Z Wang

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts
    Z Wang
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 272:24064-71. 1997
  2. ncbi request reprint DNA damage-induced mutagenesis : a novel target for cancer prevention
    Z Wang
    Graduate Center for Toxicology, University of Kentucky, Lexington 40536, USA
    Mol Interv 1:269-81. 2001
  3. ncbi request reprint Translesion synthesis by the UmuC family of DNA polymerases
    Z Wang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Mutat Res 486:59-70. 2001
  4. pmc Response of human DNA polymerase iota to DNA lesions
    Y Zhang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA and Department of Chemistry, Washington University, St Louis, MO 63130, USA
    Nucleic Acids Res 29:928-35. 2001
  5. ncbi request reprint Specificity of DNA lesion bypass by the yeast DNA polymerase eta
    F Yuan
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 275:8233-9. 2000
  6. pmc Accessibility of DNA polymerases to repair synthesis during nucleotide excision repair in yeast cell-free extracts
    X Wu
    306 Health Sciences Research Building, Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 29:3123-30. 2001
  7. pmc The human RAD18 gene product interacts with HHR6A and HHR6B
    H Xin
    306 Health Sciences Research Building, Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 28:2847-54. 2000
  8. pmc The human REV1 gene codes for a DNA template-dependent dCMP transferase
    W Lin
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 27:4468-75. 1999
  9. pmc Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene
    D Guo
    Graduate Center for Toxicology, 306 Health Sciences Research Building, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 29:2875-83. 2001
  10. pmc Highly frequent frameshift DNA synthesis by human DNA polymerase mu
    Y Zhang
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    Mol Cell Biol 21:7995-8006. 2001

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts
    Z Wang
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 272:24064-71. 1997
    ..The processing of the 5'-deoxyribose phosphate moieties was found to be a rate-limiting step. During BER of uracil-containing DNA, repair patch sizes of 1-5 nucleotides were detected, with single nucleotide repair patches predominant...
  2. ncbi request reprint DNA damage-induced mutagenesis : a novel target for cancer prevention
    Z Wang
    Graduate Center for Toxicology, University of Kentucky, Lexington 40536, USA
    Mol Interv 1:269-81. 2001
    ..Based on the mutagenesis hypothesis of cancer formation, DNA damage-induced mutagenesis and its underlying molecular biology offer an intriguing potential target for cancer prevention...
  3. ncbi request reprint Translesion synthesis by the UmuC family of DNA polymerases
    Z Wang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Mutat Res 486:59-70. 2001
    ..Recent studies of the UmuC superfamily are summarized and evidence is presented suggesting that this family of DNA polymerases is involved in translesion DNA synthesis...
  4. pmc Response of human DNA polymerase iota to DNA lesions
    Y Zhang
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA and Department of Chemistry, Washington University, St Louis, MO 63130, USA
    Nucleic Acids Res 29:928-35. 2001
    ..In contrast, human Pol iota was largely unresponsive to a template TT cis-syn cyclobutane dimer. These results suggest a role for human Pol iota in DNA lesion bypass...
  5. ncbi request reprint Specificity of DNA lesion bypass by the yeast DNA polymerase eta
    F Yuan
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 275:8233-9. 2000
    ..These results suggest that other than UV damage, Pol(eta) may also play a role in bypassing additional DNA lesions, some of which can be error-prone...
  6. pmc Accessibility of DNA polymerases to repair synthesis during nucleotide excision repair in yeast cell-free extracts
    X Wu
    306 Health Sciences Research Building, Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 29:3123-30. 2001
    ..These results suggest that efficient repair synthesis of yeast NER requires both Poldelta and Polvarepsilon in vitro, and that the low fidelity Poleta is not accessible to repair synthesis during NER...
  7. pmc The human RAD18 gene product interacts with HHR6A and HHR6B
    H Xin
    306 Health Sciences Research Building, Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 28:2847-54. 2000
    ..Consistent with its role as a fundamental lesion bypass protein, the RAD18 gene is ubiquitously expressed in various human tissues...
  8. pmc The human REV1 gene codes for a DNA template-dependent dCMP transferase
    W Lin
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 27:4468-75. 1999
    ..Consistent with its role as a fundamental mutagenic protein, the REV1 gene is ubiquitously expressed in various human tissues...
  9. pmc Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene
    D Guo
    Graduate Center for Toxicology, 306 Health Sciences Research Building, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 29:2875-83. 2001
    ..Secondly, more efficient bypass of these lesions may require nucleotide incorporation by other DNA polymerases followed by extension DNA synthesis by Polzeta...
  10. pmc Highly frequent frameshift DNA synthesis by human DNA polymerase mu
    Y Zhang
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    Mol Cell Biol 21:7995-8006. 2001
    ..The biochemical properties of human Polmu suggest a function in nonhomologous end joining and V(D)J recombination through its microhomology searching and pairing activities but do not support a function in somatic hypermutation...
  11. pmc Relationships between yeast Rad27 and Apn1 in response to apurinic/apyrimidinic (AP) sites in DNA
    X Wu
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 27:956-62. 1999
    ..In contrast, nucleotide excision repair and BER of oxidative damage were not affected in rad27 mutant extracts, indicating that Rad27 is specifically required for BER of AP sites in DNA...
  12. ncbi request reprint DNA ligation during excision repair in yeast cell-free extracts is specifically catalyzed by the CDC9 gene product
    X Wu
    Graduate Center for Toxicology, University of Kentucky, Lexington 40536, USA
    Biochemistry 38:2628-35. 1999
    ..These results demonstrate that the ligation step of excision repair in yeast cell-free extracts is catalyzed specifically by the Cdc9 protein, the homologue of mammalian DNA ligase I...
  13. ncbi request reprint A full-length cDNA of hREV3 is predicted to encode DNA polymerase zeta for damage-induced mutagenesis in humans
    W Lin
    Graduate Center for Toxicology, University of Kentucky, Lexington 40536, USA
    Mutat Res 433:89-98. 1999
    ..Human DNA polymerase zeta is ubiquitously expressed in various tissues, consistent with the notion that the hREV3 pathway may be a fundamental mechanism of damage-induced mutagenesis in humans...
  14. pmc Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p
    Z Wang
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Mol Cell Biol 21:5742-52. 2001
    ..Defective glycogen storage in snf1 cells can be attributed to both defective synthesis upon entry into stationary phase and impaired maintenance of glycogen levels caused by the lack of autophagy...
  15. ncbi request reprint A highly conserved mechanism of regulated ribosome stalling mediated by fungal arginine attenuator peptides that appears independent of the charging status of arginyl-tRNAs
    Z Wang
    Department of Biochemistry, Oregon Graduate Institute of Science and Technology, Beaverton, Oregon 97006 8921, USA
    J Biol Chem 274:37565-74. 1999
    ..Therefore, AAP-mediated Arg-specific regulation appeared independent of the charging status of arginyl-tRNA...
  16. ncbi request reprint Replication-related activities establish cohesion between sister chromatids
    Z Wang
    Department of Genetics and Genomics, Boston University School of Medicine, MA 02118, USA
    Cell Biochem Biophys 35:289-301. 2001
    ..Here, we review the molecular events in the chromosome cycle with respect to cohesion. Failure of sister chromatid cohesion results in the aneuploidy characteristic of many birth defects and tumors in humans...
  17. ncbi request reprint Identification of functional domains within the RAD1.RAD10 repair and recombination endonuclease of Saccharomyces cerevisiae
    K Rodriguez
    Institute of Biotechnology Center for Molecular Medicine, University of Texas Health Science Center at San Antonio, 78245, USA
    J Biol Chem 271:20551-8. 1996
    ..These reagents also inhibit nucleotide excision repair in vitro, confirming the essential role of the RAD1 RAD10 endonuclease in this pathway...
  18. pmc Physical evidence for distinct mechanisms of translational control by upstream open reading frames
    A Gaba
    Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, 20 000 NW Walker Road, Beaverton, OR 97006-8921, USA
    EMBO J 20:6453-63. 2001
    ..The GCN4 and CPA1 uORFs thus control translation in fundamentally different ways...
  19. ncbi request reprint Functional link between the mammalian exosome and mRNA decapping
    Z Wang
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Cell 107:751-62. 2001
    ..These findings indicate that following deadenylation of mammal mRNA, degradation proceeds by a coupled 3' to 5' exoribonucleolytic activity and subsequent hydrolysis of the cap structure by a scavenger decapping activity...
  20. ncbi request reprint Pol kappa: A DNA polymerase required for sister chromatid cohesion
    Z Wang
    Department of Microbiology, University of Virginia, Box 441, Jordan Hall, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Science 289:774-9. 2000
    ..Trf4 and Trf5 represent the fourth class of essential nuclear DNA polymerases (designated DNA polymerase kappa) in Saccharomyces cerevisiae and probably in all eukaryotes...
  21. pmc The RAD7, RAD16, and RAD23 genes of Saccharomyces cerevisiae: requirement for transcription-independent nucleotide excision repair in vitro and interactions between the gene products
    Z Wang
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Mol Cell Biol 17:635-43. 1997
    ..This process may involve a unique protein complex which is distinct from the repairosome and which contains at least the Rad4, Rad7, and Rad16 proteins...
  22. pmc Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae
    Z Wang
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 90:4907-11. 1993
    ..The nuclear extracts also contain base-excision repair activity that is present at wild-type levels in rad mutant extracts. This cell-free system is expected to facilitate studies on the biochemical pathway of NER in S. cerevisiae...
  23. ncbi request reprint Heme regulates SOD2 transcription by activation and repression in Saccharomyces cerevisiae
    J L Pinkham
    Department of Biochemistry and Molecular Biology, Lederle GRC Tower, University of Massachusetts, Box 34505, Amherst, MA 01003 4505, USA
    Curr Genet 31:281-91. 1997
    ..Interestingly, the DNA sequences necessary for repression in the absence of heme overlap those that mediate Hap1p activation. Genetic results suggest a novel role for Hap1p in the regulation of repression in the absence of heme...
  24. pmc The yeast TFB1 and SSL1 genes, which encode subunits of transcription factor IIH, are required for nucleotide excision repair and RNA polymerase II transcription
    Z Wang
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235
    Mol Cell Biol 15:2288-93. 1995
    ..Our results also suggest that the repair and transcription functions of Tfb1 and Ssl1 are separable...
  25. ncbi request reprint Different forms of TFIIH for transcription and DNA repair: holo-TFIIH and a nucleotide excision repairosome
    J Q Svejstrup
    Department of Structural Biology, Stanford University School of Medicine, California 94305 5400
    Cell 80:21-8. 1995
    ..This repairosome is not active in reconstituted transcription in vitro and is significantly more active than any of the constituent polypeptides in correcting defective repair in extracts from strains mutated in NER genes...
  26. ncbi request reprint p53 modulation of TFIIH-associated nucleotide excision repair activity
    X W Wang
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Nat Genet 10:188-95. 1995
    ..Moreover, repair of UV-induced dimers is slower in Li-Fraumeni syndrome cells (heterozygote p53 mutant) than in normal human cells. Our findings indicate that p53 may play a direct role in modulating nucleotide excision repair pathways...
  27. ncbi request reprint Affinity purification and partial characterization of a yeast multiprotein complex for nucleotide excision repair using histidine-tagged Rad14 protein
    K Rodriguez
    Department of Molecular Medicine, Institute of Biotechnology, The University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 273:34180-9. 1998
    ..The affinity purified NER complex catalyzed the incision of UV-irradiated DNA in an ATP-dependent reaction. We conclude that active high molecular weight complexes of NER proteins exist in undamaged yeast cells...
  28. ncbi request reprint Loss of mitochondrial DNA in rabbit bladder smooth muscle following partial outlet obstruction results from lack of organellar DNA replication
    Z Wang
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Mol Urol 5:99-104. 2001
    ..Thus, lack of mt SSB protein, and consequently attenuated mt DNA replication, is a primary factor in the loss of mt genome copies in bladder smooth muscle after outlet obstruction in the rabbit model of benign bladder dysfunction...
  29. ncbi request reprint The yeast cyclins Pc16p and Pc17p are involved in the control of glycogen storage by the cyclin-dependent protein kinase Pho85p
    Z Wang
    Department of Biochemistry and Molecular Biology and Center for Diabetes Research, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202 5122, USA
    FEBS Lett 506:277-80. 2001
    ..Pho85p thus affects glycogen accumulation through multiple Cdks composed of different cyclin partners...
  30. doi request reprint Stochastic dynamic modeling of short gene expression time-series data
    Z Wang
    Department of Information Systems and Computing, Brunel University, Uxbridge, UK
    IEEE Trans Nanobioscience 7:44-55. 2008
    ..Several indices are proposed to evaluate the models of inferred gene regulatory networks, and the relevant biological properties are discussed...
  31. pmc WdChs2p, a class I chitin synthase, together with WdChs3p (class III) contributes to virulence in Wangiella (Exophiala) dermatitidis
    Z Wang
    Section of Molecular Genetics and Microbiology, School of Biological Science and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 78712, USA
    Infect Immun 69:7517-26. 2001
    ..dermatitidis was then confirmed by reconstituting virulence in the double mutant by the reintroduction of either WdCHS2 or WdCHS3 into the wdchs2Deltawdchs3Delta mutant background...
  32. ncbi request reprint Eukaryotic DNA polymerases: proposal for a revised nomenclature
    P M Burgers
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 276:43487-90. 2001
  33. pmc The amazing diversity of cap-independent translation elements in the 3'-untranslated regions of plant viral RNAs
    W A Miller
    Plant Pathology Department, 351 Bessey Hall, Iowa State University, Ames, IA 50011, USA
    Biochem Soc Trans 35:1629-33. 2007
    ..These results greatly expand our understanding of ways in which mRNAs can recruit ribosomes, and they provide insight into the regulation of virus gene expression...
  34. ncbi request reprint Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo
    Z Wang
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Gene Ther 10:2105-11. 2003
    ....
  35. ncbi request reprint [Cloning of liver cancer-related gene HCCA2 and association of that gene with liver cancer]
    Z Wang
    International Co-operation Lab on Cellular Signal Transduction, The East Hospital of Hepatobiliary Surgery, The Second Military Medical University, Shanghai 200438, China
    Zhonghua Yi Xue Za Zhi 81:332-5. 2001
    ..Its expression was associated with the completeness of the tumor envelop and the expression of KI-67 PROTEIN (P < 0.01). CONCLUSION: The novel gene HCCA2 may be related with the infiltration and proliferation of liver cancer...
  36. ncbi request reprint Illustration of the maternal animal model used for genetic evaluation of beef cattle
    D H Crews
    Agriculture and Agri Food Canada Research Centre, Lethbridge, AB, Canada
    J Anim Sci 85:1842-8. 2007
    ..This example should lead to increased student and producer understanding of genetic improvement programs for weaning weight in beef cattle...
  37. ncbi request reprint Screening of taxol-producing endophytic fungi from Taxus chinensis var. mairei
    X Zhou
    Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan SJTU Nottingham Plant Biotechnology R and D Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Prikl Biokhim Mikrobiol 43:490-4. 2007
    ..This study indicates that molecular detection of the ts gene is an efficient method for primary screening of taxol or its related compounds-producing endophytic fungi which can improve prominently screening efficiency...
  38. ncbi request reprint Protein expression changed by nicotine in rat vascular smooth muscle cells
    Z Wang
    School of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, PR China
    J Physiol Biochem 63:161-9. 2007
    ..The affected proteins turned out to be mainly associated with cell migration, proliferation and energy metabolism, and are responsible for nicotine-related cardiovascular damage...
  39. ncbi request reprint [Studies on transference of hydrogenase genes of Rhizobium arachis]
    Z Wang
    Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China
    Wei Sheng Wu Xue Bao 41:421-6. 2001
    ..8%, 10.0% and 6.0%; the output increased 18.8%, 10.5% and 10.7%. This suggested that legume plants inoculated with Rhizobium strains (Hup+) were more efficient to accumulate N and to increase its output...
  40. ncbi request reprint A new yeast display vector permitting free scFv amino termini can augment ligand binding affinities
    Z Wang
    Section on Biophysical Chemistry, Laboratory of Molecular Biology, National Institute of Mental Health, Building 10, 36 Convent Drive, Bethesda, MD 28092 4034, USA
    Protein Eng Des Sel 18:337-43. 2005
    ..These data show that for certain yeast-displayed scFvs a carboxy-tethered scFv can result in increased ligand-scFv equilibrium association constants and thereby extend the low range of affinity maturation measurements...
  41. ncbi request reprint [Comparative research on two different killer strains of Saccharomyces cerevisiae]
    Y Qin
    Department of Microbiology, State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100
    Wei Sheng Wu Xue Bao 38:92-7. 1998
    ..Toxins of SK4 and ERR1 have the different highest killer activity at pH 4.8, 16 degrees C and pH4.2, 22 degrees C, but both of two toxins have the greatest effect on the sensitive strain in the late-log phase...
  42. ncbi request reprint Characterization of WdChs3p, a class III chitin synthase, of Wangiella (Exophiala) dermatitidis, overexpressed in Saccharomyces cerevisiae
    Z Wang
    Section of Molecular Genetics and Microbiology, School of Biological Sciences, The University of Texas at Austin, 78712, USA
    Med Mycol 40:283-9. 2002
    ....
  43. ncbi request reprint Spontaneous second-site suppressors of the filamentation defect of prr1Delta mutants define a critical domain of Rim101p in Candida albicans
    A Porta
    International Institute of Genetics and Biophysics, Via Marconi 12, 80125 Naples, Italy
    Mol Genet Genomics 266:624-31. 2001
    ..The results define a critical region in the C-terminal region of Rim101p and are consistent with the proposed proteolytic activation of Rim101p...
  44. pmc Technical knockout, a Drosophila model of mitochondrial deafness
    J M Toivonen
    Institute of Medical Technology and Tampere University Hospital, FIN 33014 University of Tampere, Finland
    Genetics 159:241-54. 2001
    ..We infer that the tko(25t) mutant provides a model of mitochondrial hearing impairment resulting from a quantitative deficiency of mitochondrial translational capacity...
  45. pmc RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA
    Z Wang
    Department of Biological Chemistry, Johns Hopkins Medical School, 725 N. Wolfe Street, Baltimore, MD 21205, USA
    EMBO J 20:4674-83. 2001
    ..These facts, together with the localization of the enzyme in two antipodal sites flanking the kDNA, show that a function of this topoisomerase II is to attach free minicircles to the network periphery following their replication...
  46. pmc Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer
    D Dankort
    Department of Biology, Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1
    Mol Cell Biol 21:1540-51. 2001
    ..These observations argue that Grb2 and Shc play important and distinct roles in ErbB-2/Neu-induced mammary tumorigenesis and metastasis...
  47. pmc A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements
    M Teichmann
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:14200-5. 2000
    ..Thus, higher eukaryotes, in contrast to the yeast Saccharomyces cerevisiae, have evolved two distinct TFIIB-related factors that mediate promoter selectivity by RNA polymerase III...
  48. ncbi request reprint The role of DOC-2/DAB2 protein phosphorylation in the inhibition of AP-1 activity. An underlying mechanism of its tumor-suppressive function in prostate cancer
    C P Tseng
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9110, USA
    J Biol Chem 274:31981-6. 1999
    ..Taken together, these data suggest that PKC-regulated phosphorylation of DOC-2/DAB2 protein may help its growth inhibitory function...
  49. ncbi request reprint Genetic analysis of the Drosophila ellipsoid body neuropil: organization and development of the central complex
    S C Renn
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Neurobiol 41:189-207. 1999
    ..The experiments performed here demonstrate the degree of resolution possible from the analysis of enhancer-trap lines and form a useful library of tools for future structure/function studies of the ellipsoid body...
  50. ncbi request reprint Cloning, expression and chromosome locations of the human DNMT3 gene family
    S Xie
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA
    Gene 236:87-95. 1999
    ..The cloning of the human DNMT3 genes will facilitate further biochemical and genetic studies of their functions in establishment of DNA methylation patterns, regulation of gene expression and tumorigenesis...
  51. ncbi request reprint New mutations, polymorphisms, and rare variants in the ATM gene detected by a novel SSCP strategy
    S Castellvi-Bel
    Department of Pathology, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1732, USA
    Hum Mutat 14:156-62. 1999
    ..This is the most comprehensive compilation of ATM polymorphisms assembled to date. Defining polymorphic sites as well as mutations in the ATM gene will be of great importance in designing automated methods for detecting mutations...
  52. pmc Ataxia-telangiectasia: identification and detection of founder-effect mutations in the ATM gene in ethnic populations
    M Telatar
    Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90095 1732
    Am J Hum Genet 62:86-97. 1998
    ..Additional mutations were observed in Japanese, Utah Mormon, and African American patients. These assays should facilitate screening for A-T heterozygotes in the populations studied...
  53. pmc Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation
    D L Dankort
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Mol Cell Biol 17:5410-25. 1997
    ..These data argue that the transforming potential of activated neu is mediated both by positive and negative regulatory tyrosine phosphorylation sites...
  54. ncbi request reprint Genomic structure of the RNA polymerase II small subunit (hRPB14.4) locus (POLRF) and mapping to 22q13.1 by sequence identity
    C Pusch
    Institute of Anthropology and Human Genetics, University of Tubingen, Tubingen, Germany
    Genomics 34:440-2. 1996
  55. pmc FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis
    M Cao
    Department of Microbiology, Cornell University, Ithaca, New York 14853 8101, USA
    J Bacteriol 183:2380-3. 2001
    ..FosB is a metallothiol transferase related to the FosA class of Mn(2+)-dependent glutathione transferases but with a preference for Mg(2+) and L-cysteine as cofactors...
  56. ncbi request reprint In situ infrared spectroelectrochemical studies on adsorption and oxidation of nucleic acids at glassy carbon electrode
    Z Wang
    Laboratory of Electroanalytical Chemistry and National Analytical and Research Center of Electrochemistry and Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, People's Republic of China
    Bioelectrochemistry 53:175-81. 2001
    ....
  57. ncbi request reprint Expression of Chlamydia trachomatis genes encoding products required for DNA synthesis and cell division during active versus persistent infection
    H C Gerard
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Gordon H Scott Hall, 540 East Canfield Ave, Detroit, MI 48201, USA
    Mol Microbiol 41:731-41. 2001
    ..These data explain, at least in part, the observed attenuation of new EB production during chlamydial persistence...
  58. ncbi request reprint MEK1/2 inhibitors promote Ara-C-induced apoptosis but not loss of Deltapsi(m) in HL-60 cells
    C Yu
    Department of Medicine, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Biochem Biophys Res Commun 286:1011-8. 2001
    ....
  59. ncbi request reprint The Y-family of DNA polymerases
    H Ohmori
    Mol Cell 8:7-8. 2001
  60. pmc Chlamydia pneumoniae expresses genes required for DNA replication but not cytokinesis during persistent infection of HEp-2 cells
    G I Byrne
    Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
    Infect Immun 69:5423-9. 2001
    ..These results provide new insight regarding molecular activities that accompany persistence of C. pneumoniae, as well as suggesting requirements for reactivation from persistent to productive growth...
  61. pmc Telomerase activation by histone deacetylase inhibitor in normal cells
    M Takakura
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8641, Japan
    Nucleic Acids Res 29:3006-11. 2001
    ..This finding suggests one way whereby histone deacetylation may be involved in silencing the hTERT gene in normal cells...
  62. ncbi request reprint [Using self-assembled monolayers to understand the interactions of surfaces with cells]
    P Ying
    Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 18:276-9. 2001
    ..The present paper reviewed the latest research in using patterned self-assembled monolayers to understand surface-cell interactions...
  63. ncbi request reprint UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo
    Y Wan
    Department of Biology, Providence College, Providence, RI 02918, USA
    Int J Mol Med 6:683-8. 2000
    ..Collectively, our data suggest that UV-induced GADD45alpha expression occur via an EGF receptor-mediated oxidative pathway sensitive to antioxidant regulation...
  64. pmc Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2
    C Mertens
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 98:7795-800. 2001
    ..We propose the existence of diverse nuclear particles in which proteins known as plaque proteins of intercellular junctions are complexed with specific nuclear proteins...
  65. pmc Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split
    X Yu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 21:4614-25. 2001
    ..These observations implicate AES as a selective repressor of ligand-dependent AR-mediated transcription that acts by directly interacting with AR and by targeting the basal transcription machinery...
  66. ncbi request reprint Fine tuning the specificity of the periplasmic phosphate transport receptor. Site-directed mutagenesis, ligand binding, and crystallographic studies
    Z Wang
    Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 269:25091-4. 1994
    ....