Research Topics
Genomes and GenesSpecies | Jessica Wang-RodriguezSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Immune response to blood transfusion invery-low-birthweight infantsJ Wang-Rodriguez
University of California, San Diego, Medical Center, Hillcrest, San Diego, California, USA
Transfusion 40:25-34. 2000..Allogeneic blood transfusion is common in the treatment of neonatal anemia of prematurity or anemia due to multiple phlebotomies. The immune response of neonates to passenger leukocytes from allogeneic red cells was investigated...- Male breast carcinoma: correlation of ER, PR, Ki-67, Her2-Neu, and p53 with treatment and survival, a study of 65 casesJessica Wang-Rodriguez
Department of Pathology, University of California, San Diego, School of Medicine, La Jolla 92093, USA
Mod Pathol 15:853-61. 2002.... 
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic statusJessica Wang-Rodriguez
Department of Pathology, University of California, San Diego, La Jolla, USA
Breast Cancer Res 5:R136-43. 2003..The aim of the present study was to examine the cellular distribution of these molecules in human breast tissue and to determine whether the relative expression level of these three genes is associated with human breast tumor metastasis...- Gefitinib inhibition of drug resistance to doxorubicin by inactivating ABCG2 in thyroid cancer cell linesJay Patrick Lopez
Department of Surgery, VA San Diego Healthcare System, and Department of Radiology, University of California, San Diego, Biomedical Sciences Bldg, Room 1202, Mail Code 0612, 9500 Gilman Dr, La Jolla, CA 92093 0612, USA
Arch Otolaryngol Head Neck Surg 133:1022-7. 2007.... - EGFR kinase promotes acquisition of stem cell-like properties: a potential therapeutic target in head and neck squamous cell carcinoma stem cellsEric L Abhold
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America
PLoS ONE 7:e32459. 2012..Drugs that target EGFR, perhaps administered in combination with conventional chemotherapy, might be an effective treatment for HNSCC... - STI-571 (Gleevec) potentiates the effect of cisplatin in inhibiting the proliferation of head and neck squamous cell carcinoma in vitroJessica Wang-Rodriguez
VA San Diego Healthcare System, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Laryngoscope 116:1409-16. 2006..Additional studies are warranted, keeping in mind that drug combinations may result in unexpected toxicities that are not frequently seen with either drug alone... - Gleevec suppresses p63 expression in head and neck squamous cell carcinoma despite p63 activation by DNA-damaging agentsWeg M Ongkeko
Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Laryngoscope 116:1390-6. 2006.... 
Gefitinib (Iressa) potentiates the effect of ionizing radiation in thyroid cancer cell linesJay Patrick Lopez
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California 92093, USA
Laryngoscope 118:1372-6. 2008..To determine whether inactivation of epidermal growth factor receptor (EGFR) kinase activity will sensitize thyroid cancer cell lines to ionizing radiation-induced death...- Enhanced touch preps improve the ease of interpretation of intraoperative breast cancer marginsSarah L Blair
Department of Surgery and Pathology, University of California San Diego, La Jolla, California 92093 0987, USA
Am Surg 73:973-6. 2007..The immunofluorescence stains may help the pathologist to identify cancer cells in fresh breast tissue and limit breast re-excisions in the future... - Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and AktSelena Z Kuo
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, CA, USA
BMC Cancer 12:556. 2012..In our study we sought to determine the effects of salinomycin on head and neck squamous cell carcinoma (HNSCC) stem cells... - Cigarette smoke promotes drug resistance and expansion of cancer stem cell-like side populationYi An
Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America
PLoS ONE 7:e47919. 2012..These findings underscore the importance of smoking cessation following a diagnosis of cancer, and elucidate the mechanisms of continued smoking that may be detrimental to treatment... - Quantitative comparison of surgical margin histology following excision with traditional electrosurgery and a low-thermal-injury dissection deviceManuel E Ruidiaz
Department of Bioengineering, University of California, San Diego UCSD, La Jolla, California, USA
J Surg Oncol 104:746-54. 2011..This study is the first to examine in vivo the effect of thermal injury in breast conservation pathology in a direct comparison of traditional electrosurgery and an alternative low-thermal-injury device... - Quantitative expression profiling of RNA from formalin-fixed, paraffin-embedded tissues using randomly assembled bead arraysMarina Bibikova
Illumina Inc, San Diego, CA, USA
Methods Mol Biol 439:159-77. 2008..Using the DASL Assay, gene expression analyses can be performed on routinely stored tumor specimens from patients with known outcomes... - p73 expression and function in vestibular schwannomaZana K Ahmad
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA 92093 0612, USA
Arch Otolaryngol Head Neck Surg 135:662-9. 2009.... - Nicotine promotes acquisition of stem cell and epithelial-to-mesenchymal properties in head and neck squamous cell carcinomaMichael Andrew Yu
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California San Diego, La Jolla, CA, USA
PLoS ONE 7:e51967. 2012..Further characterization of such pathways remains a promising avenue for the understanding and treatment of tobacco-related cancers... - Expression signatures that correlated with Gleason score and relapse in prostate cancerMarina Bibikova
Illumina, Inc, 9885 Towne Centre Drive, San Diego, CA 92121, USA
Genomics 89:666-72. 2007..007). These results suggest that the approach we used is effective for expression profiling in heterogeneous FFPE tissues for cancer diagnosis/prognosis biomarker discovery and validation... - Quantitative automated image analysis system with automated debris filtering for the detection of breast carcinoma cellsDavid T Martin
Department of Electrical and Computer Engineering, University of California San Diego, San Diego, CA 92161, USA
Acta Cytol 55:271-80. 2011..To develop an intraoperative method for margin status evaluation during breast conservation therapy (BCT) using an automated analysis of imprint cytology specimens... - EGFR regulates the side population in head and neck squamous cell carcinomaJocelyn S Chen
Division of Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California 92093, USA
Laryngoscope 116:401-6. 2006..This finding could help explain the role of EGFR in regulating cancer stem cells and thus tumorigenesis in HNSCC... - EGF and bFGF promote invasion that is modulated by PI3/Akt kinase and Erk in vestibular schwannomaKatherine J Blair
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California San Diego and the VA San Diego Healthcare System, San Diego, California, USA
Otol Neurotol 32:308-14. 2011..We aimed to determine the role of the growth factors EGF, bFGF, and the hormone, Epo, in promoting such invasive behavior in VS, as well as their mechanisms of action... - The onco-embryonic antigen ROR1 is expressed by a variety of human cancersSuping Zhang
Moores UCSD Cancer Center, University of California San Diego, 3855 Health Sciences Dr 0820, La Jolla, CA 92093, USA
Am J Pathol 181:1903-10. 2012.... - Activation of PDGFR and EGFR promotes the acquisition of a stem cell-like phenotype in schwannomasDavid Yi
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California, San Diego, California, USA
Otol Neurotol 33:1640-7. 2012.... - Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissuesJing Chen
Illumina Inc, San Diego, CA 92121, USA
Int J Cancer 122:2249-54. 2008..Taken together, our results demonstrated the utility of the BeadArray technology for high-throughput genetic analysis in FFPE tumor tissues and provided a detailed genetic profiling of cancer-related genes in human esophageal cancer... - Gastrointestinal stromal tumors express ras oncogene: a potential role for diagnosis and treatmentSarah L Blair
Department of Surgery, University of California at San Diego, 92093 0987, USA
Arch Surg 140:543-7; discussion 547-8. 2005..There is some evidence that phosphorylation of these receptors leads to a cascade that may activate the ras/mitogen-activated protein kinase pathway, which may, in turn, allow other oncogenes to become active... - Computerized decision support system for intraoperative analysis of margin status in breast conservation therapyManuel E Ruidiaz
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
ISRN Surg 2012:546721. 2012.... - ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growthSuping Zhang
Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 7:e31127. 2012..This study demonstrates that ROR1 is expressed in human breast cancers and has biological and clinical significance, indicating that it may be a potential target for breast cancer therapy... - Recombinant human erythropoietin promotes the acquisition of a malignant phenotype in head and neck squamous cell carcinoma cell lines in vitroEric Abhold
Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, CA, USA
BMC Res Notes 4:553. 2011..abstract:.. - Motility induction in breast carcinoma by mammary epithelial laminin 332 (laminin 5)Philip M Carpenter
Department of Pathology and Laboratory Medicine, University of California, Orange, CA 92868, USA
Mol Cancer Res 7:462-75. 2009.... - A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variantsQing Lu
Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
Nucleic Acids Res 36:e130. 2008..The assay should facilitate clinical and basic studies for fusion gene screening in clinical specimens, as it can be readily adapted to include multiple gene loci... - Automated microscopy to evaluate surgical specimens via touch prep in breast cancerMaria Jose Cortes-Mateos
Moores Cancer Center, University of California San Diego, San Diego, CA 92093 0987, USA
Ann Surg Oncol 16:709-20. 2009..An automated image screening process has been developed to discern cancer cells from normal epithelial cells. This technique is based on cellularity of the imprint specimen and does not require expertise in cytopathology... - Rare case of a primary non-dural central nervous system low grade B-cell lymphoma and literature reviewAntonios Papanicolau-Sengos
Department of Pathology, University of California San Diego School of Medicine and Veteran Administration Medical Center of San Diego, 9500 Gilman Drive 9113, La Jolla, CA 92093 9113, USA
Int J Clin Exp Pathol 5:89-95. 2012..This is the first reported case of a primary CNS MZBCL with flow cytometric analysis. A review of literature on this rare entity is also included... - Two-dimensional transcriptome profiling: identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimensHai-Ri Li
Department of Cellular and Molecular Medicine, San Diego Supercomputer Center, University of California, San Diego, La Jolla 92093-0651, USA
Cancer Res 66:4079-88. 2006.... - Oncologic safety of skin-sparing and nipple-sparing mastectomy: a discussion and review of the literatureChristopher Tokin
Department of Surgery, University of San Diego, San Diego, CA 92103, USA
Int J Surg Oncol 2012:921821. 2012..In addition, this paper will discuss the oncologic importance of margin status and type of mastectomy as it pertains to risk of local recurrence and relative need for adjuvant therapy... - Expression of protein tyrosine kinases in head and neck squamous cell carcinomasWeg M Ongkeko
Department of Surgery, Division of Head and Neck, Surgery, University of California, San Diego, CA 92161, USA
Am J Clin Pathol 124:71-6. 2005..None of the kinase expressions correlated with disease-free survival. The expression of the kinases raises the possibility of treatment of HNSCC by tyrosine and serine-threonine kinase inhibitors... - Diagnosis of prostate cancer using differentially expressed genes in stromaZhenyu Jia
Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA
Cancer Res 71:2476-87. 2011.... - Laminin 5 expression in metaplastic breast carcinomasPhilip M Carpenter
The Department of Pathology and Laboratory Medicine, The University of California, Orange, CA 92868, USA
Am J Surg Pathol 32:345-53. 2008..Further study of other basal-like tumors for laminin 5 expression is warranted to determine the usefulness of laminin 5 in their diagnosis... - The signaling adapter protein PINCH is up-regulated in the stroma of common cancers, notably at invasive edgesJessica Wang-Rodriguez
Department of Pathology, University of California, San Diego, La Jolla 92093, USA
Cancer 95:1387-95. 2002..Because of this and because PINCH functions as a "molecular switch" in signal transduction, PINCH may be a new target for drug discovery aimed at the tumor-associated stroma... - Gene expression profiles in formalin-fixed, paraffin-embedded tissues obtained with a novel assay for microarray analysisMarina Bibikova
Illumina, Inc, San Diego, CA 92161, USA
Clin Chem 50:2384-6. 2004 - Profiling alternatively spliced mRNA isoforms for prostate cancer classificationChaolin Zhang
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
BMC Bioinformatics 7:202. 2006..Here, we investigate the advantage of using splice isoforms, which couple transcriptional and splicing regulation, for cancer classification...