Shuxia Wang

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis
    Wenpeng Cui
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg, Rm 583, 900 S Limestone St, Lexington, KY 40536
    Am J Physiol Renal Physiol 306:F996-F1007. 2014
  2. pmc Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model
    Yanzhang Li
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 6:e26656. 2011
  3. pmc Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function
    Hasiyeti Maimaitiyiming
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg Rm 583, 900 S Limestone St, Lexington, KY 40536
    Am J Physiol Renal Physiol 305:F881-90. 2013
  4. pmc Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity
    Wenpeng Cui
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg Rm 583, 900 S Limestone St, Lexington, KY 40536
    Am J Physiol Renal Physiol 305:F871-80. 2013
  5. doi request reprint Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation
    Shuxia Wang
    Graduate Center for Nutritional Sciences, University of Kentucky, Wethington Bldg, Rm 517, 900 S Limestone St, Lexington, KY, USA
    Am J Physiol Heart Circ Physiol 297:H2075-83. 2009
  6. pmc Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cells
    Shuxia Wang
    Univ of Kentucky, Lexington, 40536, USA
    Am J Physiol Cell Physiol 298:C1188-97. 2010
  7. doi request reprint Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice
    Lihua Shi
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg Rm 517, 900 S Limestone St, Lexington, KY 40536 0200, USA
    Am J Physiol Renal Physiol 296:F257-65. 2009
  8. pmc Overexpression of cGMP-dependent protein kinase I (PKG-I) attenuates ischemia-reperfusion-induced kidney injury
    Yanzhang Li
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Lexington, KY 40536, USA
    Am J Physiol Renal Physiol 302:F561-70. 2012
  9. pmc Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury
    Rong Gao
    The Second Hospital of Jilin University, Changchun, Jilin, China Center for Research on Environmental Disease, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 9:e98909. 2014
  10. ncbi request reprint Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury
    Shu Liu
    Graduate Center for Nutritional Sciences, University of Kentucky, Wethington Bldg Rm 517, 900 S Limestone St, Lexington, KY 40536, USA
    Am J Physiol Renal Physiol 293:F1727-35. 2007

Collaborators

Detail Information

Publications19

  1. pmc Increasing cGMP-dependent protein kinase activity attenuates unilateral ureteral obstruction-induced renal fibrosis
    Wenpeng Cui
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg, Rm 583, 900 S Limestone St, Lexington, KY 40536
    Am J Physiol Renal Physiol 306:F996-F1007. 2014
    ..Taken together, these data suggest that increasing PKG activity ameliorates renal fibrosis in part through regulation of macrophage and tubular cell function, leading to reduced TGF-β-induced fibrosis. ..
  2. pmc Thrombospondin1 deficiency reduces obesity-associated inflammation and improves insulin sensitivity in a diet-induced obese mouse model
    Yanzhang Li
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 6:e26656. 2011
    ..However, the direct effect of TSP1 on obesity and insulin resistance is not known. Therefore, we investigated the role of TSP1 in mediating obesity-associated inflammation and insulin resistance by using TSP1 knockout mice...
  3. pmc Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function
    Hasiyeti Maimaitiyiming
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg Rm 583, 900 S Limestone St, Lexington, KY 40536
    Am J Physiol Renal Physiol 305:F881-90. 2013
    ..Taken together, these results suggest that increasing PKG activity may be a novel option for renoprotection during cisplatin-based chemotherapy. ..
  4. pmc Thrombospondin 1 mediates renal dysfunction in a mouse model of high-fat diet-induced obesity
    Wenpeng Cui
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg Rm 583, 900 S Limestone St, Lexington, KY 40536
    Am J Physiol Renal Physiol 305:F871-80. 2013
    ..These leptin-stimulated effects were abolished in TSP1-deficient mesangial cells. Taken together, these data suggest that TSP1 is an important mediator for obesity- or hyperleptinemia-induced kidney dysfunction. ..
  5. doi request reprint Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation
    Shuxia Wang
    Graduate Center for Nutritional Sciences, University of Kentucky, Wethington Bldg, Rm 517, 900 S Limestone St, Lexington, KY, USA
    Am J Physiol Heart Circ Physiol 297:H2075-83. 2009
    ....
  6. pmc Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cells
    Shuxia Wang
    Univ of Kentucky, Lexington, 40536, USA
    Am J Physiol Cell Physiol 298:C1188-97. 2010
    ..Together, these data establish that glucose-mediated downregulation of PKG levels stimulates TSP1 expression and enhances TGF-beta activity and matrix protein expression, which can contribute to vascular remodeling in diabetes...
  7. doi request reprint Activation of renal renin-angiotensin system in upstream stimulatory factor 2 transgenic mice
    Lihua Shi
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Wethington Bldg Rm 517, 900 S Limestone St, Lexington, KY 40536 0200, USA
    Am J Physiol Renal Physiol 296:F257-65. 2009
    ..In addition, renin-dependent ANG II generation mediates the effect of USF2 on TGF-beta production in mesangial cells, which may contribute to the development of nephropathy in USF2 (Tg) mice...
  8. pmc Overexpression of cGMP-dependent protein kinase I (PKG-I) attenuates ischemia-reperfusion-induced kidney injury
    Yanzhang Li
    Graduate Center for Nutritional Sciences, Univ of Kentucky, Lexington, KY 40536, USA
    Am J Physiol Renal Physiol 302:F561-70. 2012
    ..Taken together, these results suggest that PKG-I protects against renal IRI, at least in part through inhibiting inflammatory cell infiltration into the kidney, reducing kidney inflammation, and inhibiting tubular cell apoptosis...
  9. pmc Sirt1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury
    Rong Gao
    The Second Hospital of Jilin University, Changchun, Jilin, China Center for Research on Environmental Disease, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 9:e98909. 2014
    ..The results indicate that Sirt1 is protective against LPS-induced acute kidney injury by suppressing kidney inflammation and down-regulating inflammatory signaling. ..
  10. ncbi request reprint Overexpression of upstream stimulatory factor 2 accelerates diabetic kidney injury
    Shu Liu
    Graduate Center for Nutritional Sciences, University of Kentucky, Wethington Bldg Rm 517, 900 S Limestone St, Lexington, KY 40536, USA
    Am J Physiol Renal Physiol 293:F1727-35. 2007
    ..Type 1 diabetes onset further augmented the urinary albumin excretion and glomerular hypertrophy in the USF2 (Tg) mice. These findings suggest that overexpression of USF2 accelerates the development of diabetic nephropathy...
  11. pmc Glycated albumin upregulates upstream stimulatory factor 2 gene transcription in mesangial cells
    Yanzhang Li
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    Am J Physiol Renal Physiol 299:F121-7. 2010
    ..Taken together, these data suggest that glycated albumin upregulated USF2 gene transcription in MCs through NF-kappaB-dependent transactivation of the USF2 promoter...
  12. pmc Glycated albumin activates NADPH oxidase in rat mesangial cells through up-regulation of p47phox
    Yanzhang Li
    Graduate Center for Nutritional Sciences, University of Kentucky, 900 S Limestone Street, Lexington, KY 40536, USA
    Biochem Biophys Res Commun 397:5-11. 2010
    ....
  13. pmc Thrombospondin 1 activates the macrophage Toll-like receptor 4 pathway
    Yanzhang Li
    1 Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA 2 Current address College of Medicine, Henan University, Kaifeng 475004, China
    Cell Mol Immunol 10:506-12. 2013
    ..Taken together, these data suggest that the stimulation of the macrophage TLR4 pathway by TSP1 is partially mediated by the interaction of TSP1 with its receptor, CD36. ..
  14. doi request reprint Overexpression of constitutively active PKG-I protects female, but not male mice from diet-induced obesity
    Dejan M Nikolic
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
    Obesity (Silver Spring) 19:784-91. 2011
    ..Together, these data demonstrate sex differences in effects of PKG-I activation on the regulation of adipose tissue function and its contribution to diet induced obesity...
  15. pmc High glucose upregulates upstream stimulatory factor 2 in human renal proximal tubular cells through angiotensin II-dependent activation of CREB
    Nishant P Visavadiya
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Nephron Exp Nephrol 117:e62-70. 2011
    ..In this study, we determined whether USF2 expression in renal proximal tubular cells is regulated by glucose and contributes to diabetic tubulointerstitial fibrosis...
  16. ncbi request reprint Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury
    Jiao Chen
    Center for Research on Environmental Disease, University of Kentucky, Lexington, KY 40536, USA
    Toxicol Appl Pharmacol 277:118-23. 2014
    ..Our findings demonstrate that AT-RvD1 is a potent anti-inflammatory mediator in LPS-induced kidney injury, and AT-RvD1 has therapeutic potential against AKI during endotoxemia. ..
  17. ncbi request reprint High glucose levels upregulate upstream stimulatory factor 2 gene transcription in mesangial cells
    Lihua Shi
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Cell Biochem 103:1952-61. 2008
    ..Taken together, these data indicate that high glucose levels up-regulate USF2 gene transcription in mesangial cells through CREB-dependent transactivation of the USF2 promoter...
  18. ncbi request reprint Glucose down-regulation of cGMP-dependent protein kinase I expression in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species
    Shu Liu
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA
    Free Radic Biol Med 42:852-63. 2007
    ....
  19. doi request reprint Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells
    Young Ok Son
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 0305, USA
    Toxicol Appl Pharmacol 245:226-35. 2010
    ..These results suggest that Cr(VI) induced a mitochondrial-mediated and caspase-dependent apoptosis in skin epidermal cells through activation of p53, which are mainly mediated by reactive oxidants generated by the chemical...