Yihong Wan

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Thiazolidinediones on PPARγ: The Roles in Bone Remodeling
    Wei Wei
    Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    PPAR Res 2011:867180. 2011
  2. pmc Bone marrow mesenchymal stem cells: fat on and blast off by FGF21
    Yihong Wan
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int J Biochem Cell Biol 45:546-9. 2013
  3. pmc Rosiglitazone activation of PPARgamma suppresses fractalkine signaling
    Yihong Wan
    Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND8 502B, Dallas, Texas 75390 9041, USA
    J Mol Endocrinol 44:135-42. 2010
  4. doi request reprint PPARγ in bone homeostasis
    Yihong Wan
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Trends Endocrinol Metab 21:722-8. 2010
  5. pmc Osteoclast progenitors reside in the peroxisome proliferator-activated receptor γ-expressing bone marrow cell population
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Mol Cell Biol 31:4692-705. 2011
  6. pmc Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:3143-8. 2012
  7. pmc Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Mol Cell Biol 31:4706-19. 2011
  8. pmc Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake
    Daniel Zeve
    Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9133, USA
    Cell Metab 15:492-504. 2012
  9. pmc Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization
    Zixue Jin
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 20:483-98. 2014
  10. pmc Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates
    Yang Du
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Commun 3:1008. 2012

Collaborators

Detail Information

Publications23

  1. pmc Thiazolidinediones on PPARγ: The Roles in Bone Remodeling
    Wei Wei
    Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    PPAR Res 2011:867180. 2011
    ..This paper will focus on current new developments that implicate potential mechanisms for how PPARγ modulates skeletal homeostasis and how TZDs exert bone-loss side effects...
  2. pmc Bone marrow mesenchymal stem cells: fat on and blast off by FGF21
    Yihong Wan
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int J Biochem Cell Biol 45:546-9. 2013
    ..These new findings will further elucidate the dynamic regulation of BMMSCs in the pathophysiological control of skeletal homeostasis, and facilitate the clinical applications of BMMSCs in regenerative medicine...
  3. pmc Rosiglitazone activation of PPARgamma suppresses fractalkine signaling
    Yihong Wan
    Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Room ND8 502B, Dallas, Texas 75390 9041, USA
    J Mol Endocrinol 44:135-42. 2010
    ..Together, these data suggest that PPARgamma activation represses FKN signaling. These findings indicate a previously unrecognized mechanism that may contribute to the anti-inflammatory effect of PPARgamma...
  4. doi request reprint PPARγ in bone homeostasis
    Yihong Wan
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Trends Endocrinol Metab 21:722-8. 2010
    ..Therefore, PPARγ plays dual roles in bone homeostasis by regulating both mesenchymal and hematopoietic lineages...
  5. pmc Osteoclast progenitors reside in the peroxisome proliferator-activated receptor γ-expressing bone marrow cell population
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Mol Cell Biol 31:4692-705. 2011
    ..These findings not only identify the long-sought-after osteoclast progenitors but also establish unprecedented tools for their visualization, isolation, characterization, and genetic manipulation...
  6. pmc Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:3143-8. 2012
    ..Therefore, FGF21 is a critical rheostat for bone turnover and a key integrator of bone and energy metabolism. These results reveal that skeletal fragility may be an undesirable consequence of chronic FGF21 administration...
  7. pmc Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Mol Cell Biol 31:4706-19. 2011
    ..Importantly, these findings suggest that Wnt activation is a more effective treatment for skeletal fragility than previously recognized that confers dual anabolic and anti-catabolic benefits...
  8. pmc Wnt signaling activation in adipose progenitors promotes insulin-independent muscle glucose uptake
    Daniel Zeve
    Department of Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 9133, USA
    Cell Metab 15:492-504. 2012
    ..Thus, adipose progenitor Wnt activation dissociates lipodystrophy from dysfunctional metabolism and highlights a fat-muscle endocrine axis, which may represent a potential therapy to lower blood glucose and improve metabolism...
  9. pmc Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization
    Zixue Jin
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 20:483-98. 2014
    ..Together, these findings reveal mitochondrial CI as a critical rheostat of innate immunity and skeletal homeostasis. ..
  10. pmc Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates
    Yang Du
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Commun 3:1008. 2012
    ....
  11. pmc HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered β-catenin switch
    Zixue Jin
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Endocrinol 27:325-35. 2013
    ..003) owing to 102% elevated bone resorption (P = 0.01). These findings are clinically significant in light of the remarkable therapeutic potentials of HDAC inhibitors for several diseases such as cancer, diabetes, and neurodegeneration...
  12. pmc PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 11:503-16. 2010
    ..These findings identify PGC1beta as an essential mediator for the PPARgamma stimulation of osteoclastogenesis by targeting both PPARgamma itself and ERRalpha, thus activating two distinct transcriptional programs...
  13. pmc Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 23:479-91. 2016
    ..These findings reveal a key step in ERRα regulation and explain the actions of two highly prescribed drugs, statins and bisphosphonates. ..
  14. pmc Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation
    Xiaoxiao Li
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States
    elife 4:e07217. 2015
    ....
  15. pmc miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2
    Jing Y Krzeszinski
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 512:431-5. 2014
    ..Together, using mouse genetic, pharmacological and disease models, we reveal miR-34a as a key osteoclast suppressor and a potential therapeutic strategy to confer skeletal protection and ameliorate bone metastasis of cancers. ..
  16. pmc A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption
    Xunde Wang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 22:811-24. 2015
    ..Therefore, the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21-induced bone loss. ..
  17. pmc HDAC9 Inhibits Osteoclastogenesis via Mutual Suppression of PPARγ/RANKL Signaling
    Zixue Jin
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390
    Mol Endocrinol 29:730-8. 2015
    ..These findings identify HDAC9 as a novel, important and physiologically relevant modulator of bone remodeling and skeletal homeostasis. ..
  18. pmc The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
    Yuan Zhang
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States
    elife 1:e00065. 2012
    ..These findings raise the possibility that FGF21 can be used to extend lifespan in other species.DOI:http://dx.doi.org/10.7554/eLife.00065.001...
  19. pmc Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity
    Yang Du
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 26:1306-11. 2012
    ..These findings unravel maternal western diet-induced inflammatory milk secretion as a novel aspect of the metabolic syndrome at the maternal offspring interface...
  20. pmc Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 19:927-40. 2014
    ..These findings reveal orexin as a critical rheostat of skeletal homeostasis that exerts a yin-yang dual regulation and highlight orexin as a therapeutic target for osteoporosis. ..
  21. pmc New therapeutic targets for cancer bone metastasis
    Jing Y Krzeszinski
    Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Trends Pharmacol Sci 36:360-73. 2015
    ..We discuss the most recent advances in the identification of new molecules and novel mechanisms during each step of bone metastasis that may serve as promising therapeutic targets. ..
  22. pmc Minireview: nuclear receptor regulation of osteoclast and bone remodeling
    Zixue Jin
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390
    Mol Endocrinol 29:172-86. 2015
    ....
  23. pmc Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen
    Laurent Gautron
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, 75235 Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, 75235
    J Comp Neurol 521:3741-67. 2013
    ..In summary, this study describes the variety of cholinergic neuronal and nonneuronal cells in a position to modulate gastrointestinal and splenic immunity in the mouse...