Ze Wang

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx
    Ze Wang
    Center for Functional Neuroimaging and Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 26:261-9. 2008
  2. pmc Resting state brain function analysis using concurrent BOLD in ASL perfusion fMRI
    Senhua Zhu
    Department of Psychology, Sun Yat Sen University, Guangzhou, Guangdong, China
    PLoS ONE 8:e65884. 2013
  3. pmc Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow
    Zhengjun Li
    Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 7:e44556. 2012
  4. pmc Improving cerebral blood flow quantification for arterial spin labeled perfusion MRI by removing residual motion artifacts and global signal fluctuations
    Ze Wang
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 30:1409-15. 2012
  5. pmc Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI
    Ze Wang
    Center for Functional Neuroimaging, Department of Radiology, School of Medicine, University of Pennsylvania, 3400 Spruce St Philadelphia, PA 19104, USA
    Neuroimage 39:973-8. 2008
  6. pmc Neural substrates of abstinence-induced cigarette cravings in chronic smokers
    Ze Wang
    Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:14035-40. 2007
  7. pmc Fixed-point algorithms for constrained ICA and their applications in fMRI data analysis
    Ze Wang
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 29:1288-303. 2011
  8. pmc Nicotine abstinence-induced cerebral blood flow changes by genotype
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Lett 438:275-80. 2008
  9. pmc Function lateralization via measuring coherence laterality
    Ze Wang
    Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
    Neuroimage 47:281-8. 2009
  10. pmc A hybrid SVM-GLM approach for fMRI data analysis
    Ze Wang
    Treatment Research Center, Department of Psychiatry, School of Medicine, University of Pennsylvania, 3900 Chestnut St, Philadelphia, PA 19104, USA
    Neuroimage 46:608-15. 2009

Detail Information

Publications38

  1. pmc Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx
    Ze Wang
    Center for Functional Neuroimaging and Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 26:261-9. 2008
    ..The implementation of all ASL data processing approaches is easily accomplished within an open-source toolbox, ASLtbx, and is advocated for most perfusion fMRI data sets...
  2. pmc Resting state brain function analysis using concurrent BOLD in ASL perfusion fMRI
    Senhua Zhu
    Department of Psychology, Sun Yat Sen University, Guangzhou, Guangdong, China
    PLoS ONE 8:e65884. 2013
    ....
  3. pmc Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow
    Zhengjun Li
    Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 7:e44556. 2012
    ..None of the assessed SBA measures was correlated with whole brain mean CBF. These findings suggest that resting BOLD fMRI-derived measures are coupled with regional CBF and are therefore linked to regional SBA...
  4. pmc Improving cerebral blood flow quantification for arterial spin labeled perfusion MRI by removing residual motion artifacts and global signal fluctuations
    Ze Wang
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 30:1409-15. 2012
    ..Dissemination of the proposed methods in a free ASL data processing toolbox should be of interest to a broad range of ASL users...
  5. pmc Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRI
    Ze Wang
    Center for Functional Neuroimaging, Department of Radiology, School of Medicine, University of Pennsylvania, 3400 Spruce St Philadelphia, PA 19104, USA
    Neuroimage 39:973-8. 2008
    ..These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function...
  6. pmc Neural substrates of abstinence-induced cigarette cravings in chronic smokers
    Ze Wang
    Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:14035-40. 2007
    ..These data suggest that increased activation in the brain's visuospatial and reward circuitry underlies abstinence-induced cravings to smoke, and thereby, may be important in relapse...
  7. pmc Fixed-point algorithms for constrained ICA and their applications in fMRI data analysis
    Ze Wang
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 29:1288-303. 2011
    ..In addition, they were more stable than OCICA and standard ICA for analyzing the sensorimotor fMRI data...
  8. pmc Nicotine abstinence-induced cerebral blood flow changes by genotype
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
    Neurosci Lett 438:275-80. 2008
    ..While preliminary, these results suggest a neural mechanism through which these genetic variants may be linked with nicotine dependence, and provide further support for increased biological vulnerability in these subgroups of smokers...
  9. pmc Function lateralization via measuring coherence laterality
    Ze Wang
    Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
    Neuroimage 47:281-8. 2009
    ....
  10. pmc A hybrid SVM-GLM approach for fMRI data analysis
    Ze Wang
    Treatment Research Center, Department of Psychiatry, School of Medicine, University of Pennsylvania, 3900 Chestnut St, Philadelphia, PA 19104, USA
    Neuroimage 46:608-15. 2009
    ..With real fMRI data, SVM-GLM showed better sensitivity than regular GLM for detecting the sensorimotor activations...
  11. ncbi request reprint Strategies for reducing large fMRI data sets for independent component analysis
    Ze Wang
    Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, 19104, USA
    Magn Reson Imaging 24:591-6. 2006
    ..Real fMRI data were used to evaluate the PC extraction precision, computational expense, and memory usage of the presented methods...
  12. pmc Support vector machine learning-based fMRI data group analysis
    Ze Wang
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 36:1139-51. 2007
    ..Providing inferences on the probability of being activated or deactivated at each voxel, these individual-level PMU-based group analysis methods can be used to threshold the analysis results of GLM RFX, SDM RFX or SDM PMU...
  13. ncbi request reprint 2D partially parallel imaging with k-space surrounding neighbors-based data reconstruction
    Ze Wang
    Center for Functional Neuroimaging and Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 56:1389-96. 2006
    ..Both simulated and in vivo 2D PPI data were used to evaluate the proposed methods...
  14. pmc Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort
    Teresa R Franklin
    Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Addict Biol 16:308-22. 2011
    ..Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs...
  15. pmc Effects of varenicline on smoking cue–triggered neural and craving responses
    Teresa Franklin
    Department of Psychiatry, University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    Arch Gen Psychiatry 68:516-26. 2011
    ....
  16. ncbi request reprint Continuous arterial spin labeling perfusion measurements using single shot 3D GRASE at 3 T
    Maria A Fernandez-Seara
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 54:1241-7. 2005
    ..The method was further improved using parallel imaging techniques to provide increased spatial resolution and better separation of the gray-white matter cerebral blood flow maps...
  17. pmc A VBM study demonstrating 'apparent' effects of a single dose of medication on T1-weighted MRIs
    Teresa R Franklin
    Department of Psychiatry, Center for Studies of Addiction, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Brain Struct Funct 218:97-104. 2013
    ....
  18. pmc Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: a longitudinal perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Center for Studies of Addiction and VA Medical Center, Philadelphia, PA, USA franklin
    Drug Alcohol Depend 117:176-83. 2011
    ..Its mechanism in humans is unknown. Here, we used continuous arterial spin labeled (CASL) perfusion fMRI to examine baclofen's effects on blood flow in the human brain...
  19. pmc Reward-related brain response and craving correlates of marijuana cue exposure: a preliminary study in treatment-seeking marijuana-dependent subjects
    Marina Goldman
    Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Addict Med 7:8-16. 2013
    ....
  20. ncbi request reprint Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cues
    Kimberly A Young
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, and Philadelphia VA Medical Center, Philadelphia, Pennsylvania 19104
    J Neurosci 34:5038-43. 2014
    ..005; cluster corrected at p < 0.05). These results suggest that baclofen may inhibit the earliest type of drug cue-induced motivational processing-that which occurs outside of awareness-before it evolves into a less manageable state. ..
  21. pmc DAT genotype modulates brain and behavioral responses elicited by cigarette cues
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:717-28. 2009
    ..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues...
  22. ncbi request reprint Imaging mesial temporal lobe activation during scene encoding: comparison of fMRI using BOLD and arterial spin labeling
    Maria A Fernandez-Seara
    Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Brain Mapp 28:1391-400. 2007
    ..Future improvements in ASL spatial and temporal resolution would allow the benefits of both approaches to be combined to further enhance the sensitivity for detecting mTL activation during memory encoding...
  23. ncbi request reprint Boost up the detection sensitivity of ASL perfusion fMRI through support vector machine
    Ze Wang
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1006-9. 2006
    ..Evaluations were performed using 7 subjects' fingertapping ASL perfusion fMRI data, yielding similar activation patterns with enhanced sensitivity compared to the standard GLM based group analysis...
  24. ncbi request reprint Wavelet-transformed temporal cerebral blood flow signals during attempted inhibition of cue-induced cocaine craving distinguish prognostic phenotypes
    Shing Chun Benny Lam
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 128:140-7. 2013
    ....
  25. pmc Applications of arterial spin labeled MRI in the brain
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 35:1026-37. 2012
    ..This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care...
  26. ncbi request reprint To smooth or not to smooth? ROC analysis of perfusion fMRI data
    Jiongjiong Wang
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Imaging 23:75-81. 2005
    ..In contrast to the BOLD fMRI, temporal smoothing or filtering reduces the power of perfusion fMRI data analyses whereas spatial smoothing is beneficial to the efficacy of analyses...
  27. pmc Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patients
    Jesse J Suh
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 99:11-7. 2009
    ..In this study, we examined the link between resting rCBF in the PFC and current depressive symptoms in methadone-maintained opiate-dependent (MM) patients with or without major depression...
  28. pmc Neuroimaging, genetics and the treatment of nicotine addiction
    Riju Ray
    Trandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 193:159-69. 2008
    ..The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment...
  29. ncbi request reprint Continuous ASL (CASL) perfusion MRI with an array coil and parallel imaging at 3T
    Ze Wang
    Center for Functional Neuroimaging, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Magn Reson Med 54:732-7. 2005
    ..Such results highlight the potential utility of array coils and parallel imaging in ASL perfusion MRI...
  30. ncbi request reprint Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:2301-9. 2007
    ....
  31. doi request reprint Arterial spin-labeled perfusion MRI in basic and clinical neuroscience
    John A Detre
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Curr Opin Neurol 22:348-55. 2009
    ....
  32. pmc Microvascular perfusion based on arterial spin labeled perfusion MRI as a measure of vascular risk in Alzheimer's disease
    Quan Zhang
    Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China
    J Alzheimers Dis 32:677-87. 2012
    ..Future prospective studies in larger cohorts with optimized ASL MRI protocols will be needed to validate these observations...
  33. ncbi request reprint Improved data reconstruction method for GRAPPA
    Ze Wang
    Center for Functional Neuroimaging, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 54:738-42. 2005
    ..Both simulations and in vivo experiments demonstrated that the proposed method yields higher-quality data reconstruction than the original GRAPPA method, especially with high acceleration factors...
  34. doi request reprint Brain entropy mapping using fMRI
    Ze Wang
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e89948. 2014
    ..These findings suggest BEN mapping as a physiologically and functionally meaningful measure for studying brain functions. ..
  35. pmc Prelude to passion: limbic activation by "unseen" drug and sexual cues
    Anna Rose Childress
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e1506. 2008
    ..conscious recognition? Can the brain response to "unseen" reward cues predict the future affective response to recognizable versions of such cues, revealing a link between affective/motivational processes inside and outside awareness?..
  36. pmc Narrative speech production: an fMRI study using continuous arterial spin labeling
    Vanessa Troiani
    Department of Neurology 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Neuroimage 40:932-9. 2008
    ..We conclude that inferior frontal cortex serves as a top-down organizational resource for narrative production and demonstrate the feasibility of collecting extended speech samples using CASL perfusion fMRI...
  37. ncbi request reprint [Prediction of drug bioavailability by genetic algorithm and artificial neural network]
    Ze Wang
    School of Mechanical Engineering, Jiangsu University, Zhenjiang 212013, China
    Yao Xue Xue Bao 41:1180-3. 2006
    ..To set up an artificial neural network system and optimize by genetic algorithm (GA) to predict drug bioavailability...

Research Grants1

  1. SVM based group data analysis for drug abuse disorder ASL perfusion study
    Ze Wang; Fiscal Year: 2007
    ..The output of these more powerful ASL data analysis methods will also pave the way for general application of ASL perfusion fMRI methods across multiple brain disorders, and for sustained states within the normal brain. ..