Affiliation: University of California
Zheng X, Han H, Liu G, Ma Y, Pan R, Sang L, et al
. LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. EMBO J. 2017;36:3325-3335 pubmed publisher
..Taken together, our study not only reveals the mechanism by which YAP reprograms glucose metabolism, but also highlights the therapeutic potential of targeting YAP-BCAR4-glycolysis axis for breast cancer treatment. ..
Han H, Qi R, Zhou J, Ta A, Yang B, Nakaoka H, et al
. Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Mol Cell. 2018;72:328-340.e8 pubmed publisher
..Taken together, our study not only reveals a role of PLD-PA lipid signaling in regulating the Hippo pathway but also indicates that the PLD-PA-YAP axis is a potential therapeutic target for cancer treatment. ..
Han H, Yang B, Nakaoka H, Yang J, Zhao Y, Le Nguyen K, et al
. Hippo signaling dysfunction induces cancer cell addiction to YAP. Oncogene. 2018;37:6414-6424 pubmed publisher
..Taken together, our results not only establish an active YAP-induced oncogene addiction in cancer cells, but also lay the foundation to develop targeted therapies for the cancers with Hippo dysfunction and YAP activation. ..
Li X, Han H, Zhou M, Yang B, Ta A, Li N, et al
. Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Rep. 2017;20:737-749 pubmed publisher
..Our proteomic study of the TNKS/2 protein interaction network provides a rich resource for further exploration of tankyrase functions in numerous cellular processes. ..