M Wallner

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?
    M Wallner
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
    Br J Pharmacol 154:288-98. 2008
  2. ncbi Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513
    M Wallner
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
    Proc Natl Acad Sci U S A 103:8540-5. 2006
  3. ncbi A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin
    P Meera
    Department of Anesthesiology, Brain Research Institute, University of California, Los Angeles, CA 90095 7115, USA
    Proc Natl Acad Sci U S A 97:5562-7. 2000
  4. ncbi Human and rodent MaxiK channel beta-subunit genes: cloning and characterization
    Z Jiang
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California, 90095 1778, USA
    Genomics 55:57-67. 1999
  5. ncbi Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog
    M Wallner
    Department of Anesthesiology, University of California, Los Angeles, CA 90095 1778, USA
    Proc Natl Acad Sci U S A 96:4137-42. 1999
  6. ncbi Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans
    M Wallner
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:15218-23. 2003
  7. ncbi Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus
    P Meera
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 94:14066-71. 1997
  8. ncbi Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus
    M Wallner
    Department of Anesthesiology, University of California Los Angeles 90095 1778, USA
    Proc Natl Acad Sci U S A 93:14922-7. 1996
  9. ncbi A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels
    P Meera
    Dept of Anesthesiology, University of California, Los Angeles 90095 1778, USA
    FEBS Lett 382:84-8. 1996
  10. ncbi Basis of the gabamimetic profile of ethanol
    G R Breese
    Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 30:731-44. 2006

Research Grants

  1. Ethanol sensitivity in delta subunit-containing GABA(A) receptors
    Martin Wallner; Fiscal Year: 2009
  2. Ethanol sensitivity in delta subunit-containing GABA(A) receptors
    Martin Wallner; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. ncbi Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?
    M Wallner
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
    Br J Pharmacol 154:288-98. 2008
    ..The utility of such drugs might range from novel alcohol antagonists that might be useful in the emergency room, to drugs for the treatment of alcoholism, as well as alcohol-mimetic drugs to harness acute positive effects of alcohol...
  2. ncbi Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513
    M Wallner
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
    Proc Natl Acad Sci U S A 103:8540-5. 2006
    ..Our findings suggest that ethanol/Ro15-4513-sensitive GABA(A) receptors are important mediators of behavioral alcohol effects...
  3. ncbi A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin
    P Meera
    Department of Anesthesiology, Brain Research Institute, University of California, Los Angeles, CA 90095 7115, USA
    Proc Natl Acad Sci U S A 97:5562-7. 2000
    ..Thus, unusually high toxin concentrations and long exposure times are necessary to determine the role of "CTx/IbTx-insensitive" MaxiK channels formed by alpha + beta4 subunits...
  4. ncbi Human and rodent MaxiK channel beta-subunit genes: cloning and characterization
    Z Jiang
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California, 90095 1778, USA
    Genomics 55:57-67. 1999
    ..Expressed rat and mouse beta subunits increase the apparent Ca2+ sensitivity of the human MaxiK channel alpha subunit...
  5. ncbi Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog
    M Wallner
    Department of Anesthesiology, University of California, Los Angeles, CA 90095 1778, USA
    Proc Natl Acad Sci U S A 96:4137-42. 1999
    ..Thus, the inactivating phenotype of MaxiK channels in native tissues can result from the association with different beta subunits...
  6. ncbi Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans
    M Wallner
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:15218-23. 2003
    ..These combined findings suggest that "extrasynaptic" delta-subunit-containing GABARs, but not their "synaptic" gamma-subunit-containing counterparts, are primary targets for EtOH...
  7. ncbi Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus
    P Meera
    Department of Anesthesiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 94:14066-71. 1997
    ..Further, our results indicate that hydrophobic segments S9-S10 in the C terminus are cytoplasmic and unequivocally demonstrate that S0 forms an additional transmembrane segment leading to an exoplasmic N terminus...
  8. ncbi Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus
    M Wallner
    Department of Anesthesiology, University of California Los Angeles 90095 1778, USA
    Proc Natl Acad Sci U S A 93:14922-7. 1996
    ..Both the unique S0 region and the exoplasmic N terminus are necessary for this gain of function...
  9. ncbi A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels
    P Meera
    Dept of Anesthesiology, University of California, Los Angeles 90095 1778, USA
    FEBS Lett 382:84-8. 1996
    ..The functional switch develops at [Ca2+]i that occur during cellular excitation, providing the molecular basis of how MaxiK channels regulate smooth muscle excitability and neurotransmitter release...
  10. ncbi Basis of the gabamimetic profile of ethanol
    G R Breese
    Bowles Center for Alcohol Studies, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 30:731-44. 2006
    ..Collectively, this series of reports support the GABAmimetic profile of acutely administered ethanol being dependent on several specific mechanisms distinct from a direct effect on the major synaptic isoforms of GABA(A) receptors...
  11. ncbi Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium
    M Wallner
    Department of Anesthesiology, UCLA, 90095, USA
    Receptors Channels 3:185-99. 1995
    ..Half maximal activation (V1/2), measured in 10 microM Ca2+, was 12 +/- 18 mV (+/- SD, n = 62) for the alpha-subunit alone and -87 +/- 10 mV (+/- SD, n = 39) in presence of the beta-subunit...
  12. ncbi A recombinant allergen chimer as novel mucosal vaccine candidate for prevention of multi-sensitivities
    C Wild
    Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria
    Allergy 62:33-41. 2007
    ..Therefore, an allergen chimer was genetically engineered for treatment of multi-sensitization with birch and grass pollen on the basis of mucosal tolerance induction...

Research Grants2

  1. Ethanol sensitivity in delta subunit-containing GABA(A) receptors
    Martin Wallner; Fiscal Year: 2009
    ....
  2. Ethanol sensitivity in delta subunit-containing GABA(A) receptors
    Martin Wallner; Fiscal Year: 2010
    ....