Wendy M Walwyn
Affiliation: University of California
- Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunitMustapha Irnaten
Department of Pharmacology, George Washington University, Washington, DC 20037, USA
Anesthesiology 97:717-24. 2002..Expression of the GABA(A) receptor epsilon subunit in cardiac parasympathetic neurons renders the GABA receptors insensitive to pentobarbital...
- Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channelsAmynah Pradhan
Department of Neuropsychiatry and Biobehavioral Sciences, Stefan and Shirley Hatos Center for Neuropharmacology, Semel Institute, University of California, Los Angeles, CA, 90095, USA
Mol Pain 9:8. 2013..In addition, as beta-arrestin 2 can regulate delta opioid receptor trafficking and signaling, we have further examined whether deleting this scaffolding and signal transduction molecule alters delta opioid receptor function...
- Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2Hoa Lam
Institute of Academic Anaesthesia, Centre for Neuroscience, University of Dundee, Dundee DD19SY, UK
Mol Pain 7:24. 2011..By contrast, the aversive effects of inverse agonists were similar in β-arr2⁻/⁻ and β-arr2+/+ mice, suggesting that hedonic tone was unaffected...
- Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout miceW M Walwyn
Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, 760 Westwood Plaza, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
Neuroscience 123:111-21. 2004..These data indicate that this return of function model in neurons recapitulates many of the characteristics of endogenous mu opioid receptor function previously identified in non-neuronal cell lines...
- HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathyW M Walwyn
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90024 1759, USA
Exp Neurol 198:260-70. 2006..These data suggest that maximal therapeutic benefit in future NGF-based gene therapy trials will be gained from early applications of such viral-mediated neurotrophin delivery...
- Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neuronsW M Walwyn
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, NPI Box 77, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
Neuroscience 142:493-503. 2006..Such ligand-independent desensitization could be a result of the observed higher rate of synthesis and degradation of this chimeric receptor...
- Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutionsWendy M Walwyn
Shirley and Stephan Hatos Center for Neuropharmacology, Semel Institute, Los Angeles, CA 90024 1759, USA
Drug Alcohol Depend 108:156-65. 2010....
- p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neuronsMiao Tan
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90024 1759, USA
J Biol Chem 284:6270-81. 2009....
- Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out miceP D Skoubis
University of California at Los Angeles, 20024, USA
Neuroscience 106:757-63. 2001..c.) failed to produce conditioned place aversion.Taken together, these data further support the notion that naloxone produces aversion by antagonizing tonic opioid activity at the mu-opioid receptor...
- Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentationChad K Otoshi
Department of Physiological Science, University of California Los Angeles, Los Angeles, California 90095 1606, USA
J Neurotrauma 26:575-84. 2009..Combined, these data demonstrate that the upregulation in 5-HT(1A)R that occurs with spinal cord transection alone is dependent on the presence of sensory input...