Research Topics
Genomes and Genes
| Jian Ying WangSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Detail Information
Publications
Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migrationJ Y Wang
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Physiol Cell Physiol 278:C303-14. 2000..1 channel expression. The subsequent membrane hyperpolarization raises [Ca(2+)](cyt) by increasing the driving force (the electrochemical gradient) for Ca(2+) influx and thus stimulates cell migration...- Polyamines and mRNA stability in regulation of intestinal mucosal growthJ Y Wang
Cell Biology Group, Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
Amino Acids 33:241-52. 2007..In this review article, we will focus on changes in expression of growth-inhibiting genes following polyamine depletion and further analyze in some detail the mechanisms through which mRNA stability is regulated by RNA-binding proteins... - Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrityJie Chen
Department of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA
Am J Physiol Gastrointest Liver Physiol 293:G568-76. 2007..These results indicate that polyamines are necessary for TLR2 expression and that polyamine-induced TLR2 activation plays an important role in regulating epithelial barrier function... - Polyamines regulate expression of E-cadherin and play an important role in control of intestinal epithelial barrier functionJian Ying Wang
Surgical Service, Baltimore Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA
Inflammopharmacology 13:91-101. 2005..Both the function of polyamines in expression of adherens junction proteins and their possible mechanisms, especially in implication of intracellular Ca2+ and c-Myc transcription factor, are the subject of this review article... - NF-kappaB-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletionTongtong Zou
Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 286:C1009-18. 2004..Increased c-IAP2 and XIAP after polyamine depletion induce the resistance to TNF-alpha/CHX-induced apoptosis, at least partially, through inhibition of the caspase-3 activity... - Cellular signaling in rapid intestinal epithelial restitution: implication of polyamines and K+ channelsJian Ying Wang
Department of Surgery, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
Sheng Li Xue Bao 55:365-72. 2003..Both the function of polyamines in rapid intestinal mucosal epithelial restitution and the underlying mechanism, especially the implication of K(+) channel activity, are the subject of this mini-review article... 
Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyaminesLan Xiao
Cell Biology Group, Department of Surgery University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 22:3055-69. 2011..Together, our findings indicate that polyamine-regulated CUGBP1 and miR-222 modulate CDK4 translation at least in part by altering the recruitment of CDK4 mRNA to processing bodies...- Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosisPeng Yuan Wang
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem J 426:293-306. 2010..Our findings indicate that MEK-1 is a key effector of the HuR-elicited anti-apoptotic programme in IECs... - miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodiesYu Hong Cui
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 23:151-62. 2012..These findings identify miR-503 as both a novel regulator of CUGBP1 expression and a modulator of intestinal epithelial homoeostasis... - Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter regionLan Liu
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem J 398:257-67. 2006..These findings confirm that p21Cip1 is one of the direct mediators of induced c-Myc following increased polyamines and that p21Cip1 repression by c-Myc is implicated in stimulation of normal IEC proliferation... - Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletionHuifang M Zhang
Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
J Biol Chem 279:22539-47. 2004..These results indicate that polyamine depletion induces the Akt activation mediating suppression of apoptosis via inhibition of caspase-3 in normal intestinal epithelial cells... - Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletionLan Xiao
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem J 403:573-81. 2007..These results indicate that induced JunD in IECs represses CDK4 transcription through its proximal promoter region following polyamine depletion... - Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cellsLan Xiao
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 18:4579-90. 2007..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis... - Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cellsTongtong Zou
Dept of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
Am J Physiol Cell Physiol 289:C686-96. 2005..These results indicate that 1) polyamine depletion increases expression of the NPM gene and enhances NPM nuclear translocation and 2) increased NPM interacts with and stabilizes p53, leading to inhibition of IEC-6 cell proliferation... - Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier functionLan Liu
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Physiol Cell Physiol 296:C801-10. 2009..These results indicate that polyamines enhance E-cadherin transcription by activating c-Myc, thus promoting function of the epithelial barrier... - Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylationLan Liu
Cell Biology Group, Department of Surgery, and Department of Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
Mol Biol Cell 20:4885-98. 2009..Our findings demonstrate that polyamines regulate c-Myc translation in IECs through HuR phosphorylation by Chk2 and provide new insight into the molecular functions of cellular polyamines... - Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletionLan Xiao
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
Am J Physiol Cell Physiol 298:C1226-34. 2010..These results indicate that induced ATF-2/JunD association following polyamine depletion represses CDK4 transcription, thus contributing to the inhibition of IEC growth... - p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletionAi Hong Zhang
Dept of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 293:C379-89. 2007..These results indicate that NDRG1 is one of the direct mediators of induced p53 following polyamine depletion and that p53-dependent NDRG1 expression plays a critical role in the negative control of IEC proliferation... - Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca²+ signaling by differentially modulating STIM1 and STIM2Jaladanki N Rao
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Physiol Cell Physiol 303:C308-17. 2012..These results indicate that polyamines differentially modulate cellular STIM1 and STIM2 levels in IECs, in turn controlling TRPC1-mediated Ca(2+) signaling and influencing cell migration after wounding... - Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAsTongtong Zou
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
J Biol Chem 281:19387-94. 2006..These results indicate that polyamines modulate cytoplasmic HuR levels in intestinal epithelial cells, in turn controlling the stability of the NPM and p53 mRNAs and influencing NPM and p53 protein levels... - STIM1 translocation to the plasma membrane enhances intestinal epithelial restitution by inducing TRPC1-mediated Ca2+ signaling after woundingJaladanki N Rao
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Physiol Cell Physiol 299:C579-88. 2010.... - Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3' untranslated region to HuR and AUF1Tongtong Zou
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Mol Cell Biol 30:5021-32. 2010..These results indicate that polyamines modulate the stability of JunD mRNA in intestinal epithelial cells through HuR and AUF1 and provide new insight into the molecular functions of cellular polyamines... - Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosisTongtong Zou
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, USA
Am J Physiol Cell Physiol 303:C102-11. 2012..These results indicate that the elevation of cellular polyamines represses the assembly of SGs in normal IECs and that increased SGs in polyamine-deficient cells are crucial for increased resistance to apoptosis... - Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferationLan Liu
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Physiol Cell Physiol 288:C89-99. 2005..These results indicate that polyamine-induced nuclear c-Myc interacts with Max, binds to the specific DNA sequence, and plays an important role in stimulation of normal intestinal epithelial cell proliferation... 
Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier functionJose Greenspon
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
Dig Dis Sci 56:1342-53. 2011..The current study determined whether S1P regulated function of the intestinal epithelial barrier by altering expression of E-cadherin, an important protein in adherens junctions...- Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1Tongtong Zou
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem J 409:389-98. 2008.... - Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cellsLan Liu
Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
Am J Physiol Gastrointest Liver Physiol 285:G1056-67. 2003.... - Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyaminesXian Zhang
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21224, USA
Nucleic Acids Res 37:7623-37. 2009..Our findings demonstrate that HuR regulates XIAP expression by stabilizing its mRNA and implicates HuR-mediated XIAP in the control of intestinal epithelial apoptosis... - Induced expression of STIM1 sensitizes intestinal epithelial cells to apoptosis by modulating store-operated Ca2+ influxJennifer A Timmons
Cell Biology Group, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
J Gastrointest Surg 16:1397-405. 2012..The current study determined whether STIM1 plays an important role in the regulation of IEC apoptosis by activating TRPC1 channel activity... - Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier functionTing Xi Yu
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore Street, Baltimore, MD 21201, USA
Nucleic Acids Res 39:8472-87. 2011..These results indicate that HuR regulates occludin mRNA translation through Chk2-dependent HuR phosphorylation and that this influence is crucial for maintenance of the epithelial barrier integrity in the intestinal tract... - Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after woundingJaladanki N Rao
Cell Biology Group, Department of Surgery, and 2Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Physiol Gastrointest Liver Physiol 292:G335-43. 2007..These results indicate that polyamines are absolutely required for PLC-gamma1 expression in IECs and that polyamine-mediated PLC-gamma1 signaling stimulates cell migration during restitution as a result of increased [Ca2+]cyt... - Induced TRPC1 expression sensitizes intestinal epithelial cells to apoptosis by inhibiting NF-kappaB activation through Ca2+ influxBernard S Marasa
Department of Pathology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
Biochem J 397:77-87. 2006..These results indicate that induced TRPC1 expression sensitizes IECs to apoptosis by inhibiting NF-kappaB activity as a result of the stimulation of Ca2+ influx... - Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after woundingJaladanki N Rao
Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 295:C1499-509. 2008..These results indicate that Rac1 promotes intestinal epithelial cell migration after wounding by increasing Ca(2+) influx as a result of its interaction with PLC-gamma1... - Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cellsHuifang M Zhang
Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 N Greene St, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 290:C1310-20. 2006..These results indicate that increased expression of FAK suppresses TNF-alpha/CHX-induced apoptosis, at least partially, through the activation of NF-kappaB signaling in IECs... - TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after woundingJaladanki N Rao
Departments of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA
Am J Physiol Gastrointest Liver Physiol 290:G782-92. 2006..These findings strongly suggest that TRPC1 functions as store-operated Ca(2+) channels and plays a critical role in intestinal epithelial restitution by regulating CCE and intracellular [Ca(2+)](cyt)... - Induced TRPC1 expression increases protein phosphatase 2A sensitizing intestinal epithelial cells to apoptosis through inhibition of NF-kappaB activationBernard S Marasa
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Physiol Cell Physiol 294:C1277-87. 2008..These results indicate that induced TRPC1 expression increases PP2A activity through Ca2+ influx and that increased PP2A sensitizes IECs to apoptosis as a result of NF-kappaB inactivation... - The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stabilityElizabeth T Chang
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem J 446:113-23. 2012..Co-transfection experiments with small interfering RNA directed against survivin suggest that the anti-apoptotic role for CUG-BP1 is not entirely dependent on its effect on survivin expression... - JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier functionJie Chen
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
Mol Biol Cell 19:3701-12. 2008..These results indicate that JunD is a biological suppressor of ZO-1 expression in intestinal epithelial cells and plays a critical role in maintaining epithelial barrier function... - The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cellsJames M Donahue
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biochem J 437:89-96. 2011..This provides an additional explanation for the increased survivin expression observed in oesophageal cancer cells that have lost p53... - NF-kappaB regulates intestinal epithelial cell and bile salt-induced migration after injuryEric D Strauch
Department of Surgery, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
Ann Surg 237:494-501. 2003..To determine if NF-kappa B regulates intestinal epithelial cell migration and if it has a role during bile salt-induced migration... - Substance P regulates migration in rat intestinal epithelial cellsDouglas J Turner
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
Ann Surg 245:408-14. 2007..The current study examined the effect of substance P (SP) upon intestinal epithelial cells and the mechanistic details of this interaction... - Bile salts induce resistance to apoptosis through NF-kappaB-mediated XIAP expressionDouglas J Turner
Departments of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
Ann Surg 245:415-25. 2007..Decreased enterocyte exposure to luminal bile salts, as occurs during starvation and parenteral nutrition, may have a detrimental effect on mucosal integrity... - Activation of Wnt3a signaling stimulates intestinal epithelial repair by promoting c-Myc-regulated gene expressionLan Liu
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Physiol Cell Physiol 302:C277-85. 2012..These results indicate that elevated Wnt3a signaling in intestinal epithelial cells after wounding stimulates epithelial repair by promoting c-Myc-regulated gene expression... - Loss of p53, rather than beta-catenin overexpression, induces survivin-mediated resistance to apoptosis in an esophageal cancer cell lineElizabeth Chang
Department of Surgery, Division of Thoracic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
J Thorac Cardiovasc Surg 140:225-32. 2010..The purpose of this study is to test whether inhibition of beta-catenin or overexpression of p53 can decrease survivin expression and render esophageal cancer cells more susceptible to apoptosis... - Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathwayJose Greenspon
Department of Surgery, Cell Biology Group, Baltimore Veterans Affairs Medical Center, University of Maryland School of Medicine, 10 N Greene Street, Baltimore, MD 21201, USA
Dig Dis Sci 54:499-510. 2009..The regulation of apoptosis of intestinal mucosal cells is important in maintenance of normal intestinal physiology... - Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier functionTing Xi Yu
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Mol Biol Cell 24:85-99. 2013.... - Posttranscriptional regulation of gene expression in epithelial cells by polyaminesLan Xiao
Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA
Methods Mol Biol 720:67-79. 2011.... - Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after woundingJaladanki N Rao
Department of Surgery, University of Maryland School of Medicine, 10 North Greene Street, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 282:C885-98. 2002..These results suggest that increased migration of differentiated intestinal epithelial cells is mediated, at least partially, by increasing Kv channel activity and Ca(2+) influx during restitution... - Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndromeMingkai Li
Department of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA
Am J Physiol Cell Physiol 297:C1445-51. 2009..Furthermore, polyamines in BUC block the BK channel. Targeting of bladder urothelial polyamine signaling may represent a novel approach for OAB treatment based on pathophysiologic mechanisms... - Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitutionJaladanki N Rao
Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Physiol Cell Physiol 284:C848-59. 2003..Activation of Rho-kinase results in increased MLC phosphorylation, leading to the stimulation of myosin stress fiber formation and cell migration... - Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cellsXin Guo
Dept. of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
Am J Physiol Gastrointest Liver Physiol 288:G1159-69. 2005..These findings indicate that polyamines are necessary for the synthesis and stability of occludin protein and that polyamine depletion disrupts the epithelial barrier function, at least partially, by decreasing occludin... - Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migrationXin Guo
Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
Am J Physiol Cell Physiol 283:C722-34. 2002..These results indicate that beta-catenin tyrosine phosphorylation plays a critical role in polyamine-dependent cell migration and that polyamines induce beta-catenin tyrosine phosphorylation at least partially through [Ca(2+)](cyt)... - Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosisJasleen Shant
Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Exp Cell Res 315:432-50. 2009..These findings provide a mechanism whereby bile acids increase resistance of colon cancer to chemotherapy and radiation... - Bile salts regulate intestinal epithelial cell migration by nuclear factor-kappa B-induced expression of transforming growth factor-betaEric D Strauch
Department of Surgery, University of Maryland, Baltimore, MD 21201, USA
J Am Coll Surg 197:974-84. 2003..Further, NF-kappa B elicits TGF-beta gene transcription during cell migration. These data support a physiologic role of bile salts in the maintenance of intestinal mucosal integrity... - Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyaminesXin Guo
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 285:C1174-87. 2003..These results indicate that polyamines regulate intestinal epithelial paracellular barrier function by altering E-cadherin expression and that polyamines are essential for E-cadherin expression at least partially through [Ca2+]cyt... - Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiationKiyoshi Masuda
Laboratory of Molecular Biology and Immunology, Baltimore, MD, USA
EMBO J 30:1040-53. 2011..We propose that the release of HuR-bound mRNAs via an IR-Chk2-HuR regulatory axis improves cell outcome following IR... - Taurodeoxycholate stimulates intestinal cell proliferation and protects against apoptotic cell death through activation of NF-kappaBAlexander Toledo
University of Maryland Hospital, Baltimore, Maryland 21201, USA
Dig Dis Sci 49:1664-71. 2004..Decreased enterocyte exposure to luminal bile salts, as occurs during starvation and parenteral nutrition, may have a detrimental effect on mucosal integrity... - Regulation of tight junction proteins and bladder epithelial paracellular permeability by an antiproliferative factor from patients with interstitial cystitisChen-Ou Zhang
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
J Urol 174:2382-7. 2005..CONCLUSIONS: Because of its apparent effects on bladder epithelial cell tight junctions and paracellular permeability in vitro, APF may contribute to the leakiness of the bladder epithelial barrier seen in IC... - Helicobacter pylori induces macrophage apoptosis by activation of arginase IIAlain P Gobert
Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
J Immunol 168:4692-700. 2002..pylori gastritis tissues, indicating the likely in vivo relevance of our findings. Therefore, we describe arginase- and ODC-dependent macrophage apoptosis, which implicates polyamines in the pathophysiology of H. pylori infection... - JunD stabilization results in inhibition of normal intestinal epithelial cell growth through P21 after polyamine depletionLi Li
Department of Surgery, University of Maryland School of Medicine, Baltimore, USA
Gastroenterology 123:764-79. 2002..CONCLUSIONS: Polyamines negatively regulate junD gene expression posttranscriptionally, and increased JunD/AP-1 inhibits intestinal epithelial cell proliferation at least partially through the activation of p21 promoter... - RNA Interference as a tool to study the function of MAD2 in mouse oocyte meiotic maturationJian Ying Wang
Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan, PR China
Mol Reprod Dev 74:116-24. 2007..In conclusion, our study shows that siRNA transfection is an effective tool to study MAD2 functions, and our results provide further evidence for the role of MAD2 as a spindle checkpoint protein in mouse oocytes... - HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuRHuiping Zhou
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, United States
Atherosclerosis 195:e134-43. 2007..Down regulation of HuR expression by siRNA prevented atazanavir-induced increase of TNF-alpha and IL-6. These results suggest that HuR might have an impact on pathophysiological processes of HIV PI-induced atherosclerosis... - Characterization of GaWRKY1, a cotton transcription factor that regulates the sesquiterpene synthase gene (+)-delta-cadinene synthase-AYan-hua Xu
National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
Plant Physiol 135:507-15. 2004..These results suggest that GaWRKY1 participates in regulation of sesquiterpene biosynthesis in cotton, and CAD1-A is a target gene of this transcription factor...
Research Grants
- Mucosal Repair in Gut Surgical DisordersJian Ying Wang; Fiscal Year: 2006..abstract_text> ..
- Intestinal Mucosal Growth in Health & Surgical DiseasesJian Ying Wang; Fiscal Year: 2007..It is hoped that these studies will identify potential therapeutic targets and agents which could be used in the future to maintain intestinal mucosal integrity in patients with critical surgical illnesses. ..
- Surgical Studies of Gut PermeabilityJian Ying Wang; Fiscal Year: 2007..Because barrier dysfunction occurs commonly in critical surgical patients and contributes to death, the subject matter of this proposal is timely, important, and has direct clinical application. ..
- Mucosal Repair in Gut Surgical DisordersJian Ying Wang; Fiscal Year: 2009....
- Intestinal Mucosal Growth in Health & Surgical DiseasesJian Ying Wang; Fiscal Year: 2010..It is hoped that these studies will identify potential therapeutic targets and agents which could be used in the future to maintain intestinal mucosal integrity in patients with critical surgical illnesses. ..
- Mucosal Repair in Gut Surgical DisordersJian Ying Wang; Fiscal Year: 2010....
- INTESTINAL MUCOSAL GROWTH IN HEALTH & SURGICAL DISEASEJian Ying Wang; Fiscal Year: 2004..The Investigators propose that these studies will enhance understanding of the biology of intestinal mucosal growth and have broader implications for the pathophysiology of mucosal growth inhibition in critical illness. ..
- Surgical Studies of Gut PermeabilityJian Ying Wang; Fiscal Year: 2010....