Research Topics
Genomes and Genes | Eugenia WangSummaryAffiliation: University of Louisville Country: USA Publications
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Publications
MicroRNA, the putative molecular control for mid-life declineEugenia Wang
Gheens Center on Aging, and Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY, USA
Ageing Res Rev 6:1-11. 2007....- Simultaneous proteomic profiling of four different growth states of human fibroblasts, using amine-reactive isobaric tagging reagents and tandem mass spectrometryYu-Sheng Cong
Department of Microbiology and Immunology, University of Louisville School of Medicine, 580 South Preston Street, Louisville, KY 40292, United States
Mech Ageing Dev 127:332-43. 2006..In conclusion, this report shows that iTRAQ proteomic profiling is a powerful technique for globally mapping protein signatures for different culture growth states... 
MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed agingDavid J Bates
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
Aging Cell 9:1-18. 2010..Furthermore, compared to its normal siblings, the dwarf mouse exhibits a head start in regulating these pathways to control their normality, which may ultimately contribute to its extended health-span and longevity...- Designer microarrays: from soup to nutsEugenia Wang
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Kentucky 40292, USA
J Gerontol A Biol Sci Med Sci 57:B400-5. 2002..The end result is the ability to use microarrays as a platform for versatile gene discovery... - Post-transcriptional regulation of IGF1R by key microRNAs in long-lived mutant miceRuqiang Liang
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 580 South Preston Street, Louisville, KY 40202, USA
Aging Cell 10:1080-8. 2011..Their up-regulation in growth hormone signaling-deficient mutant mouse brain suggests reduced IGF1 signaling at the posttranscriptional level, for numerous gains of neuronal function in these long-lived mice... 
Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblastsOlivier C Maes
Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Cell Physiol 221:109-19. 2009....- Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brainNa Li
Gheens Center on Aging, University of Louisville School of Medicine, USA
Neurobiol Aging 32:944-55. 2011..We found unique de-regulated microRNAs shared between aging brain and aging liver, as well as brain- vs. liver-specific microRNAs during normal aging... - Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1Na Li
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
Mech Ageing Dev 132:75-85. 2011.... - Secretome from mesenchymal stem cells induces angiogenesis via Cyr61Rosendo Estrada
Gheens Center on Aging, University of Louisville School of Medicine, Louisville, Kentucky, USA
J Cell Physiol 219:563-71. 2009..J. Cell. Physiol. 219: 563-571, 2009. (c) 2009 Wiley-Liss, Inc... - Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cellsRosendo Estrada
Gheens Center on Aging, University of Louisville Health Sciences Center, Louisville, Kentucky 40202, USA
J Biol Chem 283:30363-75. 2008..These results indicate that the impairment of function in senescent ECs in culture is mediated by an increase in S1P signaling through S1P(2)-mediated activation of the lipid phosphatase PTEN... - Changes in MicroRNA expression patterns in human fibroblasts after low-LET radiationOlivier C Maes
Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky 40292, USA
J Cell Biochem 105:824-34. 2008..Taken together, miRNAs may mediate signaling pathways in sequential fashion in response to radiation, and may serve as biodosimetric markers of radiation exposure... - MicroRNA group disorganization in agingJoel Lanceta
Gheens Center on Aging, University of Louisville, Kentucky 40202, USA
Exp Gerontol 45:269-78. 2010..e. how particular groups of non-coding RNAs, functioning together, contribute to mechanisms regulating aging and longevity... - Gain of survival signaling by down-regulation of three key miRNAs in brain of calorie-restricted miceAmit Khanna
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
Aging (Albany NY) 3:223-36. 2011.... - Murine microRNAs implicated in liver functions and aging processOlivier C Maes
Gheens Center on Aging and Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
Mech Ageing Dev 129:534-41. 2008..Taken together, we identified the up-regulation of key miRNAs that may participate in the decline of regeneration and oxidative defense mechanisms in aging liver... - Prosaposin in the secretome of marrow stroma-derived neural progenitor cells protects neural cells from apoptotic deathNa Li
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Gheens Center on Aging, Louisville, Kentucky 40202, USA
J Neurochem 112:1527-38. 2010..We suggest that upon injury, a subgroup of MSCs differentiates into neural/neuronal progenitor cells, and remains in this intermediate stem cell-like stage, defending injured neighboring mature neurons from apoptosis by secreting PSAP... - Circulatory miR34a as an RNAbased, noninvasive biomarker for brain agingXiaoli Li
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Kentucky, USA
Aging (Albany NY) 3:985-1002. 2011..these changes are predictors of impending decline in brain function, as early as in young adult mice... - Full-length 3'-untranslated region reporter construction with recombineeringRuqiang Liang
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
Anal Biochem 424:162-7. 2012..This method will advance functional studies of regulation of gene expression at the post-transcriptional level through microRNA suppression... - Transcriptional analysis of normal human fibroblast responses to microgravity stressYongqing Liu
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
Genomics Proteomics Bioinformatics 6:29-41. 2008..Hence, our results suggest that microgravity travel may impact changes in gene expression mostly associated with cellular stress signaling, directing cells to either apoptotic death or premature senescence... - A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer diseaseOlivier C Maes
Gheens Center on Aging, Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY 40202, USA
Neurobiol Aging 31:34-45. 2010..Reduced antioxidant defense and genome maintenance associated with the GSTM3 polymorphism suggest a common hub of regulatory networks which, when impaired, may lead to AD... - PEDF from mouse mesenchymal stem cell secretome attracts fibroblastsHarshini Sarojini
Gheens Center on Aging, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Cell Biochem 104:1793-802. 2008..These differential functional effects of PEDF toward fibroblasts and endothelial cells may serve to program an ordered temporal sequence of scaffold building followed by angiogenesis during wound healing... - Epigenetic Control of MicroRNA Expression and AgingRuqiang Liang
Gheens Center on Aging, University of Louisville School of Medicine, Louisville, KY, USA
Curr Genomics 10:184-93. 2009..Overriding and dampening the activation of these noncoding RNAs may prove to be a new frontier for future research, to delay aging and extend healthy life-span... - Transcription profiling of estrogen target genes in young and old mouse uterusAbdelnaby Khalyfa
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 570 South Preson St Baxter Building RM. 304, Louisville, KY 40292, USA
Exp Gerontol 38:1087-99. 2003.... - The impact of noncoding RNA on the biochemical and molecular mechanisms of agingDavid J Bates
Gheens Center on Aging, Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, KY 40202, USA
Biochim Biophys Acta 1790:970-9. 2009..Here we report a brief overview of noncoding RNA as well as the potential roles of microRNAs in biochemical equilibriums where imbalance contributes to the many phenotypes of aging... - Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stressRuying Chang
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Cell Biochem 100:267-78. 2007..Thus, our results suggest that eEF1A-2 interacts with Prdx-I to functionally provide cells with extraordinary resistance to oxidative stress-induced cell death... - Localized delivery of DNA to the cells by viral collagen-loaded silica colloidal crystalsHarshini Sarojini
University of Louisville School of Medicine, Louisville, KY, USA
Biotechniques 43:213-4, 216-8, 220-1. 2007..This specificity in the delivery mode is beneficial for functional studies of gene-directed impact on a particular cell population of interest in a heterogeneous cell culture... - Microarray analysis of E-box binding-related gene expression in young and replicatively senescent human fibroblastsAlexandre Semov
Bloomfield Center for Research in Aging, McGill University, Montreal, Quebec, Canada
Anal Biochem 302:38-51. 2002..Alterations in the expression of E-box-binding transcription factors and c-Myc-binding proteins demonstrate the importance of these genes in establishing the contact-inhibited quiescent or senescent phenotypes... - Senescent fibroblasts resist apoptosis by downregulating caspase-3Richard Marcotte
The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B. Davis-Jewish General Hospital, and Department of Medicine, McGill University, , , Canada
Mech Ageing Dev 125:777-83. 2004.... - Alterations in TNF- and IL-related gene expression in space-flown WI38 human fibroblastsAlexandre Semov
U Louisville, KY
FASEB J 16:899-901. 2002..Most of these are involved in either the regulation of bone density, and as such the development of spaceflight osteopenia, or in the development of proinflammatory status... - Identification of high caspase-3 mRNA expression as a unique signature profile for extremely old individualsChantale Lacelle
Department of Anatomy and Cell Biology, McGill University, 3640 University St, Quebec, Montreal, Canada, H3A 2B2
Mech Ageing Dev 123:1133-44. 2002.... - Replicative senescence revisitedRichard Marcotte
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, and Department of Medicine, McGill University, , , Canada
J Gerontol A Biol Sci Med Sci 57:B257-69. 2002..Effectors of this growth-arrested state are being discovered at a great pace. This review discusses the latest findings on the players responsible for establishing replicative senescence, as well as the associated telomere shortening... - Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulatedLouis Bruno Ruest
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and Department of Medicine, McGill University, Montreal, Quebec, Canada
J Cell Biochem 86:21-8. 2002..The post-transcriptional regulation of caspase-3 might serve as a fail-safe mechanism to avoid accidental cell death... - hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblastsRichard Marcotte
The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis-Jewish General Hospital and Department of Medicine, McGill University, , , Canada
J Cell Biochem 89:576-88. 2003..This phenotype was accompanied by s-beta-galactosidase and PAI-1 expression. These results suggest that hMad4 might be an important regulator of replicative senescence in human cells... - Science fact and the SENS agenda. What can we reasonably expect from ageing research?Huber Warner
Buck Institute for Age Research, Novato, CA, USA
EMBO Rep 6:1006-8. 2005 - c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblastsRichard Marcotte
The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
J Cell Biochem 96:1071-85. 2005.... - Transcriptional profiling of Alzheimer blood mononuclear cells by microarrayOlivier C Maes
Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755 Cote Ste Catherine Road, Montreal, Canada
Neurobiol Aging 28:1795-809. 2007..BMC are highly accessible and may reflect molecular events germane to the neuropathophysiology of AD... - The accidental biologistIngfei Chen
Sci Aging Knowledge Environ 2003:NF8. 2003
Research Grants
- GROWTH CONTROL IN AGING FIBROBLASTSEugenia Wang; Fiscal Year: 2003..Answers to this ques- tion will add to our knowledge of cell cycle control, a fundamental mechanism pivotal to the wellbeing of significant processes such as terminal differentiation and cellular aging. ..