Research Topics
Genomes and Genes | Jinghua WangSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappa B signalingJinghua Wang
Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 180:3594-600. 2008..pneumoniae infection in resident macrophages during the early stages of infection, leading to a compromised innate immune response...
PPARgamma gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitusJing Wan
Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China
Cardiovasc Diabetol 9:13. 2010..PPARgamma C161-->T substitution is associated with a reduced risk of coronary artery disease (CAD). Whether or not the gene substitution alters the risk of CAD in type 2 diabetes mellitus (T2DM) patients remains unclear...
Opiate abuse, innate immunity, and bacterial infectious diseasesJinghua Wang
Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Mayo Mail Code 195, 420 Delaware Street Southeast, Minneapolis, MN, 55455, USA
Arch Immunol Ther Exp (Warsz) 56:299-309. 2008....- Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infectionJing Ma
Division of Basic and Translational Research, Department of Surgery, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Infect Immun 78:830-7. 2010..pneumoniae lung infection. This leads to diminished release of antimicrobial S100A8/A9 proteins, compromised neutrophil recruitment, and more-severe infection... - Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathwaySabita Roy
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 175:6361-7. 2005..We also demonstrate that chronic morphine treatment increases anti-CD3/CD28 Ab-induced IL-4 promoter activity and IL-4 immunoprotein expression through a p38 MAPK-dependent, but protein kinase A- and Erk1/Erk2-independent, mechanism... - Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-betSabita Roy
Department of Surgery, University of Minnesota, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55455, USA
J Neuroimmunol 147:78-81. 2004..From these data, we conclude that chronic morphine treatment differentiates T helper cell to Th2 effector cells by modulating key master switches that results in committing T helper cell to a Th2 phenotype... - Morphine withdrawal inhibits IL-12 induction in a macrophage cell line through a mechanism that involves cAMPJennifer Kelschenbach
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 180:3670-9. 2008.... - Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infectionJinghua Wang
Department of Pharmacology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
J Immunol 174:426-34. 2005..pneumoniae infection after morphine treatment... - Mu-opioid receptor mediates chronic restraint stress-induced lymphocyte apoptosisJinghua Wang
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 169:3630-6. 2002.... - Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signalingJinghua Wang
Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 286:10225-32. 2011..Taken together, our study shows that morphine impairs S. pneumoniae induced IL-23 production through MyD88-IRAK1/4-dependent TLR2 and Nod2 signaling in DCs... - Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathwaysJinghua Wang
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 278:37622-31. 2003..In summary, our data indicate that morphine modulation of IFN-gamma promoter activity is mediated through two distinct cAMP-dependent pathways, the NF-kappaB signaling pathway and the ERK1/2, p38 MAPK, AP-1/NFAT pathway... - Morphine modulation of toll-like receptors in microglial cells potentiates neuropathogenesis in a HIV-1 model of coinfection with pneumococcal pneumoniaeRaini Dutta
Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 32:9917-30. 2012..pneumoniae infection may be a potential mechanism for the increased prevalence of HAND in HIV-infected opioid-dependent patients... - Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphineJinghua Wang
Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 282:7164-71. 2007..These findings suggest that chronic morphine treatment may function through both transcriptional and epigenetic mechanisms to inhibit IL-2 production... - The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptorJinghua Wang
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55417, USA
J Leukoc Biol 71:782-90. 2002.... - Morphine inhibits VEGF expression in myocardial ischemiaS Roy
Department of Pharmacology, University of Minnesota, Minneapolis Veterans Affairs Medical Center, Minneapois, MN 55417, USA
Surgery 134:336-44. 2003.... - Modulation of immune function by morphine: implications for susceptibility to infectionSabita Roy
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
J Neuroimmune Pharmacol 1:77-89. 2006 - TGF-beta expression by allogeneic bone marrow stromal cells ameliorates diabetes in NOD mice through modulating the distribution of CD4+ T cell subsetsWei Zhao
Department of Neurobiology, Harbin Medical University Provincial Key Lad of Neurobiology, 194 XueFu Road, Harbin, Heilongjiang 150081, China
Cell Immunol 253:23-30. 2008..And the positive effects of allogeneic BMSCs in the treatment of NOD mice depend on the regulation of TGF-beta secreted by BMSCs... - Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatmentJinghua Wang
Department of Neurobiology, Harbin Medical University, 194 XueFu Road, Harbin, Heilongjiang 150081, China
J Autoimmun 30:222-9. 2008..These results demonstrate that BMSCs may suppress the development of EAE, possibly via secretion of IL-27, which can inhibit IL-17 production or Th17 cell generation...
Research Grants
- Opioid abuse and host defense against streptococcus pneumoniae lung infectionJinghua Wang; Fiscal Year: 2007..Ultimately, the studies will afford better development and design options when treating substance-abusing associated pneumoniae. ..