C Y Wang
Affiliation: University of Michigan
- NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosisC Y Wang
Laboratory of Molecular Signaling and Apoptotsis, School of Dentistry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Cell Biol 19:5923-9. 1999..Our findings demonstrate that A1 is an important antiapoptotic gene controlled by NF-kappaB and establish that the prosurvival function of NF-kappaB can be manifested at multiple levels...
- NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activationC Y Wang
Department of Endodontics, School of Dentistry, Lineberger Comprehensive Cancer Center, and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599 7295, USA
Science 281:1680-3. 1998..Thus, NF-kappaB activates a group of gene products that function cooperatively at the earliest checkpoint to suppress TNF-alpha-mediated apoptosis and that function more distally to suppress genotoxic agent-mediated apoptosis...
- Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signalingS Chen
Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 276:39259-63. 2001..Our results suggest that BMPs not only stimulate osteoblast differentiation but can also promote cell survival during the induction of bone formation, offering new insight into the biological functions of BMPs...
- NF-kappaB activation in human dental pulp stem cells by TNF and LPSJ Chang
Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, 1011 N University Ave, Ann Arbor, MI 48109 1078, USA
J Dent Res 84:994-8. 2005..In summary, our studies suggest that DPSCs may be involved in immune responses during pulpal infection through activating NF-kappaB...
- TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBC Y Wang
Curriculum in Genetics and Molecular Biology and Department of Endodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7295, USA
Science 274:784-7. 1996..These results provide a mechanism of cellular resistance to killing by some apoptotic reagents, offer insight into a new role for NF-kappaB, and have potential for improvement of the efficacy of cancer therapies...
- Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activityZ You
Laboratory of Molecular Signaling and Apoptosis, the Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 276:26398-404. 2001....
- Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcriptionS Chen
Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, 48109, USA
J Cell Biol 152:87-96. 2001..These results provide the first demonstration that Wnt-1 inhibits cancer therapy-mediated apoptosis and suggests that Wnt-1 may exhibit its oncogenic potential through a mechanism of anti-apoptosis...
- Potentiation of tumor necrosis factor-mediated apoptosis of oral squamous cell carcinoma cells by adenovirus-mediated gene transfer of NF-kappaB inhibitorS Chen
Department of Biologic and Materials Science, University of Michigan, Ann Arbor 48109 1078, USA
J Dent Res 81:98-102. 2002....
- Astrocytic expression of transgene in the rat brain mediated by baculovirus vectors containing an astrocyte-specific promoterC Y Wang
Institute of Bioengineering and Nanotechnology, National University of Singapore, Singapore, Singapore
Gene Ther 13:1447-56. 2006..Taken together, our findings suggest that these baculovirus vectors may serve as useful tools for astrocyte-specific gene expression in the brain...
- Improved neuronal transgene expression from an AAV-2 vector with a hybrid CMV enhancer/PDGF-beta promoterC Y Wang
Institute of Bioengineering and Nanotechnology, National University of Singapore, Singapore
J Gene Med 7:945-55. 2005..This study aimed to develop AAV-2 vectors that also facilitate a high level of neuronal expression by enhancing the strength of a neuron-specific promoter, the human platelet-derived growth factor beta-chain (PDGF) promoter...
- CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexesY Li
Institute of Bioengineering and Nanotechnology, Singapore
Gene Ther 11:109-14. 2004..The results established the potential of PPE-EA as a new and biocompatible gene carrier to achieve sustained gene expression in the CNS...
- Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of ageQ Z Li
Department of Pathology, Immunology and Laboratory Medicine, Box 100275, Center for Mammalian Genetics, and Diabetes Center of Excellence, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
Mamm Genome 12:830-6. 2001..These results suggest that the Mscp gene is decreased during splenic lymphocyte maturation in these mice...
- Ca(2+) binding protein frequenin mediates GDNF-induced potentiation of Ca(2+) channels and transmitter releaseC Y Wang
Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Neuron 32:99-112. 2001..These results identify an important molecular target that mediates the long-term, synaptic action of a neurotrophic factor...
- Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamilyQ Z Li
Department of Pathology, Immunology and Laboratory Medicine, Center for Mammalian Genetics and Diabetes Center of Excellence, College of Medicine, University of Florida, Gainesville, FL 32610, USA
Gene 273:275-84. 2001....
- A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cellsJ M Leiden
Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650
J Virol 66:5890-7. 1992..These results may explain differences in the clinical spectra of diseases caused by HIV-1 and HIV-2 and may also have implications for the design of therapeutic approaches to HIV-2 infection...
- Antitumor effect on murine renal cell carcinoma by autologous tumor vaccines genetically modified with granulocyte-macrophage colony-stimulating factor and interleukin-6 cellsY Kinoshita
Departments of Urology, Osaka City University School of Medicine, Osaka, Japan
J Immunother 24:205-11. 2001..Autologous tumor cell vaccine secreting GM-CSF is effective in preventing and treating established tumors. Its efficacy is enhanced by the cosecretion of IL-6...
- Expression and alternative splicing of the mouse autoimmune regulator gene (Aire)Q G Ruan
Department of Pathology, Immunology and Laboratory Medicine and Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
J Autoimmun 13:307-13. 1999..These forms result from combinations of four alternative splicing units (exon 10, exon 11, 12 bp in exon 6 and 3 bp in exon 8). The relative abundance of these splicing forms was also determined...
- Selective expression of PDGF A and its receptor during early mouse embryogenesisM Mercola
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts
Dev Biol 138:114-22. 1990..PDGF A, but not PDGF B, may be particularly important in modulating early events in mouse embryonic development...
- Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR miceX Kuang
Department of Pharmacology, Sichuan University College of Pharmacy, Chengdu, P R China
Brain Res 1102:145-53. 2006..The antioxidant and anti-apoptotic properties of LIG may contribute to the neuroprotective potential of LIG in cerebral ischemic damage...