Yanming Wang

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. ncbi request reprint Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease
    Yanming Wang
    Department of Medicinal Chemistry and Pharmacology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Mol Neurosci 24:55-62. 2004
  2. ncbi request reprint Lipophilic analogs of thioflavin S as novel amyloid-imaging agents
    Chunying Wu
    College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Alzheimer Res 3:259-66. 2006
  3. pmc A novel fluorescent probe that is brain permeable and selectively binds to myelin
    Chunying Wu
    Department of Medical Chemistry and Pharmacognosy, University of Illinois at Chicago, USA, and Biologie des Interactions Neurones Glie, Hopital de la Salpetriere, Paris, France
    J Histochem Cytochem 54:997-1004. 2006
  4. ncbi request reprint Amyloid imaging: from benchtop to bedside
    Chunying Wu
    Department of Medicinal Chemistry, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Top Dev Biol 70:171-213. 2005
  5. ncbi request reprint Development of novel amyloid imaging agents based upon thioflavin S
    Jingjun Wei
    School of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Alzheimer Res 2:109-14. 2005
  6. ncbi request reprint A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
    Chester A Mathis
    PET Facility, Department of Radiology, University of Pittsburgh, PA 15213, USA
    Bioorg Med Chem Lett 12:295-8. 2002
  7. pmc Imaging of CNS myelin by positron-emission tomography
    Bruno Stankoff
    Institut National de la Sante et de la Recherche Medicale, U711, Hopital de la Salpetriere, F 75013 Paris, France
    Proc Natl Acad Sci U S A 103:9304-9. 2006
  8. ncbi request reprint Dibenzothiazoles as novel amyloid-imaging agents
    Chunying Wu
    Department of Chemistry and Radiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Bioorg Med Chem 15:2789-96. 2007
  9. ncbi request reprint Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Ann Neurol 55:306-19. 2004
  10. pmc Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice
    Brian J Bacskai
    Department of Neurology Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 100:12462-7. 2003

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease
    Yanming Wang
    Department of Medicinal Chemistry and Pharmacology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Mol Neurosci 24:55-62. 2004
    ..These results suggest that the new radioiodinated benzothiazole ligand might be useful as a surrogate marker for the in vivo quantitation of amyloid deposition in human brain for use with either PET or SPECT...
  2. ncbi request reprint Lipophilic analogs of thioflavin S as novel amyloid-imaging agents
    Chunying Wu
    College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Alzheimer Res 3:259-66. 2006
    ..Potential applications of these amyloid binding agents include facilitating drug screening in animal models and use as in vivo markers of early and definitive diagnosis of AD...
  3. pmc A novel fluorescent probe that is brain permeable and selectively binds to myelin
    Chunying Wu
    Department of Medical Chemistry and Pharmacognosy, University of Illinois at Chicago, USA, and Biologie des Interactions Neurones Glie, Hopital de la Salpetriere, Paris, France
    J Histochem Cytochem 54:997-1004. 2006
    ..These studies justified further investigation of BDB as a potential myelin-imaging probe to monitor myelin pathology in vivo...
  4. ncbi request reprint Amyloid imaging: from benchtop to bedside
    Chunying Wu
    Department of Medicinal Chemistry, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Top Dev Biol 70:171-213. 2005
    ..Furthermore, the success in the development of amyloid-imaging agents helps with the development of imaging agents for in vivo studies of other AD pathologies in particular and of neurodegenerative disorders in general...
  5. ncbi request reprint Development of novel amyloid imaging agents based upon thioflavin S
    Jingjun Wei
    School of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Alzheimer Res 2:109-14. 2005
    ..We hypothesized that neutral analogs, based upon the major component, could be developed as novel amyloid imaging agents, that exhibit complementary binding properties and pharmacokinetic profiles compatible with potential human studies...
  6. ncbi request reprint A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
    Chester A Mathis
    PET Facility, Department of Radiology, University of Pittsburgh, PA 15213, USA
    Bioorg Med Chem Lett 12:295-8. 2002
    ..Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease...
  7. pmc Imaging of CNS myelin by positron-emission tomography
    Bruno Stankoff
    Institut National de la Sante et de la Recherche Medicale, U711, Hopital de la Salpetriere, F 75013 Paris, France
    Proc Natl Acad Sci U S A 103:9304-9. 2006
    ..Our results provide a perspective for developing a brain myelin imaging technique by positron-emission tomography...
  8. ncbi request reprint Dibenzothiazoles as novel amyloid-imaging agents
    Chunying Wu
    Department of Chemistry and Radiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Bioorg Med Chem 15:2789-96. 2007
    ....
  9. ncbi request reprint Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Ann Neurol 55:306-19. 2004
    ..This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects...
  10. pmc Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice
    Brian J Bacskai
    Department of Neurology Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 100:12462-7. 2003
    ..WT mice showed rapid brain entry and clearance of PIB without any binding. These results demonstrate that the compound PIB has the properties required for a good amyloid-imaging agent in humans with or at risk for AD...
  11. ncbi request reprint Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives
    Yanming Wang
    P E T Facility, Department of Radiology, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Mol Neurosci 20:255-60. 2003
    ..These results provide important SAR information to guide the development of novel amyloid-binding agents and provide further insights into the molecular interaction between 2-aryl benzothiazole ligands and Abeta fibrils...
  12. ncbi request reprint Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    Chester A Mathis
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Med Chem 46:2740-54. 2003
    ..The encouraging in vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition...
  13. ncbi request reprint The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    William E Klunk
    Laboratory of Molecular Neuropharmacology, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:2086-92. 2003
    ..Finally, BTA-1 did not appear to bind significantly to common neuroreceptors or transporter sites. These data suggest that the binding of BTA-1 to AD brain is dominated by a specific interaction with Abeta amyloid deposits...
  14. ncbi request reprint Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Neuropathol Exp Neurol 61:797-805. 2002
    ....
  15. ncbi request reprint Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease
    Yanming Wang
    PET Facility, Department of Radiology, School of Medicine, University of Pittsburgh, PA 15213, USA
    J Mol Neurosci 19:11-6. 2002
    ..43+/-0.62%ID/g detected in the whole brain at 2 min post i.v. injection. At 30 min, the radioactivity concentration decreased to 0.40+/-0.05%ID/g, indicating good clearance in the absence of amyloid deposits in the brain...
  16. ncbi request reprint Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography
    William E Klunk
    Laboratory of Molecular Neuropharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, 705 Parran Hall, Pittsburgh, PA 15213, USA
    Neuroimaging Clin N Am 13:781-9, ix. 2003
    ..The capability to use positron emission tomography and selective markers for amyloid protein deposition promises to substantially alter the way we diagnosis and manage patients who have AD...