K Wang

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data
    Kai Wang
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 17:1665-74. 2007
  2. pmc Protein meta-functional signatures from combining sequence, structure, evolution, and amino acid property information
    Kai Wang
    Department of Microbiology, Computational Genomics Group, University of Washington, Seattle, Washington, United States of America
    PLoS Comput Biol 4:e1000181. 2008
  3. ncbi request reprint FSSA: a novel method for identifying functional signatures from structural alignments
    Kai Wang
    Computational Genomics Group, Department of Microbiology, University of Washington Seattle, WA 98195, USA
    Bioinformatics 21:2969-77. 2005
  4. pmc Regularized regression method for genome-wide association studies
    Jin Liu
    Department of Statistics and Actuarial Science, University of Iowa, 241 Schaeffer Hall, Iowa City, IA 52242, USA
    BMC Proc 5:S67. 2011
  5. doi request reprint Statistical tests of genetic association for case-control study designs
    Kai Wang
    Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA
    Biostatistics 13:724-33. 2012
  6. pmc Statistical tests for detecting rare variants using variance-stabilising transformations
    Kai Wang
    Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA
    Ann Hum Genet 76:402-9. 2012
  7. pmc Treating phenotype as given: a simple resampling method for genome-wide association studies
    Kai Wang
    Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA
    BMC Proc 5:S60. 2011
  8. pmc Accommodating population stratification in case-control association analysis: a new test and its application to genome-wide study on rheumatoid arthritis
    Yufang Zhang
    Program of Public Health Genetics, University of Iowa, 200 Hawkins Drive E177 GH, Iowa City, Iowa 52242 USA
    BMC Proc 3:S111. 2009
  9. pmc Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
    Xiangjun Xiao
    Program of Public Health Genetics, University of Iowa, 200 Hawkins Drive E177 GH, Iowa City, Iowa 52242, USA
    BMC Proc 3:S134. 2009
  10. pmc Evaluation of variants in the selectin genes in age-related macular degeneration
    Robert F Mullins
    Department of Ophthalmology and Visual Sciences, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    BMC Med Genet 12:58. 2011

Detail Information

Publications82

  1. pmc PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data
    Kai Wang
    Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genome Res 17:1665-74. 2007
    ..3%. Our results demonstrate the feasibility of whole-genome fine-mapping of CNVs via high-density SNP genotyping...
  2. pmc Protein meta-functional signatures from combining sequence, structure, evolution, and amino acid property information
    Kai Wang
    Department of Microbiology, Computational Genomics Group, University of Washington, Seattle, Washington, United States of America
    PLoS Comput Biol 4:e1000181. 2008
    ..Our results indicate that the MFS approach, which can combine multiple sources of information and also give biological interpretation to each component, greatly facilitates the understanding and characterization of protein function...
  3. ncbi request reprint FSSA: a novel method for identifying functional signatures from structural alignments
    Kai Wang
    Computational Genomics Group, Department of Microbiology, University of Washington Seattle, WA 98195, USA
    Bioinformatics 21:2969-77. 2005
    ..However, the presence of many proteins with the same structural fold but different functions suggests that global structure and function do not always correlate well...
  4. pmc Regularized regression method for genome-wide association studies
    Jin Liu
    Department of Statistics and Actuarial Science, University of Iowa, 241 Schaeffer Hall, Iowa City, IA 52242, USA
    BMC Proc 5:S67. 2011
    ..Its applicability to a simulated data from Genetic Analysis Workshop 17 replication one is illustrated. Our method selects three SNPs (C13S522, C13S523, and C13S524), whereas the LASSO method selects two SNPs (C13S522 and C13S523)...
  5. doi request reprint Statistical tests of genetic association for case-control study designs
    Kai Wang
    Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA
    Biostatistics 13:724-33. 2012
    ..The likelihood ratio statistic, score statistic, and Wald statistic associated with this framework are introduced. Their performance is evaluated by extensive computer simulation in comparison with existing methods...
  6. pmc Statistical tests for detecting rare variants using variance-stabilising transformations
    Kai Wang
    Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA
    Ann Hum Genet 76:402-9. 2012
    ..Based on theoretical considerations and results from simulation studies, we recommend the test based on the Anscombe transformation over tests with other transformations...
  7. pmc Treating phenotype as given: a simple resampling method for genome-wide association studies
    Kai Wang
    Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA
    BMC Proc 5:S60. 2011
    ..However, none of the selected SNPs are in genes that are disease-causing. This may be due to the weak effect that each genetic factor has on Q2...
  8. pmc Accommodating population stratification in case-control association analysis: a new test and its application to genome-wide study on rheumatoid arthritis
    Yufang Zhang
    Program of Public Health Genetics, University of Iowa, 200 Hawkins Drive E177 GH, Iowa City, Iowa 52242 USA
    BMC Proc 3:S111. 2009
    ..Compared with the Pearson chi-square genotype test, the association strength of many single-nucleotide polymorphisms is decreased while the signal at the HLA region on 6p21 is maintained...
  9. pmc Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1
    Xiangjun Xiao
    Program of Public Health Genetics, University of Iowa, 200 Hawkins Drive E177 GH, Iowa City, Iowa 52242, USA
    BMC Proc 3:S134. 2009
    ..Fifteen single-nucleotide polymorphisms from this gene were chosen. The association of KCNB1 gene to rheumatoid arthritis seems to be moderate...
  10. pmc Evaluation of variants in the selectin genes in age-related macular degeneration
    Robert F Mullins
    Department of Ophthalmology and Visual Sciences, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    BMC Med Genet 12:58. 2011
    ..We sought to determine whether common ancestral variants in genes encoding the selectin family of proteins are associated with AMD...
  11. pmc Genome-wide linkage analysis of blood pressure under locus heterogeneity
    Xinqun Yang
    Department of Biostatistics, Division of Statistical Genetics, The University of Iowa, Iowa City, USA
    BMC Genet 4:S78. 2003
    ..01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals...
  12. pmc Bivariate linkage analysis of cholesterol and triglyceride levels in the Framingham Heart Study
    Xuyang Zhang
    Department of Biostatistics, Division of Statistical Genetics, The University of Iowa, Iowa City, Iowa, USA
    BMC Genet 4:S62. 2003
    ..A strong linkage signal was also found at marker GATA112F07 by both the bivariate analysis and the univariate analysis, a marker for which evidence for linkage had been reported previously in a related study...
  13. pmc A constrained-likelihood approach to marker-trait association studies
    Kai Wang
    Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, IA, 52242, USA
    Am J Hum Genet 77:768-80. 2005
    ..it is a single-marker analysis). However, given the latest findings that powerful inferential procedures for haplotype analyses can be constructed from single-marker analyses, we expect this approach to be useful for haplotype analyses...
  14. ncbi request reprint A likelihood approach for quantitative-trait-locus mapping with selected pedigrees
    K Wang
    Program in Public Health Genetics, University of Iowa, Iowa City, Iowa 52242, USA
    Biometrics 61:465-73. 2005
    ..A computer implementation of the methods for single-locus univariate-phenotype models is provided for nuclear families with arbitrary number of sibs and is freely available...
  15. ncbi request reprint Mapping quantitative trait loci using multiple phenotypes in general pedigrees
    Kai Wang
    Division of Statistical Genetics, Departments of Biostatistics, The University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 55:1-15. 2003
    ..These methods are straightforward to calculate. Finite-sample properties of these score statistics are studied through extensive simulations. These score statistics are for use with general pedigrees...
  16. ncbi request reprint Quantitative-trait-locus mapping in the presence of locus heterogeneity
    K Wang
    Program in Public Health Genetics, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA
    Ann Hum Genet 70:882-92. 2006
    ..The type I error rates and the power of these statistics are assessed through simulation studies. These statistics are applied to a linkage study of asthma genes...
  17. ncbi request reprint A principal components regression approach to multilocus genetic association studies
    Kai Wang
    Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA
    Genet Epidemiol 32:108-18. 2008
    ..An application to CHI3L2 gene expression data confirms a significant association between CHI3L2 gene expression level and SNPs from this gene that has been previously reported by others...
  18. doi request reprint Genetic association tests in the presence of epistasis or gene-environment interaction
    Kai Wang
    Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
    Genet Epidemiol 32:606-14. 2008
    ..For each model, the asymptotic distribution of the likelihood ratio statistic is derived. Simulation studies suggest that the proposed methods are more powerful than existing ones under certain circumstances...
  19. doi request reprint An analytic study of the power of popular quantitative-trait-locus mapping methods
    Kai Wang
    Department of Biostatistics, C22 B GH, College of Public Health, The University of Iowa, Iowa City, IA 52242, USA
    Behav Genet 38:554-9. 2008
    ..I also show by using an example that such ordering can fail for family structures other than sibpairs...
  20. doi request reprint Testing for genetic association in the presence of population stratification in genome-wide association studies
    Kai Wang
    Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
    Genet Epidemiol 33:637-45. 2009
    ..Extensive simulation study indicates that this new method provides an appealing alternative for genetic association analysis in the presence of population stratification...
  21. ncbi request reprint A note on the asymptotic properties of affected-sib-pair linkage tests
    K Wang
    Program in Public Health Genetics, College of Public Health, The University of Iowa, Iowa City 52242, USA
    Ann Hum Genet 68:367-75. 2004
    ..The implications of these results are discussed...
  22. ncbi request reprint The consistency of the posterior probability of linkage
    K Wang
    Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City 52242, USA
    Ann Hum Genet 64:533-53. 2000
    ..5, even when the admixture model misrepresents the true model...
  23. pmc A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size
    K Wang
    Division of Statistical Genetics, Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 70:412-24. 2002
    ..The proposed test is naturally applicable to sibships of arbitrary size. The finite-sample properties of the proposed score statistic are evaluated via simulations...
  24. pmc Linkage analysis of systolic blood pressure: a score statistic and computer implementation
    Kai Wang
    Department of Biostatistics, Division of Statistical Genetics, The University of Iowa, Iowa City, Iowa, USA
    BMC Genet 4:S77. 2003
    ..The score statistic was applied to the sibships derived from the general pedigrees. An add-on R program to GENEHUNTER was developed for this analysis and is freely available...
  25. ncbi request reprint Efficient score statistics for mapping quantitative trait loci with extended pedigrees
    Kai Wang
    Division of Statistical Genetics, Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 54:57-68. 2002
    ..Simulation studies indicate that, compared to the method of variance components, both score statistics have comparable or higher power, and their false-positive rates are closer to their respective nominal significance levels...
  26. ncbi request reprint Score test for mapping quantitative-trait loci with sibships of arbitrary size when the dominance effect is not negligible
    Kai Wang
    Division of Statistical Genetics, Department of Biostatistics, University of Iowa, Iowa City, Iowa 52242, USA
    Genet Epidemiol 23:398-412. 2002
    ..Weights for distribution components are functions of the informativeness of the marker data. The type I error rate and the power of the proposed statistic in finite sample are evaluated via simulations...
  27. ncbi request reprint Score tests for epistasis models on quantitative traits using general pedigree data
    Kai Wang
    Division of Statistical Genetics, Departments of Biostatistics, University of Iowa, Iowa City, Iowa 52242, USA
    Genet Epidemiol 25:314-26. 2003
    ..The finite-sample properties of these tests are investigated through simulations. Extensions to more complicated models and to other search strategies are discussed...
  28. ncbi request reprint Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: comparative evaluation of model-based linkage methods for affected sib pair data
    V J Vieland
    Department of Biostatistics, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 51:199-208. 2001
    ....
  29. ncbi request reprint Combined multipoint analysis of multiple asthma data sets based on the posterior probability of linkage
    K Wang
    Department of Biostatistics, 2800 SB, University of Iowa, Iowa City, IA 52242, USA
    Genet Epidemiol 21:S73-8. 2001
    ..We find linkage signals at location (in the order of the strength of the signal) 45 cM on chromosome 6, 23 cM on chromosome 20, and 30 cM on chromosome 1. No linkage signal is found on chromosome 5...
  30. ncbi request reprint Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis
    Jose A Morcuende
    Department of Orthopaedic Surgery, University of Iowa, Iowa City, Iowa, USA
    Spine (Phila Pa 1976) 28:2025-8; discussion 2029. 2003
    ..A genetic study of patients with familial adolescent idiopathic scoliosis...
  31. pmc Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, USA
    Schizophr Res 106:192-9. 2008
    ..rs2344484-C-allele may affect NEUROG1's role in transcription regulation such that brain morphology and cognitive abilities are altered resulting in increased susceptibility to develop schizophrenia...
  32. pmc Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis
    William Shyy
    Departments of Orthopaedic Surgery and Rehabilitation, Howard Hughes Medical Institute, University of Iowa, Iowa City, IA 52242, USA
    J Pediatr Orthop 30:539-43. 2010
    ....
  33. pmc Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot
    William Shyy
    Department of Orthopaedic Surgery, University of Iowa, Iowa City, IA, USA
    J Pediatr Orthop 30:231-4. 2010
    ..In this study, we hypothesized that a mutation in an embryonic or perinatal myosin gene could be associated with congenital idiopathic clubfoot...
  34. ncbi request reprint The prevalence of hereditary neuropathy with liability to pressure palsies in patients with multiple surgically treated entrapment neuropathies
    Michael D Sander
    Department of Orthopaedic Surgery and Rehabilitation, University of Iowa, Iowa City, IA 52242, USA
    J Hand Surg Am 30:1236-41. 2005
    ..We hypothesized that some of these patients have an underlying hereditary neuropathy. The purpose of this study was to determine the prevalence of HNPP in patients with multiple surgically treated upper-extremity entrapment neuropathies...
  35. pmc Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders
    John H Fingert
    Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA
    Mol Vis 16:596-601. 2010
    ....
  36. pmc Quantitative trait loci associated with murine central corneal thickness
    Geoffrey D Lively
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA
    Physiol Genomics 42:281-6. 2010
    ..Future identification of the genes for these QTL will provide improved understanding of the processes regulating CCT and the pathophysiology of glaucoma...
  37. ncbi request reprint A non-parametric approach to the design and analysis of two-dimensional dose-finding trials
    Anastasia Ivanova
    Department of Biostatistics, CB 7420, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Stat Med 23:1861-70. 2004
    ..We conclude that the new design and the bivariate isotonic estimator are superior to the procedure where several independent dose-finding trials are run...
  38. ncbi request reprint Bivariate isotonic design for dose-finding with ordered groups
    Anastasia Ivanova
    Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7420, USA
    Stat Med 25:2018-26. 2006
    ..We propose a non-parametric design for this problem. Toxicity is estimated using the bivariate isotonic regression estimator. The new design is compared with the two-sample continual reassessment method...
  39. pmc Genetic dependence of central corneal thickness among inbred strains of mice
    Geoffrey D Lively
    Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, Iowa, USA
    Invest Ophthalmol Vis Sci 51:160-71. 2010
    ..The purpose of this study was to test the strain dependence of CCT variability among inbred mice and identify cellular and molecular factors associated with differing CCT...
  40. pmc Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis
    Xingshen Sun
    Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Invest 120:3149-60. 2010
    ..The animals described in this study are likely to be useful tools for dissecting CF disease pathogenesis and developing treatments...
  41. pmc A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas
    Kartik M Mani
    Department of Biomedical Informatics DBMI, Columbia University, New York, NY 10032, USA
    Mol Syst Biol 4:169. 2008
    ..The method consistently ranked the known gene in the top 20 (0.3%), outperforming conventional approaches in 3 of 4 cases...
  42. doi request reprint Genotype, haplotype and copy-number variation in worldwide human populations
    Mattias Jakobsson
    Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 451:998-1003. 2008
    ..Our results produce new inferences about inter-population variation, support the utility of CNVs in human population-genetic research, and serve as a genomic resource for human-genetic studies in diverse worldwide populations...
  43. ncbi request reprint Comment on "Evidence for positive epistasis in HIV-1"
    Kai Wang
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Science 312:848; author reply 848. 2006
    ..We demonstrate that biases in the original and simulated data sets may lead to erroneous evidence for epistasis. More rigorous statistical tests must be used to account for such biases before one can infer epistasis...
  44. pmc A microsatellite-based, gene-rich linkage map reveals genome structure, function and evolution in Gossypium
    Wangzhen Guo
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing 210095, China
    Genetics 176:527-41. 2007
    ..The results presented here will provide new insights for future investigations of functional and evolutionary genomics, especially those associated with cotton fiber improvement...
  45. ncbi request reprint A comparison of genetic maps constructed from haploid and BC1 mapping populations from the same crossing between Gossypium hirsutum L. and Gossypium barbadense L
    Xianliang Song
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing, Jiangsu Province, China
    Genome 48:378-90. 2005
    ..Map comparison and combined data provided an essential basis for further mapping of interested genes and QTLs and for studies of diversity, population structure, and phylogeny in Gossypium species...
  46. ncbi request reprint A statistical approach designed for finding mathematically defined repeats in shotgun data and determining the length distribution of clone-inserts
    Lan Zhong
    College of Life Sciences, Peking University, Beijing 100871, China
    Genomics Proteomics Bioinformatics 1:43-51. 2003
    ..Thus with optimal length distribution of clone-inserts, a given genome could be assembled better at lower coverage...
  47. ncbi request reprint Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD
    Hirokazu Honda
    Division of Renal Medicine, Department of Clinical Science, Interventions and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 47:139-48. 2006
    ..In this study, multivariate analyses were performed to assess these 4 biomarkers as predictors of malnutrition, CVD, and mortality in patients with ESRD...
  48. ncbi request reprint Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin
    Peter Stenvinkel
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska University Hospital, Stockholm, Sweden
    Kidney Int 67:2383-92. 2005
    ..In the present study, we evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome...
  49. ncbi request reprint A 384-well microtiter-plate-based template preparation and sequencing method
    Lei He
    PhenoGenomics Corp, Bothell, WA, USA
    Methods Mol Biol 192:411-6. 2002
  50. ncbi request reprint Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen
    Lee Rowen
    Institute for Systems Biology, Seattle, Washington, USA
    Mol Biol Evol 22:1712-20. 2005
    ..These residues could be involved in interactions with inhibitors...
  51. ncbi request reprint Profile-based string kernels for remote homology detection and motif extraction
    Rui Kuang
    Department of Computer Science, Columbia University, 475 Riverside Dr, Mail Code 7717, New York, NY 10115, USA
    J Bioinform Comput Biol 3:527-50. 2005
    ..We show that our profile kernel results also outperform cluster kernels while providing much better scalability to large datasets...
  52. ncbi request reprint The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart
    Yoshioki Satoh
    Department of Medicine, Koshu Rehabilitation Hospital, Faefuki city, Japan
    J Pharmacol Sci 97:101-6. 2005
    ..Thus, caution has to be paid on the use of prochlorperazine particularly for patients with risks of the elevated plasma drug concentration, compromised cardiac repolarization, and/or frequent ventricular premature beats...
  53. ncbi request reprint Complete assignment of the chromosomes of Gossypium hirsutum L. by translocation and fluorescence in situ hybridization mapping
    Kai Wang
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China
    Theor Appl Genet 113:73-80. 2006
    ..Therefore, the 13 homeologous chromosome pairs have been established, and we have proposed a new chromosome nomenclature for tetraploid cotton...
  54. ncbi request reprint Denoising array-based comparative genomic hybridization data using wavelets
    Li Hsu
    Biostatistics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B500, Seattle, WA 98109, USA
    Biostatistics 6:211-26. 2005
    ..A simulation study shows that denoising data prior to testing can achieve greater power in detecting the aberrant spot than using the raw data without denoising. Finally, we illustrate the method on two array-CGH data sets...
  55. ncbi request reprint [Construction of rAAV2-GPIIb/IIIa vector and test of its expression and function in vitro]
    Kai Wang
    Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:369-74. 2006
    ..This result may provide a basis for application of rAAV2 vector in Glanzmann's thrombasthenia gene therapy in furture...
  56. ncbi request reprint Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model
    Atsushi Sugiyama
    Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
    J Pharmacol Sci 96:436-43. 2004
    ....
  57. ncbi request reprint Antivirogram or phenosense: a comparison of their reproducibility and an analysis of their correlation
    Kai Wang
    Department of Microbiology, University of Washington, Wash, USA
    Antivir Ther 9:703-12. 2004
    ..0, respectively). Since the cutoff values for both assays are relatively low, our analysis suggests that one should be very careful when interpreting measurements that are near the cutoff values for drug resistance...
  58. ncbi request reprint HIV-1 genotypic drug-resistance interpretation algorithms need to include hypersusceptibility-associated mutations
    Kai Wang
    J Infect Dis 190:2055-6; author reply 2056. 2004
  59. ncbi request reprint Endothelium-targeted gene and cell-based therapies for cardiovascular disease
    Luis G Melo
    Department of Physiology, Queen s University, 18 Stuart Street, Kingston, Ontario, K7L 3N6, Canada
    Arterioscler Thromb Vasc Biol 24:1761-74. 2004
    ....
  60. ncbi request reprint Simple linear model provides highly accurate genotypic predictions of HIV-1 drug resistance
    Kai Wang
    Department of Microbiology, University of Washington, Seattle, Wash, USA
    Antivir Ther 9:343-52. 2004
    ..The resulting linear models are easy to understand and can potentially assist in choosing combination therapy regimens...
  61. pmc Weak agreement between Antivirogram and Phenosense assays in predicting reduced susceptibility to antiretroviral drugs
    Kai Wang
    J Clin Microbiol 42:2353-4; author reply 2354. 2004
  62. ncbi request reprint Cost-effectiveness of implantable cardioverter-defibrillators in Brugada syndrome treatment
    Kai Wang
    Department of Medical Information and Management Science, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, 466 8550 Nagoya, Japan
    J Med Syst 32:51-7. 2008
    ..The control therapy of quinidine may be a good choice for patients who are infants or living in developing countries...
  63. ncbi request reprint A survivin double point mutant has potent inhibitory effect on the growth of hepatocellular cancer cells
    Rui Zhang
    State Key Laboratory of Cancer Biology and Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi an, China
    Cancer Biol Ther 7:547-54. 2008
    ..Our results suggest that adenovirus-delivered dominant-negative survivin TC34,84AA promotes apoptosis-mediated hepatocellular carcinoma suppression, and could potentially be a promising candidate for cancer therapies...
  64. ncbi request reprint Local adenoviral-mediated inducible nitric oxide synthase gene transfer inhibits neointimal formation in the porcine coronary stented model
    Kai Wang
    Experimental Animal Laboratory, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Ohio 44195, USA
    Mol Ther 7:597-603. 2003
    ..68 mm(2), P < 0.05). We concluded that efficient intramural adenovirus-mediated iNOS transfer can be achieved by using Infiltrator catheters. iNOS gene transfer significantly reduces neointimal hyperplasia following stent injury...
  65. pmc Automated functional classification of experimental and predicted protein structures
    Kai Wang
    Computational Genomics Group, Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    BMC Bioinformatics 7:278. 2006
    ..Proteins that are similar in sequence or structure may perform different functions in nature. In such cases, function cannot be inferred from sequence or structural similarity...
  66. pmc Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adults
    Dahui You
    Louisiana State University, Department of Biological Sciences, Baton Rouge, USA
    Respir Res 7:107. 2006
    ....
  67. ncbi request reprint Using T4 DNA polymerase to generate clonable PCR products
    Kai Wang
    PhenoGenomics Corp, Bothell, WA, USA
    Methods Mol Biol 226:469-74. 2003
  68. ncbi request reprint Support vector machine-based feature selection for classification of liver fibrosis grade in chronic hepatitis C
    Zheng Jiang
    Department of Medical Information and Management Science, Graduate School of Medicine, Nagoya University, 65, Tsurumai cho, Showa Ku, Nagoya, 466 8550, Japan
    J Med Syst 30:389-94. 2006
    ..Our study showed that application of this model could identify CHC patients with clinically significant fibrosis with a high degree of accuracy and may decrease the need for liver biopsy...
  69. ncbi request reprint In vivo electropharmacological effects of amiodarone and candesartan on atria of chronic atrioventricular block dogs
    Kai Wang
    Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409 3898, Japan
    J Pharmacol Sci 103:207-13. 2007
    ....
  70. ncbi request reprint Reverse engineering cellular networks
    Adam A Margolin
    Department of Biomedical Informatics, Columbia University, New York, New York 10032, USA
    Nat Protoc 1:662-71. 2006
    ..Reconstructing a genome-wide network generally requires a computational cluster, especially if the recommended bootstrapping procedure is used...
  71. ncbi request reprint Different fates of donor mitochondrial DNA in bovine-rabbit and cloned bovine-rabbit reconstructed embryos during preimplantation development
    Yan Jiang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Front Biosci 11:1425-32. 2006
    ..Our results demonstrate that: 1) the fates of donor mtDNAs in bovine-rabbit and cloned bovine-rabbit reconstructed embryos were different; and 2) recipient mtDNAs replicate at blastocyst regardless of the difference of donor cells...
  72. pmc Detection and mapping of homologous and homoeologous segments in homoeologous groups of allotetraploid cotton by BAC-FISH
    Kai Wang
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing, China
    BMC Genomics 8:178. 2007
    ..In polyploids, it also presents a useful approach for identification and localization of duplicated segments. Here, two types of BACs that contained the duplicated segments were isolated and analyzed in tetraploid cotton by FISH...
  73. ncbi request reprint Development of one set of chromosome-specific microsatellite-containing BACs and their physical mapping in Gossypium hirsutum L
    Kai Wang
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China
    Theor Appl Genet 115:675-82. 2007
    ....
  74. ncbi request reprint Comparative analysis of microarray normalization procedures: effects on reverse engineering gene networks
    Wei Keat Lim
    Department of Biomedical Informatics, Columbia University, 622 West 168th Street, Vanderbilt Clinic 5th Floor, New York, NY 10032, USA
    Bioinformatics 23:i282-8. 2007
    ..We propose an alternative implementation to eliminate such side effect...
  75. ncbi request reprint Quantifying noise levels of intercellular signals
    Kai Wang
    Center for Theoretical Biological Physics, University of California San Diego, La Jolla, California 92093 0319, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 75:061905. 2007
    ..e., the waiting time needed to obtain statistically independent data, diverges, both for large receptor numbers. This result has important implications for such processes as eukaryotic chemotaxis...
  76. ncbi request reprint The other side of staying out of a BIND
    Kai Wang
    Nat Biotechnol 25:971-2. 2007
  77. ncbi request reprint [A and D genome evolution in Gossypium revealed using SSR molecular markers]
    Wang Zhen Guo
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing 210095, China
    Yi Chuan Xue Bao 30:183-8. 2003
    ..Further evolution research on cotton species based on the transcription level of cotton genome is being carried on...
  78. ncbi request reprint Inhibitory effect of acetamide-45 on airway inflammation and phosphodiesterase 4 in allergic rats
    Kai Wang
    Respiratory Department, Second Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310009, China
    Acta Pharmacol Sin 26:1492-6. 2005
    ..To determine the effects of acetamide-45 on respiratory function, airway inflammation, and the activity of phosphodiesterase 4 (PDE4) in allergic rats...
  79. pmc Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex
    Shuzhang Yang
    Department of Genetics and Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Biol 8:R247. 2007
    ..Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances...
  80. ncbi request reprint Association analysis of the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia
    Jeffrey R Bishop
    Psychiatr Genet 17:358. 2007
  81. ncbi request reprint Binding and photocleavage of cationic porphyrin-phenylpiperazine hybrids to DNA
    Tao Jia
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, Hubei, PR China
    Biophys Chem 119:295-302. 2006
    ..In the presence of sodium azide, a quencher of 1O2, the cleavage of DNA by the porphyrin of intercalation was less inhibited...
  82. ncbi request reprint A microtiter-plate-based high throughput PCR product purification method
    Ryan Smith
    PhenoGenomics Corp, Bothell, WA, USA
    Methods Mol Biol 192:417-21. 2002