Research Topics
Genomes and Genes | Jennifer P WangSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Toll like receptors and virusesRobert W Finberg
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Rev Med Virol 17:35-43. 2007..A greater understanding of relationships between viruses or viral products and TLRs should improve understanding of pathogenesis and lead to the development of new anti-viral therapies...
Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonistsHaibin Huang
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, LRB317, Worcester, MA 01605, USA
Infect Immun 77:1774-81. 2009..These patterns of response might contribute to the skewing of immune responses during mycotic infections and have implications for the design of immunomodulators and vaccines containing beta-glucans...- Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infantsJennifer P Wang
Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation, Worcester, MA 01605, USA
BMC Immunol 13:35. 2012..Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs)... - Toll-like receptor-mediated activation of neutrophils by influenza A virusJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Blood 112:2028-34. 2008..These studies demonstrate neutrophil activation by influenza virus and highlight the importance of TLR7 and TLR8 in that response... - MDA5 and MAVS mediate type I interferon responses to coxsackie B virusJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Virol 84:254-60. 2010..These data highlight the importance of type I interferon in host defense and provide insight on the mechanisms of innate immune responses following coxsackievirus infection... - Role of specific innate immune responses in herpes simplex virus infection of the central nervous systemJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Virol 86:2273-81. 2012..These results illustrate the complex but important roles that innate immune receptors play in host responses to HSV-1 during infection of the central nervous system... - Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformansJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 6:e26232. 2011..In summary, we found that multiple signaling components can contribute the MyD88-dependent host responses to cryptococcal infection in vivo and each drives distinct pulmonary responses... - Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNAJennifer P Wang
Department of Medicine, University of Massachusetts, 364 Plantation, Worcester, MA 01605, USA
J Immunol 178:3363-7. 2007..These data define a pathway by which intracellular TLR7 senses viral RNA and indicate a role for TLRs in association with Abs in sustaining virus-specific responses... - Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2Jennifer P Wang
Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
J Virol 79:12658-66. 2005..Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection... - CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophagesJennifer P Wang
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
FEMS Immunol Med Microbiol 45:303-10. 2005..These data indicate that CpG-ODN can improve the ability of hMDM to contain growth of virulent M. tuberculosis... - Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognitionJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 177:7114-21. 2006..A greater understanding of viral RNA-TLR7 activity relationships will promote rational approaches to interventional and vaccine strategies for important human viral pathogens... - Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotidesJennifer M Dan
Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America
PLoS ONE 3:e2046. 2008.... - Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infectionShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
J Immunol 178:5173-81. 2007..We believe that these results explain how the route of infection, probably by virtue of activating different cell populations, can lead to entirely different outcomes of infection based on the underlying genetics of the host... - Innate immunity to respiratory virusesJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Cell Microbiol 9:1641-6. 2007..We also provide an overview of the current knowledge of regulation of type I interferons and inflammatory cytokines in viral infection... - The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responsesRachel F Madera
Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 6:e29412. 2011..A better understanding of the critical signaling pathways by which RNA-like IRMs stimulate CD4+ Th1 responses is relevant to the rational design of improved vaccine adjuvants... - A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatusZaida G Ramirez-Ortiz
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Cell Host Microbe 9:415-24. 2011..These data demonstrate the antifungal activity of pDCs against A. fumigatus and establish their nonredundant role in host defenses against invasive aspergillosis in vivo... - Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNAZaida G Ramirez-Ortiz
Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA 01605, USA
Infect Immun 76:2123-9. 2008..fumigatus DNA. Taken together, these data demonstrate that TLR9 detects A. fumigatus DNA, resulting in the secretion of proinflammatory cytokines, which may contribute to the immune response to the pathogen... - Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infectionJennifer P Wang
University of California, San Diego, Department of Medicine 0640, 9500 Gilman Drive, La Jolla, CA 92093-0640, USA
FEMS Immunol Med Microbiol 39:163-72. 2003..Augmentation of the respiratory burst and preservation of the response to interferon-gamma were also demonstrated. These data supplement existing knowledge on macrophage responses to tuberculosis infection... - Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virusGabriel L Hendricks
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 288:8061-73. 2013.... 
Antiviral responses: different roles for different tollsRobert W Finberg
University of Massachusetts Medical School, Worcester, MA 01605, USA
Immunity 30:173-5. 2009..2009) show the interplay between Toll-like receptors (TLRs) and cytokines during West Nile virus infection and define a role for TLR-mediated production of interleukin-23 in immune cell homing and pathogenesis...
Research Grants
- Macrophage defense againt M. tuberculosisJennifer Wang; Fiscal Year: 2007..abstract_text> ..