Jinghua Wang

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappa B signaling
    Jinghua Wang
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:3594-600. 2008
  2. pmc PPARgamma gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitus
    Jing Wan
    Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China
    Cardiovasc Diabetol 9:13. 2010
  3. doi request reprint Opiate abuse, innate immunity, and bacterial infectious diseases
    Jinghua Wang
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Mayo Mail Code 195, 420 Delaware Street Southeast, Minneapolis, MN, 55455, USA
    Arch Immunol Ther Exp (Warsz) 56:299-309. 2008
  4. pmc Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection
    Jing Ma
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Infect Immun 78:830-7. 2010
  5. ncbi request reprint Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet
    Sabita Roy
    Department of Surgery, University of Minnesota, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55455, USA
    J Neuroimmunol 147:78-81. 2004
  6. ncbi request reprint Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway
    Sabita Roy
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 175:6361-7. 2005
  7. ncbi request reprint Morphine withdrawal inhibits IL-12 induction in a macrophage cell line through a mechanism that involves cAMP
    Jennifer Kelschenbach
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:3670-9. 2008
  8. pmc Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner
    Jingjing Meng
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    PLoS ONE 8:e54040. 2013
  9. ncbi request reprint Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infection
    Jinghua Wang
    Department of Pharmacology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Immunol 174:426-34. 2005
  10. ncbi request reprint Mu-opioid receptor mediates chronic restraint stress-induced lymphocyte apoptosis
    Jinghua Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 169:3630-6. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Morphine induces defects in early response of alveolar macrophages to Streptococcus pneumoniae by modulating TLR9-NF-kappa B signaling
    Jinghua Wang
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:3594-600. 2008
    ..pneumoniae infection in resident macrophages during the early stages of infection, leading to a compromised innate immune response...
  2. pmc PPARgamma gene C161T substitution alters lipid profile in Chinese patients with coronary artery disease and type 2 diabetes mellitus
    Jing Wan
    Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China
    Cardiovasc Diabetol 9:13. 2010
    ..PPARgamma C161-->T substitution is associated with a reduced risk of coronary artery disease (CAD). Whether or not the gene substitution alters the risk of CAD in type 2 diabetes mellitus (T2DM) patients remains unclear...
  3. doi request reprint Opiate abuse, innate immunity, and bacterial infectious diseases
    Jinghua Wang
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Mayo Mail Code 195, 420 Delaware Street Southeast, Minneapolis, MN, 55455, USA
    Arch Immunol Ther Exp (Warsz) 56:299-309. 2008
    ....
  4. pmc Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection
    Jing Ma
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Infect Immun 78:830-7. 2010
    ..pneumoniae lung infection. This leads to diminished release of antimicrobial S100A8/A9 proteins, compromised neutrophil recruitment, and more-severe infection...
  5. ncbi request reprint Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet
    Sabita Roy
    Department of Surgery, University of Minnesota, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN 55455, USA
    J Neuroimmunol 147:78-81. 2004
    ..From these data, we conclude that chronic morphine treatment differentiates T helper cell to Th2 effector cells by modulating key master switches that results in committing T helper cell to a Th2 phenotype...
  6. ncbi request reprint Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway
    Sabita Roy
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 175:6361-7. 2005
    ..We also demonstrate that chronic morphine treatment increases anti-CD3/CD28 Ab-induced IL-4 promoter activity and IL-4 immunoprotein expression through a p38 MAPK-dependent, but protein kinase A- and Erk1/Erk2-independent, mechanism...
  7. ncbi request reprint Morphine withdrawal inhibits IL-12 induction in a macrophage cell line through a mechanism that involves cAMP
    Jennifer Kelschenbach
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 180:3670-9. 2008
    ....
  8. pmc Morphine induces bacterial translocation in mice by compromising intestinal barrier function in a TLR-dependent manner
    Jingjing Meng
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    PLoS ONE 8:e54040. 2013
    ....
  9. ncbi request reprint Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infection
    Jinghua Wang
    Department of Pharmacology, University of Minnesota, 321 Church Street SE, Minneapolis, MN 55455, USA
    J Immunol 174:426-34. 2005
    ..pneumoniae infection after morphine treatment...
  10. ncbi request reprint Mu-opioid receptor mediates chronic restraint stress-induced lymphocyte apoptosis
    Jinghua Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 169:3630-6. 2002
    ....
  11. pmc Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling
    Jinghua Wang
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 286:10225-32. 2011
    ..Taken together, our study shows that morphine impairs S. pneumoniae induced IL-23 production through MyD88-IRAK1/4-dependent TLR2 and Nod2 signaling in DCs...
  12. ncbi request reprint Morphine negatively regulates interferon-gamma promoter activity in activated murine T cells through two distinct cyclic AMP-dependent pathways
    Jinghua Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 278:37622-31. 2003
    ..In summary, our data indicate that morphine modulation of IFN-gamma promoter activity is mediated through two distinct cAMP-dependent pathways, the NF-kappaB signaling pathway and the ERK1/2, p38 MAPK, AP-1/NFAT pathway...
  13. pmc Morphine modulation of toll-like receptors in microglial cells potentiates neuropathogenesis in a HIV-1 model of coinfection with pneumococcal pneumoniae
    Raini Dutta
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 32:9917-30. 2012
    ..pneumoniae infection may be a potential mechanism for the increased prevalence of HAND in HIV-infected opioid-dependent patients...
  14. ncbi request reprint Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine
    Jinghua Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 282:7164-71. 2007
    ..These findings suggest that chronic morphine treatment may function through both transcriptional and epigenetic mechanisms to inhibit IL-2 production...
  15. ncbi request reprint The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor
    Jinghua Wang
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55417, USA
    J Leukoc Biol 71:782-90. 2002
    ....
  16. ncbi request reprint Morphine inhibits VEGF expression in myocardial ischemia
    S Roy
    Department of Pharmacology, University of Minnesota, Minneapolis Veterans Affairs Medical Center, Minneapois, MN 55417, USA
    Surgery 134:336-44. 2003
    ....
  17. ncbi request reprint Modulation of immune function by morphine: implications for susceptibility to infection
    Sabita Roy
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 1:77-89. 2006
  18. doi request reprint TGF-beta expression by allogeneic bone marrow stromal cells ameliorates diabetes in NOD mice through modulating the distribution of CD4+ T cell subsets
    Wei Zhao
    Department of Neurobiology, Harbin Medical University Provincial Key Lad of Neurobiology, 194 XueFu Road, Harbin, Heilongjiang 150081, China
    Cell Immunol 253:23-30. 2008
    ..And the positive effects of allogeneic BMSCs in the treatment of NOD mice depend on the regulation of TGF-beta secreted by BMSCs...
  19. ncbi request reprint Interleukin-27 suppresses experimental autoimmune encephalomyelitis during bone marrow stromal cell treatment
    Jinghua Wang
    Department of Neurobiology, Harbin Medical University, 194 XueFu Road, Harbin, Heilongjiang 150081, China
    J Autoimmun 30:222-9. 2008
    ..These results demonstrate that BMSCs may suppress the development of EAE, possibly via secretion of IL-27, which can inhibit IL-17 production or Th17 cell generation...

Research Grants2

  1. Opioid abuse and host defense against streptococcus pneumoniae lung infection
    Jinghua Wang; Fiscal Year: 2007
    ..Ultimately, the studies will afford better development and design options when treating substance-abusing associated pneumoniae. ..