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Genomes and Genes | Qiang WangSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathwayQiang Wang
Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Exp Mol Pathol 79:100-7. 2005....- The centrosome in normal and transformed cellsQiang Wang
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
DNA Cell Biol 23:475-89. 2004..Here we review the current understanding of how the centrosome is assembled and duplicated. We also discuss the possible mechanisms by which centrosome abnormality contributes to the development of malignant phenotype... - Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosomeQiang Wang
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
DNA Cell Biol 25:554-62. 2006..Finally, we provide evidence indicating that SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome... 
Characterization of Su48, a centrosome protein essential for cell divisionQiang Wang
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 103:6512-7. 2006..We speculate that Su48 abnormalities may cause aberrant chromosome segregation and may contribute to aneuploidy and malignant transformation...- Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancerQingdu Liu
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute, 252 John Morgan Building, 3600 Hamilton Walk, Philadelphia, PA 19104, USA
Exp Mol Pathol 88:225-33. 2010..We propose that overexpression of Nek2 may promote aneuploidy by disrupting the control of the mitotic checkpoint... - Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelopeZhaocai Zhou
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 287:5317-26. 2012..These findings provide the structural basis for understanding the function and the regulation of the LINC complex... - UXT is a novel centrosomal protein essential for cell viabilityHuiwu Zhao
Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
Mol Biol Cell 16:5857-65. 2005..Together, our findings suggest that UXT is a component of centrosome and is essential for cell viability. We propose that UXT may facilitate transformation by corrupting regulated centrosome functions... - Suppression of human prostate tumor growth by a unique prostate-specific monoclonal antibody F77 targeting a glycolipid markerGeng Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
Proc Natl Acad Sci U S A 107:732-7. 2010..Thus, the present study indicates that mAb F77 defines a unique prostate cancer marker and shows promising potential for diagnosis and treatment of prostate cancer, especially for androgen-independent metastatic prostate cancer... - DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcriptionXiulian Du
Department of Pathology and Laboratory Medicine, 252 John Morgan Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Exp Mol Pathol 81:184-90. 2006..We propose that dysfunction of DIPA may contribute to malignant transformation by affecting the functions of p78... - Mechanisms of resistance to ErbB-targeted cancer therapeuticsQiang Wang
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 118:2389-92. 2008..Understanding the mechanisms involved in the resistance of some tumors to ErbB-targeted molecules may provide guidelines for developing more efficient therapeutic approaches... - Reversion of the ErbB malignant phenotype and the DNA damage responseE Aaron Runkle
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Exp Mol Pathol 93:324-33. 2012..Some studies have identified a mechanism by which DNA damage is coordinated to assemblies of proteins that associate with SUN domain containing proteins. These assemblies represent a new target for therapy of resistant tumor cells... - ErbB receptors: from oncogenes to targeted cancer therapiesHongtao Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
J Clin Invest 117:2051-8. 2007..However, current therapy has not yet been optimized, allowing for opportunities for optimization of the next generation of targeted therapy, particularly with regards to inhibiting heteromeric ErbB family receptor complexes... 
Targeting erbB receptorsZheng Cai
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
Semin Cell Dev Biol 21:961-6. 2010....- TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3Arabinda Samanta
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
Proc Natl Acad Sci U S A 105:14023-7. 2008..Collectively, our data provide a framework of how different signals affect intranuclear redistribution, posttranslational modifications, and chromatin binding patterns of FOXP3... - The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapiesJaclyn A Freudenberg
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
Exp Mol Pathol 87:1-11. 2009.... - Structural and biological features of FOXP3 dimerization relevant to regulatory T cell functionXiaomin Song
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China 200031
Cell Rep 1:665-75. 2012..Overall, the regulatory machinery involving homooligomerization, acetylation, and heteroassociation has been dissected, defining atomic insights into the biological and pathological characteristics of the FOXP3 complex... - FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune diseaseBin Li
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 252 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
Int Immunol 19:825-35. 2007..This study explains some features of the pathogenesis of a disease syndrome that arises as a consequence of specific assembly failure of a transcriptional repressor due to certain mutations within the FOXP3 leucine zipper... - Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthaseQiong Wei
Program in Molecular and Translational Medicine, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
Proteins 78:2058-74. 2010.... - Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primatesSoumitra Roy
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
PLoS Pathog 5:e1000503. 2009..Furthermore, the presence of persistent and/or latent adenovirus infections in the gut should be considered in the design and interpretation of human and non-human primate studies with adenovirus vectors... - The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancerArthur B McKie
Ovarian Cancer Action Research Centre, Division of Cancer, Imperial College London Hammersmith Campus, London, United Kingdom
Cancer Discov 2:156-71. 2012..Recombinant OPCML domain 1-3 recapitulates this mechanism and may allow for the implementation of an extracellular tumor-suppressor replacement strategy... - Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responsesGuangping Gao
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
Hum Gene Ther 20:930-42. 2009..There was no evidence of T cell activation in response to the AAV capsid. These studies indicate that under some conditions primates may activate more robust T cell responses to transgene products than is observed in mice... - SCWRL and MolIDE: computer programs for side-chain conformation prediction and homology modelingQiang Wang
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Nat Protoc 3:1832-47. 2008..SCWRL and MolIDE can be obtained at (http://dunbrack.fccc.edu/Software.php)... - Regulation of intracellular MEK1/2 translocation in mouse oocytes: cytoplasmic dynein/dynactin-mediated poleward transport and cyclin B degradation-dependent release from spindle polesBo Xiong
State Key Laboratory of Reproductive Biology, Institute of Zoology and Graduate School, Chinese Academy of Sciences, Beijing, PR China
Cell Cycle 6:1521-7. 2007.... - A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeastQiang Wang
Department of Biology and Department of Chemistry, University of Kentucky, Lexington, KY 40506 0225, USA
Nucleic Acids Res 36:2787-98. 2008..In addition, our results suggest the possibility that the Mud2p may enhance the turnover of pre-mRNA with impaired BBP-branchpoint association... - Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolinQiang Wang
Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Cell Biol 160:565-75. 2003..Together, our results suggest that PYK2 is a regulator of gelsolin, revealing a novel PYK2-gelsolin pathway in regulating actin cytoskeletal organization in multiple cells, including osteoclasts... - Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cellsShengbao Li
Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan Hubei, China
Cancer Invest 26:333-7. 2008..NS-398 could inhibit cell proliferation in cancer cells whether or no COX-2 expression. Nevertheless, apoptosis in the cancer cells expressing COX-2 protein increase more than those lacking COX-2... - Regulation of peripheral spindle movement and spindle rotation during mouse oocyte meiosis: new perspectivesJun Shu Ai
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Microsc Microanal 14:349-56. 2008..Furthermore, we found that the calcium/CaM/CaMKII pathway was important for regulating spindle rotation... - Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosisQiang Wang
Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
Anesthesiology 108:1071-80. 2008.... - Single-molecule force spectroscopy study of interaction between transforming growth factor beta1 and its receptor in living cellsJunping Yu
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
J Phys Chem B 111:13619-25. 2007..The results suggested a more stable binding of TGF-beta1 with the receptor after TbetaRI is recruited and the important contribution of TbetaRI to the signaling complex formation during TGF-beta1 signaling... - Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytesShen Yin
Cell Cycle 6:2990-2. 2007 - A new isopentenyl diphosphate isomerase gene from Camptotheca acuminata: cloning, characterization and functional expression in Escherichia coliXichun Pan
Lab of Natural Products and Metabolic Engineering, Chongqing Sweetpotato Research Center, Key Lab of Eco environments in Three Gorges Reservoir Region Ministry of Education, School of Life Sciences, Southwest University, People s Republic of China
DNA Seq 19:98-105. 2008..In summary, cloning, characterization and functional expression of CaIPI will facilitate to understand the function of CaIPI at the level of molecular genetics and unveil the biosynthetic mechanism of camptothecin precursors... - Prediction of the binding modes between BB-83698 and peptide deformylase from Bacillus stearothermophilus by docking and molecular dynamics simulationQiang Wang
Institute of Theoretical Chemistry, Shandong University, Jinan 250100, China
Biophys Chem 134:178-84. 2008..Mode 2 represents a new binding mode. Additionally, if the hydrophilic group is introduced to the benzo-[1,3]-dioxole ring, the binding affinity of BB-83698 to the peptide deformylase from B. stearothermophilus will be greatly improved... - Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERTJunjie Lv
Department of Pathology, Health Science Center of Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, China
Biochem Biophys Res Commun 311:506-13. 2003..The investigation suggested that hALP influences the activity of histone acetylation and could up-regulate telomerase activity through transactivation of hTERT promoter... - Safety and immunogenicity of a malaria vaccine, Plasmodium falciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adultsJinhong Hu
Changhai Hospital, Second Military Medical University, Shanghai, China
PLoS ONE 3:e1952. 2008..Fifty-two subjects were randomly assigned to 4 dose groups of 10 participants, each receiving the test vaccine of 20, 50, 100, or 200 microg respectively, and 1 placebo group of 12 participants receiving the adjuvant only... - Identification and characterization of a novel 1-Cys peroxiredoxin from silkworm, Bombyx moriQiang Wang
Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China
Comp Biochem Physiol B Biochem Mol Biol 149:176-82. 2008..In addition, real-time PCR analysis indicated that significant rise of the transcripts level of BmPrx was induced by temperature stress including low and high temperature stimuli... - Effects of static magnetic fields on the physical and chemical properties of cell culture medium RPM1 1640Farong Li
School of Electrical and Communication Engineering, Xi an Jiaotong University Xi an P R China
Electromagn Biol Med 26:25-32. 2007..Surface tension showed no significant difference in the two groups. This data suggests that SMF can change some of the physical and chemical properties of RPM1 1640 solution, and may contribute to understanding biological effects of SMF... - Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cellsQiang Wang
The Provincial Key Laboratory of Mechanisms of Development and Gene Control, Life Science School of Shandong University, Jinan 250100
Chin Med Sci J 19:157-63. 2004..CONCLUSION: The human COUP-TFII can firmly bind to hTERT promoter, and inhibit telomerase activity through decreasing hTERT transcription. It will greatly facilitate understanding of telomerase regulation in normal and cancer cells... - Focal adhesion kinase in netrin-1 signalingXiu Rong Ren
Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
Nat Neurosci 7:1204-12. 2004..Taken together, these results indicate a new signaling mechanism for DCC, in which FAK is activated upon netrin-1 stimulation and mediates netrin-1 function; they also identify a critical role for FAK in axon navigation... - The evidences of human orphan receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcriptionQiang Wang
The Provincial Key Laboratory of Mechanisms of Development and Gene Control, Life Science School of Shandong University, Jinan, China
Cancer Lett 214:81-90. 2004..The results suggested that the human COUP-TFII could specifically interact with hTERT promoter, in part via the E-box, and suppress the expression of hTERT... - [In vitro amplification and identification of immature dendritic cells from murine bone marrow]Qiang Wang
Institute of Burn Research, Southwestern Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, P.R. China
Zhonghua Shao Shang Za Zhi 19:332-5. 2003..The dosage of rm GM-CSF has direct relationship with the maturation degree of DC. Generally speaking, mature DC was mainly induced by high dosage of rmGM-CSF, while immature DC by low dosage... - Rds3p is required for stable U2 snRNP recruitment to the splicing apparatusQiang Wang
Department of Biology, University of Kentucky, Lexington, Kentucky 40506 0225, USA
Mol Cell Biol 23:7339-49. 2003..Together these data establish Rds3p as an essential component of the U2 snRNP SF3b complex and suggest a new link between the nuclear processes of pre-mRNA splicing and RNA export... - Inhibitory effects of pimozide on cloned and native voltage-gated potassium channelsZhi-Hao Zhang
Department of Neuroscience, Wyeth Research, Princeton, NJ, USA
Brain Res Mol Brain Res 115:29-38. 2003..It is thus conceivable that the time-dependent and/or subunit-specific inhibition of Kv channels may increase the release of neurotransmitters such as serotonin and glutamate... - G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interactionD Scott Witherow
Department of Molecular and Cellular Pharmacology and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
J Biol Chem 278:21307-13. 2003..Gbeta5 complex and cyan fluorescence protein-tagged Galphaq, indicating a direct interaction between these molecules... - [Molecular cloning and analysis of bovine prolactin full-long genomic as well as cDNA sequences]Xin Cao
Shanghai Institute of Medical Genetics, Shanghai Children s Hospital, Shanghai 200040, China
Yi Chuan Xue Bao 29:768-73. 2002..These SNP sites did not alter the related amino acids encoded. In addition, mRNA sequences encoding 5' signal sequence of bPRL gene was highly conserve... - Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and functionYang Z Huang
Department of Neurobiology, Pathology, Physical Medicine and Rehabilitation, University of Alabama at Birmingham, 35294 0021, USA
Int J Dev Neurosci 20:173-85. 2002..Such mechanisms could be important for the maintenance and function of the synapse... - [Demecolcine-induced enucleation of Kunming mouse oocyte.]Qiang Wang
Institute of Bio-Engineering, Northwest Sci-Tech University of Agriculture and Forestry, Shaanxi, Yangling 712 100, China
Yi Chuan 26:653-7. 2004..In experiment 3,oocytes collected from Kunming mouse at 17 -approximately 18h after hCG administration were favoriate to demecolcine-IE(27.1%). By comparison and analysis of the data, we established the optimized IE procedure... - Fas ligand expression in colon cancer: a possible mechanism of tumor immune privilegeWei Zhang
Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 20003, China
World J Gastroenterol 11:3632-5. 2005..To detect the expression of Fas ligand (FasL) in colon cancer tissues and cell lines and analyze the function of FasL-expressing colon cancer cells in inducing Fas-sensitive T lymphocyte apoptosis... - Neuroprotective effect of sodium ferulate on transient focal cerebral ischemia by weakening activation of postsynaptic density-95 in ratsQiang Wang
Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, China
Chin J Traumatol 8:297-302. 2005..To investigate the effects of sodium ferulate (SF), an intravenous drug made from traditional Chinese herbs, on activation of postsynaptic density-95 (PSD-95) and neuroprotection after transient cerebral artery occlusion in rats... - Lateral diffusion of TGF-beta type I receptor studied by single-molecule imagingXinyong Ma
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Biochem Biophys Res Commun 356:67-71. 2007..Our observations suggest that membrane lipid-rafts provide an environment that facilitates the association of TbetaRI and TbetaRII for cell signaling... - MEK1/2 regulates microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte meiotic maturationLing Zhu Yu
State Key Laboratory of Reproductive Biology, Institute of Zoology, Graduate School, Chinese Academy of Sciences, Beijing, China
Cell Cycle 6:330-8. 2007..Our results suggest that MEK1/2 may function as a centrosomal protein and may have roles in microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte maturation... - Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat developmentQiang Wang
Department of Occupational and Environmental Health, Faculty of Military Preventive Medicine, Fourth Military Medical University, 17 Changlexi Street, Xi an, 710032, China
Toxicol Appl Pharmacol 219:33-41. 2007..The increased BBB permeability may facilitate the accumulation of Pb. Fe supplement appears to protect the integrity of the BBB against Pb insults, a beneficial effect that may have significant clinical implications... - Bub1 prevents chromosome misalignment and precocious anaphase during mouse oocyte meiosisShen Yin
State Key Laboratory of Reproductive Biology, Institute of Zoology, Beijing, China
Cell Cycle 5:2130-7. 2006..Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis... - Histone phosphorylation and pericentromeric histone modifications in oocyte meiosisQiang Wang
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Cell Cycle 5:1974-82. 2006..Furthermore, by using ZM447439, an inhibitor of Aurora kinases, we revealed that Aurora kinases may participate in the regulation of histone phosphorylation during mouse oocyte maturation... - [Separation and identification of active constituents of Paris vietnamensis]Yun Huang
Department of Pharmacognosy, Hebei Medical Universty, Shijiazhuang, China
Yao Xue Xue Bao 41:361-4. 2006..CONCLUSION: Compound 1 is a new spirostanol saponin, and compounds 2, 3, 6-11 were obtained from Paris vietnamensis (Takht.) for the first time. Compounds 3, 4, 6, 8 had cytotoxic bioactivities against tumor cells HepG2 and SGC-7901... - Histone deacetylation is required for orderly meiosisQiang Wang
State Key Laboratory of Reproductive Biology, Institute of Zoology and Graduate School, Chinese Academy of Sciences, Beijing, China
Cell Cycle 5:766-74. 2006..The results showed that subcellular translocation, expression level and phosphorylated modification of HDAC1 were temporally regulated and likely to coparticipate in the establishment of histone acetylation profiles in oocyte meiosis... - Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokineticsDavid A Katz
Department of Pharmacogenetics, Abbott Laboratories, Abbott Park, IL 60064, USA
Clin Pharmacol Ther 79:186-96. 2006..Our objective was to learn whether genetic polymorphisms of metabolic enzymes or transport proteins provide a mechanistic understanding of the in vivo disposition of atrasentan, a selective endothelin A receptor antagonist... - Interactions of the yeast SF3b splicing factorQiang Wang
Department of Biology, University of Kentucky, Lexington, 40506, USA
Mol Cell Biol 25:10745-54. 2005..These data establish the concordance of yeast and mammalian SF3b complexes, implicate accessory splicing factors in U2 snRNP function, and support SF3b contribution from early pre-mRNP recognition to late steps in splicing... - Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1Zhen G Luo
Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294, USA
Neuron 35:489-505. 2002..Inhibition of PAK1 activity attenuates AChR clustering. These results demonstrate important roles of Dvl and PAK in Agrin/MuSK-induced AChR clustering and reveal a novel function of Dvl in synapse development...