Yisong Y Wan

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc GATA3: a master of many trades in immune regulation
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA Electronic address
    Trends Immunol 35:233-42. 2014
  2. pmc GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling
    Yunqi Wang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Immunol 14:714-22. 2013
  3. pmc An essential role for TAK1 in the contact hypersensitivity response
    Yan G Zhao
    Department of Toxicology, School of Public Health, Peking University, Beijing, China
    Cell Mol Immunol 8:315-24. 2011
  4. pmc Multi-tasking of helper T cells
    Yisong Y Wan
    Department of Microbiology and Immunology, School of Medicine, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, North Carolina, NC 27599 7295, USA
    Immunology 130:166-71. 2010
  5. pmc How diverse--CD4 effector T cells and their functions
    Yisong Y Wan
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 27599, USA
    J Mol Cell Biol 1:20-36. 2009
  6. pmc TGF-beta and regulatory T cell in immunity and autoimmunity
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, CB 7295, 450 West Drive, Chapel Hill, North Carolina, NC 27599 7295, USA
    J Clin Immunol 28:647-59. 2008
  7. pmc Regulatory T cells: immune suppression and beyond
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, North Carolina, NC 27599 7295, USA
    Cell Mol Immunol 7:204-10. 2010
  8. pmc Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions
    Ai Di Gu
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:905-10. 2012
  9. pmc An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    Yunqi Wang
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 35:337-48. 2011
  10. pmc An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo
    Yunqi Wang
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 185:5983-92. 2010

Collaborators

Detail Information

Publications13

  1. pmc GATA3: a master of many trades in immune regulation
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC 27599, USA Electronic address
    Trends Immunol 35:233-42. 2014
    ..Here, I discuss recent discoveries and the current understanding of the functions of GATA3 in immune regulation. ..
  2. pmc GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling
    Yunqi Wang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Immunol 14:714-22. 2013
    ..Our study thus demonstrates an essential role for GATA-3 in controlling the maintenance and proliferation of T cells and provides insight into immunoregulation...
  3. pmc An essential role for TAK1 in the contact hypersensitivity response
    Yan G Zhao
    Department of Toxicology, School of Public Health, Peking University, Beijing, China
    Cell Mol Immunol 8:315-24. 2011
    ..Collectively, this study demonstrates an essential role of TAK1 in the induction of CHS and suggests that targeting TAK1 could be a viable approach to treat CHS...
  4. pmc Multi-tasking of helper T cells
    Yisong Y Wan
    Department of Microbiology and Immunology, School of Medicine, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, North Carolina, NC 27599 7295, USA
    Immunology 130:166-71. 2010
    ..Finally, we will discuss our current understanding of the underlying mechanisms on how a particular type of Th cells may convert into other types of Th cells...
  5. pmc How diverse--CD4 effector T cells and their functions
    Yisong Y Wan
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 27599, USA
    J Mol Cell Biol 1:20-36. 2009
    ..We will discuss the classification and immunological functions of effector T cells, the determinants for effector T cell differentiation, as well as the relationship between different lineages of effector T cells...
  6. pmc TGF-beta and regulatory T cell in immunity and autoimmunity
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, CB 7295, 450 West Drive, Chapel Hill, North Carolina, NC 27599 7295, USA
    J Clin Immunol 28:647-59. 2008
    ..Common to these mechanisms are inhibitory cytokines such as interleukin-10 and transforming growth factor-beta (TGF-beta). TGF-beta and Foxp3-expressing Treg cells are critical in maintaining self-tolerance and immune homeostasis...
  7. pmc Regulatory T cells: immune suppression and beyond
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, North Carolina, NC 27599 7295, USA
    Cell Mol Immunol 7:204-10. 2010
    ..This review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation...
  8. pmc Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions
    Ai Di Gu
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:905-10. 2012
    ..Therefore, Smad-dependent and -independent TGF-β signaling discretely controls non-Treg and Treg function to modulate immune tolerance and immune homeostasis...
  9. pmc An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    Yunqi Wang
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 35:337-48. 2011
    ..Furthermore, the combined function of GATA-3 and Foxp3 was essential for Foxp3 expression. These findings provide insights into immune regulatory mechanisms and uncover a critical function of GATA-3 in Treg cells and immune tolerance...
  10. pmc An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo
    Yunqi Wang
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 185:5983-92. 2010
    ..Thus, we have identified an intrinsic mechanism that imposes a Th2/Th1 imbalance and predisposes Foxp3-expressing cells to IL-4 production independent of STAT-6 signaling...
  11. pmc Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway
    Yan G Zhao
    Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 189:4417-25. 2012
    ..It addresses how DHA regulates immune function and suggests a new type of drug for treating diseases in which mTOR activity is to be tempered...
  12. pmc Protein phosphatase 2A catalytic subunit α plays a MyD88-dependent, central role in the gene-specific regulation of endotoxin tolerance
    Ling Xie
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell Rep 3:678-88. 2013
    ....
  13. pmc Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
    Masahito Kamanaka
    Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA
    J Exp Med 208:1027-40. 2011
    ..Our results highlight characteristic differences between colitis induced by naive (CD45RB(hi)) and memory/effector (T(reg) cell-depleted CD45RB(lo)) cells and different ways that IL-22 impacts inflammatory bowel disease...