Miao Wang

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury
    Miao Wang
    Institute for Translational Medicine and Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, USA
    Circulation 123:631-9. 2011
  2. pmc Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness
    Miao Wang
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 334:63-8. 2010
  3. pmc Targeted deletions of cyclooxygenase-2 and atherogenesis in mice
    Yiqun Hui
    School of Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 153 Johnson Pavilion, Philadelphia, PA 19104, USA
    Circulation 121:2654-60. 2010
  4. ncbi Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans
    Wen Liang Song
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 283:1179-88. 2008
  5. doi Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation
    Miao Wang
    Institute for Translational Medicine and Therapeutics, 153 Johnson Pavilion, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Circulation 117:1302-9. 2008
  6. pmc Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis
    Miao Wang
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:14507-12. 2006
  7. pmc Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells
    Gautam Damera
    University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Am J Physiol Lung Cell Mol Physiol 296:L674-83. 2009
  8. pmc Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
    Yan Cheng
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:1391-9. 2006
  9. pmc Prostanoids in health and disease
    Emer M Smyth
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA 19104, USA
    J Lipid Res 50:S423-8. 2009
  10. ncbi Noninvasive assessment of the role of cyclooxygenases in cardiovascular health: a detailed HPLC/MS/MS method
    Wen Liang Song
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Methods Enzymol 433:51-72. 2007

Collaborators

Detail Information

Publications14

  1. doi Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury
    Miao Wang
    Institute for Translational Medicine and Therapeutics, Department of Pharmacology, University of Pennsylvania, Philadelphia, USA
    Circulation 123:631-9. 2011
    ..Indeed, deletion of mPGES-1 retards atherogenesis and angiotensin II-induced aortic aneurysm formation. The role of mPGES-1 in the response to vascular injury is unknown...
  2. pmc Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness
    Miao Wang
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Pharmacol Exp Ther 334:63-8. 2010
    ..Pharmacologically targeting mPGES-1 may not predispose patients at risk to airway dysfunction...
  3. pmc Targeted deletions of cyclooxygenase-2 and atherogenesis in mice
    Yiqun Hui
    School of Medicine, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, 153 Johnson Pavilion, Philadelphia, PA 19104, USA
    Circulation 121:2654-60. 2010
    ..Floxed mice were used to parse distinct cellular contributions of COX-2 in macrophages and T cells (TCs) to atherogenesis...
  4. ncbi Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans
    Wen Liang Song
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 283:1179-88. 2008
    ..Niacin increased tetranor PGDM and 2,3-dinor-11beta-PGF(2alpha) in humans coincident with facial flushing. Tetranor PGDM is an abundant metabolite in urine that reflects modulated biosynthesis of PGD(2) in humans and mice...
  5. doi Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation
    Miao Wang
    Institute for Translational Medicine and Therapeutics, 153 Johnson Pavilion, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Circulation 117:1302-9. 2008
    ..Deletion of mPGES-1 modulates experimentally evoked pain and inflammation and retards atherogenesis. The role of mPGES-1 in abdominal aortic aneurysm is unknown...
  6. pmc Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis
    Miao Wang
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:14507-12. 2006
    ..Inhibitors of mPGES-1 may be less likely than those selective for cyclooxygenase 2 to result in cardiovascular complications because of a divergent impact on the biosynthesis of PGI(2)...
  7. pmc Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells
    Gautam Damera
    University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Am J Physiol Lung Cell Mol Physiol 296:L674-83. 2009
    ..Collectively, our data for the first time suggest a dual role of ozone in modulating IL-6 secretion and TEER outcomes in a PGE(2)-dependent (in presence of TNF stimulus) and -independent manner (in absence of cytokine stimulus)...
  8. pmc Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
    Yan Cheng
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 116:1391-9. 2006
    ..These results suggest that inhibitors of mPGES-1 may retain their antiinflammatory efficacy by depressing PGE(2), while avoiding the adverse cardiovascular consequences associated with PGHS-2-mediated PGI(2) suppression...
  9. pmc Prostanoids in health and disease
    Emer M Smyth
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA 19104, USA
    J Lipid Res 50:S423-8. 2009
    ..This review summarizes the current knowledge on prostanoid generation and the roles of individual mediators, their biosynthetic pathways, and their receptors in health and disease...
  10. ncbi Noninvasive assessment of the role of cyclooxygenases in cardiovascular health: a detailed HPLC/MS/MS method
    Wen Liang Song
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Methods Enzymol 433:51-72. 2007
    ..Included are the addition of stable isotope-labeled internal standards, solid phase extraction, and quantitation by liquid chromatography/tandem mass spectrometry using selected reaction monitoring (SRM) techniques...
  11. doi Analysis of five single nucleotide polymorphisms in the ESR1 gene in cryptorchidism
    Yanping Wang
    Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Birth Defects Res A Clin Mol Teratol 82:482-5. 2008
    ....
  12. pmc Cardiovascular biology of microsomal prostaglandin E synthase-1
    Miao Wang
    Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 5158, USA
    Trends Cardiovasc Med 20:189-95. 2010
    ..This review considers the cardiovascular biology of mPGES1 and the complex challenge of developing inhibitors of this enzyme...
  13. doi Functionalized low-density lipoprotein nanoparticles for in vivo enhancement of atherosclerosis on magnetic resonance images
    Andrew N Lowell
    Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104 6323, USA
    Bioconjug Chem 23:2313-9. 2012
    ....
  14. ncbi Cardiovascular hazard and non-steroidal anti-inflammatory drugs
    Dairong Wang
    Institute for Translational Medicine and Therapeutics and the Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Pharmacol 5:204-10. 2005
    ..Although there is no information from randomized placebo-controlled trials, traditional non-steroidal anti-inflammatory drugs, such as naproxen, dicofenac and ibuprofen, might differ in their effects of cardiovascular biology...