Zefeng Wang

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Splicing regulation: from a parts list of regulatory elements to an integrated splicing code
    Zefeng Wang
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    RNA 14:802-13. 2008
  2. pmc A complex network of factors with overlapping affinities represses splicing through intronic elements
    Yang Wang
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Nat Struct Mol Biol 20:36-45. 2013
  3. pmc Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules
    Yang Wang
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Struct Mol Biol 19:1044-52. 2012
  4. pmc Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders
    Hu Zhu
    Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e43227. 2012
  5. pmc Engineering splicing factors with designed specificities
    Yang Wang
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Methods 6:825-30. 2009
  6. pmc Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains
    Shuyun Dong
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:26732-42. 2011
  7. pmc Engineered proteins with Pumilio/fem-3 mRNA binding factor scaffold to manipulate RNA metabolism
    Yang Wang
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA
    FEBS J 280:3755-67. 2013
  8. pmc Engineering RNA endonucleases with customized sequence specificities
    Rajarshi Choudhury
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Commun 3:1147. 2012
  9. pmc Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method
    Atheir I Abbas
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Nucleic Acids Res 38:e118. 2010
  10. pmc Coevolutionary networks of splicing cis-regulatory elements
    Xinshu Xiao
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:18583-8. 2007

Collaborators

  • Gene Yeo
  • Xinshu Xiao
  • Traci M Tanaka Hall
  • Gang Lu
  • C B Burge
  • Yang Wang
  • Rajarshi Choudhury
  • Meng Ma
  • Hu Zhu
  • Bryan L Roth
  • Shuyun Dong
  • Daniel J Urban
  • Wesley K Kroeze
  • Piotr Mieczkowski
  • Atheir I Abbas
  • James C Morris
  • Traci M Tanaka Hall
  • Alex Robertson
  • Jianming Zhang
  • Kai Li
  • Jared Blashka
  • Craig A Stockmeier
  • Daniel Dominguez
  • George J Jurjus
  • Gouri J Mahajan
  • Yihsuan S Tsai
  • Grazyna Rajkowska
  • Patrick F Sullivan
  • James C Overholser
  • Matthew T McPheeters
  • Lesa Dieter
  • Chunhua Li
  • Mark R Jezyk
  • Caleb Cassidy-Amstutz
  • Rebecca Bigler
  • Niels H Jensen
  • Martilias S Farrell
  • Cheom Gil Cheong
  • Mark E Drew
  • Paul T Englund

Detail Information

Publications13

  1. pmc Splicing regulation: from a parts list of regulatory elements to an integrated splicing code
    Zefeng Wang
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    RNA 14:802-13. 2008
    ..Here, we summarize the current state of knowledge of splicing cis-regulatory elements and their context-dependent effects on splicing, emphasizing recent global/genome-wide studies and open questions...
  2. pmc A complex network of factors with overlapping affinities represses splicing through intronic elements
    Yang Wang
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    Nat Struct Mol Biol 20:36-45. 2013
    ..This arrangement enables individual cis elements to function differently in distinct cellular contexts, depending on the spectrum of regulatory factors present...
  3. pmc Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules
    Yang Wang
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Struct Mol Biol 19:1044-52. 2012
    ..We provide a comprehensive picture of general ISE activities and suggest new models of how single elements can function oppositely, depending on locations and binding factors...
  4. pmc Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders
    Hu Zhu
    Department of Pharmacology, University of North Carolina Chapel Hill Medical School, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e43227. 2012
    ....
  5. pmc Engineering splicing factors with designed specificities
    Yang Wang
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Methods 6:825-30. 2009
    ..Our approach permitted the creation of artificial factors to target virtually any pre-mRNA, providing a strategy to study splicing regulation and to manipulate disease-associated splicing events...
  6. pmc Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains
    Shuyun Dong
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:26732-42. 2011
    ..This work deepens our understanding of natural PUF protein target recognition and expands the ability to engineer PUF domains to recognize any RNA sequence...
  7. pmc Engineered proteins with Pumilio/fem-3 mRNA binding factor scaffold to manipulate RNA metabolism
    Yang Wang
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA
    FEBS J 280:3755-67. 2013
    ..We summarize the advances made with respect to developing RNA regulatory tools, as well as opportunities for the future. ..
  8. pmc Engineering RNA endonucleases with customized sequence specificities
    Rajarshi Choudhury
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Commun 3:1147. 2012
    ....
  9. pmc Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method
    Atheir I Abbas
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Nucleic Acids Res 38:e118. 2010
    ....
  10. pmc Coevolutionary networks of splicing cis-regulatory elements
    Xinshu Xiao
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:18583-8. 2007
    ..Thus, the splicing elements defining exons coevolve in a way that preserves overall exon strength, allowing specific elements to substitute for loss or weakening of others...
  11. pmc General and specific functions of exonic splicing silencers in splicing control
    Zefeng Wang
    Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Mol Cell 23:61-70. 2006
    ..Together, our findings provide a comprehensive picture of the functions of ESSs in the control of diverse types of splicing decisions...
  12. ncbi request reprint Systematic identification and analysis of exonic splicing silencers
    Zefeng Wang
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 119:831-45. 2004
    ..ExonScan and related bioinformatic analyses suggest that these ESS motifs play important roles in suppression of pseudoexons, in splice site definition, and in AS...
  13. pmc Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library
    James C Morris
    Department of Biological Chemistry, Johns Hopkins Medical School, 725 N Wolfe Street, Baltimore, MD 21205, USA
    EMBO J 21:4429-38. 2002
    ..These data suggest that T.brucei 'senses' changes in glucose level and modulates procyclin expression accordingly...