Tobias C Walther

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Eisosomes mark static sites of endocytosis
    Tobias C Walther
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California at San Francisco, 600 16th Street, San Francisco, California 94143 2200, USA
    Nature 439:998-1003. 2006
  2. pmc Seg1 controls eisosome assembly and shape
    Karen E Moreira
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 198:405-20. 2012
  3. pmc Pil1 controls eisosome biogenesis
    Karen E Moreira
    Howard Hughes Medical Institute, and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA
    Mol Biol Cell 20:809-18. 2009
  4. pmc Pkh-kinases control eisosome assembly and organization
    Tobias C Walther
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
    EMBO J 26:4946-55. 2007
  5. pmc Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating
    Pablo S Aguilar
    Departments of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:4170-5. 2010
  6. pmc Cellular Fatty Acid metabolism and cancer
    Erin Currie
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Metab 18:153-61. 2013
  7. pmc Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL)
    Andrew D Nguyen
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    J Biol Chem 288:8627-35. 2013
  8. pmc The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA
    Cell Metab 15:570-3. 2012
  9. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009
  10. pmc Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    Yi Guo
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 453:657-61. 2008

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Eisosomes mark static sites of endocytosis
    Tobias C Walther
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California at San Francisco, 600 16th Street, San Francisco, California 94143 2200, USA
    Nature 439:998-1003. 2006
    ..Loss of Pil1 leads to clustering of eisosome remnants and redirects endocytosis and endocytic effector proteins to these clusters...
  2. pmc Seg1 controls eisosome assembly and shape
    Karen E Moreira
    Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 198:405-20. 2012
    ..The function of Seg1 in the stepwise biogenesis of eisosomes reveals striking architectural similarities between eisosomes in yeast and caveolae in mammals...
  3. pmc Pil1 controls eisosome biogenesis
    Karen E Moreira
    Howard Hughes Medical Institute, and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA
    Mol Biol Cell 20:809-18. 2009
    ..Pil1 expression is regulated by the cell cycle, which synchronizes eisosome formation with plasma membrane growth. Our results establish a first framework of the molecular principles that define eisosome assembly and distribution...
  4. pmc Pkh-kinases control eisosome assembly and organization
    Tobias C Walther
    Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
    EMBO J 26:4946-55. 2007
    ..Taken together with our previous results that link eisosomes to endocytosis, these observations suggest that Pkh-kinase signaling relayed to Pil1 may help regulate endocytic events to modulate the organization of the plasma membrane...
  5. pmc Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating
    Pablo S Aguilar
    Departments of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:4170-5. 2010
    ..Thus, a two-atom change in the aliphatic moiety of ergosterol is sufficient to obstruct cell shape remodeling and cell fusion...
  6. pmc Cellular Fatty Acid metabolism and cancer
    Erin Currie
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Metab 18:153-61. 2013
    ..Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation. ..
  7. pmc Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL)
    Andrew D Nguyen
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    J Biol Chem 288:8627-35. 2013
    ..We conclude that circulating progranulin exists as a dimer and is not likely a component of HDL...
  8. pmc The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA
    Cell Metab 15:570-3. 2012
    ..Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions...
  9. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009
    ..In light of this newfound respect, we discuss emerging views on lipid droplet biology and speculate on the major advances to come...
  10. pmc Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    Yi Guo
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
    Nature 453:657-61. 2008
    ..These phenotypes are conserved in mammalian cells, suggesting that insights from these studies are likely to be central to our understanding of human diseases involving excessive lipid storage...
  11. pmc The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import
    Tobias C Walther
    Gene Expression Program, EMBL, D 69117 Heidelberg, Germany
    J Cell Biol 158:63-77. 2002
    ..We conclude that RanBP2 is the major nucleoporin component of the cytoplasmic filaments of the NPC, and that these filaments do not have an essential role in importin alpha/beta- or transportin-dependent import...