K Wang

..3%. Our results demonstrate the feasibility of whole-genome fine-mapping of CNVs via high-density SNP genotyping...

..Our results indicate that the MFS approach, which can combine multiple sources of information and also give biological interpretation to each component, greatly facilitates the understanding and characterization of protein function...

..Our results indicate that the contributions of amino acid residue types and positions to structure and function are largely separable for proteins in multi-functional fold families...

..The likelihood ratio statistic, score statistic, and Wald statistic associated with this framework are introduced. Their performance is evaluated by extensive computer simulation in comparison with existing methods...

..Based on theoretical considerations and results from simulation studies, we recommend the test based on the Anscombe transformation over tests with other transformations...

..However, none of the selected SNPs are in genes that are disease-causing. This may be due to the weak effect that each genetic factor has on Q2...

..Compared with the Pearson chi-square genotype test, the association strength of many single-nucleotide polymorphisms is decreased while the signal at the HLA region on 6p21 is maintained...

..Fifteen single-nucleotide polymorphisms from this gene were chosen. The association of KCNB1 gene to rheumatoid arthritis seems to be moderate...

..We sought to determine whether common ancestral variants in genes encoding the selectin family of proteins are associated with AMD...

..01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals...

..A strong linkage signal was also found at marker GATA112F07 by both the bivariate analysis and the univariate analysis, a marker for which evidence for linkage had been reported previously in a related study...

..For each model, the asymptotic distribution of the likelihood ratio statistic is derived. Simulation studies suggest that the proposed methods are more powerful than existing ones under certain circumstances...

..The implications of these results are discussed...

..A computer implementation of the methods for single-locus univariate-phenotype models is provided for nuclear families with arbitrary number of sibs and is freely available...

..it is a single-marker analysis). However, given the latest findings that powerful inferential procedures for haplotype analyses can be constructed from single-marker analyses, we expect this approach to be useful for haplotype analyses...

..These methods are straightforward to calculate. Finite-sample properties of these score statistics are studied through extensive simulations. These score statistics are for use with general pedigrees...

..Extensive simulation study indicates that this new method provides an appealing alternative for genetic association analysis in the presence of population stratification...

..The type I error rates and the power of these statistics are assessed through simulation studies. These statistics are applied to a linkage study of asthma genes...

..I also show by using an example that such ordering can fail for family structures other than sibpairs...

..An application to CHI3L2 gene expression data confirms a significant association between CHI3L2 gene expression level and SNPs from this gene that has been previously reported by others...

..5, even when the admixture model misrepresents the true model...

..Weights for distribution components are functions of the informativeness of the marker data. The type I error rate and the power of the proposed statistic in finite sample are evaluated via simulations...

..The finite-sample properties of these tests are investigated through simulations. Extensions to more complicated models and to other search strategies are discussed...

..The proposed test is naturally applicable to sibships of arbitrary size. The finite-sample properties of the proposed score statistic are evaluated via simulations...

..The score statistic was applied to the sibships derived from the general pedigrees. An add-on R program to GENEHUNTER was developed for this analysis and is freely available...

..Simulation studies indicate that, compared to the method of variance components, both score statistics have comparable or higher power, and their false-positive rates are closer to their respective nominal significance levels...

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..We find linkage signals at location (in the order of the strength of the signal) 45 cM on chromosome 6, 23 cM on chromosome 20, and 30 cM on chromosome 1. No linkage signal is found on chromosome 5...

..rs2344484-C-allele may affect NEUROG1's role in transcription regulation such that brain morphology and cognitive abilities are altered resulting in increased susceptibility to develop schizophrenia...

..A genetic study of patients with familial adolescent idiopathic scoliosis...

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..In this study, we hypothesized that a mutation in an embryonic or perinatal myosin gene could be associated with congenital idiopathic clubfoot...

..We hypothesized that some of these patients have an underlying hereditary neuropathy. The purpose of this study was to determine the prevalence of HNPP in patients with multiple surgically treated upper-extremity entrapment neuropathies...

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..Future identification of the genes for these QTL will provide improved understanding of the processes regulating CCT and the pathophysiology of glaucoma...

..We propose a non-parametric design for this problem. Toxicity is estimated using the bivariate isotonic regression estimator. The new design is compared with the two-sample continual reassessment method...

..We conclude that the new design and the bivariate isotonic estimator are superior to the procedure where several independent dose-finding trials are run...

..The animals described in this study are likely to be useful tools for dissecting CF disease pathogenesis and developing treatments...

..The purpose of this study was to test the strain dependence of CCT variability among inbred mice and identify cellular and molecular factors associated with differing CCT...

..We demonstrate that biases in the original and simulated data sets may lead to erroneous evidence for epistasis. More rigorous statistical tests must be used to account for such biases before one can infer epistasis...

..The method consistently ranked the known gene in the top 20 (0.3%), outperforming conventional approaches in 3 of 4 cases...

..Our results produce new inferences about inter-population variation, support the utility of CNVs in human population-genetic research, and serve as a genomic resource for human-genetic studies in diverse worldwide populations...

..Map comparison and combined data provided an essential basis for further mapping of interested genes and QTLs and for studies of diversity, population structure, and phylogeny in Gossypium species...

..Thus with optimal length distribution of clone-inserts, a given genome could be assembled better at lower coverage...

..The results presented here will provide new insights for future investigations of functional and evolutionary genomics, especially those associated with cotton fiber improvement...

..In the present study, we evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome...

..We show that our profile kernel results also outperform cluster kernels while providing much better scalability to large datasets...

..The control therapy of quinidine may be a good choice for patients who are infants or living in developing countries...

..Our results suggest that adenovirus-delivered dominant-negative survivin TC34,84AA promotes apoptosis-mediated hepatocellular carcinoma suppression, and could potentially be a promising candidate for cancer therapies...

..A simulation study shows that denoising data prior to testing can achieve greater power in detecting the aberrant spot than using the raw data without denoising. Finally, we illustrate the method on two array-CGH data sets...

..This comparative analysis indicates that of these biomarkers, IL-6 level may be the most reliable predictor of CVD and mortality in patients with ESRD...

..Thus, caution has to be paid on the use of prochlorperazine particularly for patients with risks of the elevated plasma drug concentration, compromised cardiac repolarization, and/or frequent ventricular premature beats...

..Reconstructing a genome-wide network generally requires a computational cluster, especially if the recommended bootstrapping procedure is used...

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..0, respectively). Since the cutoff values for both assays are relatively low, our analysis suggests that one should be very careful when interpreting measurements that are near the cutoff values for drug resistance...

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..The resulting linear models are easy to understand and can potentially assist in choosing combination therapy regimens...

..In the presence of sodium azide, a quencher of 1O2, the cleavage of DNA by the porphyrin of intercalation was less inhibited...

..Acetamide-45 was an effective anti-inflammatory agent in respiratory inflammation, and the mechanism of its action might depend on inhibition of PDE4...

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..Our study showed that application of this model could identify CHC patients with clinically significant fibrosis with a high degree of accuracy and may decrease the need for liver biopsy...

..Further evolution research on cotton species based on the transcription level of cotton genome is being carried on...

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..The FSSA algorithm has also been implemented as a webserver and is available at http://protinfo.compbio.washington.edu/fssa...

..Our results demonstrate that: 1) the fates of donor mtDNAs in bovine-rabbit and cloned bovine-rabbit reconstructed embryos were different; and 2) recipient mtDNAs replicate at blastocyst regardless of the difference of donor cells...

..This result may provide a basis for application of rAAV2 vector in Glanzmann's thrombasthenia gene therapy in furture...

..These residues could be involved in interactions with inhibitors...

..In polyploids, it also presents a useful approach for identification and localization of duplicated segments. Here, two types of BACs that contained the duplicated segments were isolated and analyzed in tetraploid cotton by FISH...

..Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances...

..Therefore, the 13 homeologous chromosome pairs have been established, and we have proposed a new chromosome nomenclature for tetraploid cotton...

..68 mm(2), P < 0.05). We concluded that efficient intramural adenovirus-mediated iNOS transfer can be achieved by using Infiltrator catheters. iNOS gene transfer significantly reduces neointimal hyperplasia following stent injury...

..e., the waiting time needed to obtain statistically independent data, diverges, both for large receptor numbers. This result has important implications for such processes as eukaryotic chemotaxis...

..We propose an alternative implementation to eliminate such side effect...

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