Jian Ying Wang

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migration
    J Y Wang
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 278:C303-14. 2000
  2. ncbi request reprint Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity
    Jie Chen
    Department of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 293:G568-76. 2007
  3. ncbi request reprint Polyamines and mRNA stability in regulation of intestinal mucosal growth
    J Y Wang
    Cell Biology Group, Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    Amino Acids 33:241-52. 2007
  4. ncbi request reprint Polyamines regulate expression of E-cadherin and play an important role in control of intestinal epithelial barrier function
    Jian Ying Wang
    Surgical Service, Baltimore Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA
    Inflammopharmacology 13:91-101. 2005
  5. ncbi request reprint NF-kappaB-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion
    Tongtong Zou
    Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 286:C1009-18. 2004
  6. ncbi request reprint Cellular signaling in rapid intestinal epithelial restitution: implication of polyamines and K+ channels
    Jian Ying Wang
    Department of Surgery, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Sheng Li Xue Bao 55:365-72. 2003
  7. ncbi request reprint Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding
    Jaladanki N Rao
    Department of Surgery, University of Maryland School of Medicine, 10 North Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 282:C885-98. 2002
  8. pmc Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines
    Lan Xiao
    Cell Biology Group, Department of Surgery University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 22:3055-69. 2011
  9. pmc Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis
    Peng Yuan Wang
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 426:293-306. 2010
  10. pmc miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies
    Yu Hong Cui
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 23:151-62. 2012

Research Grants

  1. Mucosal Repair in Gut Surgical Disorders
    Jian Ying Wang; Fiscal Year: 2006
  2. Intestinal Mucosal Growth in Health & Surgical Diseases
    Jian Ying Wang; Fiscal Year: 2007
  3. Surgical Studies of Gut Permeability
    Jian Ying Wang; Fiscal Year: 2007
  4. Mucosal Repair in Gut Surgical Disorders
    Jian Ying Wang; Fiscal Year: 2009
  5. Intestinal Mucosal Growth in Health & Surgical Diseases
    Jian Ying Wang; Fiscal Year: 2010
  6. Mucosal Repair in Gut Surgical Disorders
    Jian Ying Wang; Fiscal Year: 2010
  7. INTESTINAL MUCOSAL GROWTH IN HEALTH & SURGICAL DISEASE
    Jian Ying Wang; Fiscal Year: 2004
  8. Surgical Studies of Gut Permeability
    Jian Ying Wang; Fiscal Year: 2010

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migration
    J Y Wang
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 278:C303-14. 2000
    ..1 channel expression. The subsequent membrane hyperpolarization raises [Ca(2+)](cyt) by increasing the driving force (the electrochemical gradient) for Ca(2+) influx and thus stimulates cell migration...
  2. ncbi request reprint Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity
    Jie Chen
    Department of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 293:G568-76. 2007
    ..These results indicate that polyamines are necessary for TLR2 expression and that polyamine-induced TLR2 activation plays an important role in regulating epithelial barrier function...
  3. ncbi request reprint Polyamines and mRNA stability in regulation of intestinal mucosal growth
    J Y Wang
    Cell Biology Group, Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    Amino Acids 33:241-52. 2007
    ..In this review article, we will focus on changes in expression of growth-inhibiting genes following polyamine depletion and further analyze in some detail the mechanisms through which mRNA stability is regulated by RNA-binding proteins...
  4. ncbi request reprint Polyamines regulate expression of E-cadherin and play an important role in control of intestinal epithelial barrier function
    Jian Ying Wang
    Surgical Service, Baltimore Veterans Affairs Medical Center, 10 North Greene Street, Baltimore, MD 21201, USA
    Inflammopharmacology 13:91-101. 2005
    ..Both the function of polyamines in expression of adherens junction proteins and their possible mechanisms, especially in implication of intracellular Ca2+ and c-Myc transcription factor, are the subject of this review article...
  5. ncbi request reprint NF-kappaB-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion
    Tongtong Zou
    Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 286:C1009-18. 2004
    ..Increased c-IAP2 and XIAP after polyamine depletion induce the resistance to TNF-alpha/CHX-induced apoptosis, at least partially, through inhibition of the caspase-3 activity...
  6. ncbi request reprint Cellular signaling in rapid intestinal epithelial restitution: implication of polyamines and K+ channels
    Jian Ying Wang
    Department of Surgery, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    Sheng Li Xue Bao 55:365-72. 2003
    ..Both the function of polyamines in rapid intestinal mucosal epithelial restitution and the underlying mechanism, especially the implication of K(+) channel activity, are the subject of this mini-review article...
  7. ncbi request reprint Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding
    Jaladanki N Rao
    Department of Surgery, University of Maryland School of Medicine, 10 North Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 282:C885-98. 2002
    ..These results suggest that increased migration of differentiated intestinal epithelial cells is mediated, at least partially, by increasing Kv channel activity and Ca(2+) influx during restitution...
  8. pmc Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines
    Lan Xiao
    Cell Biology Group, Department of Surgery University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 22:3055-69. 2011
    ..Together, our findings indicate that polyamine-regulated CUGBP1 and miR-222 modulate CDK4 translation at least in part by altering the recruitment of CDK4 mRNA to processing bodies...
  9. pmc Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis
    Peng Yuan Wang
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 426:293-306. 2010
    ..Our findings indicate that MEK-1 is a key effector of the HuR-elicited anti-apoptotic programme in IECs...
  10. pmc miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies
    Yu Hong Cui
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 23:151-62. 2012
    ..These findings identify miR-503 as both a novel regulator of CUGBP1 expression and a modulator of intestinal epithelial homoeostasis...
  11. ncbi request reprint Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion
    Huifang M Zhang
    Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA
    J Biol Chem 279:22539-47. 2004
    ..These results indicate that polyamine depletion induces the Akt activation mediating suppression of apoptosis via inhibition of caspase-3 in normal intestinal epithelial cells...
  12. ncbi request reprint p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion
    Ai Hong Zhang
    Dept of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 293:C379-89. 2007
    ..These results indicate that NDRG1 is one of the direct mediators of induced p53 following polyamine depletion and that p53-dependent NDRG1 expression plays a critical role in the negative control of IEC proliferation...
  13. pmc Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region
    Lan Liu
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 398:257-67. 2006
    ..These findings confirm that p21Cip1 is one of the direct mediators of induced c-Myc following increased polyamines and that p21Cip1 repression by c-Myc is implicated in stimulation of normal IEC proliferation...
  14. pmc Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells
    Lan Xiao
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 18:4579-90. 2007
    ..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis...
  15. pmc Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation
    Lan Liu
    Cell Biology Group, Department of Surgery, and Department of Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    Mol Biol Cell 20:4885-98. 2009
    ..Our findings demonstrate that polyamines regulate c-Myc translation in IECs through HuR phosphorylation by Chk2 and provide new insight into the molecular functions of cellular polyamines...
  16. pmc Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function
    Lan Liu
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 296:C801-10. 2009
    ..These results indicate that polyamines enhance E-cadherin transcription by activating c-Myc, thus promoting function of the epithelial barrier...
  17. ncbi request reprint Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells
    Tongtong Zou
    Dept of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Physiol Cell Physiol 289:C686-96. 2005
    ..These results indicate that 1) polyamine depletion increases expression of the NPM gene and enhances NPM nuclear translocation and 2) increased NPM interacts with and stabilizes p53, leading to inhibition of IEC-6 cell proliferation...
  18. pmc Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion
    Lan Xiao
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 403:573-81. 2007
    ..These results indicate that induced JunD in IECs represses CDK4 transcription through its proximal promoter region following polyamine depletion...
  19. ncbi request reprint Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution
    Jaladanki N Rao
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 284:C848-59. 2003
    ..Activation of Rho-kinase results in increased MLC phosphorylation, leading to the stimulation of myosin stress fiber formation and cell migration...
  20. pmc Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion
    Lan Xiao
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Am J Physiol Cell Physiol 298:C1226-34. 2010
    ..These results indicate that induced ATF-2/JunD association following polyamine depletion represses CDK4 transcription, thus contributing to the inhibition of IEC growth...
  21. pmc Competitive binding of CUGBP1 and HuR to occludin mRNA controls its translation and modulates epithelial barrier function
    Ting Xi Yu
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 24:85-99. 2013
    ....
  22. pmc Polyamines regulate intestinal epithelial restitution through TRPC1-mediated Ca²+ signaling by differentially modulating STIM1 and STIM2
    Jaladanki N Rao
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 303:C308-17. 2012
    ..These results indicate that polyamines differentially modulate cellular STIM1 and STIM2 levels in IECs, in turn controlling TRPC1-mediated Ca(2+) signaling and influencing cell migration after wounding...
  23. ncbi request reprint Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR leading to stabilization of nucleophosmin and p53 mRNAs
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    J Biol Chem 281:19387-94. 2006
    ..These results indicate that polyamines modulate cytoplasmic HuR levels in intestinal epithelial cells, in turn controlling the stability of the NPM and p53 mRNAs and influencing NPM and p53 protein levels...
  24. ncbi request reprint Polyamines are necessary for synthesis and stability of occludin protein in intestinal epithelial cells
    Xin Guo
    Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1159-69. 2005
    ..These findings indicate that polyamines are necessary for the synthesis and stability of occludin protein and that polyamine depletion disrupts the epithelial barrier function, at least partially, by decreasing occludin...
  25. pmc STIM1 translocation to the plasma membrane enhances intestinal epithelial restitution by inducing TRPC1-mediated Ca2+ signaling after wounding
    Jaladanki N Rao
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 299:C579-88. 2010
    ....
  26. pmc Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3' untranslated region to HuR and AUF1
    Tongtong Zou
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mol Cell Biol 30:5021-32. 2010
    ..These results indicate that polyamines modulate the stability of JunD mRNA in intestinal epithelial cells through HuR and AUF1 and provide new insight into the molecular functions of cellular polyamines...
  27. ncbi request reprint Polyamines regulate beta-catenin tyrosine phosphorylation via Ca(2+) during intestinal epithelial cell migration
    Xin Guo
    Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA
    Am J Physiol Cell Physiol 283:C722-34. 2002
    ..These results indicate that beta-catenin tyrosine phosphorylation plays a critical role in polyamine-dependent cell migration and that polyamines induce beta-catenin tyrosine phosphorylation at least partially through [Ca(2+)](cyt)...
  28. ncbi request reprint JunD stabilization results in inhibition of normal intestinal epithelial cell growth through P21 after polyamine depletion
    Li Li
    Department of Surgery, University of Maryland School of Medicine, Baltimore, USA
    Gastroenterology 123:764-79. 2002
    ....
  29. pmc Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, USA
    Am J Physiol Cell Physiol 303:C102-11. 2012
    ..These results indicate that the elevation of cellular polyamines represses the assembly of SGs in normal IECs and that increased SGs in polyamine-deficient cells are crucial for increased resistance to apoptosis...
  30. doi request reprint Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function
    Jose Greenspon
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Dig Dis Sci 56:1342-53. 2011
    ..The current study determined whether S1P regulated function of the intestinal epithelial barrier by altering expression of E-cadherin, an important protein in adherens junctions...
  31. ncbi request reprint Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells
    Lan Liu
    Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1056-67. 2003
    ....
  32. ncbi request reprint Polyamine-modulated expression of c-myc plays a critical role in stimulation of normal intestinal epithelial cell proliferation
    Lan Liu
    Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 288:C89-99. 2005
    ..These results indicate that polyamine-induced nuclear c-Myc interacts with Max, binds to the specific DNA sequence, and plays an important role in stimulation of normal intestinal epithelial cell proliferation...
  33. ncbi request reprint Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1
    Tongtong Zou
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 409:389-98. 2008
    ....
  34. pmc Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines
    Xian Zhang
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21224, USA
    Nucleic Acids Res 37:7623-37. 2009
    ..Our findings demonstrate that HuR regulates XIAP expression by stabilizing its mRNA and implicates HuR-mediated XIAP in the control of intestinal epithelial apoptosis...
  35. pmc Induced expression of STIM1 sensitizes intestinal epithelial cells to apoptosis by modulating store-operated Ca2+ influx
    Jennifer A Timmons
    Cell Biology Group, Department of Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    J Gastrointest Surg 16:1397-405. 2012
    ..The current study determined whether STIM1 plays an important role in the regulation of IEC apoptosis by activating TRPC1 channel activity...
  36. pmc Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function
    Ting Xi Yu
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore Street, Baltimore, MD 21201, USA
    Nucleic Acids Res 39:8472-87. 2011
    ..These results indicate that HuR regulates occludin mRNA translation through Chk2-dependent HuR phosphorylation and that this influence is crucial for maintenance of the epithelial barrier integrity in the intestinal tract...
  37. pmc Induced TRPC1 expression sensitizes intestinal epithelial cells to apoptosis by inhibiting NF-kappaB activation through Ca2+ influx
    Bernard S Marasa
    Department of Pathology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    Biochem J 397:77-87. 2006
    ..These results indicate that induced TRPC1 expression sensitizes IECs to apoptosis by inhibiting NF-kappaB activity as a result of the stimulation of Ca2+ influx...
  38. pmc miR-195 competes with HuR to modulate stim1 mRNA stability and regulate cell migration
    Ran Zhuang
    Department of Surgery, Cell Biology Group, University of Maryland School of Medicine, MD 21201, USA, Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA, Department of Pathology, University of Maryland School of Medicine, MD 21201, USA and Laboratory of Genetics, National Institute on Aging IRP, NIH, Baltimore, MD 21224, USA
    Nucleic Acids Res 41:7905-19. 2013
    ..In sum, Stim1 expression is controlled by two factors competing for influence on stim1 mRNA stability: the mRNA-stabilizing protein HuR and the decay-promoting miR-195...
  39. ncbi request reprint Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding
    Jaladanki N Rao
    Cell Biology Group, Department of Surgery, and 2Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Gastrointest Liver Physiol 292:G335-43. 2007
    ..These results indicate that polyamines are absolutely required for PLC-gamma1 expression in IECs and that polyamine-mediated PLC-gamma1 signaling stimulates cell migration during restitution as a result of increased [Ca2+]cyt...
  40. ncbi request reprint Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines
    Xin Guo
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 285:C1174-87. 2003
    ..These results indicate that polyamines regulate intestinal epithelial paracellular barrier function by altering E-cadherin expression and that polyamines are essential for E-cadherin expression at least partially through [Ca2+]cyt...
  41. pmc Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after wounding
    Jaladanki N Rao
    Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 295:C1499-509. 2008
    ..These results indicate that Rac1 promotes intestinal epithelial cell migration after wounding by increasing Ca(2+) influx as a result of its interaction with PLC-gamma1...
  42. ncbi request reprint TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding
    Jaladanki N Rao
    Departments of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA
    Am J Physiol Gastrointest Liver Physiol 290:G782-92. 2006
    ..These findings strongly suggest that TRPC1 functions as store-operated Ca(2+) channels and plays a critical role in intestinal epithelial restitution by regulating CCE and intracellular [Ca(2+)](cyt)...
  43. ncbi request reprint Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells
    Huifang M Zhang
    Dept of Surgery, Baltimore Veterans Affairs Medical Center, 10 N Greene St, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 290:C1310-20. 2006
    ..These results indicate that increased expression of FAK suppresses TNF-alpha/CHX-induced apoptosis, at least partially, through the activation of NF-kappaB signaling in IECs...
  44. doi request reprint Induced TRPC1 expression increases protein phosphatase 2A sensitizing intestinal epithelial cells to apoptosis through inhibition of NF-kappaB activation
    Bernard S Marasa
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 294:C1277-87. 2008
    ..These results indicate that induced TRPC1 expression increases PP2A activity through Ca2+ influx and that increased PP2A sensitizes IECs to apoptosis as a result of NF-kappaB inactivation...
  45. doi request reprint The RNA-binding protein CUG-BP1 increases survivin expression in oesophageal cancer cells through enhanced mRNA stability
    Elizabeth T Chang
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 446:113-23. 2012
    ..Co-transfection experiments with small interfering RNA directed against survivin suggest that the anti-apoptotic role for CUG-BP1 is not entirely dependent on its effect on survivin expression...
  46. pmc JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function
    Jie Chen
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Mol Biol Cell 19:3701-12. 2008
    ..These results indicate that JunD is a biological suppressor of ZO-1 expression in intestinal epithelial cells and plays a critical role in maintaining epithelial barrier function...
  47. doi request reprint Sphingosine kinase 1 overexpression stimulates intestinal epithelial cell proliferation through increased c-Myc translation
    Ping Jiang
    Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 304:C1187-97. 2013
    ..Our findings demonstrate that S1P modulates intestinal cell proliferation and provides new insights as to the mechanistic actions of SphK1 and S1P in maintaining intestinal epithelial homeostasis...
  48. doi request reprint The RNA-binding protein HuR stabilizes survivin mRNA in human oesophageal epithelial cells
    James M Donahue
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 437:89-96. 2011
    ..This provides an additional explanation for the increased survivin expression observed in oesophageal cancer cells that have lost p53...
  49. pmc Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway
    Jose Greenspon
    Department of Surgery, Cell Biology Group, Baltimore Veterans Affairs Medical Center, University of Maryland School of Medicine, 10 N Greene Street, Baltimore, MD 21201, USA
    Dig Dis Sci 54:499-510. 2009
    ..The regulation of apoptosis of intestinal mucosal cells is important in maintenance of normal intestinal physiology...
  50. pmc Substance P regulates migration in rat intestinal epithelial cells
    Douglas J Turner
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Ann Surg 245:408-14. 2007
    ..The current study examined the effect of substance P (SP) upon intestinal epithelial cells and the mechanistic details of this interaction...
  51. pmc NF-kappaB regulates intestinal epithelial cell and bile salt-induced migration after injury
    Eric D Strauch
    Department of Surgery, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    Ann Surg 237:494-501. 2003
    ..To determine if NF-kappa B regulates intestinal epithelial cell migration and if it has a role during bile salt-induced migration...
  52. pmc Activation of Wnt3a signaling stimulates intestinal epithelial repair by promoting c-Myc-regulated gene expression
    Lan Liu
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 302:C277-85. 2012
    ..These results indicate that elevated Wnt3a signaling in intestinal epithelial cells after wounding stimulates epithelial repair by promoting c-Myc-regulated gene expression...
  53. pmc Bile salts induce resistance to apoptosis through NF-kappaB-mediated XIAP expression
    Douglas J Turner
    Departments of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    Ann Surg 245:415-25. 2007
    ..Decreased enterocyte exposure to luminal bile salts, as occurs during starvation and parenteral nutrition, may have a detrimental effect on mucosal integrity...
  54. ncbi request reprint Bile salts regulate intestinal epithelial cell migration by nuclear factor-kappa B-induced expression of transforming growth factor-beta
    Eric D Strauch
    Department of Surgery, University of Maryland, Baltimore, MD 21201, USA
    J Am Coll Surg 197:974-84. 2003
    ..The objectives of this study were to determine if this is a property shared by other bile salts or an effect specific to TDCA, and to determine if NF-kappa B regulates TGF-beta expression...
  55. doi request reprint Loss of p53, rather than beta-catenin overexpression, induces survivin-mediated resistance to apoptosis in an esophageal cancer cell line
    Elizabeth Chang
    Department of Surgery, Division of Thoracic Surgery, University of Maryland School of Medicine, Baltimore, MD, USA
    J Thorac Cardiovasc Surg 140:225-32. 2010
    ..The purpose of this study is to test whether inhibition of beta-catenin or overexpression of p53 can decrease survivin expression and render esophageal cancer cells more susceptible to apoptosis...
  56. pmc miR-29b represses intestinal mucosal growth by inhibiting translation of cyclin-dependent kinase 2
    Lan Xiao
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201 Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201 Laboratory of Genetics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224
    Mol Biol Cell 24:3038-46. 2013
    ..These results indicate that miR-29b inhibits intestinal mucosal growth by repressing CDK2 translation. ..
  57. ncbi request reprint Regulation of tight junction proteins and bladder epithelial paracellular permeability by an antiproliferative factor from patients with interstitial cystitis
    Chen Ou Zhang
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    J Urol 174:2382-7. 2005
    ..We then determined the effect of APF on the permeability of normal bladder epithelial cell monolayers and the expression of tight junction proteins...
  58. doi request reprint Posttranscriptional regulation of gene expression in epithelial cells by polyamines
    Lan Xiao
    Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA
    Methods Mol Biol 720:67-79. 2011
    ....
  59. ncbi request reprint Helicobacter pylori induces macrophage apoptosis by activation of arginase II
    Alain P Gobert
    Department of Medicine, Division of Gastroenterology, University of Maryland School of Medicine, and Veterans Affairs Maryland Health Care System, Baltimore, MD 21201, USA
    J Immunol 168:4692-700. 2002
    ..pylori gastritis tissues, indicating the likely in vivo relevance of our findings. Therefore, we describe arginase- and ODC-dependent macrophage apoptosis, which implicates polyamines in the pathophysiology of H. pylori infection...
  60. pmc Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome
    Mingkai Li
    Department of Surgery, University of Maryland School of Medicine, Baltimore, 21201, USA
    Am J Physiol Cell Physiol 297:C1445-51. 2009
    ..Furthermore, polyamines in BUC block the BK channel. Targeting of bladder urothelial polyamine signaling may represent a novel approach for OAB treatment based on pathophysiologic mechanisms...
  61. ncbi request reprint Taurodeoxycholate stimulates intestinal cell proliferation and protects against apoptotic cell death through activation of NF-kappaB
    Alexander Toledo
    University of Maryland Hospital, Baltimore, Maryland 21201, USA
    Dig Dis Sci 49:1664-71. 2004
    ..Decreased enterocyte exposure to luminal bile salts, as occurs during starvation and parenteral nutrition, may have a detrimental effect on mucosal integrity...
  62. pmc Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis
    Jasleen Shant
    Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Exp Cell Res 315:432-50. 2009
    ..These findings provide a mechanism whereby bile acids increase resistance of colon cancer to chemotherapy and radiation...
  63. pmc Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation
    Kiyoshi Masuda
    Laboratory of Molecular Biology and Immunology, Baltimore, MD, USA
    EMBO J 30:1040-53. 2011
    ..We propose that the release of HuR-bound mRNAs via an IR-Chk2-HuR regulatory axis improves cell outcome following IR...
  64. ncbi request reprint HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR
    Huiping Zhou
    Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, United States
    Atherosclerosis 195:e134-43. 2007
    ..Down regulation of HuR expression by siRNA prevented atazanavir-induced increase of TNF-alpha and IL-6. These results suggest that HuR might have an impact on pathophysiological processes of HIV PI-induced atherosclerosis...
  65. ncbi request reprint RNA Interference as a tool to study the function of MAD2 in mouse oocyte meiotic maturation
    Jian Ying Wang
    Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan, PR China
    Mol Reprod Dev 74:116-24. 2007
    ..In conclusion, our study shows that siRNA transfection is an effective tool to study MAD2 functions, and our results provide further evidence for the role of MAD2 as a spindle checkpoint protein in mouse oocytes...
  66. pmc Characterization of GaWRKY1, a cotton transcription factor that regulates the sesquiterpene synthase gene (+)-delta-cadinene synthase-A
    Yan hua Xu
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Plant Physiol 135:507-15. 2004
    ..These results suggest that GaWRKY1 participates in regulation of sesquiterpene biosynthesis in cotton, and CAD1-A is a target gene of this transcription factor...

Research Grants24

  1. Mucosal Repair in Gut Surgical Disorders
    Jian Ying Wang; Fiscal Year: 2006
    ..abstract_text> ..
  2. Intestinal Mucosal Growth in Health & Surgical Diseases
    Jian Ying Wang; Fiscal Year: 2007
    ..It is hoped that these studies will identify potential therapeutic targets and agents which could be used in the future to maintain intestinal mucosal integrity in patients with critical surgical illnesses. ..
  3. Surgical Studies of Gut Permeability
    Jian Ying Wang; Fiscal Year: 2007
    ..Because barrier dysfunction occurs commonly in critical surgical patients and contributes to death, the subject matter of this proposal is timely, important, and has direct clinical application. ..
  4. Mucosal Repair in Gut Surgical Disorders
    Jian Ying Wang; Fiscal Year: 2009
    ....
  5. Intestinal Mucosal Growth in Health & Surgical Diseases
    Jian Ying Wang; Fiscal Year: 2010
    ..It is hoped that these studies will identify potential therapeutic targets and agents which could be used in the future to maintain intestinal mucosal integrity in patients with critical surgical illnesses. ..
  6. Mucosal Repair in Gut Surgical Disorders
    Jian Ying Wang; Fiscal Year: 2010
    ....
  7. INTESTINAL MUCOSAL GROWTH IN HEALTH & SURGICAL DISEASE
    Jian Ying Wang; Fiscal Year: 2004
    ..The Investigators propose that these studies will enhance understanding of the biology of intestinal mucosal growth and have broader implications for the pathophysiology of mucosal growth inhibition in critical illness. ..
  8. Surgical Studies of Gut Permeability
    Jian Ying Wang; Fiscal Year: 2010
    ....