Qiang Wang

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway
    Qiang Wang
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Mol Pathol 79:100-7. 2005
  2. ncbi request reprint The centrosome in normal and transformed cells
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 23:475-89. 2004
  3. ncbi request reprint Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 25:554-62. 2006
  4. pmc Characterization of Su48, a centrosome protein essential for cell division
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:6512-7. 2006
  5. pmc Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer
    Qingdu Liu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute, 252 John Morgan Building, 3600 Hamilton Walk, Philadelphia, PA 19104, USA
    Exp Mol Pathol 88:225-33. 2010
  6. pmc Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope
    Zhaocai Zhou
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:5317-26. 2012
  7. pmc UXT is a novel centrosomal protein essential for cell viability
    Huiwu Zhao
    Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 16:5857-65. 2005
  8. pmc Suppression of human prostate tumor growth by a unique prostate-specific monoclonal antibody F77 targeting a glycolipid marker
    Geng Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Proc Natl Acad Sci U S A 107:732-7. 2010
  9. ncbi request reprint DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription
    Xiulian Du
    Department of Pathology and Laboratory Medicine, 252 John Morgan Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:184-90. 2006
  10. pmc Mechanisms of resistance to ErbB-targeted cancer therapeutics
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2389-92. 2008

Collaborators

Detail Information

Publications58

  1. ncbi request reprint EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway
    Qiang Wang
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Mol Pathol 79:100-7. 2005
    ....
  2. ncbi request reprint The centrosome in normal and transformed cells
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 23:475-89. 2004
    ..Here we review the current understanding of how the centrosome is assembled and duplicated. We also discuss the possible mechanisms by which centrosome abnormality contributes to the development of malignant phenotype...
  3. ncbi request reprint Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    DNA Cell Biol 25:554-62. 2006
    ..Finally, we provide evidence indicating that SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome...
  4. pmc Characterization of Su48, a centrosome protein essential for cell division
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:6512-7. 2006
    ..We speculate that Su48 abnormalities may cause aberrant chromosome segregation and may contribute to aneuploidy and malignant transformation...
  5. pmc Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer
    Qingdu Liu
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute, 252 John Morgan Building, 3600 Hamilton Walk, Philadelphia, PA 19104, USA
    Exp Mol Pathol 88:225-33. 2010
    ..We propose that overexpression of Nek2 may promote aneuploidy by disrupting the control of the mitotic checkpoint...
  6. pmc Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope
    Zhaocai Zhou
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 287:5317-26. 2012
    ..These findings provide the structural basis for understanding the function and the regulation of the LINC complex...
  7. pmc UXT is a novel centrosomal protein essential for cell viability
    Huiwu Zhao
    Department of Pathology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 16:5857-65. 2005
    ..Together, our findings suggest that UXT is a component of centrosome and is essential for cell viability. We propose that UXT may facilitate transformation by corrupting regulated centrosome functions...
  8. pmc Suppression of human prostate tumor growth by a unique prostate-specific monoclonal antibody F77 targeting a glycolipid marker
    Geng Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Proc Natl Acad Sci U S A 107:732-7. 2010
    ..Thus, the present study indicates that mAb F77 defines a unique prostate cancer marker and shows promising potential for diagnosis and treatment of prostate cancer, especially for androgen-independent metastatic prostate cancer...
  9. ncbi request reprint DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription
    Xiulian Du
    Department of Pathology and Laboratory Medicine, 252 John Morgan Building, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Mol Pathol 81:184-90. 2006
    ..We propose that dysfunction of DIPA may contribute to malignant transformation by affecting the functions of p78...
  10. pmc Mechanisms of resistance to ErbB-targeted cancer therapeutics
    Qiang Wang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, and Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2389-92. 2008
    ..Understanding the mechanisms involved in the resistance of some tumors to ErbB-targeted molecules may provide guidelines for developing more efficient therapeutic approaches...
  11. pmc Reversion of the ErbB malignant phenotype and the DNA damage response
    E Aaron Runkle
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Mol Pathol 93:324-33. 2012
    ..Some studies have identified a mechanism by which DNA damage is coordinated to assemblies of proteins that associate with SUN domain containing proteins. These assemblies represent a new target for therapy of resistant tumor cells...
  12. pmc ErbB receptors: from oncogenes to targeted cancer therapies
    Hongtao Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6082, USA
    J Clin Invest 117:2051-8. 2007
    ..However, current therapy has not yet been optimized, allowing for opportunities for optimization of the next generation of targeted therapy, particularly with regards to inhibiting heteromeric ErbB family receptor complexes...
  13. doi request reprint Targeting erbB receptors
    Zheng Cai
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Semin Cell Dev Biol 21:961-6. 2010
    ....
  14. pmc TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3
    Arabinda Samanta
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Proc Natl Acad Sci U S A 105:14023-7. 2008
    ..Collectively, our data provide a framework of how different signals affect intranuclear redistribution, posttranslational modifications, and chromatin binding patterns of FOXP3...
  15. pmc The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies
    Jaclyn A Freudenberg
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Exp Mol Pathol 87:1-11. 2009
    ....
  16. pmc Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function
    Xiaomin Song
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China 200031
    Cell Rep 1:665-75. 2012
    ..Overall, the regulatory machinery involving homooligomerization, acetylation, and heteroassociation has been dissected, defining atomic insights into the biological and pathological characteristics of the FOXP3 complex...
  17. ncbi request reprint FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease
    Bin Li
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 252 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Int Immunol 19:825-35. 2007
    ..This study explains some features of the pathogenesis of a disease syndrome that arises as a consequence of specific assembly failure of a transcriptional repressor due to certain mutations within the FOXP3 leucine zipper...
  18. pmc Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase
    Qiong Wei
    Program in Molecular and Translational Medicine, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA
    Proteins 78:2058-74. 2010
    ....
  19. pmc Isolation and characterization of adenoviruses persistently shed from the gastrointestinal tract of non-human primates
    Soumitra Roy
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
    PLoS Pathog 5:e1000503. 2009
    ..Furthermore, the presence of persistent and/or latent adenovirus infections in the gut should be considered in the design and interpretation of human and non-human primate studies with adenovirus vectors...
  20. pmc The OPCML tumor suppressor functions as a cell surface repressor-adaptor, negatively regulating receptor tyrosine kinases in epithelial ovarian cancer
    Arthur B McKie
    Ovarian Cancer Action Research Centre, Division of Cancer, Imperial College London Hammersmith Campus, London, United Kingdom
    Cancer Discov 2:156-71. 2012
    ..These findings demonstrate a novel mechanism of OPCML-mediated tumor suppression and provide a proof-of-concept for recombinant OPCML protein therapy in epithelial ovarian cancers...
  21. pmc Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses
    Guangping Gao
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Hum Gene Ther 20:930-42. 2009
    ..There was no evidence of T cell activation in response to the AAV capsid. These studies indicate that under some conditions primates may activate more robust T cell responses to transgene products than is observed in mice...
  22. pmc SCWRL and MolIDE: computer programs for side-chain conformation prediction and homology modeling
    Qiang Wang
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Nat Protoc 3:1832-47. 2008
    ..SCWRL and MolIDE can be obtained at (http://dunbrack.fccc.edu/Software.php)...
  23. ncbi request reprint Regulation of intracellular MEK1/2 translocation in mouse oocytes: cytoplasmic dynein/dynactin-mediated poleward transport and cyclin B degradation-dependent release from spindle poles
    Bo Xiong
    State Key Laboratory of Reproductive Biology, Institute of Zoology and Graduate School, Chinese Academy of Sciences, Beijing, PR China
    Cell Cycle 6:1521-7. 2007
    ....
  24. pmc A BBP-Mud2p heterodimer mediates branchpoint recognition and influences splicing substrate abundance in budding yeast
    Qiang Wang
    Department of Biology and Department of Chemistry, University of Kentucky, Lexington, KY 40506 0225, USA
    Nucleic Acids Res 36:2787-98. 2008
    ..In addition, our results suggest the possibility that the Mud2p may enhance the turnover of pre-mRNA with impaired BBP-branchpoint association...
  25. pmc Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin
    Qiang Wang
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Cell Biol 160:565-75. 2003
    ..Together, our results suggest that PYK2 is a regulator of gelsolin, revealing a novel PYK2-gelsolin pathway in regulating actin cytoskeletal organization in multiple cells, including osteoclasts...
  26. doi request reprint Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells
    Shengbao Li
    Department of Gastroenterology, Taihe Hospital, Yunyang Medical College, Shiyan Hubei, China
    Cancer Invest 26:333-7. 2008
    ..NS-398 could inhibit cell proliferation in cancer cells whether or no COX-2 expression. Nevertheless, apoptosis in the cancer cells expressing COX-2 protein increase more than those lacking COX-2...
  27. pmc Regulation of peripheral spindle movement and spindle rotation during mouse oocyte meiosis: new perspectives
    Jun Shu Ai
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    Microsc Microanal 14:349-56. 2008
    ..Furthermore, we found that the calcium/CaM/CaMKII pathway was important for regulating spindle rotation...
  28. doi request reprint Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis
    Qiang Wang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Anesthesiology 108:1071-80. 2008
    ....
  29. ncbi request reprint Single-molecule force spectroscopy study of interaction between transforming growth factor beta1 and its receptor in living cells
    Junping Yu
    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    J Phys Chem B 111:13619-25. 2007
    ..The results suggested a more stable binding of TGF-beta1 with the receptor after TbetaRI is recruited and the important contribution of TbetaRI to the signaling complex formation during TGF-beta1 signaling...
  30. ncbi request reprint Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes
    Shen Yin
    Cell Cycle 6:2990-2. 2007
  31. doi request reprint A new isopentenyl diphosphate isomerase gene from Camptotheca acuminata: cloning, characterization and functional expression in Escherichia coli
    Xichun Pan
    Lab of Natural Products and Metabolic Engineering, Chongqing Sweetpotato Research Center, Key Lab of Eco environments in Three Gorges Reservoir Region Ministry of Education, School of Life Sciences, Southwest University, People s Republic of China
    DNA Seq 19:98-105. 2008
    ..In summary, cloning, characterization and functional expression of CaIPI will facilitate to understand the function of CaIPI at the level of molecular genetics and unveil the biosynthetic mechanism of camptothecin precursors...
  32. doi request reprint Prediction of the binding modes between BB-83698 and peptide deformylase from Bacillus stearothermophilus by docking and molecular dynamics simulation
    Qiang Wang
    Institute of Theoretical Chemistry, Shandong University, Jinan 250100, China
    Biophys Chem 134:178-84. 2008
    ..Mode 2 represents a new binding mode. Additionally, if the hydrophilic group is introduced to the benzo-[1,3]-dioxole ring, the binding affinity of BB-83698 to the peptide deformylase from B. stearothermophilus will be greatly improved...
  33. ncbi request reprint Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT
    Junjie Lv
    Department of Pathology, Health Science Center of Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, China
    Biochem Biophys Res Commun 311:506-13. 2003
    ..The investigation suggested that hALP influences the activity of histone acetylation and could up-regulate telomerase activity through transactivation of hTERT promoter...
  34. pmc Safety and immunogenicity of a malaria vaccine, Plasmodium falciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adults
    Jinhong Hu
    Changhai Hospital, Second Military Medical University, Shanghai, China
    PLoS ONE 3:e1952. 2008
    ..Fifty-two subjects were randomly assigned to 4 dose groups of 10 participants, each receiving the test vaccine of 20, 50, 100, or 200 microg respectively, and 1 placebo group of 12 participants receiving the adjuvant only...
  35. ncbi request reprint Identification and characterization of a novel 1-Cys peroxiredoxin from silkworm, Bombyx mori
    Qiang Wang
    Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, China
    Comp Biochem Physiol B Biochem Mol Biol 149:176-82. 2008
    ..In addition, real-time PCR analysis indicated that significant rise of the transcripts level of BmPrx was induced by temperature stress including low and high temperature stimuli...
  36. ncbi request reprint Effects of static magnetic fields on the physical and chemical properties of cell culture medium RPM1 1640
    Farong Li
    School of Electrical and Communication Engineering, Xi an Jiaotong University Xi an P R China
    Electromagn Biol Med 26:25-32. 2007
    ..Surface tension showed no significant difference in the two groups. This data suggests that SMF can change some of the physical and chemical properties of RPM1 1640 solution, and may contribute to understanding biological effects of SMF...
  37. ncbi request reprint Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells
    Qiang Wang
    The Provincial Key Laboratory of Mechanisms of Development and Gene Control, Life Science School of Shandong University, Jinan 250100
    Chin Med Sci J 19:157-63. 2004
    ..To clone and identify the proteins involved in regulating the transcription of hTERT and study the role of genes in both hTERT transcription and telomerase activity...
  38. ncbi request reprint Focal adhesion kinase in netrin-1 signaling
    Xiu Rong Ren
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    Nat Neurosci 7:1204-12. 2004
    ..Taken together, these results indicate a new signaling mechanism for DCC, in which FAK is activated upon netrin-1 stimulation and mediates netrin-1 function; they also identify a critical role for FAK in axon navigation...
  39. ncbi request reprint The evidences of human orphan receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcription
    Qiang Wang
    The Provincial Key Laboratory of Mechanisms of Development and Gene Control, Life Science School of Shandong University, Jinan, China
    Cancer Lett 214:81-90. 2004
    ..The results suggested that the human COUP-TFII could specifically interact with hTERT promoter, in part via the E-box, and suppress the expression of hTERT...
  40. ncbi request reprint [In vitro amplification and identification of immature dendritic cells from murine bone marrow]
    Qiang Wang
    Institute of Burn Research, Southwestern Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, P R China
    Zhonghua Shao Shang Za Zhi 19:332-5. 2003
    ..To establish a method for in vitro amplification of immature dendritic cells from murine bone marrow, and to identify it with morphological, immunological phenotype determination, and functional examination...
  41. pmc Rds3p is required for stable U2 snRNP recruitment to the splicing apparatus
    Qiang Wang
    Department of Biology, University of Kentucky, Lexington, Kentucky 40506 0225, USA
    Mol Cell Biol 23:7339-49. 2003
    ..Together these data establish Rds3p as an essential component of the U2 snRNP SF3b complex and suggest a new link between the nuclear processes of pre-mRNA splicing and RNA export...
  42. ncbi request reprint Inhibitory effects of pimozide on cloned and native voltage-gated potassium channels
    Zhi Hao Zhang
    Department of Neuroscience, Wyeth Research, Princeton, NJ, USA
    Brain Res Mol Brain Res 115:29-38. 2003
    ..It is thus conceivable that the time-dependent and/or subunit-specific inhibition of Kv channels may increase the release of neurotransmitters such as serotonin and glutamate...
  43. ncbi request reprint G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction
    D Scott Witherow
    Department of Molecular and Cellular Pharmacology and the Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 278:21307-13. 2003
    ..Gbeta5 complex and cyan fluorescence protein-tagged Galphaq, indicating a direct interaction between these molecules...
  44. ncbi request reprint [Molecular cloning and analysis of bovine prolactin full-long genomic as well as cDNA sequences]
    Xin Cao
    Shanghai Institute of Medical Genetics, Shanghai Children s Hospital, Shanghai 200040, China
    Yi Chuan Xue Bao 29:768-73. 2002
    ..These SNP sites did not alter the related amino acids encoded. In addition, mRNA sequences encoding 5' signal sequence of bPRL gene was highly conserve...
  45. ncbi request reprint Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function
    Yang Z Huang
    Department of Neurobiology, Pathology, Physical Medicine and Rehabilitation, University of Alabama at Birmingham, 35294 0021, USA
    Int J Dev Neurosci 20:173-85. 2002
    ..Such mechanisms could be important for the maintenance and function of the synapse...
  46. ncbi request reprint [Demecolcine-induced enucleation of Kunming mouse oocyte]
    Qiang Wang
    Institute of Bio Engineering, Northwest Sci Tech University of Agriculture and Forestry, Shaanxi, Yangling 712 100, China
    Yi Chuan 26:653-7. 2004
    ..In experiment 3,oocytes collected from Kunming mouse at 17 -approximately 18h after hCG administration were favoriate to demecolcine-IE(27.1%). By comparison and analysis of the data, we established the optimized IE procedure...
  47. ncbi request reprint Fas ligand expression in colon cancer: a possible mechanism of tumor immune privilege
    Wei Zhang
    Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 20003, China
    World J Gastroenterol 11:3632-5. 2005
    ..To detect the expression of Fas ligand (FasL) in colon cancer tissues and cell lines and analyze the function of FasL-expressing colon cancer cells in inducing Fas-sensitive T lymphocyte apoptosis...
  48. ncbi request reprint Neuroprotective effect of sodium ferulate on transient focal cerebral ischemia by weakening activation of postsynaptic density-95 in rats
    Qiang Wang
    Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, China
    Chin J Traumatol 8:297-302. 2005
    ..To investigate the effects of sodium ferulate (SF), an intravenous drug made from traditional Chinese herbs, on activation of postsynaptic density-95 (PSD-95) and neuroprotection after transient cerebral artery occlusion in rats...
  49. ncbi request reprint Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging
    Xinyong Ma
    Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
    Biochem Biophys Res Commun 356:67-71. 2007
    ..Our observations suggest that membrane lipid-rafts provide an environment that facilitates the association of TbetaRI and TbetaRII for cell signaling...
  50. ncbi request reprint MEK1/2 regulates microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte meiotic maturation
    Ling Zhu Yu
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Graduate School, Chinese Academy of Sciences, Beijing, China
    Cell Cycle 6:330-8. 2007
    ..Our results suggest that MEK1/2 may function as a centrosomal protein and may have roles in microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte maturation...
  51. ncbi request reprint Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat development
    Qiang Wang
    Department of Occupational and Environmental Health, Faculty of Military Preventive Medicine, Fourth Military Medical University, 17 Changlexi Street, Xi an, 710032, China
    Toxicol Appl Pharmacol 219:33-41. 2007
    ..The increased BBB permeability may facilitate the accumulation of Pb. Fe supplement appears to protect the integrity of the BBB against Pb insults, a beneficial effect that may have significant clinical implications...
  52. ncbi request reprint Bub1 prevents chromosome misalignment and precocious anaphase during mouse oocyte meiosis
    Shen Yin
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Beijing, China
    Cell Cycle 5:2130-7. 2006
    ..Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis...
  53. ncbi request reprint Histone phosphorylation and pericentromeric histone modifications in oocyte meiosis
    Qiang Wang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    Cell Cycle 5:1974-82. 2006
    ..Furthermore, by using ZM447439, an inhibitor of Aurora kinases, we revealed that Aurora kinases may participate in the regulation of histone phosphorylation during mouse oocyte maturation...
  54. ncbi request reprint [Separation and identification of active constituents of Paris vietnamensis]
    Yun Huang
    Department of Pharmacognosy, Hebei Medical Universty, Shijiazhuang, China
    Yao Xue Xue Bao 41:361-4. 2006
    ..To study the anti-tumor bioactive steroid saponins of Paris vietnamensis (Takht.)...
  55. ncbi request reprint Histone deacetylation is required for orderly meiosis
    Qiang Wang
    State Key Laboratory of Reproductive Biology, Institute of Zoology and Graduate School, Chinese Academy of Sciences, Beijing, China
    Cell Cycle 5:766-74. 2006
    ..The results showed that subcellular translocation, expression level and phosphorylated modification of HDAC1 were temporally regulated and likely to coparticipate in the establishment of histone acetylation profiles in oocyte meiosis...
  56. ncbi request reprint Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics
    David A Katz
    Department of Pharmacogenetics, Abbott Laboratories, Abbott Park, IL 60064, USA
    Clin Pharmacol Ther 79:186-96. 2006
    ..Our objective was to learn whether genetic polymorphisms of metabolic enzymes or transport proteins provide a mechanistic understanding of the in vivo disposition of atrasentan, a selective endothelin A receptor antagonist...
  57. pmc Interactions of the yeast SF3b splicing factor
    Qiang Wang
    Department of Biology, University of Kentucky, Lexington, 40506, USA
    Mol Cell Biol 25:10745-54. 2005
    ..These data establish the concordance of yeast and mammalian SF3b complexes, implicate accessory splicing factors in U2 snRNP function, and support SF3b contribution from early pre-mRNP recognition to late steps in splicing...
  58. ncbi request reprint Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1
    Zhen G Luo
    Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294, USA
    Neuron 35:489-505. 2002
    ..Inhibition of PAK1 activity attenuates AChR clustering. These results demonstrate important roles of Dvl and PAK in Agrin/MuSK-induced AChR clustering and reveal a novel function of Dvl in synapse development...