Research Topics
Genomes and GenesSpecies | Ze WangSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbxZe Wang
Center for Functional Neuroimaging and Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 26:261-9. 2008..The implementation of all ASL data processing approaches is easily accomplished within an open-source toolbox, ASLtbx, and is advocated for most perfusion fMRI data sets...- Improving cerebral blood flow quantification for arterial spin labeled perfusion MRI by removing residual motion artifacts and global signal fluctuationsZe Wang
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 30:1409-15. 2012..Dissemination of the proposed methods in a free ASL data processing toolbox should be of interest to a broad range of ASL users... - Nicotine abstinence-induced cerebral blood flow changes by genotypeZe Wang
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, United States
Neurosci Lett 438:275-80. 2008..While preliminary, these results suggest a neural mechanism through which these genetic variants may be linked with nicotine dependence, and provide further support for increased biological vulnerability in these subgroups of smokers... - Function lateralization via measuring coherence lateralityZe Wang
Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia PA 19104, USA
Neuroimage 47:281-8. 2009.... - Support vector machine learning-based fMRI data group analysisZe Wang
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Neuroimage 36:1139-51. 2007..Providing inferences on the probability of being activated or deactivated at each voxel, these individual-level PMU-based group analysis methods can be used to threshold the analysis results of GLM RFX, SDM RFX or SDM PMU... - Assessment of functional development in normal infant brain using arterial spin labeled perfusion MRIZe Wang
Center for Functional Neuroimaging, Department of Radiology, School of Medicine, University of Pennsylvania, 3400 Spruce St Philadelphia, PA 19104, USA
Neuroimage 39:973-8. 2008..These results are consistent with current understanding of infant brain development and demonstrate the feasibility of using perfusion MRI to noninvasively monitor developing brain function... - Fixed-point algorithms for constrained ICA and their applications in fMRI data analysisZe Wang
Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 29:1288-303. 2011..In addition, they were more stable than OCICA and standard ICA for analyzing the sensorimotor fMRI data... 
2D partially parallel imaging with k-space surrounding neighbors-based data reconstructionZe Wang
Center for Functional Neuroimaging and Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 56:1389-96. 2006..Both simulated and in vivo 2D PPI data were used to evaluate the proposed methods...- Strategies for reducing large fMRI data sets for independent component analysisZe Wang
Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, 19104, USA
Magn Reson Imaging 24:591-6. 2006..Real fMRI data were used to evaluate the PC extraction precision, computational expense, and memory usage of the presented methods... - Neural substrates of abstinence-induced cigarette cravings in chronic smokersZe Wang
Department of Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 27:14035-40. 2007..These data suggest that increased activation in the brain's visuospatial and reward circuitry underlies abstinence-induced cravings to smoke, and thereby, may be important in relapse... - A hybrid SVM-GLM approach for fMRI data analysisZe Wang
Treatment Research Center, Department of Psychiatry, School of Medicine, University of Pennsylvania, 3900 Chestnut St, Philadelphia, PA 19104, USA
Neuroimage 46:608-15. 2009..With real fMRI data, SVM-GLM showed better sensitivity than regular GLM for detecting the sensorimotor activations... - Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohortTeresa R Franklin
Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Addict Biol 16:308-22. 2011..Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs... 
Effects of varenicline on smoking cue–triggered neural and craving responsesTeresa Franklin
Department of Psychiatry, University of Pennsylvania and Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
Arch Gen Psychiatry 68:516-26. 2011....- Continuous arterial spin labeling perfusion measurements using single shot 3D GRASE at 3 TMaria A Fernandez-Seara
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 54:1241-7. 2005..The method was further improved using parallel imaging techniques to provide increased spatial resolution and better separation of the gray-white matter cerebral blood flow maps... - Modulation of resting brain cerebral blood flow by the GABA B agonist, baclofen: a longitudinal perfusion fMRI studyTeresa R Franklin
Department of Psychiatry, University of Pennsylvania, Center for Studies of Addiction and VA Medical Center, Philadelphia, PA, USA franklin
Drug Alcohol Depend 117:176-83. 2011..Its mechanism in humans is unknown. Here, we used continuous arterial spin labeled (CASL) perfusion fMRI to examine baclofen's effects on blood flow in the human brain... - Boost up the detection sensitivity of ASL perfusion fMRI through support vector machineZe Wang
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
Conf Proc IEEE Eng Med Biol Soc 1:1006-9. 2006..Evaluations were performed using 7 subjects' fingertapping ASL perfusion fMRI data, yielding similar activation patterns with enhanced sensitivity compared to the standard GLM based group analysis... - Imaging mesial temporal lobe activation during scene encoding: comparison of fMRI using BOLD and arterial spin labelingMaria A Fernandez Seara
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Hum Brain Mapp 28:1391-400. 2007..Future improvements in ASL spatial and temporal resolution would allow the benefits of both approaches to be combined to further enhance the sensitivity for detecting mTL activation during memory encoding... - DAT genotype modulates brain and behavioral responses elicited by cigarette cuesTeresa R Franklin
Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
Neuropsychopharmacology 34:717-28. 2009..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues... - Applications of arterial spin labeled MRI in the brainJohn A Detre
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Magn Reson Imaging 35:1026-37. 2012..This review covers selected research and clinical applications of ASL MRI in the brain to illustrate its potential in both neuroscience research and clinical care... - To smooth or not to smooth? ROC analysis of perfusion fMRI dataJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 23:75-81. 2005..In contrast to the BOLD fMRI, temporal smoothing or filtering reduces the power of perfusion fMRI data analyses whereas spatial smoothing is beneficial to the efficacy of analyses... - Reward-related Brain Response and Craving Correlates of Marijuana Cue Exposure: A Preliminary Study in Treatment-seeking Marijuana-dependent SubjectsMarina Goldman
From the Department of Psychiatry MG, RPS R, KJ, ZW, yl, JJS, KK, CPO, ARC, TRF, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Philadelphia Veterans Affairs Medical Center and VISN 4 Mental Illness Research, Education, and Clinical Center RNE, JJS, CPO, ARC, Philadelphia and Department of Neurology ZW, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia
J Addict Med 7:8-16. 2013.... - Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patientsJesse J Suh
Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, United States
Drug Alcohol Depend 99:11-7. 2009..In this study, we examined the link between resting rCBF in the PFC and current depressive symptoms in methadone-maintained opiate-dependent (MM) patients with or without major depression... - A VBM study demonstrating 'apparent' effects of a single dose of medication on T1-weighted MRIsTeresa R Franklin
Department of Psychiatry, Center for Studies of Addiction, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Brain Struct Funct 218:97-104. 2013.... - Arterial spin-labeled perfusion MRI in basic and clinical neuroscienceJohn A Detre
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Opin Neurol 22:348-55. 2009.... - Continuous ASL (CASL) perfusion MRI with an array coil and parallel imaging at 3TZe Wang
Center for Functional Neuroimaging, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Med 54:732-7. 2005..Such results highlight the potential utility of array coils and parallel imaging in ASL perfusion MRI... - Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI studyTeresa R Franklin
Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Neuropsychopharmacology 32:2301-9. 2007.... - Neuroimaging, genetics and the treatment of nicotine addictionRiju Ray
Trandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Behav Brain Res 193:159-69. 2008..The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment... - Improved data reconstruction method for GRAPPAZe Wang
Center for Functional Neuroimaging, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 54:738-42. 2005..Both simulations and in vivo experiments demonstrated that the proposed method yields higher-quality data reconstruction than the original GRAPPA method, especially with high acceleration factors... - Wavelet-transformed temporal cerebral blood flow signals during attempted inhibition of cue-induced cocaine craving distinguish prognostic phenotypesShing Chun Benny Lam
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Drug Alcohol Depend 128:140-7. 2013.... - Narrative speech production: an fMRI study using continuous arterial spin labelingVanessa Troiani
Department of Neurology 3 West Gates, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
Neuroimage 40:932-9. 2008..We conclude that inferior frontal cortex serves as a top-down organizational resource for narrative production and demonstrate the feasibility of collecting extended speech samples using CASL perfusion fMRI... - Prelude to passion: limbic activation by "unseen" drug and sexual cuesAnna Rose Childress
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
PLoS ONE 3:e1506. 2008..recognition? Can the brain response to "unseen" reward cues predict the future affective response to recognizable versions of such cues, revealing a link between affective/motivational processes inside and outside awareness?.. - Microvascular perfusion based on arterial spin labeled perfusion MRI as a measure of vascular risk in Alzheimer's diseaseQuan Zhang
Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, USA Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China
J Alzheimers Dis 32:677-87. 2012..Future prospective studies in larger cohorts with optimized ASL MRI protocols will be needed to validate these observations... - [Prediction of drug bioavailability by genetic algorithm and artificial neural network]Ze Wang
School of Mechanical Engineering, Jiangsu University, Zhenjiang 212013, China
Yao Xue Xue Bao 41:1180-3. 2006..To set up an artificial neural network system and optimize by genetic algorithm (GA) to predict drug bioavailability...
Research Grants
- SVM based group data analysis for drug abuse disorder ASL perfusion studyZe Wang; Fiscal Year: 2007..The output of these more powerful ASL data analysis methods will also pave the way for general application of ASL perfusion fMRI methods across multiple brain disorders, and for sustained states within the normal brain. ..