Xuemin Wang

Summary

Affiliation: University of Missouri-St. Louis
Country: USA

Publications

  1. ncbi request reprint The mTOR pathway in the control of protein synthesis
    Xuemin Wang
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
    Physiology (Bethesda) 21:362-9. 2006
  2. doi request reprint Quantitative analysis of major plant hormones in crude plant extracts by high-performance liquid chromatography-mass spectrometry
    Xiangqing Pan
    Department of Biology, University of Missouri, St Louis, MO, USA
    Nat Protoc 5:986-92. 2010
  3. ncbi request reprint Signaling functions of phosphatidic acid
    Xuemin Wang
    Department of Biology, University of Missouri, St Louis, MO 63121, USA
    Prog Lipid Res 45:250-78. 2006
  4. pmc Regulatory functions of phospholipase D and phosphatidic acid in plant growth, development, and stress responses
    Xuemin Wang
    Department of Biology, University of Missouri, St Louis, 63121, USA
    Plant Physiol 139:566-73. 2005
  5. doi request reprint Phospholipase D epsilon and phosphatidic acid enhance Arabidopsis nitrogen signaling and growth
    Yueyun Hong
    Department of Biology, University of Missouri, St Louis, MO 63121, USA
    Plant J 58:376-87. 2009
  6. pmc Patatin-related phospholipase pPLAIIIδ increases seed oil content with long-chain fatty acids in Arabidopsis
    Maoyin Li
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Physiol 162:39-51. 2013
  7. pmc Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis
    Liang Guo
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    J Biol Chem 287:8286-96. 2012
  8. pmc Patatin-related phospholipase pPLAIIIβ-induced changes in lipid metabolism alter cellulose content and cell elongation in Arabidopsis
    Maoyin Li
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Cell 23:1107-23. 2011
  9. pmc Phospholipase Dalpha3 is involved in the hyperosmotic response in Arabidopsis
    Yueyun Hong
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Cell 20:803-16. 2008
  10. pmc Nonspecific phospholipase C NPC4 promotes responses to abscisic acid and tolerance to hyperosmotic stress in Arabidopsis
    Carlotta Peters
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Cell 22:2642-59. 2010

Collaborators

  • Yueyun Hong
  • Ruth Welti
  • Xiangqing Pan
  • Jia Li
  • Joseph M Jez
  • Yu Liu
  • Jan Jaworski
  • Wensheng Qin
  • Feng Chen
  • Oliver Yu
  • Jian Zhao
  • Jonathan E Markham
  • Howard Berg
  • Christopher G Proud
  • Cunxi Wang
  • DAVID KUSNER
  • Wei Li
  • Maoyin Li
  • Liang Guo
  • Chunbo Qin
  • Wenhua Zhang
  • Rama Narasimhan
  • Girish Mishra
  • Shivakumar P Devaiah
  • Geliang Wang
  • Sung Chul Bahn
  • Mary Roth
  • Zixu Mao
  • Sang Chul Kim
  • Xiaoli Tang
  • Xiaoming Gong
  • Carlotta Peters
  • Mary R Roth
  • Li Zheng
  • Yanyan Zhang
  • Wenyu Yang
  • Yansheng Zhang
  • C B Rajashekar
  • Shivakumar Pattada Devaiah
  • Patrice D Smith
  • Yuanbin Xie
  • Sassan Hafizi
  • Kirk Pappan
  • Anne Beugnet
  • J David McGee
  • Ramaswamy Krishnamoorthi
  • Jashmin Patel
  • Michael Ortiz
  • Tien Phan
  • Chuchuan Fan
  • Stephen Ryu
  • Amanda Tawfall
  • William Musgrave
  • Kyle Taylor
  • Giorgis Isaac
  • Pamela Tamura
  • Raj Shree
  • Matthew P Mount
  • Han E Zhou
  • Steve Callaghan
  • Ruth S Slack
  • Ethan Baughman
  • Rebecca E Cahoon
  • Yuwen Zhang
  • Richard Jeannotte
  • Inez Vincent
  • Fan Deng
  • David S Park
  • Song Zhe Li
  • Hymie Anisman
  • Zhengui Xia
  • Ming Tong
  • Lijun Yu
  • David Park
  • Ruzhu Chen
  • Zhongmin Yuan
  • Xianguo Liu
  • Chi Ma
  • Magdi H Yacoub
  • Shoujian Huang
  • Adrian H Chester
  • Guoquan Gao
  • Mingtao Li
  • Zhenyu Zhu
  • Wenya Wang
  • Xiaonan Zhu
  • Hengxin Yuan
  • Teresa A Sweat
  • Gudrun Olafsdottir
  • Leslie A C Blair

Detail Information

Publications63

  1. ncbi request reprint The mTOR pathway in the control of protein synthesis
    Xuemin Wang
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada
    Physiology (Bethesda) 21:362-9. 2006
    ..mTOR plays key roles in cell physiology. mTOR regulates numerous components involved in protein synthesis, including initiation and elongation factors, and the biogenesis of ribosomes themselves...
  2. doi request reprint Quantitative analysis of major plant hormones in crude plant extracts by high-performance liquid chromatography-mass spectrometry
    Xiangqing Pan
    Department of Biology, University of Missouri, St Louis, MO, USA
    Nat Protoc 5:986-92. 2010
    ..The method provides quantification of most major plant hormones in a single run from 50 mg of fresh plant tissue. Extraction and quantitative analysis of 40 samples takes 2-3 d...
  3. ncbi request reprint Signaling functions of phosphatidic acid
    Xuemin Wang
    Department of Biology, University of Missouri, St Louis, MO 63121, USA
    Prog Lipid Res 45:250-78. 2006
    ..The regulatory processes in which PA has been implicated include signaling pathways in cell growth, proliferation, reproduction, and responses to hormones and biotic and abiotic stresses...
  4. pmc Regulatory functions of phospholipase D and phosphatidic acid in plant growth, development, and stress responses
    Xuemin Wang
    Department of Biology, University of Missouri, St Louis, 63121, USA
    Plant Physiol 139:566-73. 2005
  5. doi request reprint Phospholipase D epsilon and phosphatidic acid enhance Arabidopsis nitrogen signaling and growth
    Yueyun Hong
    Department of Biology, University of Missouri, St Louis, MO 63121, USA
    Plant J 58:376-87. 2009
    ..The lipid-signaling process may play a role in connecting membrane sensing of nutrient status to increased plant growth and biomass production...
  6. pmc Patatin-related phospholipase pPLAIIIδ increases seed oil content with long-chain fatty acids in Arabidopsis
    Maoyin Li
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Physiol 162:39-51. 2013
    ..These results indicate that pPLAIIIδ-mediated phospholipid turnover plays a role in fatty acid remodeling and glycerolipid production...
  7. pmc Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling pathway in Arabidopsis
    Liang Guo
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    J Biol Chem 287:8286-96. 2012
    ..PA is involved in the activation of SPHK, and activation of PLDα1 requires SPHK activity. The data suggest that SPHK/phyto-S1P and PLDα1A are co-dependent in amplification of response to ABA, mediating stomatal closure in Arabidopsis...
  8. pmc Patatin-related phospholipase pPLAIIIβ-induced changes in lipid metabolism alter cellulose content and cell elongation in Arabidopsis
    Maoyin Li
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Cell 23:1107-23. 2011
    ..These data suggest that alteration of pPLAIIIβ expression and the resulting lipid changes alter cellulose content and cell elongation in Arabidopsis...
  9. pmc Phospholipase Dalpha3 is involved in the hyperosmotic response in Arabidopsis
    Yueyun Hong
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Cell 20:803-16. 2008
    ..These data suggest that PLDalpha3 positively mediates plant responses to hyperosmotic stresses and that increased PLDalpha3 expression and associated lipid changes promote root growth, flowering, and stress avoidance...
  10. pmc Nonspecific phospholipase C NPC4 promotes responses to abscisic acid and tolerance to hyperosmotic stress in Arabidopsis
    Carlotta Peters
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Cell 22:2642-59. 2010
    ..These data suggest that NPC4-produced DAG is converted to PA and that NPC4 and its derived lipids positively modulate ABA response and promote plant tolerance to drought and salt stresses...
  11. pmc Cytosolic glyceraldehyde-3-phosphate dehydrogenases interact with phospholipase Dδ to transduce hydrogen peroxide signals in the Arabidopsis response to stress
    Liang Guo
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Cell 24:2200-12. 2012
    ..The results indicate that the H(2)O(2)-promoted interaction of GAPC and PLDδ may provide a direct connection between membrane lipid-based signaling, energy metabolism and growth control in the plant response to ROS and water stress...
  12. ncbi request reprint AtPLAI is an acyl hydrolase involved in basal jasmonic acid production and Arabidopsis resistance to Botrytis cinerea
    Wenyu Yang
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    J Biol Chem 282:18116-28. 2007
    ..The study shows that AtPLAI is an acyl hydrolase, rather than a specific phospholipase A. AtPLAI is involved in basal JA production and Arabidopsis resistance to the necrotrophic fungus B. cinerea...
  13. ncbi request reprint Enhancing seed quality and viability by suppressing phospholipase D in Arabidopsis
    Shivakumar P Devaiah
    Department of Biology, University of Missouri, St Louis, MO 63121, USA
    Plant J 50:950-7. 2007
    ..A high level of PLDalpha1 is detrimental to seed quality, and attenuation of PLDalpha1 expression has the potential to improve oil stability, seed quality and seed longevity...
  14. doi request reprint Dual functions of phospholipase Dalpha1 in plant response to drought
    Yueyun Hong
    Department of Biology, University of Missouri, St Louis, MO 63121, USA
    Mol Plant 1:262-9. 2008
    ..It promotes stomatal closure at earlier stages, but disrupts membranes in prolonged drought stress. These findings are discussed in relation to the understanding of PLD functions and potential applications...
  15. doi request reprint Differential changes in galactolipid and phospholipid species in soybean leaves and roots under nitrogen deficiency and after nodulation
    Rama Narasimhan
    Department of Biology, University of Missouri, St Louis, MO 63121, United States Donald Danforth Plant Science Center, St Louis, MO 63132, United States
    Phytochemistry 96:81-91. 2013
    ..Increased N availability leads to increased galactolipid accumulation in leaves, regardless of whether N is supplied from the soil or symbiotic fixation. ..
  16. doi request reprint Plant phospholipases: an overview
    Geliang Wang
    Department of Biology, University of Missouri, St Louis, MO, USA
    Methods Mol Biol 861:123-37. 2012
    ..These differences provide insights into determining the cellular function of specific phospholipases in plants, and they can be explored for different industrial applications...
  17. pmc Phosphatidic acid binds and stimulates Arabidopsis sphingosine kinases
    Liang Guo
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    J Biol Chem 286:13336-45. 2011
    ..The PA-SPHK interaction depends on the PA molecular species. The data suggest that these two Arabidopsis SPHKs are molecular targets of PA, and the PA stimulation of SPHK is part of the signaling networks in Arabidopsis...
  18. doi request reprint Phospholipase D- and phosphatidic acid-mediated signaling in plants
    Maoyin Li
    Department of Biology, University of Missouri, St Louis, MO 63121, USA
    Biochim Biophys Acta 1791:927-35. 2009
    ....
  19. pmc Phosphatidic acid binds to cytosolic glyceraldehyde-3-phosphate dehydrogenase and promotes its cleavage in Arabidopsis
    Sang Chul Kim
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    J Biol Chem 288:11834-44. 2013
    ..These data suggest that PA binds to oxidized GAPDH and promotes its cleavage and that the PA and GAPC interaction may provide a signaling link coordinating carbohydrate and lipid metabolism...
  20. doi request reprint Simultaneous quantification of major phytohormones and related compounds in crude plant extracts by liquid chromatography-electrospray tandem mass spectrometry
    Xiangqing Pan
    Department of Biology, University of Missouri, St Louis, MO 63121, United States
    Phytochemistry 69:1773-81. 2008
    ..Structurally diverse compounds from complicated biological matrices are determined with high selectivity and sensitivity...
  21. pmc Quantitative profiling of Arabidopsis polar glycerolipids in response to phosphorus starvation. Roles of phospholipases D zeta1 and D zeta2 in phosphatidylcholine hydrolysis and digalactosyldiacylglycerol accumulation in phosphorus-starved plants
    Maoyin Li
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Plant Physiol 142:750-61. 2006
    ..The results suggest that hydrolysis of phosphatidylcholine by PLD zetas during phosphorus starvation contributes to the supply of inorganic phosphorus for cell metabolism and diacylglycerol moieties for galactolipid synthesis...
  22. ncbi request reprint Expression and characterization of Arabidopsis phospholipase Dgamma2
    Chunbo Qin
    Department of Biology, University of Missouri, St Louis, MO 63121, USA
    Biochim Biophys Acta 1761:1450-8. 2006
    ..These differences in biochemical and molecular properties suggest that the highly homologous PLDgammas are subjected to unique regulations and might have distinguishable functions...
  23. doi request reprint Profiling of plant hormones by mass spectrometry
    Xiangqing Pan
    Department of Biology, University of Missouri, St Louis, MO 63121, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2806-13. 2009
    ..The capacity to simultaneously quantify multiple classes of phytohormones will facilitate the study of hormone function and cross-talk...
  24. doi request reprint Phosphatidic acid-mediated signaling
    Yu Liu
    Department of Biology, University of Missouri, St Louis, MO, USA
    Adv Exp Med Biol 991:159-76. 2013
    ..Further investigations of PA's function and mechanisms of action will advance not only the understanding of cell signaling networks but also may lead to biotechnological and pharmacological applications...
  25. ncbi request reprint A bifurcating pathway directs abscisic acid effects on stomatal closure and opening in Arabidopsis
    Girish Mishra
    Department of Biology, University of Missouri, St Louis, MO 63121, USA, and Donald Danforth Plant Science Center, St Louis, MO 63132, USA
    Science 312:264-6. 2006
    ..The results reveal a bifurcating signaling pathway that regulates plant water loss...
  26. pmc Crosstalk between Phospholipase D and Sphingosine Kinase in Plant Stress Signaling
    Liang Guo
    Department of Biology, University of Missouri St Louis, MO, USA
    Front Plant Sci 3:51. 2012
    ....
  27. ncbi request reprint Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and Mammalian cells
    Yansheng Zhang
    Donald Danforth Plant Science Center, St Louis, Missouri 63132, USA
    J Am Chem Soc 128:13030-1. 2006
    ..We successfully engineered an entire plant natural product pathway into a mammalian host...
  28. ncbi request reprint Phospholipid-derived signaling in plant response to temperature and water stresses
    Xuemin Wang
    Department of Biology, University of Missouri, St Louis, Missouri 63121, USA
    Genet Eng (N Y) 27:57-66. 2006
  29. pmc The oleate-stimulated phospholipase D, PLDdelta, and phosphatidic acid decrease H2O2-induced cell death in Arabidopsis
    Wenhua Zhang
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Cell 15:2285-95. 2003
    ..These results demonstrate that activation of oleate-stimulated PLDdelta constitutes an important step in the plant response to H2O2 and increasing plant stress tolerance...
  30. ncbi request reprint Phospholipase D in hormonal and stress signaling
    Xuemin Wang
    Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA
    Curr Opin Plant Biol 5:408-14. 2002
    ..PLDs and their product phosphatidic acid are involved in various stress responses, including water deficits, salts, wounding, and elicitation. Increasing evidence supports a role of PLD in the abscisic acid signaling cascades...
  31. pmc The Arabidopsis phospholipase D family. Characterization of a calcium-independent and phosphatidylcholine-selective PLD zeta 1 with distinct regulatory domains
    Chunbo Qin
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Physiol 128:1057-68. 2002
    ....
  32. ncbi request reprint Lipid signaling
    Xuemin Wang
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Curr Opin Plant Biol 7:329-36. 2004
    ..Phospholipase D enzymes and phosphatidic acid may play a broader role in lipid signaling in plants than in other systems...
  33. ncbi request reprint Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis
    Xiaoming Gong
    The Liver Research Center, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Neuron 38:33-46. 2003
    ..Our studies reveal a nuclear pathway by which neurotoxin/Cdk5 induces neuronal apoptosis through inhibiting prosurvival nuclear machinery...
  34. ncbi request reprint Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1
    Anne Beugnet
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 278:40717-22. 2003
    ..The RAIP motif thus promotes the mTOR-dependent phosphorylation of multiple sites in 4E-BP1 independently of the 4E-BP1/raptor interaction...
  35. ncbi request reprint Rice phospholipase D isoforms show differential cellular location and gene induction
    J David McGee
    Department of Plant Pathology, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Cell Physiol 44:1013-26. 2003
    ..This combined information on structural features, expression profiles, and cellular localization will assist the basis for dissection of PLD isoform function in rice...
  36. ncbi request reprint Evolutionary conservation of physical and functional interactions between phospholipase D and actin
    David J Kusner
    Department of Internal Medicine, University of Iowa Carrer College of Medicine and VA Medical Center, Iowa City, IA 52242, USA
    Arch Biochem Biophys 412:231-41. 2003
    ..Thus, physical and functional interactions between PLD and actin in PLD family members from bacteria to mammals are highly conserved throughout evolution...
  37. ncbi request reprint Electrospray ionization tandem mass spectrometry scan modes for plant chloroplast lipids
    Ruth Welti
    Division of Biology, Kansas State University, Ackert Hall, Manhattan, KS 66506 4901, USA
    Anal Biochem 314:149-52. 2003
  38. pmc The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation
    Xuemin Wang
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 23:1546-57. 2003
    ..However, in 4E-BP3, replacement of the alanine at the position corresponding to S112 by serine or glutamate did not confer the ability to be released from eIF4E in response to insulin...
  39. ncbi request reprint Regulation of phospholipase D activity by actin. Actin exerts bidirectional modulation of Mammalian phospholipase D activity in a polymerization-dependent, isoform-specific manner
    David J Kusner
    Department of Internal Medicine, Division of Infectious Diseases, Inflammation Program, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 277:50683-92. 2002
    ..These data are consistent with a model in which the physical state of the actin cytoskeleton is a critical determinant of its regulation of PLD activity...
  40. ncbi request reprint Kinetic analysis of Arabidopsis phospholipase Ddelta. Substrate preference and mechanism of activation by Ca2+ and phosphatidylinositol 4,5-biphosphate
    Chunbo Qin
    Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 277:49685-90. 2002
    ..This indicates that Ca(2+) activates PLD by promoting the binding of phospholipid substrate to the catalytic site of the enzyme...
  41. pmc Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin
    Xuemin Wang
    Division of Molecular Physiology, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 367:475-81. 2002
    ....
  42. ncbi request reprint Profiling membrane lipids in plant stress responses. Role of phospholipase D alpha in freezing-induced lipid changes in Arabidopsis
    Ruth Welti
    Division of Biology, Ackert Hall, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 277:31994-2002. 2002
    ....
  43. ncbi request reprint Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors
    Jashmin Patel
    Department of Biosciences, University of Kent at Canterbury, Canterbury, UK
    Eur J Biochem 269:3076-85. 2002
    ..Our data reveal that these stress-inducing agents, which are widely used to study stress-signalling in mammalian cells, exert multiple and complex inhibitory effects on the translational machinery...
  44. ncbi request reprint Activation of plant phospholipase Dbeta by phosphatidylinositol 4,5-bisphosphate: characterization of binding site and mode of action
    Li Zheng
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Biochemistry 41:4546-53. 2002
    ..The results taken together allow us to describe an anchorage-scooting model for the synergistic activation of PLDbeta by PI(4,5)P2 and Ca2+...
  45. pmc A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B
    Xuemin Wang
    Department of Biochemistry and Molecular Biology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada
    Mol Cell Biol 28:1429-42. 2008
    ..These findings identify a new way in which amino acids regulate a key step in translation initiation and indicate that this involves a novel amino acid-sensitive signaling mechanism...
  46. ncbi request reprint Differential degradation of extraplastidic and plastidic lipids during freezing and post-freezing recovery in Arabidopsis thaliana
    Weiqi Li
    Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650204, China
    J Biol Chem 283:461-8. 2008
    ..These data suggest a negative role for PLDalpha1 and a positive role for PLDdelta in freezing tolerance...
  47. ncbi request reprint Evidence for and characterization of Ca2+ binding to the catalytic region of Arabidopsis thaliana phospholipase Dbeta
    Kirk Pappan
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 279:47833-9. 2004
    ..These results demonstrate the contrasting and complementary effects of the Ca(2+)- and lipid-binding properties of the C2 and catalytic domains of plant PLD and provide insight into the mechanism by which Ca(2+) regulates PLD activity...
  48. ncbi request reprint Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival
    Xuemin Wang
    Department of Medicine, Brown University Medical School and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Biol Chem 280:16705-13. 2005
    ..This study identifies the transcription factor MEF2 as a target of cAMP-PKA pathway and demonstrates that PKA phosphorylation of MEF2 is a key step in modulating its DNA binding activity and ability to promote neuronal survival...
  49. ncbi request reprint ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells
    Sassan Hafizi
    Department of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Heart Science Centre, Harefield Hospital, Middlesex, United Kingdom
    Am J Physiol Heart Circ Physiol 287:H1232-8. 2004
    ..These signaling mechanisms may mediate the growth-promoting effect of ANG II in human cSMCs...
  50. ncbi request reprint Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2
    Xiaoli Tang
    Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    J Neurosci 25:4823-34. 2005
    ....
  51. ncbi request reprint Phospholipase D in the signaling networks of plant response to abscisic acid and reactive oxygen species
    Wenhua Zhang
    College of Life Science, State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanijing 210095, P R China
    Biochim Biophys Acta 1736:1-9. 2005
    ..PLD and PA play multiple roles in the signaling networks of plant response to abscisic acid and reactive oxygen species...
  52. pmc Phospholipase D alpha 1-derived phosphatidic acid interacts with ABI1 phosphatase 2C and regulates abscisic acid signaling
    Wenhua Zhang
    Department of Biochemistry, Kansas State University, Manhattan, 66506, USA
    Proc Natl Acad Sci U S A 101:9508-13. 2004
    ..The identification of ABI1 as a direct target of the lipid messenger PA provides a functional link between the two families of important signaling enzymes, PLD and PP2C...
  53. pmc Double knockouts of phospholipases Dzeta1 and Dzeta2 in Arabidopsis affect root elongation during phosphate-limited growth but do not affect root hair patterning
    Maoyin Li
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Physiol 140:761-70. 2006
    ..These results indicate that PLDzeta1 and PLDzeta2 play a role in regulating root development in response to nutrient limitation...
  54. ncbi request reprint Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2
    Patrice D Smith
    Ottawa Health Research Institute, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 26:440-7. 2006
    ..Together, these data indicate that calpain-p35-p25/cdk5-mediated inactivation of MEF2 plays a critical role in dopaminergic loss in vivo...
  55. ncbi request reprint Lipid species profiling: a high-throughput approach to identify lipid compositional changes and determine the function of genes involved in lipid metabolism and signaling
    Ruth Welti
    Division of Biology, Kansas State University, Manhattan, Kansas 66506, USA
    Curr Opin Plant Biol 7:337-44. 2004
    ....
  56. ncbi request reprint Quantitative profiling of polar glycerolipid species from organs of wild-type Arabidopsis and a phospholipase Dalpha1 knockout mutant
    Shivakumar Pattada Devaiah
    Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA
    Phytochemistry 67:1907-24. 2006
    ....
  57. ncbi request reprint Suppression of phospholipase Dalpha1 induces freezing tolerance in Arabidopsis: response of cold-responsive genes and osmolyte accumulation
    C B Rajashekar
    Division of Horticulture, Kansas State University, Manhattan, KS 66506, USA
    J Plant Physiol 163:916-26. 2006
    ..These results suggest that PLDalpha1 plays a key role in freezing tolerance of Arabidopsis by modulating the cold-responsive genes and accumulation of osmolytes...
  58. pmc Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins
    Xuemin Wang
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 25:2558-72. 2005
    ..These data have important implications for understanding signaling downstream of mTOR and the development of new strategies to impair mTOR signaling...
  59. ncbi request reprint Plant lipidomics: discerning biological function by profiling plant complex lipids using mass spectrometry
    Ruth Welti
    Kansas Lipidomics Research Center, Division of Biology, Kansas State University, Manhattan, KS 66506, USA
    Front Biosci 12:2494-506. 2007
    ..Such lipidomic analyses have been used to uncover roles for lipids in plant response to stresses and to identify in vivo functions of genes involved in lipid metabolism...
  60. ncbi request reprint The plasma membrane-bound phospholipase Ddelta enhances freezing tolerance in Arabidopsis thaliana
    Weiqi Li
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506 3702, USA
    Nat Biotechnol 22:427-33. 2004
    ....
  61. ncbi request reprint Arabidopsis phospholipase Dalpha1 interacts with the heterotrimeric G-protein alpha-subunit through a motif analogous to the DRY motif in G-protein-coupled receptors
    Jian Zhao
    Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 279:1794-800. 2004
    ....
  62. ncbi request reprint Methods for studying signal-dependent regulation of translation factor activity
    Xuemin Wang
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    Methods Enzymol 431:113-42. 2007
    ..In addition, we provide guidelines on using small molecule inhibitors to assess the involvement of specific signaling pathways in controlling translation factors and protein synthesis...
  63. ncbi request reprint Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons
    Yuanbin Xie
    Department of Pharmacology, Zhongshan Medical College, Sun Yat Sen University, No 74, Zhongshan Rd 2, Guangzhou 510080, China
    Neurosci Lett 367:355-9. 2004
    ..Our studies give further supports for JNK-targeting strategy in preventing neuronal apoptosis...