Research Topics
Genomes and GenesSpecies | Li San WangSummaryAffiliation: University of Pennsylvania Country: USA Publications
| Collaborators
|
Detail Information
Publications
Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's diseaseLi San Wang
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Alzheimers Dis 31:439-45. 2012....
A Bayesian approach to efficient differential allocation for resampling-based significance testingShane T Jensen
Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA 19104, USA
BMC Bioinformatics 10:198. 2009..Using resampling-based procedures for multiple testing is computationally intensive and typically requires large numbers of resamples...- The impact of multiple protein sequence alignment on phylogenetic estimationLi San Wang
Department of Pathology and Laboratory Medicine and Penn Center for Bioinformatics, 1424 Blockley Hall, 423 Guardian Drive, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE/ACM Trans Comput Biol Bioinform 8:1108-19. 2011..We discuss these observations and implications for future work... - Population-based study of genetic variation in individuals with autism spectrum disorders from CroatiaLi San Wang
Department of Pathology, Laboratory Medicine, Biomedical Graduate Studies, University of Pennsylvania, Philadelphia 19104, USA
BMC Med Genet 11:134. 2010..Genome-wide studies on autism spectrum disorders (ASDs) have mostly focused on large-scale population samples, but examination of rare variations in isolated populations may provide additional insights into the disease pathogenesis... - Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platformsDavid J Irwin
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
Arch Neurol 69:1018-25. 2012..To use values of cerebrospinal fluid tau and β-amyloid obtained from 2 different analytical immunoassays to differentiate Alzheimer disease (AD) from frontotemporal lobar degeneration (FTLD)... 
Enhanced position weight matrices using mixture modelsSridhar Hannenhalli
Department of Genetics, University of Pennsylvania Philadelphia, PA 19104, USA
Bioinformatics 21:i204-12. 2005..Intuitively, the subclasses correspond to either distinct binding preference of the same transcription factor in different contexts or distinct subtypes of the transcription factor...- Genomic landscape of a three-generation pedigree segregating affective disorderShuzhang Yang
Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 4:e4474. 2009..Our analysis suggests that family based studies of the combined effect of common and rare CNVs at many loci may represent a useful approach in the genetic analysis of disease susceptibility of mental disorders... - Distance-based genome rearrangement phylogenyLi San Wang
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Mol Evol 63:473-83. 2006..Our study shows that tree reconstruction under these two methods is much more accurate when based on EDE distances than when based on other distances previously suggested for whole genomes... - Correcting population stratification in genetic association studies using a phylogenetic approachMingyao Li
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Bioinformatics 26:798-806. 2010.... - Frequency and clinicopathological characteristics of presenilin 1 Gly206Ala mutation in Puerto Rican Hispanics with dementiaSteven E Arnold
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
J Alzheimers Dis 33:1089-95. 2013..Considered together with the increased prevalence and mortality of AD reported in Puerto Rico, these high rates may reflect hereditary risk concentrated in the island which warrants further study... - The microRNA miR-34 modulates ageing and neurodegeneration in DrosophilaNan Liu
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nature 482:519-23. 2012.... - Computational approaches to the detection and analysis of sequences with intramolecular G-quadruplex forming potentialPaul Ryvkin
Department of Pathology, Penn Center for Bioinformatics, and Graduate Group in Genomics and Computational Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Methods Mol Biol 608:39-50. 2010..We also discuss methods for assessing the significance and specificity of associations between the sequences and different biological functions... - SAVoR: a server for sequencing annotation and visualization of RNA structuresFan Li
Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA
Nucleic Acids Res 40:W59-64. 2012..These values can then be visualized on a customizable secondary structure model. SAVoR is freely available at http://tesla.pcbi.upenn.edu/savor... - Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's diseaseSteven E Arnold
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neurobiol Aging 34:157-68. 2013..These data characterize cellular and synaptic features and identify novel biochemical targets that may be associated with resilient cognitive brain aging in the setting of pathological AD... - Global analysis of RNA secondary structure in two metazoansFan Li
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell Rep 1:69-82. 2012..Overall, our findings provide a global assessment of RNA folding in animals... - Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control studyMi Ryung Han
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
BMC Neurol 10:90. 2010..We carried out a genome-wide association study (GWAS) in order to better define the genetic backgrounds to these three states in relation to CSF levels... - Selection of individual VH genes occurs at the pro-B to pre-B cell transitionWenzhao Meng
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 187:1835-44. 2011.... - TREMOR--a tool for retrieving transcriptional modules by incorporating motif covarianceLarry N Singh
Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
Nucleic Acids Res 35:7360-71. 2007..The application of TREMOR on human muscle-specific, liver-specific and cell-cycle-related genes reveals TFs and TMs that were validated from literature and also reveals additional related genes... - Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemiaKaren A Urtishak
Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA
Blood 121:2689-703. 2013..This in vitro obatoclax activity and its multiple killing mechanisms across molecular cytogenetic subsets provide a rationale to incorporate a similarly acting compound into combination strategies to combat infant ALL... - Design of comprehensive Alzheimer's disease centers to address unmet national needsJohn Q Trojanowski
Institute on Aging, Philadelphia, PA, USA
Alzheimers Dement 6:150-5. 2010..The intent of this position paper is to stimulate thinking and foster the development of other or alternative models for a systematic approach to the study of dementia and movement disorders... - Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potentialJay E Johnson
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Nucleic Acids Res 38:1114-22. 2010..These findings indicate that, like Sgs1, WRN and BLM can regulate transcription globally by targeting G4-DNA... - Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiaeSteve G Hershman
College of Arts and Sciences and Vagelos Scholars Program, University of Pennsylvania, Philadelphia, PA, USA
Nucleic Acids Res 36:144-56. 2008..These findings raise the possibility that QFP sequences form bona fide G-quadruplexes in vivo and thus regulate transcription...