Jennifer P Wang

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Toll like receptors and viruses
    Robert W Finberg
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Rev Med Virol 17:35-43. 2007
  2. pmc Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists
    Haibin Huang
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, LRB317, Worcester, MA 01605, USA
    Infect Immun 77:1774-81. 2009
  3. pmc Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants
    Jennifer P Wang
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation, Worcester, MA 01605, USA
    BMC Immunol 13:35. 2012
  4. pmc Toll-like receptor-mediated activation of neutrophils by influenza A virus
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 112:2028-34. 2008
  5. pmc MDA5 and MAVS mediate type I interferon responses to coxsackie B virus
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Virol 84:254-60. 2010
  6. pmc Role of specific innate immune responses in herpes simplex virus infection of the central nervous system
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:2273-81. 2012
  7. pmc Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e26232. 2011
  8. ncbi request reprint Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA
    Jennifer P Wang
    Department of Medicine, University of Massachusetts, 364 Plantation, Worcester, MA 01605, USA
    J Immunol 178:3363-7. 2007
  9. pmc Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
    J Virol 79:12658-66. 2005
  10. ncbi request reprint CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages
    Jennifer P Wang
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    FEMS Immunol Med Microbiol 45:303-10. 2005

Research Grants

  1. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Toll like receptors and viruses
    Robert W Finberg
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Rev Med Virol 17:35-43. 2007
    ..A greater understanding of relationships between viruses or viral products and TLRs should improve understanding of pathogenesis and lead to the development of new anti-viral therapies...
  2. pmc Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists
    Haibin Huang
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, LRB317, Worcester, MA 01605, USA
    Infect Immun 77:1774-81. 2009
    ..These patterns of response might contribute to the skewing of immune responses during mycotic infections and have implications for the design of immunomodulators and vaccines containing beta-glucans...
  3. pmc Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants
    Jennifer P Wang
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation, Worcester, MA 01605, USA
    BMC Immunol 13:35. 2012
    ..Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs)...
  4. pmc Toll-like receptor-mediated activation of neutrophils by influenza A virus
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Blood 112:2028-34. 2008
    ..These studies demonstrate neutrophil activation by influenza virus and highlight the importance of TLR7 and TLR8 in that response...
  5. pmc MDA5 and MAVS mediate type I interferon responses to coxsackie B virus
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Virol 84:254-60. 2010
    ..These data highlight the importance of type I interferon in host defense and provide insight on the mechanisms of innate immune responses following coxsackievirus infection...
  6. pmc Role of specific innate immune responses in herpes simplex virus infection of the central nervous system
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:2273-81. 2012
    ..These results illustrate the complex but important roles that innate immune receptors play in host responses to HSV-1 during infection of the central nervous system...
  7. pmc Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e26232. 2011
    ..In summary, we found that multiple signaling components can contribute the MyD88-dependent host responses to cryptococcal infection in vivo and each drives distinct pulmonary responses...
  8. ncbi request reprint Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA
    Jennifer P Wang
    Department of Medicine, University of Massachusetts, 364 Plantation, Worcester, MA 01605, USA
    J Immunol 178:3363-7. 2007
    ..These data define a pathway by which intracellular TLR7 senses viral RNA and indicate a role for TLRs in association with Abs in sustaining virus-specific responses...
  9. pmc Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
    J Virol 79:12658-66. 2005
    ..Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection...
  10. ncbi request reprint CpG oligonucleotides partially inhibit growth of Mycobacterium tuberculosis, but not Salmonella or Listeria, in human monocyte-derived macrophages
    Jennifer P Wang
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    FEMS Immunol Med Microbiol 45:303-10. 2005
    ..These data indicate that CpG-ODN can improve the ability of hMDM to contain growth of virulent M. tuberculosis...
  11. ncbi request reprint Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:7114-21. 2006
    ..A greater understanding of viral RNA-TLR7 activity relationships will promote rational approaches to interventional and vaccine strategies for important human viral pathogens...
  12. pmc Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides
    Jennifer M Dan
    Department of Microbiology and Immunology Training Program, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2046. 2008
    ....
  13. ncbi request reprint Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection
    Shenghua Zhou
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    J Immunol 178:5173-81. 2007
    ..We believe that these results explain how the route of infection, probably by virtue of activating different cell populations, can lead to entirely different outcomes of infection based on the underlying genetics of the host...
  14. ncbi request reprint Innate immunity to respiratory viruses
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell Microbiol 9:1641-6. 2007
    ..We also provide an overview of the current knowledge of regulation of type I interferons and inflammatory cytokines in viral infection...
  15. pmc The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses
    Rachel F Madera
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e29412. 2011
    ..A better understanding of the critical signaling pathways by which RNA-like IRMs stimulate CD4+ Th1 responses is relevant to the rational design of improved vaccine adjuvants...
  16. pmc A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus
    Zaida G Ramirez-Ortiz
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell Host Microbe 9:415-24. 2011
    ..These data demonstrate the antifungal activity of pDCs against A. fumigatus and establish their nonredundant role in host defenses against invasive aspergillosis in vivo...
  17. pmc Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA
    Zaida G Ramirez-Ortiz
    Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Infect Immun 76:2123-9. 2008
    ..fumigatus DNA. Taken together, these data demonstrate that TLR9 detects A. fumigatus DNA, resulting in the secretion of proinflammatory cytokines, which may contribute to the immune response to the pathogen...
  18. ncbi request reprint Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection
    Jennifer P Wang
    University of California, San Diego, Department of Medicine 0640, 9500 Gilman Drive, La Jolla, CA 92093 0640, USA
    FEMS Immunol Med Microbiol 39:163-72. 2003
    ..Augmentation of the respiratory burst and preservation of the response to interferon-gamma were also demonstrated. These data supplement existing knowledge on macrophage responses to tuberculosis infection...
  19. pmc Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus
    Gabriel L Hendricks
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 288:8061-73. 2013
    ....
  20. doi request reprint Antiviral responses: different roles for different tolls
    Robert W Finberg
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Immunity 30:173-5. 2009
    ..2009) show the interplay between Toll-like receptors (TLRs) and cytokines during West Nile virus infection and define a role for TLR-mediated production of interleukin-23 in immune cell homing and pathogenesis...

Research Grants2

  1. Macrophage defense againt M. tuberculosis
    Jennifer Wang; Fiscal Year: 2007
    ..abstract_text> ..