Yisong Y Wan

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi TGF-beta and regulatory T cell in immunity and autoimmunity
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, CB 7295, 450 West Drive, Chapel Hill, North Carolina, NC 27599 7295, USA
    J Clin Immunol 28:647-59. 2008
  2. ncbi How diverse--CD4 effector T cells and their functions
    Yisong Y Wan
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 27599, USA
    J Mol Cell Biol 1:20-36. 2009
  3. ncbi Regulatory T cells: immune suppression and beyond
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, North Carolina, NC 27599 7295, USA
    Cell Mol Immunol 7:204-10. 2010
  4. ncbi Multi-tasking of helper T cells
    Yisong Y Wan
    Department of Microbiology and Immunology, School of Medicine, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, North Carolina, NC 27599 7295, USA
    Immunology 130:166-71. 2010
  5. ncbi An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    Yunqi Wang
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 35:337-48. 2011
  6. ncbi Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions
    Ai Di Gu
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:905-10. 2012
  7. ncbi Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway
    Yan G Zhao
    Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 189:4417-25. 2012
  8. ncbi An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo
    Yunqi Wang
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 185:5983-92. 2010
  9. ncbi Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
    Masahito Kamanaka
    Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA
    J Exp Med 208:1027-40. 2011

Collaborators

  • R A Flavell
  • Lin Lin
  • Susumu Nakae
  • Samuel Huber
  • Yunqi Wang
  • Ai Di Gu
  • Yan G Zhao
  • Masahito Kamanaka
  • Weidong Hao
  • Albert S Baldwin
  • Song S Zhang
  • Zengli Guo
  • Han C Dan
  • Chozhavendan Rathinam
  • Maureen A Su
  • Liming Hao
  • Nicola Gagliani
  • William O'Connor
  • Yoichiro Iwakura
  • Lauren A Zenewicz
  • Abdallah Souabni

Detail Information

Publications9

  1. ncbi TGF-beta and regulatory T cell in immunity and autoimmunity
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, CB 7295, 450 West Drive, Chapel Hill, North Carolina, NC 27599 7295, USA
    J Clin Immunol 28:647-59. 2008
    ..In this paper, we will discuss the role of these mechanisms in the control of immunity and autoimmunity and the mechanisms that underlie how these molecules control these responses...
  2. ncbi How diverse--CD4 effector T cells and their functions
    Yisong Y Wan
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 27599, USA
    J Mol Cell Biol 1:20-36. 2009
    ..We will discuss the classification and immunological functions of effector T cells, the determinants for effector T cell differentiation, as well as the relationship between different lineages of effector T cells...
  3. ncbi Regulatory T cells: immune suppression and beyond
    Yisong Y Wan
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, North Carolina, NC 27599 7295, USA
    Cell Mol Immunol 7:204-10. 2010
    ..This review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation...
  4. ncbi Multi-tasking of helper T cells
    Yisong Y Wan
    Department of Microbiology and Immunology, School of Medicine, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, North Carolina, NC 27599 7295, USA
    Immunology 130:166-71. 2010
    ..Finally, we will discuss our current understanding of the underlying mechanisms on how a particular type of Th cells may convert into other types of Th cells...
  5. ncbi An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    Yunqi Wang
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 35:337-48. 2011
    ..Furthermore, the combined function of GATA-3 and Foxp3 was essential for Foxp3 expression. These findings provide insights into immune regulatory mechanisms and uncover a critical function of GATA-3 in Treg cells and immune tolerance...
  6. ncbi Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions
    Ai Di Gu
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:905-10. 2012
    ..Therefore, Smad-dependent and -independent TGF-β signaling discretely controls non-Treg and Treg function to modulate immune tolerance and immune homeostasis...
  7. ncbi Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of rapamycin pathway
    Yan G Zhao
    Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 189:4417-25. 2012
    ..It addresses how DHA regulates immune function and suggests a new type of drug for treating diseases in which mTOR activity is to be tempered...
  8. ncbi An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo
    Yunqi Wang
    Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 185:5983-92. 2010
    ..Thus, we have identified an intrinsic mechanism that imposes a Th2/Th1 imbalance and predisposes Foxp3-expressing cells to IL-4 production independent of STAT-6 signaling...
  9. ncbi Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology
    Masahito Kamanaka
    Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA
    J Exp Med 208:1027-40. 2011
    ..Our results highlight characteristic differences between colitis induced by naive (CD45RB(hi)) and memory/effector (T(reg) cell-depleted CD45RB(lo)) cells and different ways that IL-22 impacts inflammatory bowel disease...