THOMAS D contact WANG

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Targeted vertical cross-sectional imaging with handheld near-infrared dual axes confocal fluorescence endomicroscope
    Zhen Qiu
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Biomed Opt Express 4:322-30. 2013
  2. pmc In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe
    Sharon J Miller
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e17384. 2011
  3. pmc In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptide
    Zhongyao Liu
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
    Gut 62:395-403. 2013
  4. pmc Targeted imaging of flat and depressed colonic neoplasms
    Thomas D Wang
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Michigan School of Medicine, 109 Zina Pitcher Place, BSRB 1522, Ann Arbor, MI 48109, USA
    Gastrointest Endosc Clin N Am 20:579-83. 2010
  5. pmc Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopy
    Thomas D Wang
    Division of Gastroenterology, Stanford University School of Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 104:15864-9. 2007
  6. doi request reprint Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture
    Jonathan T C Liu
    Stanford University, Department of Electrical Engineering, Ginzton Laboratory, and School of Medicine, James H Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
    J Biomed Opt 13:034020. 2008
  7. ncbi request reprint Autofluorescence imaging: have we finally seen the light?
    Thomas D Wang
    Gastrointest Endosc 61:686-8. 2005
  8. pmc Optical biopsy: a new frontier in endoscopic detection and diagnosis
    Thomas D Wang
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA 94305, USA
    Clin Gastroenterol Hepatol 2:744-53. 2004
  9. pmc Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection
    Thomas D Wang
    Stanford University School of Medicine, Stanford, California 94305, USA
    Opt Lett 28:1915-7. 2003
  10. ncbi request reprint Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence
    Stephan Brand
    Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Boston, Massachusetts, USA
    Gastrointest Endosc 56:479-87. 2002

Collaborators

  • George Triadafilopoulos
  • James M Crawford
  • G Y Lauwers
  • Zhongyao Liu
  • Sharon J Miller
  • Zhen Qiu
  • Bishnu P Joshi
  • Michael J Mandella
  • Jonathan T C Liu
  • Stephan Brand
  • Katsuo Kurabayashi
  • Kenn Oldham
  • Supang Khondee
  • Bishnu Joshi
  • Xiyu Duan
  • Adam Gaustad
  • Ying Feng
  • Eric R Fearon
  • Christopher H Contag
  • Gordon S Kino
  • Marcos C Pedrosa
  • John M Poneros
  • Carolyn C Compton
  • Kevin T Schomacker
  • Norman S Nishioka

Detail Information

Publications12

  1. pmc Targeted vertical cross-sectional imaging with handheld near-infrared dual axes confocal fluorescence endomicroscope
    Zhen Qiu
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Biomed Opt Express 4:322-30. 2013
    ..NIR vertical cross-sectional fluorescence images of fresh mouse colonic mucosa demonstrate histology-like imaging performance with this miniature instrument...
  2. pmc In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe
    Sharon J Miller
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e17384. 2011
    ..This finding highlights an innovative strategy for targeted detection to localize pre-malignant lesions that can be generalized to the epithelium of hollow organs...
  3. pmc In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptide
    Zhongyao Liu
    Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
    Gut 62:395-403. 2013
    ..To demonstrate a near-infrared (NIR) peptide that is highly specific for colonic adenomas on fluorescence endoscopy in vivo...
  4. pmc Targeted imaging of flat and depressed colonic neoplasms
    Thomas D Wang
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Michigan School of Medicine, 109 Zina Pitcher Place, BSRB 1522, Ann Arbor, MI 48109, USA
    Gastrointest Endosc Clin N Am 20:579-83. 2010
    ..These methods are being applied to detect the presence of flat and depressed colonic neoplasms and to identify tumor margins...
  5. pmc Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopy
    Thomas D Wang
    Division of Gastroenterology, Stanford University School of Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
    Proc Natl Acad Sci U S A 104:15864-9. 2007
    ....
  6. doi request reprint Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architecture
    Jonathan T C Liu
    Stanford University, Department of Electrical Engineering, Ginzton Laboratory, and School of Medicine, James H Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
    J Biomed Opt 13:034020. 2008
    ..Our results demonstrate efficient rejection of scattered light in a DACM, which enables deep optical sectioning in tissue with subcellular resolution that can distinguish between normal and premalignant pathologies...
  7. ncbi request reprint Autofluorescence imaging: have we finally seen the light?
    Thomas D Wang
    Gastrointest Endosc 61:686-8. 2005
  8. pmc Optical biopsy: a new frontier in endoscopic detection and diagnosis
    Thomas D Wang
    Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA 94305, USA
    Clin Gastroenterol Hepatol 2:744-53. 2004
    ..This review describes the basic biophysics of light-tissue interactions, assesses the strengths and weaknesses of each method, and examines clinical and preclinical evidence for each approach...
  9. pmc Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detection
    Thomas D Wang
    Stanford University School of Medicine, Stanford, California 94305, USA
    Opt Lett 28:1915-7. 2003
    ..This architecture can be scaled down to millimeter dimensions with microelectromechanical systems technology for performance of in vivo optical biopsy...
  10. ncbi request reprint Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescence
    Stephan Brand
    Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Boston, Massachusetts, USA
    Gastrointest Endosc 56:479-87. 2002
    ..This study used quantitative methods to determine whether aminolevulinic acid-induced protoporphyrin IX fluorescence can differentiate between Barrett's mucosa with and without dysplasia...

Research Grants8

  1. Peptide Reagents for Detection of Colonic Dysplasia
    Thomas Wang; Fiscal Year: 2007
    ..Candidate peptide-FITC reagents will then be administered topically to additional freshly resected adenomas, and then imaged first with the tabletop dual axes confocal microscope, and then with the miniature prototype. ..
  2. Novel Confocal Microscope for Molecular/Cellular Imaging
    Thomas Wang; Fiscal Year: 2007
    ..7) Collect images from Barrett's epithelium and colonic adenomas during routine endoscopy. ..
  3. Miniature Confocal Theta Flourescence Microscope
    Thomas Wang; Fiscal Year: 2007
    ..Miniaturization to this scale will permit insertion through the uterine cervix or implantation into the cranium of small animal models for studying embryonic development, cell-cell interactions, cell migration, and tumor biology. ..
  4. Targeted Multi-Spectral Dual Axes Confocal Imaging of In Vivo Molecular Expressio
    THOMAS D contact WANG; Fiscal Year: 2010
    ....