Eugenia Wang

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint MicroRNA, the putative molecular control for mid-life decline
    Eugenia Wang
    Gheens Center on Aging, and Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY, USA
    Ageing Res Rev 6:1-11. 2007
  2. ncbi request reprint Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry
    Yu Sheng Cong
    Department of Microbiology and Immunology, University of Louisville School of Medicine, 580 South Preston Street, Louisville, KY 40292, United States
    Mech Ageing Dev 127:332-43. 2006
  3. pmc MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging
    David J Bates
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Aging Cell 9:1-18. 2010
  4. ncbi request reprint Designer microarrays: from soup to nuts
    Eugenia Wang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Kentucky 40292, USA
    J Gerontol A Biol Sci Med Sci 57:B400-5. 2002
  5. pmc Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice
    Ruqiang Liang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 South Preston Street, Louisville, KY 40202, USA
    Aging Cell 10:1080-8. 2011
  6. doi request reprint Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts
    Olivier C Maes
    Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Physiol 221:109-19. 2009
  7. doi request reprint Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain
    Na Li
    Gheens Center on Aging, University of Louisville School of Medicine, USA
    Neurobiol Aging 32:944-55. 2011
  8. doi request reprint Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
    Na Li
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Mech Ageing Dev 132:75-85. 2011
  9. pmc Secretome from mesenchymal stem cells induces angiogenesis via Cyr61
    Rosendo Estrada
    Gheens Center on Aging, University of Louisville School of Medicine, Louisville, Kentucky, USA
    J Cell Physiol 219:563-71. 2009
  10. pmc Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells
    Rosendo Estrada
    Gheens Center on Aging, University of Louisville Health Sciences Center, Louisville, Kentucky 40202, USA
    J Biol Chem 283:30363-75. 2008

Research Grants

  1. GROWTH CONTROL IN AGING FIBROBLASTS
    Eugenia Wang; Fiscal Year: 2003

Collaborators

Detail Information

Publications36

  1. ncbi request reprint MicroRNA, the putative molecular control for mid-life decline
    Eugenia Wang
    Gheens Center on Aging, and Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY, USA
    Ageing Res Rev 6:1-11. 2007
    ....
  2. ncbi request reprint Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometry
    Yu Sheng Cong
    Department of Microbiology and Immunology, University of Louisville School of Medicine, 580 South Preston Street, Louisville, KY 40292, United States
    Mech Ageing Dev 127:332-43. 2006
    ..In conclusion, this report shows that iTRAQ proteomic profiling is a powerful technique for globally mapping protein signatures for different culture growth states...
  3. pmc MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging
    David J Bates
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Aging Cell 9:1-18. 2010
    ..Furthermore, compared to its normal siblings, the dwarf mouse exhibits a head start in regulating these pathways to control their normality, which may ultimately contribute to its extended health-span and longevity...
  4. ncbi request reprint Designer microarrays: from soup to nuts
    Eugenia Wang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Kentucky 40292, USA
    J Gerontol A Biol Sci Med Sci 57:B400-5. 2002
    ..The end result is the ability to use microarrays as a platform for versatile gene discovery...
  5. pmc Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant mice
    Ruqiang Liang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 South Preston Street, Louisville, KY 40202, USA
    Aging Cell 10:1080-8. 2011
    ..Their up-regulation in growth hormone signaling-deficient mutant mouse brain suggests reduced IGF1 signaling at the posttranscriptional level, for numerous gains of neuronal function in these long-lived mice...
  6. doi request reprint Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts
    Olivier C Maes
    Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Physiol 221:109-19. 2009
    ....
  7. doi request reprint Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain
    Na Li
    Gheens Center on Aging, University of Louisville School of Medicine, USA
    Neurobiol Aging 32:944-55. 2011
    ..We found unique de-regulated microRNAs shared between aging brain and aging liver, as well as brain- vs. liver-specific microRNAs during normal aging...
  8. doi request reprint Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
    Na Li
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Mech Ageing Dev 132:75-85. 2011
    ....
  9. pmc Secretome from mesenchymal stem cells induces angiogenesis via Cyr61
    Rosendo Estrada
    Gheens Center on Aging, University of Louisville School of Medicine, Louisville, Kentucky, USA
    J Cell Physiol 219:563-71. 2009
    ..J. Cell. Physiol. 219: 563-571, 2009. (c) 2009 Wiley-Liss, Inc...
  10. pmc Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells
    Rosendo Estrada
    Gheens Center on Aging, University of Louisville Health Sciences Center, Louisville, Kentucky 40202, USA
    J Biol Chem 283:30363-75. 2008
    ..These results indicate that the impairment of function in senescent ECs in culture is mediated by an increase in S1P signaling through S1P(2)-mediated activation of the lipid phosphatase PTEN...
  11. doi request reprint Changes in MicroRNA expression patterns in human fibroblasts after low-LET radiation
    Olivier C Maes
    Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky 40292, USA
    J Cell Biochem 105:824-34. 2008
    ..Taken together, miRNAs may mediate signaling pathways in sequential fashion in response to radiation, and may serve as biodosimetric markers of radiation exposure...
  12. doi request reprint MicroRNA group disorganization in aging
    Joel Lanceta
    Gheens Center on Aging, University of Louisville, Kentucky 40202, USA
    Exp Gerontol 45:269-78. 2010
    ..e. how particular groups of non-coding RNAs, functioning together, contribute to mechanisms regulating aging and longevity...
  13. pmc Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted mice
    Amit Khanna
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Aging (Albany NY) 3:223-36. 2011
    ....
  14. doi request reprint Murine microRNAs implicated in liver functions and aging process
    Olivier C Maes
    Gheens Center on Aging and Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    Mech Ageing Dev 129:534-41. 2008
    ..Taken together, we identified the up-regulation of key miRNAs that may participate in the decline of regeneration and oxidative defense mechanisms in aging liver...
  15. doi request reprint Prosaposin in the secretome of marrow stroma-derived neural progenitor cells protects neural cells from apoptotic death
    Na Li
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Gheens Center on Aging, Louisville, Kentucky 40202, USA
    J Neurochem 112:1527-38. 2010
    ..We suggest that upon injury, a subgroup of MSCs differentiates into neural/neuronal progenitor cells, and remains in this intermediate stem cell-like stage, defending injured neighboring mature neurons from apoptosis by secreting PSAP...
  16. pmc Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging
    Xiaoli Li
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Kentucky, USA
    Aging (Albany NY) 3:985-1002. 2011
    ..these changes are predictors of impending decline in brain function, as early as in young adult mice...
  17. doi request reprint Full-length 3'-untranslated region reporter construction with recombineering
    Ruqiang Liang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Anal Biochem 424:162-7. 2012
    ..This method will advance functional studies of regulation of gene expression at the post-transcriptional level through microRNA suppression...
  18. doi request reprint Transcriptional analysis of normal human fibroblast responses to microgravity stress
    Yongqing Liu
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Genomics Proteomics Bioinformatics 6:29-41. 2008
    ..Hence, our results suggest that microgravity travel may impact changes in gene expression mostly associated with cellular stress signaling, directing cells to either apoptotic death or premature senescence...
  19. doi request reprint A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease
    Olivier C Maes
    Gheens Center on Aging, Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Neurobiol Aging 31:34-45. 2010
    ..Reduced antioxidant defense and genome maintenance associated with the GSTM3 polymorphism suggest a common hub of regulatory networks which, when impaired, may lead to AD...
  20. doi request reprint PEDF from mouse mesenchymal stem cell secretome attracts fibroblasts
    Harshini Sarojini
    Gheens Center on Aging, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 104:1793-802. 2008
    ..These differential functional effects of PEDF toward fibroblasts and endothelial cells may serve to program an ordered temporal sequence of scaffold building followed by angiogenesis during wound healing...
  21. pmc Epigenetic Control of MicroRNA Expression and Aging
    Ruqiang Liang
    Gheens Center on Aging, University of Louisville School of Medicine, Louisville, KY, USA
    Curr Genomics 10:184-93. 2009
    ..Overriding and dampening the activation of these noncoding RNAs may prove to be a new frontier for future research, to delay aging and extend healthy life-span...
  22. ncbi request reprint Transcription profiling of estrogen target genes in young and old mouse uterus
    Abdelnaby Khalyfa
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 570 South Preson St Baxter Building RM 304, Louisville, KY 40292, USA
    Exp Gerontol 38:1087-99. 2003
    ....
  23. doi request reprint The impact of noncoding RNA on the biochemical and molecular mechanisms of aging
    David J Bates
    Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Biochim Biophys Acta 1790:970-9. 2009
    ..Here we report a brief overview of noncoding RNA as well as the potential roles of microRNAs in biochemical equilibriums where imbalance contributes to the many phenotypes of aging...
  24. ncbi request reprint Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress
    Ruying Chang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 100:267-78. 2007
    ..Thus, our results suggest that eEF1A-2 interacts with Prdx-I to functionally provide cells with extraordinary resistance to oxidative stress-induced cell death...
  25. ncbi request reprint Localized delivery of DNA to the cells by viral collagen-loaded silica colloidal crystals
    Harshini Sarojini
    University of Louisville School of Medicine, Louisville, KY, USA
    Biotechniques 43:213-4, 216-8, 220-1. 2007
    ..This specificity in the delivery mode is beneficial for functional studies of gene-directed impact on a particular cell population of interest in a heterogeneous cell culture...
  26. ncbi request reprint Microarray analysis of E-box binding-related gene expression in young and replicatively senescent human fibroblasts
    Alexandre Semov
    Bloomfield Center for Research in Aging, McGill University, Montreal, Quebec, Canada
    Anal Biochem 302:38-51. 2002
    ..Alterations in the expression of E-box-binding transcription factors and c-Myc-binding proteins demonstrate the importance of these genes in establishing the contact-inhibited quiescent or senescent phenotypes...
  27. ncbi request reprint Senescent fibroblasts resist apoptosis by downregulating caspase-3
    Richard Marcotte
    The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    Mech Ageing Dev 125:777-83. 2004
    ....
  28. ncbi request reprint Alterations in TNF- and IL-related gene expression in space-flown WI38 human fibroblasts
    Alexandre Semov
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    FASEB J 16:899-901. 2002
    ..Most of these are involved in either the regulation of bone density, and as such the development of spaceflight osteopenia, or in the development of proinflammatory status...
  29. ncbi request reprint Identification of high caspase-3 mRNA expression as a unique signature profile for extremely old individuals
    Chantale Lacelle
    Department of Anatomy and Cell Biology, McGill University, 3640 University St, Quebec, Montreal, Canada, H3A 2B2
    Mech Ageing Dev 123:1133-44. 2002
    ....
  30. ncbi request reprint Replicative senescence revisited
    Richard Marcotte
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Gerontol A Biol Sci Med Sci 57:B257-69. 2002
    ..Effectors of this growth-arrested state are being discovered at a great pace. This review discusses the latest findings on the players responsible for establishing replicative senescence, as well as the associated telomere shortening...
  31. pmc Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulated
    Louis Bruno Ruest
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Cell Biochem 86:21-8. 2002
    ..The post-transcriptional regulation of caspase-3 might serve as a fail-safe mechanism to avoid accidental cell death...
  32. ncbi request reprint hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblasts
    Richard Marcotte
    The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital and Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Cell Biochem 89:576-88. 2003
    ..This phenotype was accompanied by s-beta-galactosidase and PAI-1 expression. These results suggest that hMad4 might be an important regulator of replicative senescence in human cells...
  33. pmc Science fact and the SENS agenda. What can we reasonably expect from ageing research?
    Huber Warner
    Buck Institute for Age Research, Novato, CA, USA
    EMBO Rep 6:1006-8. 2005
  34. ncbi request reprint c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts
    Richard Marcotte
    The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Cell Biochem 96:1071-85. 2005
    ....
  35. ncbi request reprint Transcriptional profiling of Alzheimer blood mononuclear cells by microarray
    Olivier C Maes
    Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Canada
    Neurobiol Aging 28:1795-809. 2007
    ..BMC are highly accessible and may reflect molecular events germane to the neuropathophysiology of AD...
  36. ncbi request reprint The accidental biologist
    Ingfei Chen
    Sci Aging Knowledge Environ 2003:NF8. 2003

Research Grants1

  1. GROWTH CONTROL IN AGING FIBROBLASTS
    Eugenia Wang; Fiscal Year: 2003
    ..Answers to this ques- tion will add to our knowledge of cell cycle control, a fundamental mechanism pivotal to the wellbeing of significant processes such as terminal differentiation and cellular aging. ..