Hsing Wen Wang
Affiliation: University of Pennsylvania
- Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcomeHsing Wen Wang
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Cancer Res 64:7553-61. 2004..These data suggest that monitoring of PDT-induced changes in tumor oxygenation may be a valuable prognostic indicator...
- Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapyHsing Wen Wang
University of Pennsylvania, Department of Physics and Astronomy, 209 South 33rd Street, Philadelphia, Pennsylvania 19104 6396, USA
J Biomed Opt 10:14004. 2005..These results provide benchmark in-vivo tissue optical property data, and demonstrate the feasibility of in-situ measurements during clinical PDT treatments...
- Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapyTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, B13 Anatomy and Chemistry, 3620 Hamilton Walk, Philadelphia, PA 19104 6072, USA
Photochem Photobiol Sci 8:1683-93. 2009..This research suggests that the benefits of low-fluence-rate PDT are mediated in part by a reduction in intratumor heterogeneity in hypoxic, vascular and cytotoxic responses...
- In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostatesMichael Solonenko
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia 19104, USA
Phys Med Biol 47:857-73. 2002..This class of in situ optical property measurement may be desirable to individualize PDT drug and light delivery...
- Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacyGuoqiang Yu
Department of Physics and Astronomy, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Clin Cancer Res 11:3543-52. 2005..To monitor tumor blood flow noninvasively during photodynamic therapy (PDT) and to correlate flow responses with therapeutic efficacy...
- A phase II trial of intraperitoneal photodynamic therapy for patients with peritoneal carcinomatosis and sarcomatosisStephen M Hahn
Department of Radiation Oncology, Division of Gynecologic Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Clin Cancer Res 12:2517-25. 2006..The primary objectives of this phase II study were to determine the efficacy and toxicities of i.p. photodynamic therapy in patients with peritoneal carcinomatosis and sarcomatosis...
- Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal carcinomatosisHsing Wen Wang
University of Pennsylvania, Department of Physics, Philadelphia, Pennsylvania, USA
J Biomed Opt 12:034023. 2007..These results further demonstrate the potential of in vivo DRS measurements in clinical PDT...
- Effect of photosensitizer dose on fluence rate responses to photodynamic therapyHsing Wen Wang
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Photochem Photobiol 83:1040-8. 2007..Clinical confirmation and application of these results will be possible through use of minimally invasive oxygen and photosensitizer monitoring technologies, which are currently under development...
- Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rateTheresa M Busch
Department of Radiation Oncology, School of Medicine, University of Pennsylvania Philadelphia, Pennsylvania 19104, USA
Radiat Res 174:331-40. 2010..Further study of low fluence rate as a means to improve responses to PDT under conditions designed to predominantly damage vasculature is warranted...