X S Wan

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells
    X Steven Wan
    University of Pennsylvania, Philadelphia, PA 19104 6072, USA
    Oncol Rep 10:2009-14. 2003
  2. ncbi request reprint Relationship between protease activity and neu oncogene expression in patients with oral leukoplakia treated with the Bowman Birk Inhibitor
    X S Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Cancer Epidemiol Biomarkers Prev 8:601-8. 1999
  3. ncbi request reprint Treatment with soybean-derived Bowman Birk inhibitor increases serum prostate-specific antigen concentration while suppressing growth of human prostate cancer xenografts in nude mice
    X S Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Prostate 41:243-52. 1999
  4. ncbi request reprint Urinary excretion of Bowman-Birk inhibitor in humans after soy consumption as determined by a monoclonal antibody-based immunoassay
    X S Wan
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104, USA
    Cancer Epidemiol Biomarkers Prev 9:741-7. 2000
  5. ncbi request reprint Three immunoassays based on monoclonal antibodies specific for prostate specific antigen (PSA), alpha-1-antichymotrypsin (ACT), and the PSA-ACT complex
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Prostate 56:131-41. 2003
  6. ncbi request reprint Detection of Bowman-Birk inhibitor and anti-Bowman-Birk inhibitor antibodies in sera of humans and animals treated with Bowman-Birk inhibitor concentrate
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nutr Cancer 43:167-73. 2002
  7. pmc Effect of SPE-like proton or photon radiation on the kinetics of mouse peripheral blood cells and radiation biological effectiveness determinations
    A L Romero-Weaver
    Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Astrobiology 13:570-7. 2013
  8. ncbi request reprint Bowman-Birk inhibitor suppresses production of superoxide anion radicals in differentiated HL-60 cells
    J H Ware
    Department of Radiation Oncology, University of Pennsylvania Medical School, Philadelphia 19104, USA
    Nutr Cancer 33:174-7. 1999
  9. ncbi request reprint Effects of Bowman-Birk inhibitor concentrate (BBIC) in patients with benign prostatic hyperplasia
    S B Malkowicz
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Prostate 48:16-28. 2001
  10. doi request reprint Kinetics of Neutrophils in Mice Exposed to Radiation and/or Granulocyte Colony-Stimulating Factor Treatment
    A L Romero-Weaver
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Radiat Res 180:177-88. 2013

Collaborators

Detail Information

Publications23

  1. ncbi request reprint In vitro evaluation of chemopreventive agents using cultured human prostate epithelial cells
    X Steven Wan
    University of Pennsylvania, Philadelphia, PA 19104 6072, USA
    Oncol Rep 10:2009-14. 2003
    ....
  2. ncbi request reprint Relationship between protease activity and neu oncogene expression in patients with oral leukoplakia treated with the Bowman Birk Inhibitor
    X S Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Cancer Epidemiol Biomarkers Prev 8:601-8. 1999
    ..By inhibiting the cleavage of neu protein on the cell surface, BBI could prevent malignant and premalignant cells expressing high levels of neu protein antigen from escaping host immunological surveillance control...
  3. ncbi request reprint Treatment with soybean-derived Bowman Birk inhibitor increases serum prostate-specific antigen concentration while suppressing growth of human prostate cancer xenografts in nude mice
    X S Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Prostate 41:243-52. 1999
    ..Bowman Birk inhibitor (BBI) is an anticarcinogenic serine protease inhibitor that may inhibit the protease activity of prostate-specific antigen (PSA) and the growth of human prostate cancer xenografts in nude mice...
  4. ncbi request reprint Urinary excretion of Bowman-Birk inhibitor in humans after soy consumption as determined by a monoclonal antibody-based immunoassay
    X S Wan
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104, USA
    Cancer Epidemiol Biomarkers Prev 9:741-7. 2000
    ..These data suggest that BBI ingested p.o. is absorbed and could be bioavailable for cancer chemoprevention in other organs in addition to those in the gastrointestinal tract...
  5. ncbi request reprint Three immunoassays based on monoclonal antibodies specific for prostate specific antigen (PSA), alpha-1-antichymotrypsin (ACT), and the PSA-ACT complex
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Prostate 56:131-41. 2003
    ....
  6. ncbi request reprint Detection of Bowman-Birk inhibitor and anti-Bowman-Birk inhibitor antibodies in sera of humans and animals treated with Bowman-Birk inhibitor concentrate
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Nutr Cancer 43:167-73. 2002
    ..These results suggest that orally ingested BBI is absorbed by human subjects and animals and that some animals develop antibodies to BBI in response to treatment with BBIC...
  7. pmc Effect of SPE-like proton or photon radiation on the kinetics of mouse peripheral blood cells and radiation biological effectiveness determinations
    A L Romero-Weaver
    Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
    Astrobiology 13:570-7. 2013
    ....
  8. ncbi request reprint Bowman-Birk inhibitor suppresses production of superoxide anion radicals in differentiated HL-60 cells
    J H Ware
    Department of Radiation Oncology, University of Pennsylvania Medical School, Philadelphia 19104, USA
    Nutr Cancer 33:174-7. 1999
    ..These results suggest that BBI inhibits superoxide anion radical generation in HL-60 cells but does not act as a simple free radical scavenger...
  9. ncbi request reprint Effects of Bowman-Birk inhibitor concentrate (BBIC) in patients with benign prostatic hyperplasia
    S B Malkowicz
    Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Prostate 48:16-28. 2001
    ....
  10. doi request reprint Kinetics of Neutrophils in Mice Exposed to Radiation and/or Granulocyte Colony-Stimulating Factor Treatment
    A L Romero-Weaver
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Radiat Res 180:177-88. 2013
    ..Thus, these results suggest that pegfilgrastim could be a potential countermeasure for the reduced number of circulating neutrophils in irradiated animals. ..
  11. pmc Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice
    J H Ware
    Department of Radiation Oncology, Division of Oncology Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 174:325-30. 2010
    ....
  12. doi request reprint Acute hematological effects of solar particle event proton radiation in the porcine model
    J K Sanzari
    Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    Radiat Res 180:7-16. 2013
    ....
  13. ncbi request reprint Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 64:1475-81. 2006
    ..To evaluate the protective effects of antioxidant agents against space radiation-induced oxidative stress in cultured human epithelial cells...
  14. ncbi request reprint Effects of Bowman-Birk inhibitor on rat colon carcinogenesis
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Nutr Cancer 43:174-86. 2002
    ..No adverse side effects on the pancreas or animal growth were observed in rats treated with PBBI or BBIC. These results demonstrate that PBBI and BBIC may be used to prevent colon cancer without significant adverse side effects...
  15. ncbi request reprint Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats
    Jun Guan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Radiat Res 162:572-9. 2004
    ....
  16. ncbi request reprint Selenomethionine protects against adverse biological effects induced by space radiation
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA, USA
    Free Radic Biol Med 36:259-66. 2004
    ....
  17. ncbi request reprint Development of the Bowman-Birk inhibitor for oral cancer chemoprevention and analysis of Neu immunohistochemical staining intensity with Bowman-Birk inhibitor concentrate treatment
    William B Armstrong
    Department of Otolaryngology Head and Neck Surgery, Chao Family Comprehensive Cancer Center, University of California Irvine, 101 The City DriveSouth, Bldg 25, Suite 191, Orange, CA 92868, USA
    Laryngoscope 113:1687-702. 2003
    ....
  18. ncbi request reprint Establishment and characterization of sublines of LNCaP human prostate cancer cells
    X Steven Wan
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA 19083, USA
    Oncol Rep 10:1569-75. 2003
    ....
  19. ncbi request reprint Effects of the Bowman-Birk inhibitor on growth, invasion, and clonogenic survival of human prostate epithelial cells and prostate cancer cells
    Ann R Kennedy
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    Prostate 50:125-33. 2002
    ..The Bowman-Birk inhibitor (BBI) is a soybean-derived serine protease inhibitor with demonstrated anticarcinogenic activity in both in vitro and in vivo systems...
  20. ncbi request reprint Detection of oxidative stress induced by low- and high-linear energy transfer radiation in cultured human epithelial cells
    X Steven Wan
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 163:364-8. 2005
    ....
  21. ncbi request reprint Adaptation of the dichlorofluorescein assay for detection of radiation-induced oxidative stress in cultured cells
    X Steven Wan
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 160:622-30. 2003
    ..These results indicate that the DCF assay optimized in this study is highly sensitive, linear and specific for measuring oxidative stress in irradiated cells...
  22. pmc Dietary antioxidants protect hematopoietic cells and improve animal survival after total-body irradiation
    Chris Wambi
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Radiat Res 169:384-96. 2008
    ....
  23. ncbi request reprint Standardization of a fluorometric assay for measuring oxidative stress in irradiated cells
    X Steven Wan
    Department of Radiation Oncology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 163:232-40. 2005
    ....