Affiliation: University of South Carolina
- Cis lethal genetic interactions attenuate and alter p53 tumorigenesisYuxun Wang
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 107:5511-5. 2010..These studies indicate that polymorphic genetic variants in cell essential genes can genetically affect closely linked tumor suppressor loci via allelic phasing, which can result in profound phenotypic variations in tumorigenesis...
- Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in miceYuxun Wang
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Nat Genet 37:750-5. 2005..These results indicate that Rpa1 functions in DNA metabolism are essential for the maintenance of chromosomal stability and tumor suppression...