THOMAS D contact WANG
Affiliation: University of Michigan
- Targeted vertical cross-sectional imaging with handheld near-infrared dual axes confocal fluorescence endomicroscopeZhen Qiu
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Biomed Opt Express 4:322-30. 2013..NIR vertical cross-sectional fluorescence images of fresh mouse colonic mucosa demonstrate histology-like imaging performance with this miniature instrument...
- In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probeSharon J Miller
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 6:e17384. 2011..This finding highlights an innovative strategy for targeted detection to localize pre-malignant lesions that can be generalized to the epithelium of hollow organs...
- In vivo targeting of colonic dysplasia on fluorescence endoscopy with near-infrared octapeptideZhongyao Liu
Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA
Gut 62:395-403. 2013..To demonstrate a near-infrared (NIR) peptide that is highly specific for colonic adenomas on fluorescence endoscopy in vivo...
- Targeted imaging of flat and depressed colonic neoplasmsThomas D Wang
Division of Gastroenterology and Hepatology, Department of Medicine, University of Michigan School of Medicine, 109 Zina Pitcher Place, BSRB 1522, Ann Arbor, MI 48109, USA
Gastrointest Endosc Clin N Am 20:579-83. 2010..These methods are being applied to detect the presence of flat and depressed colonic neoplasms and to identify tumor margins...
- Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopyThomas D Wang
Division of Gastroenterology, Stanford University School of Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
Proc Natl Acad Sci U S A 104:15864-9. 2007....
- Efficient rejection of scattered light enables deep optical sectioning in turbid media with low-numerical-aperture optics in a dual-axis confocal architectureJonathan T C Liu
Stanford University, Department of Electrical Engineering, Ginzton Laboratory, and School of Medicine, James H Clark Center for Biomedical Engineering and Science, Stanford, California 94305, USA
J Biomed Opt 13:034020. 2008..Our results demonstrate efficient rejection of scattered light in a DACM, which enables deep optical sectioning in tissue with subcellular resolution that can distinguish between normal and premalignant pathologies...
- Autofluorescence imaging: have we finally seen the light?Thomas D Wang
Gastrointest Endosc 61:686-8. 2005
- Optical biopsy: a new frontier in endoscopic detection and diagnosisThomas D Wang
Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA 94305, USA
Clin Gastroenterol Hepatol 2:744-53. 2004..This review describes the basic biophysics of light-tissue interactions, assesses the strengths and weaknesses of each method, and examines clinical and preclinical evidence for each approach...
- Dual-axes confocal microscopy with post-objective scanning and low-coherence heterodyne detectionThomas D Wang
Stanford University School of Medicine, Stanford, California 94305, USA
Opt Lett 28:1915-7. 2003..This architecture can be scaled down to millimeter dimensions with microelectromechanical systems technology for performance of in vivo optical biopsy...
- Detection of high-grade dysplasia in Barrett's esophagus by spectroscopy measurement of 5-aminolevulinic acid-induced protoporphyrin IX fluorescenceStephan Brand
Gastrointestinal Unit, Wellman Laboratories of Photomedicine, Boston, Massachusetts, USA
Gastrointest Endosc 56:479-87. 2002..This study used quantitative methods to determine whether aminolevulinic acid-induced protoporphyrin IX fluorescence can differentiate between Barrett's mucosa with and without dysplasia...
- Peptide Reagents for Detection of Colonic DysplasiaThomas Wang; Fiscal Year: 2007..Candidate peptide-FITC reagents will then be administered topically to additional freshly resected adenomas, and then imaged first with the tabletop dual axes confocal microscope, and then with the miniature prototype. ..
- Novel Confocal Microscope for Molecular/Cellular ImagingThomas Wang; Fiscal Year: 2007..7) Collect images from Barrett's epithelium and colonic adenomas during routine endoscopy. ..
- Miniature Confocal Theta Flourescence MicroscopeThomas Wang; Fiscal Year: 2007..Miniaturization to this scale will permit insertion through the uterine cervix or implantation into the cranium of small animal models for studying embryonic development, cell-cell interactions, cell migration, and tumor biology. ..
- Targeted Multi-Spectral Dual Axes Confocal Imaging of In Vivo Molecular ExpressioTHOMAS D contact WANG; Fiscal Year: 2010....