Research Topics
| James A WaltzSummaryAffiliation: University of Maryland Country: USA Publications
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Detail Information
Publications
The roles of reward, default, and executive control networks in set-shifting impairments in schizophreniaJames A Waltz
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
PLoS ONE 8:e57257. 2013..These results also confirm a role for ventrolateral and dorsomedial PFC in the execution of response-set shifts...
Altered probabilistic learning and response biases in schizophrenia: behavioral evidence and neurocomputational modelingJames A Waltz
Department of Psychiatry, University of Maryland School of Medicine, MD Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
Neuropsychology 25:86-97. 2011..Patients with schizophrenia (SZ) show reinforcement learning impairments related to both the gradual/procedural acquisition of reward contingencies, and the ability to use trial-to-trial feedback to make rapid behavioral adjustments...
Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophreniaJames A Waltz
Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Neuropsychopharmacology 35:2427-39. 2010....
Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcersJames A Waltz
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Neuropsychopharmacology 34:1567-77. 2009..These results provide evidence that SZ patients show abnormal brain responses associated with the processing of a primary reinforcer, which may be a source of motivational deficits...
Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunctionJames A Waltz
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, United States
Schizophr Res 93:296-303. 2007..Further studies are required to investigate the roles of dopaminergic systems in these impairments...
Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunctionJames A Waltz
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
Biol Psychiatry 62:756-64. 2007..We investigated whether fronto-striatal dysfunction in schizophrenia (SZ) is characterized by selective impairment in either reward- (Go) or punishment-driven (NoGo) learning...
Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuliGregory P Strauss
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Schizophr Bull 37:1295-304. 2011..These data suggest that individuals with SZ are impaired in developing or maintaining nuanced representations of the different attributes of a stimulus, thus making stimuli of similar general value easily confusable...
Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophreniaGregory P Strauss
Department of Psychiatry and Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Biol Psychiatry 69:424-31. 2011..The current study examines whether deficits in reinforcement learning and uncertainty-driven exploration predict specific negative symptom domains...
Cognition-emotion interactions are modulated by working memory capacity in individuals with schizophreniaGregory P Strauss
Department of Psychiatry, University of Maryland School of Medicine and Maryland Psychiatric Research Center, Baltimore, MD, USA
Schizophr Res 141:257-61. 2012..Thus, findings provide further evidence for normal evaluative response in schizophrenia, but clarify that these normal experiences may not hold when working memory demands are too high...
Optimizing vs. matching: response strategy in a probabilistic learning task is associated with negative symptoms of schizophreniaZuzana Kasanova
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Schizophr Res 127:215-22. 2011..These data provide a rare example of a greater clinical impairment being associated with better behavioral performance...
Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidenceJames M Gold
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Arch Gen Psychiatry 69:129-38. 2012..Negative symptoms are a core feature of schizophrenia, but their pathogenesis remains unclear. Negative symptoms are defined by the absence of normal function. However, there must be a productive mechanism that leads to this absence...
Turning it upside down: areas of preserved cognitive function in schizophreniaJames M Gold
Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Neuropsychol Rev 19:294-311. 2009..The documentation of preserved cognitive function in schizophrenia may serve to sharpen hypotheses about the biological mechanisms that are implicated in the illness...
Reward processing in schizophrenia: a deficit in the representation of valueJames M Gold
Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Schizophr Bull 34:835-47. 2008..In contrast, patients often (but not always) approach normal performance levels on the slow learning achieved by the integration of reinforcement signals over many trials, thought to be mediated by the basal ganglia...
Relational integration and executive function in Alzheimer's diseaseJames A Waltz
Departjment of Psychology, University of California, Los Angeles, CA 90095-1563, USA
Neuropsychology 18:296-305. 2004....
