Research Topics
Genomes and GenesSpecies | Jiongjiong WangSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Publications
When perfusion meets diffusion: in vivo measurement of water permeability in human brainJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Cereb Blood Flow Metab 27:839-49. 2007..The potential for in vivo magnetic resonance mapping of water permeability was showed using two diffusion weighted ASL measurements with b=0 and 50 secs/mm2 in both healthy subjects and a case of brain tumor...- Amplitude-modulated continuous arterial spin-labeling 3.0-T perfusion MR imaging with a single coil: feasibility studyJiongjiong Wang
Department of Radiology, and Center for Functional Neuroimaging, University of Pennsylvania, 3 W Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA
Radiology 235:218-28. 2005..Comparison of multisection continuous and pulsed arterial spin-labeling methods at 3.0 T showed a 33% improvement in signal-to-noise ratio by using the former approach... 
Perfusion functional MRI reveals cerebral blood flow pattern under psychological stressJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:17804-9. 2005..Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response...- Gender difference in neural response to psychological stressJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Soc Cogn Affect Neurosci 2:227-39. 2007..Our study may represent an initial step in uncovering the neurobiological basis underlying the contrasting health consequences of psychosocial stress in men and women... - Pediatric perfusion MR imaging using arterial spin labelingJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimaging Clin N Am 16:149-67, ix. 2006.... - Why perfusion in neonates with congenital heart defects is negative--technical issues related to pulsed arterial spin labelingJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 24:249-54. 2006.... - Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRIWen Chau Wu
Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Magn Reson Imaging 28:445-52. 2008..To test the hypothesis that flow measurements using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) in muscle depend upon transit delay, and examine the repeatability of CASL measurements... - Reduced susceptibility effects in perfusion fMRI with single-shot spin-echo EPI acquisitions at 1.5 TeslaJiongjiong Wang
Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
Magn Reson Imaging 22:1-7. 2004..ASL images, either with or without subtraction of the control, provide a robust alternative to blood oxygenation level dependant (BOLD) methods for activation imaging in regions of high static field inhomogeneity... - Altered resting cerebral blood flow in adolescents with in utero cocaine exposure revealed by perfusion functional MRIHengyi Rao
Department of Radiology and Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Pediatrics 120:e1245-54. 2007.... - Serotonin transporter genotype modulates amygdala activity during mood regulationSeth J Gillihan
Center for Cognitive Neuroscience, Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
Soc Cogn Affect Neurosci 5:1-10. 2010.... - Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbxZe Wang
Center for Functional Neuroimaging and Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 26:261-9. 2008..The implementation of all ASL data processing approaches is easily accomplished within an open-source toolbox, ASLtbx, and is advocated for most perfusion fMRI data sets... - Continuous arterial spin labeling perfusion measurements using single shot 3D GRASE at 3 TMaria A Fernandez-Seara
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 54:1241-7. 2005..The method was further improved using parallel imaging techniques to provide increased spatial resolution and better separation of the gray-white matter cerebral blood flow maps... - Continuous ASL perfusion fMRI investigation of higher cognition: quantification of tonic CBF changes during sustained attention and working memory tasksJunghoon Kim
Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, 1200 W Tabor Road, Philadelphia, PA 19141, USA
Neuroimage 31:376-85. 2006..Increased applications of the method to the investigation of cognitively impaired populations are expected to follow... - Support vector machine learning-based fMRI data group analysisZe Wang
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Neuroimage 36:1139-51. 2007..Providing inferences on the probability of being activated or deactivated at each voxel, these individual-level PMU-based group analysis methods can be used to threshold the analysis results of GLM RFX, SDM RFX or SDM PMU... - Diagnosis of brain abnormality using both structural and functional MR imagesYong Fan
Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, 3600 Market Street, Suite 380, Philadelphia, PA 19104, USA
Conf Proc IEEE Eng Med Biol Soc . 2006..8% correct classification rate using a leave-one-out cross-validation. Comparison results show the effectiveness of our method and also the importance of simultaneously using both structural and functional images for brain classification... - Imaging mesial temporal lobe activation during scene encoding: comparison of fMRI using BOLD and arterial spin labelingMaria A Fernandez Seara
Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Hum Brain Mapp 28:1391-400. 2007..Future improvements in ASL spatial and temporal resolution would allow the benefits of both approaches to be combined to further enhance the sensitivity for detecting mTL activation during memory encoding... - Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRIWen Chau Wu
Department of Radiology, The Hospital of University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
Am J Physiol Heart Circ Physiol 294:H2129-36. 2008..These results demonstrate that CASL is sensitive to flow heterogeneity between diverse muscle groups and that nonuniform hyperemic flow patterns following an ischemic paradigm correlate with relative fiber-type predominance... - Arterial spin labeling perfusion MRI in pediatric arterial ischemic stroke: initial experiencesJuan Chen
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
J Magn Reson Imaging 29:282-90. 2009..To investigate the feasibility and utility of arterial spin labeling (ASL) perfusion MRI for characterizing alterations of cerebral blood flow (CBF) in pediatric patients with arterial ischemic stroke (AIS)... - Diagnosis of brain abnormality using both structural and functional MR imagesYong Fan
Department of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Conf Proc IEEE Eng Med Biol Soc 1:1044-7. 2006..8% correct classification rate using a leave-one-out cross-validation. Comparison results show the effectiveness of our method and also the importance of simultaneously using both structural and functional images for brain classification... - Continuous ASL (CASL) perfusion MRI with an array coil and parallel imaging at 3TZe Wang
Center for Functional Neuroimaging, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Med 54:732-7. 2005..Such results highlight the potential utility of array coils and parallel imaging in ASL perfusion MRI... - Strategies for reducing large fMRI data sets for independent component analysisZe Wang
Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, 19104, USA
Magn Reson Imaging 24:591-6. 2006..Real fMRI data were used to evaluate the PC extraction precision, computational expense, and memory usage of the presented methods... - Early parental care is important for hippocampal maturation: evidence from brain morphology in humansHengyi Rao
Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 49:1144-50. 2010..Our results provide neuroimaging evidence supporting the important role of warm parental care during early childhood for brain maturation... - Using perfusion fMRI to measure continuous changes in neural activity with learningIngrid R Olson
Centers for Cognitive Neuroscience, CCN, and Functional Neuroimaging, CfN, University of Pennsylvania, 3400 Spruce Street, Philadelphia, 19104, USA
Brain Cogn 60:262-71. 2006..More generally, our results show that perfusion fMRI may be applied to the study of mental operations that produce gradual changes in neural activity... - Altered hemodynamics and regional cerebral blood flow in patients with hemodynamically significant stenosesAnne C Roc
Center for Functional Neuroimaging, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
Stroke 37:382-7. 2006..A simple visuomotor BOLD activation paradigm can reflect alterations in the hemodynamic response in patients with hemodynamically significant stenoses... 
Physiological modulations in arterial spin labeling perfusion magnetic resonance imagingWen Chau Wu
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE Trans Med Imaging 28:703-9. 2009..CASL with a labeling duration at a multiple of an R-R interval can be used to minimize signal fluctuation originating from cardiac pulsation...- Imaging brain activity during natural vision using CASL perfusion fMRIHengyi Rao
Department of Neurology, Center of Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Hum Brain Mapp 28:593-601. 2007.... - Genetic variation in serotonin transporter alters resting brain function in healthy individualsHengyi Rao
Center for Functional Neuroimaging, Department of Neurology and Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Biol Psychiatry 62:600-6. 2007..Perfusion functional magnetic resonance imaging (fMRI) was used to investigate the effect of genetic variation of the human serotonin transporter (5-HTT) gene (5-HTTLPR, SLC6A4) on resting brain function of healthy individuals... - Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 TeslaRonald L Wolf
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
J Magn Reson Imaging 22:475-82. 2005..To differentiate glioma grade based on blood flow measured using continuous arterial spin labeled (CASL) perfusion MRI, implemented at 3 Tesla for improved signal-to-noise ratio (SNR) and spin labeling effect... - Effects of heavy in utero cocaine exposure on adolescent caudate morphologyBrian B Avants
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Pediatr Neurol 37:275-9. 2007..The right (P < 0.025) and left (P < 0.035) caudate, studied independently, show the same significant trend. Permutation testing and the false discovery rate were used to assess significance... - Concurrent CBF and CMRGlc changes during human brain activation by combined fMRI-PET scanningAndrew B Newberg
Department of Radiology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
Neuroimage 28:500-6. 2005..Although initially validated using a brief, non-quantitative protocol, this approach can provide quantitative CBF and CMRGlc, with a broad range of potential applications in functional physiology and pathophysiology... - Arterial spin-labeled perfusion MRI in basic and clinical neuroscienceJohn A Detre
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Curr Opin Neurol 22:348-55. 2009.... - Pediatric perfusion imaging using pulsed arterial spin labelingJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
J Magn Reson Imaging 18:404-13. 2003..To test the feasibility of pediatric perfusion imaging using a pulsed arterial spin labeling (ASL) technique at 1.5 T... - To smooth or not to smooth? ROC analysis of perfusion fMRI dataJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Magn Reson Imaging 23:75-81. 2005..In contrast to the BOLD fMRI, temporal smoothing or filtering reduces the power of perfusion fMRI data analyses whereas spatial smoothing is beneficial to the efficacy of analyses... - Multivariate examination of brain abnormality using both structural and functional MRIYong Fan
Department of Radiology, University of Pennsylvania, PA 19104, USA
Neuroimage 36:1189-99. 2007..Therefore, the proposed approach provided not only a multivariate classification method for detecting brain abnormalities, but also an alternative way for group analysis of multimodality images... - Arterial spin labeling perfusion fMRI with very low task frequencyJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Magn Reson Med 49:796-802. 2003..The improved sensitivity of the ASL contrast for low task frequency and longitudinal studies, along with its superior power in group analysis, is expected to extend the range of experimental designs that can be studied using fMRI... - Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)Jiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 50:599-607. 2003..Application of the FEAST technique in two patients with cerebrovascular disease demonstrated prolonged tissue transit times in the affected vascular territories which were consistent with results from other MR imaging modalities... - Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activationTurgut Durduran
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Opt Lett 29:1766-8. 2004..The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored... - Actinomycotic brain infection: registered diffusion, perfusion MR imaging and MR spectroscopySumei Wang
Department of Radiology, Division of Neuroradiology, Hospital of the University of Pennsylvania, 219 Dulles Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
Neuroradiology 48:346-50. 2006..Actinomycotic brain infection is caused by an organism of the Actinomyces genus. We report here one such case... - Remifentanil-induced cerebral blood flow effects in normal humans: dose and ApoE genotypeW Andrew Kofke
Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Anesth Analg 105:167-75. 2007..We tested the hypothesis that, in the absence of surgery, small doses of remifentanil produce limbic system activation in humans which varies with dose and ApoE genotype... - Empirical analyses of null-hypothesis perfusion FMRI data at 1.5 and 4 TJiongjiong Wang
Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Neuroimage 19:1449-62. 2003.... - Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular diseaseRonald L Wolf
Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Neuroimaging 13:17-27. 2003.... - Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 TeslaJiongjiong Wang
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
Magn Reson Med 48:242-54. 2002..5T functional data, with reduced fractional perfusion signal change and increased intersubject variability. Possible reasons for these experimental results, including susceptibility effects and physiological noise, are discussed... - Precision of the CASL-perfusion MRI technique for the measurement of cerebral blood flow in whole brain and vascular territoriesThomas F Floyd
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Magn Reson Imaging 18:649-55. 2003..To analyze the precision of cerebral blood flow (CBF) measurements made with continuous arterial spin labeling(CASL) perfusion magnetic resonance imaging (MRI) over experimentally relevant intervals... - Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defectsDaniel J Licht
Division of Neurology, Department of Pediatrics, The Children s Hospital of Philadelphia, Wood Building 6th Floor, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
J Thorac Cardiovasc Surg 128:841-9. 2004..The hypothesis of this study is that preoperative cerebral blood flow is substantially diminished and might relate to preoperative neurologic conditions... - Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effectJulian Lim
Unit for Experimental Psychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 49:3426-35. 2010.... - Spatially-confined arterial spin-labeling with FAIRYan Zhang
Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
J Magn Reson Imaging 22:119-24. 2005..CONCLUSION: The data suggest that it is advantageous to replace nonselective global tagging in FAIR perfusion imaging with body coil excitation by spatially-confined tagging to reduce undesired residual tagged blood in large vessels... - Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI studyTeresa R Franklin
Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
Neuropsychopharmacology 32:2301-9. 2007.... - A theoretical and experimental investigation of the tagging efficiency of pseudocontinuous arterial spin labelingWen Chau Wu
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 58:1020-7. 2007..These improvements provide a better balance between tagging efficiency and SNR... - Improved data reconstruction method for GRAPPAZe Wang
Center for Functional Neuroimaging, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Magn Reson Med 54:738-42. 2005..Both simulations and in vivo experiments demonstrated that the proposed method yields higher-quality data reconstruction than the original GRAPPA method, especially with high acceleration factors... - Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defectsTurgut Durduran
ICFO Institut de Ciencies Fotoniques, Av Canal Olimpic s n, Castelldefels 08860, Spain
J Biomed Opt 15:037004. 2010..7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population... - Technical aspects and utility of fMRI using BOLD and ASLJohn A Detre
Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia 19104, USA
Clin Neurophysiol 113:621-34. 2002.... - Perfusion fMRI for functional neuroimagingGeoffrey K Aguirre
Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Int Rev Neurobiol 66:213-36. 2005 - Minimizing acquisition time of arterial spin labeling at 3TMaria A Fernandez-Seara
Neuroimaging Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Spain
Magn Reson Med 59:1467-71. 2008..It is shown that perfusion measurements obtained in less than 1 min of scan time are reproducible, with a coefficient of variation of 7%. The perfusion maps generated from these data can be used to characterize the stroke lesion...
Research Grants
- Pediatric template of brain perfusionJiongjiong Wang; Fiscal Year: 2006....
- Hemodynamic neuroimaging of pediatric strokeJiongjiong Wang; Fiscal Year: 2006..This project is therefore expected to advance the general application of ASL in the diagnosis, prognosis and management of pediatric brain disorders. ..