Gaofeng Wang

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. doi request reprint Chromosome 10q26 locus and age-related macular degeneration: a progress update
    Gaofeng Wang
    John P Hussman Institute for Human Genomics, Dr John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, 1501 N W 10th Avenue, BRB 525, M860, Miami, FL 33136, United States Electronic address
    Exp Eye Res 119:1-7. 2014
  2. ncbi request reprint Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina
    Gaofeng Wang
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Exp Eye Res 112:102-5. 2013
  3. pmc Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria
    Gaofeng Wang
    Miami Institute for Human Genomics, University of Miami, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 50:3084-90. 2009
  4. pmc Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration
    Gaofeng Wang
    Dr John T Macdonald Foundation Department of Human Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Hum Genet 127:595-602. 2010
  5. doi request reprint The ARMS2 A69S variant and bilateral advanced age-related macular degeneration
    Stephen G Schwartz
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Retina 32:1486-91. 2012
  6. doi request reprint AMD-associated variants at the chromosome 10q26 locus and the stability of ARMS2 transcripts
    Emily A Minor
    John P Hussman Institute for Human Genomics, Dr John T Macdonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 54:5913-9. 2013
  7. pmc Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphisms
    Digna R Velez Edwards
    Dr John T Macdonald Foundation Department of Human Genetics and John P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 51:1873-9. 2010
  8. pmc Analysis of single nucleotide polymorphisms in the NOS2A gene and interaction with smoking in age-related macular degeneration
    Juan A Ayala-Haedo
    John P Hussman Institute for Human Genomics and the Dr John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Ann Hum Genet 74:195-201. 2010
  9. doi request reprint Vitamin D receptor and Alzheimer's disease: a genetic and functional study
    Liyong Wang
    Hussman Institute for Human Genomics, University of Miami Miller School of Medicine 1501 NW 10 Ave, Miami, Florida, USA
    Neurobiol Aging 33:1844.e1-9. 2012
  10. doi request reprint Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate
    Kevin M Dickson
    John P Hussman Institute for Human Genomics, Dr John T Macdonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem Biophys Res Commun 439:522-7. 2013

Collaborators

Detail Information

Publications14

  1. doi request reprint Chromosome 10q26 locus and age-related macular degeneration: a progress update
    Gaofeng Wang
    John P Hussman Institute for Human Genomics, Dr John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, 1501 N W 10th Avenue, BRB 525, M860, Miami, FL 33136, United States Electronic address
    Exp Eye Res 119:1-7. 2014
    ..A discussion, which entails the possible multi-faceted approaches for pinpointing the gene(s) in the locus underlying the pathogenesis of AMD, is also included. ..
  2. ncbi request reprint Variants at chromosome 10q26 locus and the expression of HTRA1 in the retina
    Gaofeng Wang
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Exp Eye Res 112:102-5. 2013
    ..These results suggest that the AMD-associated variants in the chromosome 10q26 locus do not significantly affect the expression of HTRA1. ..
  3. pmc Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria
    Gaofeng Wang
    Miami Institute for Human Genomics, University of Miami, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 50:3084-90. 2009
    ....
  4. pmc Analysis of the indel at the ARMS2 3'UTR in age-related macular degeneration
    Gaofeng Wang
    Dr John T Macdonald Foundation Department of Human Genetics, John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Hum Genet 127:595-602. 2010
    ..Conclusively, the indel at 3'UTR of ARMS2 actually contains two side-by-side indels. The indels are associated with risk of AMD, but not correlated with ARMS2 mRNA level...
  5. doi request reprint The ARMS2 A69S variant and bilateral advanced age-related macular degeneration
    Stephen G Schwartz
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA
    Retina 32:1486-91. 2012
    ....
  6. doi request reprint AMD-associated variants at the chromosome 10q26 locus and the stability of ARMS2 transcripts
    Emily A Minor
    John P Hussman Institute for Human Genomics, Dr John T Macdonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 54:5913-9. 2013
    ..To analyze the effect of variants including age-related macular degeneration (AMD)-associated combinative insertion/deletion polymorphism (indel) at 3'UTR of ARMS2 and possibly associated R38X on the stability of ARMS2 transcripts...
  7. pmc Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphisms
    Digna R Velez Edwards
    Dr John T Macdonald Foundation Department of Human Genetics and John P Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 51:1873-9. 2010
    ..These results highlight the genetic and environmental complexity of the etiologic architecture of AMD; however, further replication is necessary to validate them...
  8. pmc Analysis of single nucleotide polymorphisms in the NOS2A gene and interaction with smoking in age-related macular degeneration
    Juan A Ayala-Haedo
    John P Hussman Institute for Human Genomics and the Dr John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Ann Hum Genet 74:195-201. 2010
    ..Our data suggests that SNPs in the NOS2A gene are associated with increased risk for AMD and might modulate the effect of smoking on AMD...
  9. doi request reprint Vitamin D receptor and Alzheimer's disease: a genetic and functional study
    Liyong Wang
    Hussman Institute for Human Genomics, University of Miami Miller School of Medicine 1501 NW 10 Ave, Miami, Florida, USA
    Neurobiol Aging 33:1844.e1-9. 2012
    ..001). We provide both statistical evidence and functional data suggesting VDR confers genetic risk for AD. Our findings are consistent with epidemiology studies suggesting that vitamin D insufficiency increases the risk of developing AD...
  10. doi request reprint Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate
    Kevin M Dickson
    John P Hussman Institute for Human Genomics, Dr John T Macdonald Foundation, Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochem Biophys Res Commun 439:522-7. 2013
    ....
  11. pmc Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
    Todd L Edwards
    John P Hussman Institute for Human Genomics, University of Miami, FL 33136, USA
    Ann Hum Genet 74:97-109. 2010
    ..79] T vs. C allele, PAR%= 8%) were genome-wide significant. No other SNPs were genome-wide significant in this analysis. This study confirms that SNCA and the MAPT region are major genes whose common variants are influencing risk of PD...
  12. pmc Next-generation sequencing of mitochondrial targeted AAV transfer of human ND4 in mice
    Hong Yu
    Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA
    Mol Vis 19:1482-91. 2013
    ....
  13. pmc Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
    Emily A Minor
    John P Hussman Institute for Human Genomics, Dr John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Biol Chem 288:13669-74. 2013
    ..Tet methylcytosine dioxygenase converts 5-mC to 5-hmC in DNA...
  14. pmc Copy number variations are a rare cause of non-CMT1A Charcot-Marie-Tooth disease
    Jia Huang
    Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Neurol 257:735-41. 2010
    ..Their potential relevance as disease modifiers remains to be evaluated. The present study design cannot rule out that specific CMT forms exist where CNVs play a larger role...