Genomes and Genes
Tobias C Walther
Affiliation: University of California
- Eisosomes mark static sites of endocytosisTobias C Walther
Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California at San Francisco, 600 16th Street, San Francisco, California 94143 2200, USA
Nature 439:998-1003. 2006..Loss of Pil1 leads to clustering of eisosome remnants and redirects endocytosis and endocytic effector proteins to these clusters...
- Seg1 controls eisosome assembly and shapeKaren E Moreira
Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
J Cell Biol 198:405-20. 2012..The function of Seg1 in the stepwise biogenesis of eisosomes reveals striking architectural similarities between eisosomes in yeast and caveolae in mammals...
- Pil1 controls eisosome biogenesisKaren E Moreira
Howard Hughes Medical Institute, and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94158, USA
Mol Biol Cell 20:809-18. 2009..Pil1 expression is regulated by the cell cycle, which synchronizes eisosome formation with plasma membrane growth. Our results establish a first framework of the molecular principles that define eisosome assembly and distribution...
- Pkh-kinases control eisosome assembly and organizationTobias C Walther
Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
EMBO J 26:4946-55. 2007..Taken together with our previous results that link eisosomes to endocytosis, these observations suggest that Pkh-kinase signaling relayed to Pil1 may help regulate endocytic events to modulate the organization of the plasma membrane...
- Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during matingPablo S Aguilar
Departments of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:4170-5. 2010..Thus, a two-atom change in the aliphatic moiety of ergosterol is sufficient to obstruct cell shape remodeling and cell fusion...
- Cellular fatty acid metabolism and cancerErin Currie
Department of Biochemistry and Biophysics, University of California, San Francisco, 94158, USA
Cell Metab 18:153-61. 2013..Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation...
- Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL)Andrew D Nguyen
Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
J Biol Chem 288:8627-35. 2013..We conclude that circulating progranulin exists as a dimer and is not likely a component of HDL...
- The problem of establishing relationships between hepatic steatosis and hepatic insulin resistanceRobert V Farese
Gladstone Institute of Cardiovascular Disease, Department of Medicine, University of California, San Francisco, CA 94158, USA
Cell Metab 15:570-3. 2012..Here we provide a perspective by defining the problem and its challenges, analyzing the possible causative relationships, and drawing some conclusions...
- Lipid droplets finally get a little R-E-S-P-E-C-TRobert V Farese
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Cell 139:855-60. 2009..In light of this newfound respect, we discuss emerging views on lipid droplet biology and speculate on the major advances to come...
- Functional genomic screen reveals genes involved in lipid-droplet formation and utilizationYi Guo
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA
Nature 453:657-61. 2008..These phenotypes are conserved in mammalian cells, suggesting that insights from these studies are likely to be central to our understanding of human diseases involving excessive lipid storage...
- The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein importTobias C Walther
Gene Expression Program, EMBL, D 69117 Heidelberg, Germany
J Cell Biol 158:63-77. 2002..We conclude that RanBP2 is the major nucleoporin component of the cytoplasmic filaments of the NPC, and that these filaments do not have an essential role in importin alpha/beta- or transportin-dependent import...