PEIJING WANG

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis
    Fang Yang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 180:673-9. 2008
  2. pmc Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis
    Fang Yang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 173:497-507. 2006
  3. pmc Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity
    Ke Zheng
    Department of Animal Biology, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 8:e1003038. 2012
  4. pmc MNS1 is essential for spermiogenesis and motile ciliary functions in mice
    Jian Zhou
    Department of Animal Biology, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 8:e1002516. 2012
  5. pmc The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis
    Fang Yang
    Department of Animal Biology, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e14017. 2010
  6. pmc STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice
    Jian Zhou
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e89471. 2014
  7. pmc The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse
    Ke Zheng
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    BMC Dev Biol 9:38. 2009
  8. ncbi request reprint The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis
    P Jeremy Wang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Chromosome Res 15:623-32. 2007
  9. ncbi request reprint X chromosomes, retrogenes and their role in male reproduction
    P Jeremy Wang
    Department of Animal Biology, University of Pennsylvania, School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 15:79-83. 2004
  10. pmc Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals
    Fang Yang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Gene Expr Patterns 7:131-6. 2007

Research Grants

  1. Regulation of Spermiogenesis in Mice
    PEIJING WANG; Fiscal Year: 2007
  2. Function of TEX11 and its Associated Proteins in Mice
    PEIJING WANG; Fiscal Year: 2009
  3. Function of TEX11 and its Associated Proteins in Mice
    PEIJING WANG; Fiscal Year: 2007
  4. Function of TEX11 and its Associated Proteins in Mice
    PEIJING WANG; Fiscal Year: 2009
  5. Regulation of chromosome synapsis in mice
    Peijing Jeremy Wang; Fiscal Year: 2010
  6. Function of TEX11 and its Associated Proteins in Mice
    Peijing Jeremy Wang; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. pmc Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis
    Fang Yang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 180:673-9. 2008
    ..Based on these data, we propose that TEX15 regulates the loading of DNA repair proteins onto sites of DSBs and, thus, its absence causes a failure in meiotic recombination...
  2. pmc Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis
    Fang Yang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 173:497-507. 2006
    ....
  3. pmc Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity
    Ke Zheng
    Department of Animal Biology, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 8:e1003038. 2012
    ....
  4. pmc MNS1 is essential for spermiogenesis and motile ciliary functions in mice
    Jian Zhou
    Department of Animal Biology, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 8:e1002516. 2012
    ..Moreover, MNS1 monomers interact with each other and are able to form polymers in cultured somatic cells. These results demonstrate that MNS1 is essential for spermiogenesis, the assembly of sperm flagella, and motile ciliary functions...
  5. pmc The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis
    Fang Yang
    Department of Animal Biology, Center for Animal Transgenesis and Germ Cell Research, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 5:e14017. 2010
    ..1 protein is absent. Our results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway...
  6. pmc STK31/TDRD8, a germ cell-specific factor, is dispensable for reproduction in mice
    Jian Zhou
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e89471. 2014
    ..Disruption of the tudor domain and kinase domain of STK31 respectively does not affect fertility in mice. Our data suggest that the function of STK31 may be redundant with other Tdrd proteins in germ cell development. ..
  7. pmc The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse
    Ke Zheng
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    BMC Dev Biol 9:38. 2009
    ....
  8. ncbi request reprint The role of spermatogonially expressed germ cell-specific genes in mammalian meiosis
    P Jeremy Wang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Chromosome Res 15:623-32. 2007
    ..In particular, we cite previously unpublished studies demonstrating that the NXF2 protein, an X-encoded factor, is present in early spermatocytes...
  9. ncbi request reprint X chromosomes, retrogenes and their role in male reproduction
    P Jeremy Wang
    Department of Animal Biology, University of Pennsylvania, School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 15:79-83. 2004
    ..The testis-specific retrogenes might be associated with human male infertility. My goal here is to integrate recent findings, highlight controversies in the field and identify areas for further study...
  10. pmc Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals
    Fang Yang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Gene Expr Patterns 7:131-6. 2007
    ..Our data suggest that evolution of Ubl4b is not due to meiotic sex chromosome inactivation (MSCI). Alternatively, origination of Ubl4b was due to MSCI, but Ubl4b eventually evolved to be restricted to post-meiotic germ cells...
  11. pmc Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse
    P Jeremy Wang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19004, USA
    Hum Mol Genet 14:2911-8. 2005
    ..The implications of these findings are discussed with respect to differential gene regulation and the function of MSCI during spermatogenesis, including epigenetic programming of the future paternal genome during spermatogenesis...
  12. pmc RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis
    Jieyan Pan
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 132:4029-39. 2005
    ..Rnf17-null round spermatids advanced to step 4 but failed to produce sperm. These results have shown that RNF17 is a component of a novel germ cell nuage and is required for differentiation of male germ cells...
  13. pmc Regulation of male fertility by X-linked genes
    Ke Zheng
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Androl 31:79-85. 2010
    ..The genetic studies of X-linked, germ cell-specific genes in mice have laid a foundation for mutational analysis of their human orthologues in infertile men...
  14. pmc Meiotic failure in male mice lacking an X-linked factor
    Fang Yang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genes Dev 22:682-91. 2008
    ..Thus, TEX11 promotes initiation and/or maintenance of synapsis and formation of crossovers, and may provide a physical link between these two meiotic processes...
  15. pmc Abnormal sperm in mice lacking the Taf7l gene
    Yong Cheng
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:2582-9. 2007
    ..Our mouse studies suggest that mutations in the human TAF7L gene might be implicated in X-linked oligozoospermia in men...

Research Grants8

  1. Regulation of Spermiogenesis in Mice
    PEIJING WANG; Fiscal Year: 2007
    ....
  2. Function of TEX11 and its Associated Proteins in Mice
    PEIJING WANG; Fiscal Year: 2009
    ..Our research will also provide insight into the molecular etiology of X-linked male infertility and birth defects (trisomy and monosomy) in humans. ..
  3. Function of TEX11 and its Associated Proteins in Mice
    PEIJING WANG; Fiscal Year: 2007
    ..abstract_text> ..
  4. Function of TEX11 and its Associated Proteins in Mice
    PEIJING WANG; Fiscal Year: 2009
    ..Our research will also provide insight into the molecular etiology of X-linked male infertility and birth defects (trisomy and monosomy) in humans. ..
  5. Regulation of chromosome synapsis in mice
    Peijing Jeremy Wang; Fiscal Year: 2010
    ..Completion of this project will provide insight into the etiology of male infertility and birth defects in humans. ..
  6. Function of TEX11 and its Associated Proteins in Mice
    Peijing Jeremy Wang; Fiscal Year: 2010
    ..Our research will also provide insight into the molecular etiology of X-linked male infertility and birth defects (trisomy and monosomy) in humans. ..