James A Waltz

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. doi Probing the Dynamic Updating of Value in Schizophrenia Using a Sensory-Specific Satiety Paradigm
    James A Waltz
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD
    Schizophr Bull 41:1115-22. 2015
  2. pmc The roles of reward, default, and executive control networks in set-shifting impairments in schizophrenia
    James A Waltz
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 8:e57257. 2013
  3. pmc Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction
    James A Waltz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 62:756-64. 2007
  4. pmc Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction
    James A Waltz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, United States
    Schizophr Res 93:296-303. 2007
  5. pmc Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers
    James A Waltz
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:1567-77. 2009
  6. pmc Altered probabilistic learning and response biases in schizophrenia: behavioral evidence and neurocomputational modeling
    James A Waltz
    Department of Psychiatry, University of Maryland School of Medicine, MD Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Neuropsychology 25:86-97. 2011
  7. pmc Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia
    James A Waltz
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Neuropsychopharmacology 35:2427-39. 2010
  8. pmc Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuli
    Gregory P Strauss
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Schizophr Bull 37:1295-304. 2011
  9. pmc Cognition-emotion interactions are modulated by working memory capacity in individuals with schizophrenia
    Gregory P Strauss
    Department of Psychiatry, University of Maryland School of Medicine and Maryland Psychiatric Research Center, Baltimore, MD, USA
    Schizophr Res 141:257-61. 2012
  10. pmc Hypothetical decision making in schizophrenia: the role of expected value computation and "irrational" biases
    Jaime K Brown
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 209:142-9. 2013

Detail Information

Publications22

  1. doi Probing the Dynamic Updating of Value in Schizophrenia Using a Sensory-Specific Satiety Paradigm
    James A Waltz
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD
    Schizophr Bull 41:1115-22. 2015
    ....
  2. pmc The roles of reward, default, and executive control networks in set-shifting impairments in schizophrenia
    James A Waltz
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    PLoS ONE 8:e57257. 2013
    ..These results also confirm a role for ventrolateral and dorsomedial PFC in the execution of response-set shifts...
  3. pmc Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction
    James A Waltz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 62:756-64. 2007
    ..We investigated whether fronto-striatal dysfunction in schizophrenia (SZ) is characterized by selective impairment in either reward- (Go) or punishment-driven (NoGo) learning...
  4. pmc Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction
    James A Waltz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, United States
    Schizophr Res 93:296-303. 2007
    ..Further studies are required to investigate the roles of dopaminergic systems in these impairments...
  5. pmc Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers
    James A Waltz
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:1567-77. 2009
    ..These results provide evidence that SZ patients show abnormal brain responses associated with the processing of a primary reinforcer, which may be a source of motivational deficits...
  6. pmc Altered probabilistic learning and response biases in schizophrenia: behavioral evidence and neurocomputational modeling
    James A Waltz
    Department of Psychiatry, University of Maryland School of Medicine, MD Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Neuropsychology 25:86-97. 2011
    ..Patients with schizophrenia (SZ) show reinforcement learning impairments related to both the gradual/procedural acquisition of reward contingencies, and the ability to use trial-to-trial feedback to make rapid behavioral adjustments...
  7. pmc Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia
    James A Waltz
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Neuropsychopharmacology 35:2427-39. 2010
    ....
  8. pmc Patients with schizophrenia demonstrate inconsistent preference judgments for affective and nonaffective stimuli
    Gregory P Strauss
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Schizophr Bull 37:1295-304. 2011
    ..These data suggest that individuals with SZ are impaired in developing or maintaining nuanced representations of the different attributes of a stimulus, thus making stimuli of similar general value easily confusable...
  9. pmc Cognition-emotion interactions are modulated by working memory capacity in individuals with schizophrenia
    Gregory P Strauss
    Department of Psychiatry, University of Maryland School of Medicine and Maryland Psychiatric Research Center, Baltimore, MD, USA
    Schizophr Res 141:257-61. 2012
    ..Thus, findings provide further evidence for normal evaluative response in schizophrenia, but clarify that these normal experiences may not hold when working memory demands are too high...
  10. pmc Hypothetical decision making in schizophrenia: the role of expected value computation and "irrational" biases
    Jaime K Brown
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Psychiatry Res 209:142-9. 2013
    ..These abnormalities likely affect everyday DM strategies in schizophrenia patients. ..
  11. pmc Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia
    Gregory P Strauss
    Department of Psychiatry and Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Biol Psychiatry 69:424-31. 2011
    ..The current study examines whether deficits in reinforcement learning and uncertainty-driven exploration predict specific negative symptom domains...
  12. pmc Optimizing vs. matching: response strategy in a probabilistic learning task is associated with negative symptoms of schizophrenia
    Zuzana Kasanova
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Res 127:215-22. 2011
    ..These data provide a rare example of a greater clinical impairment being associated with better behavioral performance...
  13. pmc Negative symptoms of schizophrenia are associated with abnormal effort-cost computations
    James M Gold
    Department of Psychiatry, University of Maryland School of Medicine and Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Biol Psychiatry 74:130-6. 2013
    ..On the basis of evidence of dysfunction in these systems in schizophrenia (SZ), we examined whether effort-cost computations were impaired in SZ patients and whether these deficits were associated with negative symptoms...
  14. pmc Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence
    James M Gold
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 69:129-38. 2012
    ..Negative symptoms are a core feature of schizophrenia, but their pathogenesis remains unclear. Negative symptoms are defined by the absence of normal function. However, there must be a productive mechanism that leads to this absence...
  15. pmc Turning it upside down: areas of preserved cognitive function in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychol Rev 19:294-311. 2009
    ..The documentation of preserved cognitive function in schizophrenia may serve to sharpen hypotheses about the biological mechanisms that are implicated in the illness...
  16. pmc Reward processing in schizophrenia: a deficit in the representation of value
    James M Gold
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Bull 34:835-47. 2008
    ..In contrast, patients often (but not always) approach normal performance levels on the slow learning achieved by the integration of reinforcement signals over many trials, thought to be mediated by the basal ganglia...
  17. pmc Schizophrenia in translation: dissecting motivation in schizophrenia and rodents
    Eleanor H Simpson
    Department of Psychiatry, Columbia University, New York, NY, USA
    Schizophr Bull 38:1111-7. 2012
    ....
  18. doi Rasagiline in the Treatment of the Persistent Negative Symptoms of Schizophrenia
    Robert W Buchanan
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Schizophr Bull 41:900-8. 2015
    ..The current study examined the efficacy and safety of rasagiline, a selective MAO-B inhibitor, for the treatment of persistent negative symptoms...
  19. doi Effort cost computation in schizophrenia: a commentary on the recent literature
    James M Gold
    Department of Psychiatry, University of Maryland School of Medicine and Maryland Psychiatric Research Center, Baltimore, Maryland Electronic address
    Biol Psychiatry 78:747-53. 2015
    ..Although questions remain, evidence available to date suggests that the study of cost/benefit decision making may shed new light on the motivational impairments seen in many people with schizophrenia. ..
  20. doi Integrating frequency and magnitude information in decision-making in schizophrenia: An account of patient performance on the Iowa Gambling Task
    Elliot C Brown
    Maryland Psychiatric Research Center MPRC, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    J Psychiatr Res 66:16-23. 2015
    ..Poor performance on the IGT is often attributed to reduced sensitivity to punishment, which contrasts with recent findings from reinforcement learning studies in schizophrenia...
  21. pmc Cognitive effort avoidance and detection in people with schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD, 21228, USA
    Cogn Affect Behav Neurosci 15:145-54. 2015
    ..Thus, it appears that individual differences in general intellectual ability and effort detection are related to cognitive effort avoidance and likely account for the subtle reduction in effort avoidance observed in schizophrenia. ..
  22. ncbi Relational integration and executive function in Alzheimer's disease
    James A Waltz
    Departjment of Psychology, University of California, Los Angeles, CA 90095 1563, USA
    Neuropsychology 18:296-305. 2004
    ....