request reprint Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling
    Stephen B Phagoo
    Developmental Biology Program, Saban Research Institute, Childrens Hospital Los Angeles, Department of Surgery, Keck School of Medicine, University of Southern California, 90027, USA
    J Pharmacol Exp Ther 313:1231-8. 2005
    ..cen. positively modulates the selective expression of B(1)R. Thus, providing evidence that B(1)R regulation may be an important and novel mechanism in the inflammatory cascade in response to chronic pulmonary infection and disease...
  77. pmc Development, repair and fibrosis: what is common and why it matters
    Wei Shi
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Respirology 14:656-65. 2009
    ..This leads us to propose the 'Goldilocks' hypothesis of regulatory signaling in lung development and injury repair that everything must be done just right!..
  78. pmc miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution
    Gianni Carraro
    Developmental Biology, Regenerative Medicine and Surgery Program, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine and School of Dentistry, Los Angeles, CA 90027, USA
    Dev Biol 333:238-50. 2009
    ....
  79. pmc Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis
    Laura Perin
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9357. 2010
    ..We therefore speculate that AFSC could represent a novel source of stem cells that may function to modulate the kidney immune milieu in renal failure caused by ATN...
  80. ncbi request reprint The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia
    Timothy J Fairbanks
    Developmental Biology Program, Division of Pediatric Surgery, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Pediatr Surg 41:132-6; discussion 132-6. 2006
    ..Fgfr2b invalidation results in an autosomal recessive intestinal atresia phenotype. This study evaluates the role of Fgfr2b signaling in regulating proliferation and apoptosis in the pathogenesis of intestinal atresia...
  81. ncbi request reprint BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction
    Jianping Sun
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    J Biol Chem 281:29349-56. 2006
    ..Similar regulatory mechanisms may be utilized by other DAN family proteins...
  82. ncbi request reprint Meeting report: the first international collaborative symposium on stem cell research, Seoul, Korea
    David Warburton
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital Los Angeles and University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Stem Cells 25:1337-8. 2007
  83. ncbi request reprint Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung
    Stijn P De Langhe
    Developmental Biology Program, Department of Surgery, USC Keck School of Medicine and the Saban Research Institute of Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 277:316-31. 2005
    ..DKK1-induced morphogenetic defects can be mimicked by inhibition of FN and overcome by addition of exogenous FN, suggesting an involvement of FN in Wnt-regulated morphogenetic processes...
  84. ncbi request reprint Functional analysis of the human Sprouty2 gene promoter
    Wei Ding
    Childrens Hospital Los Angeles Research Institute, Department of Pediatric Surgery, USC Keck School of Medicine, Los Angeles, CA 90027, USA
    Gene 322:175-85. 2003
    ..To our knowledge, this is the first promoter study of any mammalian Sprouty gene. We propose that the high-level basal expression of hSpry2 is controlled by multiple transcription factors binding to its proximal promoter...
  85. ncbi request reprint TACE is required for fetal murine cardiac development and modeling
    Wei Shi
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar St, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 261:371-80. 2003
    ..The data suggest that TACE-mediated cell surface protein ectodomain shedding plays an essential and a novel regulatory role during cardiac development and modeling...
  86. ncbi request reprint Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells
    Raghava Reddy
    Childrens Hospital Los Angeles Research Institute, Smith Research Towe, MS 35, 4650 Sunset Blvd, Los Angeles, CA 90027, USA
    Am J Physiol Lung Cell Mol Physiol 286:L658-67. 2004
    ....
  87. ncbi request reprint Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia
    Timothy J Fairbanks
    Developmental Biology Program, Division of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Pediatr Surg 39:872-4. 2004
    ..This study shows the key role of Fgfr2b in normal duodenal development and the pathogenesis of DA...
  88. pmc Genes and signals regulating murine trophoblast cell development
    Ahmed H K El-Hashash
    Developmental Biology, Saban Research Institute, Children s Hospital Los Angeles, Keck School of Medicine of University of Southern California, Los Angeles, CA 90027, USA
    Mech Dev 127:1-20. 2010
    ..In particular, we discuss the molecular aspects of murine TGC differentiation. We also focus on the role of growth and transcription factors in TGC development...
  89. pmc Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice
    Varsha V Gupte
    Division of Surgery, Saban Research Institute of Children s Hospital Los Angeles, University of Southern California, Keck School of Medicine, Los Angeles, CA 90027, USA
    Am J Respir Crit Care Med 180:424-36. 2009
    ..Fibroblast growth factor-10 (FGF10) controls survival, proliferation, and differentiation of distal-alveolar epithelial progenitor cells during lung development...
  90. pmc Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications
    Stefano DA Sacco
    Division of Urology, Laboratory for Organ Regenerative Research and Cell Therapeutics, Saban Research Institute, Children s Hospital Los Angeles and Developmental Biology Program, Keck School of Medicine, University of Southern California, Los Angeles, California 90027, USA
    J Urol 183:1193-200. 2010
    ..Human amniotic fluid contains multiple cell types, including pluripotent and committed progenitor cells, and fully differentiated cells. We characterized various cell populations in amniotic fluid...
  91. ncbi request reprint Lung development and adult lung diseases
    Wei Shi
    Developmental Biology Program, Saban Research Institute, Children s Hospital Los Angeles, 4650 Sunset Blvd MS35, Los Angeles, CA 90027, USA
    Chest 132:651-6. 2007
    ..Subtle abnormalities of lung structure and function are found in clinically asymptomatic CF infants. Finally, airway remodeling due to chronic inflammation is important in infants who later acquire asthma...
  92. ncbi request reprint Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis
    D Warburton
    Division of Neonatology and Pediatric Pulmonology, Childrens Hospital Los Angeles, California 90027
    Dev Biol 149:123-33. 1992
    ..We speculate that the peptide growth factor EGF serves a function in secondary embryonic morphogenetic inductions, which may be modulated by interaction with other growth factors...
  93. ncbi request reprint Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice
    Timothy J Fairbanks
    Developmental Biology Program, Division of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Pediatr Surg 39:360-5; discussion 360-5. 2004
    ..The authors therefore hypothesized that Fgf10 signaling has a central role in normal anorectal development...
  94. ncbi request reprint Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase
    Krisanavane Reddi
    Developmental Biology Program, Childrens Hospital, Los Angeles Research Institute, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA
    Pediatr Res 54:297-305. 2003
    ..In conclusion, B. cepacia-induced IL-8 secretion in A549 airway epithelial cells is more potent than P. aeruginosa; is mediated through LPS, which is CD14 dependent; and involves activation of the p38 and ERK MAPK pathways...
  95. ncbi request reprint Stem/progenitor cells in lung morphogenesis, repair, and regeneration
    David Warburton
    Developmental Biology Program, Saban Research Institute, Childrens Hospital Los Angeles, Los Angeles, California 90027, USA
    Curr Top Dev Biol 64:1-16. 2004
  96. ncbi request reprint Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse
    Michael J Leinwand
    Division of Pediatric Surgery and Developmental Biology Program, Childrens Hospital Los Angeles Research Institute, Los Angeles, CA, USA
    J Pediatr Surg 37:1263-8. 2002
    ..Using the murine nitrofen-induced model of CDH, the authors evaluated lung growth and development before diaphragm closure or herniation...
  97. ncbi request reprint Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction
    Wai Yee Li
    Department of Surgery, The Saban Research Institute of Childrens Hospital, Los Angeles, California 90027, USA
    Wound Repair Regen 14:516-25. 2006
    ..These findings provide a further avenue for the interactive role of TGF-beta3 and PAI-1 during fetal scarless repair...
  98. pmc O-GlcNAc mediated glycosylation down-regulation in mice with cyclophosphamide induced cystitis
    Seyung Chung
    Developmental Biology, Regenerative Medicine and Surgery Program, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California, USA
    J Urol 183:351-6. 2010
    ..We determined the effect of cyclophosphamide induced cystitis on O-GlcNAc mediated glycosylation in the bladder...
  99. ncbi request reprint Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway
    Timothy J Fairbanks
    Department of Pediatric Surgery, Developmental Biology Program, Children s Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Pediatr Surg 40:390-6. 2005
    ..Classically, disturbance of the mesenteric vasculature has been thought to cause many forms of intestinal atresia. The purpose of this study was to evaluate the role of vascular occlusion in the pathogenesis of colonic atresia...
  100. pmc Bcr and Abr cooperate in negatively regulating acute inflammatory responses
    Jess M Cunnick
    Division of Hematology Oncology, Saban Research Institute of Childrens Hospital, Los Angeles, CA 90027, USA
    Mol Cell Biol 29:5742-50. 2009
    ..These data show that Abr and Bcr normally curb very specific functions of mature tissue innate immune cells, and that each protein has distinct as well as partly overlapping functions in the downregulation of inflammatory processes...
  101. ncbi request reprint Fibroblast growth factor-10 serves a regulatory role in duodenal development
    Robert C Kanard
    Department of Pediatric Surgery, Developmental Biology Program, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Saban Research Building 524, Mail stop 100, Los Angeles, CA 90027, USA
    J Pediatr Surg 40:313-6. 2005
    ..The authors hypothesized that Fgf10 could serve a regulatory role in establishing normal duodenal development...

Research Grants44

  1. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  2. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2006
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  3. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2005
    ..abstract_text> ..
  4. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  5. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  6. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2004
    ....
  7. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2003
    ..abstract_text> ..
  8. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2003
    ....
  9. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2003
    ....
  10. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2002
    ....
  11. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  12. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2006
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  13. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  14. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2009
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  15. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  16. Molecular Basis of Lung Morphogenesis Injury & Repair
    David Warburton; Fiscal Year: 2007
    ..Project 3. Derynck. Non-Smad mechanisms of TGFB signaling Project 4. Groffen. Negative regulation of lung inflammation by Abr/Bcr. Project 5. Bellusci. FGFR2b pathway in Bronchopulmonary Dysplasia. ..
  17. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2007
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  18. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2007
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  19. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2002
    ....
  20. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2001
    ....
  21. AUTOCRINE/ PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 1993
    ....
  22. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 1999
    ..Clinical relevance: To provide the basis for novel therapeutic approaches to lung development, lung injury repair, and prevention or treatment of lung cancer. ..
  23. AUROCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 1999
    ....
  24. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2001
    ....
  25. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2001
    ....
  26. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2000
    ....
  27. AUTOCRINE/ PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 1992
    ....
  28. AUTOCRINE/ PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 1991
    ....
  29. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 1993
    ..This will lead to novel molecular strategies for the prevention and treatment of both the neonatal and adult forms of respiratory distress syndrome...
  30. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 1992
    ..This will lead to novel molecular strategies for the prevention and treatment of both the neonatal and adult forms of respiratory distress syndrome...
  31. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 1991
    ..This will lead to novel molecular strategies for the prevention and treatment of both the neonatal and adult forms of respiratory distress syndrome...
  32. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2000
    ....