Research Topics
| M S WallaceSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
NGX426, an oral AMPA-kainate antagonist, is effective in human capsaicin-induced pain and hyperalgesiaMark S Wallace
Division of Pain Medicine, Department of Anesthesiology, University of California, San Diego, La Jolla, CA, USA
Pain Med 13:1601-10. 2012..This study evaluated the effects of an oral prodrug to tezampanel, a selective α-amino-3-hydroxy-5-methly-4-isoxazole-proprionic acid/kainate receptor antagonist, on intradermal capsaicin-induced pain and hyperalgesia...
Characteristics of distribution of morphine and metabolites in cerebrospinal fluid and plasma with chronic intrathecal morphine infusion in humansMark Wallace
Department of Anesthesiology, University of California San Diego, La Jolla, CA, USA
Anesth Analg 115:797-804. 2012..We sought to address these issues in patients receiving chronic IT morphine infusion...- Current developments in intraspinal agents for cancer and noncancer painErin F Lawson
Division of Pain Medicine, Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92037, USA
Curr Pain Headache Rep 14:8-16. 2010..We review this algorithm and the emerging therapy included. This article provides an update on newly approved as well as emerging IT agents and the advances in technology for their delivery... 
Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic painMark S Wallace
Center for Pain Medicine, University of California, San Diego, 9500 Gilman Drive, 0924, San Diego, CA 92093, USA
Expert Rev Neurother 6:1423-8. 2006..The drug requires a slow titration in order to achieve analgesia while avoiding dose-limiting side effects. This review examines the currently available information on this new analgesic...- Gabapentin extended-release tablets for the treatment of patients with postherpetic neuralgia: a randomized, double-blind, placebo-controlled, multicentre studyMark S Wallace
Center for Pain Medicine, University of California, San Diego School of Medicine, La Jolla, California 92037 765092093, USA
Clin Drug Investig 30:765-76. 2010..Postherpetic neuralgia (PHN) is a neuropathic pain syndrome that may develop subsequent to healing of herpes zoster rash... - Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteersMark Wallace
Department of Anesthesiology, University of California, San Diego, USA
Anesthesiology 107:785-96. 2007..Using a human experimental pain model, the authors hypothesized that inhaled cannabis would reduce the pain and hyperalgesia induced by intradermal capsaicin... - Intrathecal ziconotide for severe chronic pain: safety and tolerability results of an open-label, long-term trialMark S Wallace
Center for Pain Medicine, University of California, San Diego, La Jolla, California 92093, USA
Anesth Analg 106:628-37, table of contents. 2008..Ziconotide is a non-opioid drug indicated for management of severe chronic pain in patients for whom intrathecal (IT) therapy is warranted and who are intolerant of or refractory to other treatments... - Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic painMark S Wallace
University of California, San Diego School of Medicine, La Jolla, California, USA
Pain Med 9:271-81. 2008..To assess the safety and efficacy of adding intrathecal ziconotide to intrathecal morphine in patients being treated with a stable intrathecal morphine dose... - Effect of chronic oral gabapentin on capsaicin-induced pain and hyperalgesia: a double-blind, placebo-controlled, crossover studyMark S Wallace
Department of Anesthesiology, University of California, San Diego, CA 92093 0924, USA
Clin J Pain 24:544-9. 2008..Two studies have demonstrated an effect of a single dose of gabapentin on experimental cutaneous hyperalgesia. This study evaluated the effect of chronic delivery of oral gabapentin on experimentally induced cutaneous hyperalgesia... - Ziconotide combination intrathecal therapy: rationale and evidenceMark S Wallace
University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
Clin J Pain 26:635-44. 2010..Although ziconotide is approved in the United States for intrathecal monotherapy only, it is often used in combination with other intrathecal drugs in clinical practice... - Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (Synera) patches compared with placebo patches applied to healthy adult volunteersMark S Wallace
Department of Anesthesiology, University of California San Diego, San Diego, CA 92037 7651, USA
Reg Anesth Pain Med 35:507-13. 2010..This study was conducted to determine the depth and duration of anesthesia provided by the patch and to evaluate safety and tolerability... - Qutenza®: a capsaicin 8% patch for the management of postherpetic neuralgiaMark Wallace
University of California at San Diego, 9310 Campus Point Drive, Ste A 114, La Jolla, CA 92037 1300, USA
Expert Rev Neurother 11:15-27. 2011..The action of capsaicin on the transient receptor potential cation channel, subfamily V, member 1 receptors will be discussed... - Open-label study on the long-term efficacy, safety, and impact on quality of life of OROS hydromorphone ER in patients with chronic low back painMark Wallace
Center for Pain Medicine, Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla, California 92037 7650, USA
Pain Med 11:1477-88. 2010..To investigate the efficacy, safety, and impact on quality of life of long-term administration of OROS hydromorphone ER (8-128mg) in patients with chronic low back pain... - Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia modelMark S Wallace
Department of Anesthesiology, University of California San Diego, 9300 Campus Point Drive, 7651, La Jolla, CA 92037 7651, USA
Pharmacol Biochem Behav 78:349-55. 2004..This lack of effect stands in contrast to reported effects of sodium channel antagonists on preclinical models of cutaneous hyperalgesia or effects of lamotrigine on clinical neuropathic pain... - Treatment options for refractory pain: the role of intrathecal therapyMark S Wallace
Center for Pain and Palliative Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, Suite 0924, La Jolla, CA 92093 0924, USA
Neurology 59:S18-24. 2002..In addition, combinations of agents with distinct mechanisms of action may be therapeutically advantageous because many clinical pain states result from more than one mechanism... - Postdelivery of alfentanil and ketamine has no effect on intradermal capsaicin-induced pain and hyperalgesiaMark S Wallace
Department of Anesthesiology, School of Medicine, University of California, San Diego, La Jolla, USA
Clin J Pain 18:373-9. 2002..The focus of this study was to determine the effects of the postdelivery of intravenous alfentanil and ketamine on intradermal capsaicin-induced secondary hyperalgesia... - The effect of chronic oral desipramine on capsaicin-induced allodynia and hyperalgesia: a double-blinded, placebo-controlled, crossover studyMark S Wallace
Department of Anesthesiology, University of California, San Diego, La Jolla 92093, USA
Anesth Analg 95:973-8, table of contents. 2002..This investigation provides further validation of human experimental pain models and demonstrates that the chronic delivery of a TCA has no effect on human experimental pain... - Pharmacologic treatment of neuropathic painM S Wallace
Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA
Curr Pain Headache Rep 5:138-50. 2001..This article provides an overview of the commonly used preclinical neuropathic pain models, followed by a summary of the efficacy of currently available agents in preclinical pain models and human correlates... - A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic painM S Wallace
University of California San Diego School of Medicine, La Jolla 92093, USA
Neurology 59:1694-700. 2002..A glycine-binding site must be occupied for the channel to open. GV196771 is a selective antagonist of the glycine-binding site of the NMDA ionophore... - Calcium and sodium channel antagonists for the treatment of painM S Wallace
Department of Anesthesiology, University of California, San Diego, School of Medicine, La Jolla 92093 0924, USA
Clin J Pain 16:S80-5. 2000..This review summarizes the current literature on the effects of the sodium and calcium channel antagonists on acute nociceptive processing, facilitated pain, and neuropathic pain... - Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and IIM S Wallace
Department of Anesthesiology, University of California San Diego, La Jolla 92093 0924, USA
Anesthesiology 92:75-83. 2000..This study sought to characterize the effects of intravenous lidocaine (a sodium channel blocker) on acute sensory thresholds within the painful area and the size of the painful area in patients suffering from CRPS I and II... - Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic painA Leung
Department of Anesthesiology, University of California, San Diego, 9500 Gilman Drive #0924, La Jolla, CA 92093-0924, USA
Pain 91:177-87. 2001..The relationship between central sensitization and regulation of peripheral NMDA-receptor expression requires further investigation... - Topical delivery of lidocaine in healthy volunteers by electroporation, electroincorporation, or iontophoresis: an evaluation of skin anesthesiaM S Wallace
Department of Anesthesiology, University of California San Diego, 9500 Gilman Drive #0924, La Jolla, CA 92093, USA
Reg Anesth Pain Med 26:229-38. 2001..CONCLUSIONS: The transdermal delivery of lidocaine by IP, EP, and EI results in similar surface skin anesthesia; however, IP results in a greater depth of anesthesia. Reg Anesth Pain Med 2001;26:229-238... - Relative sensitivity to alfentanil and reliability of current perception threshold vs von Frey tactile stimulation and thermal sensory testingR Park
Department of Anesthesiology, University of California, San Diego, School of Medicine, La Jolla 2093-0924, USA
J Peripher Nerv Syst 6:232-40. 2001..From these studies, there is some evidence that similar fiber tracts may be measured between the CPT, TST, and VF methods, especially with the CPT 5 Hz measures and C-fiber tract activity... - Effect of oral mexiletine on capsaicin-induced allodynia and hyperalgesia: a double-blind, placebo-controlled, crossover studyK Ando
Department of Anesthesiology, University of California, San Diego, La Jolla 92093-0924, USA
Reg Anesth Pain Med 25:468-74. 2000..It is severely limited by side effects and tolerable doses seem to be void of effects on normal neurosensation and facilitated pain induced by capsaicin and thermal heat pulses... - rTMS for suppressing neuropathic pain: a meta-analysisAlbert Leung
Department of Anesthesiology, The University of California, San Diego, School of Medicine, VA San Diego Healthcare System, USA
J Pain 10:1205-16. 2009..The derived information serves as a useful resource in regards to treatment parameters and patient population selection for future rTMS-pain studies... - The use of a computer-based decision support system facilitates primary care physicians' management of chronic painJ H Knab
Anesthesia Services Medical Group, CA, USA
Anesth Analg 93:712-20. 2001..The use of a CBDS system may improve the ability of PCPs to manage chronic pain and may also facilitate screening of consults to optimize specialist utilization... - Intravenous lidocaine relieves severe pain: results of an inpatient hospice chart reviewJay Thomas
San Diego Hospice and Palliative Care, San Diego, California 92103, USA
J Palliat Med 7:660-7. 2004..Parenteral lidocaine has been reported to relieve neuropathic pain and/or pain refractory to opioid therapy... - Long-term safety, tolerability, and efficacy of OROS hydromorphone in patients with chronic painMark Wallace
San Diego Medical Center, University of California, La Jolla, California, USA
J Opioid Manag 5:97-105. 2009..To assess the safety and efficacy of long-term repeated dosing of OROS hydromorphone in chronic pain patients... - A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomitingKeith A Candiotti
Department of Anesthesiology, University of Miami, Miami, Florida, USA
Anesth Analg 107:445-51. 2008.... - Tolerability of two sequential electroporation treatments using MedPulser DNA delivery system (DDS) in healthy adultsMark Wallace
Department of Anesthesiology, University of California San Diego, San Diego, California, USA
Mol Ther 17:922-8. 2009..This study supports the clinical application of MedPulser DDS for the improvement of antigen-induced immune responses for prophylactic or therapeutic vaccines, especially in gene-based therapies for cancer... - Efficacy and safety evaluation of once-daily OROS hydromorphone in patients with chronic low back pain: a pilot open-label study (DO-127)Mark Wallace
University of California, San Diego Medical Center, La Jolla, CA, USA
Curr Med Res Opin 23:981-9. 2007..To evaluate the safety, tolerability, and efficacy of once-daily osmotic controlled-release oral delivery system (OROS) hydromorphone in patients with chronic low back pain of moderate-to-severe intensity... - Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trialPeter S Staats
Division of Pain Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
JAMA 291:63-70. 2004..Ziconotide (formerly SNX-111) selectively blocks N-type voltage-sensitive calcium channels and may be effective in patients with pain that is refractory to opioid therapy or those with intolerable opioid-related adverse effects... - The effect of opioids on sleep architectureJoel E Dimsdale
Department of Psychiatry, University of California, San Diego, USA
J Clin Sleep Med 3:33-6. 2007..This study examined whether commonly used opioid medications have an adverse effect on sleep architecture in healthy adults... - Intradermal capsaicin causes dose-dependent pain, allodynia, and hyperalgesia in humansGraham C Scanlon
Department of Anesthesiology and the Center for Pain and Palliative Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093-0924, USA
J Investig Med 54:238-44. 2006.... - A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic painRichard L Rauck
Wake Forest University School of Medicine, The Center for Clinical Research, Carolinas Pain Institute, Winston Salem, North Carolina 27103, USA
J Pain Symptom Manage 31:393-406. 2006..Slow titration of ziconotide, a nonopioid analgesic, to a low maximum dose resulted in significant improvement in pain and was better tolerated than in two previous controlled trials that used a faster titration to a higher mean dose... - Qualitative and quantitative characterization of the thermal grillAlbert Y Leung
Department of Anesthesiology, University of California, San Diego School of Medicine, 9500 Gilman Drive 0924, La Jolla, CA 92093 0924, USA
Pain 116:26-32. 2005..The time course variation in the perception of the combined stimuli suggests an adaptation occurred in central processing... - A Phase II, multicenter, randomized, double-blind, placebo-controlled crossover study of CJC-1008--a long-acting, parenteral opioid analgesic--in the treatment of postherpetic neuralgiaMark S Wallace
Department of Anesthesiology, University of California San Diego, USA
J Opioid Manag 2:167-73. 2006..However, the effect only lasted through eight hours postdose and diminished by 24 hours. This study provides evidence of a peripheral action of dynorphin, since CJC-1008 does not cross the blood-brain barrier... - Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trialJ Hampton Atkinson
Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA 92161, USA
J Clin Psychopharmacol 27:135-42. 2007.... - Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathiaMark S Wallace
Department of Anesthesiology, University of California, San Diego School of Medicine, La Jolla 92093-0924, USA
J Clin Pharmacol 42:70-80. 2002..These studies suggest that experimental human pain models may be used to study analgesic pharmacology and may serve as important methods for defining the analgesic efficacy of drugs in phase I clinical trials... - The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesiaKeeran Kumar
Department of Anesthesiology, University of California San Diego, San Diego, California, USA
Anesth Analg 103:696-702. 2006..The findings of this study support the feasibility of further pharmacological studies using the IM capsaicin pain model... - Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendationsRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Meedicine and Dentistry, Rochester, NY 14642
Arch Neurol 60:1524-34. 2003..Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach... - Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendationsDennis C Turk
University of Washington, Seattle, WA 98195, USA
Pain 125:208-15. 2006 - Recommendations for the management of herpes zosterRobert H Dworkin
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642, USA
Clin Infect Dis 44:S1-26. 2007..Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ... - NanoStore: a concept for logistical improvements of compound handling in high-throughput screeningNeil Benson
Discovery Biology, Pfizer Global Research and Development, Ramsgate Road, Sandwich, CT13 9NJ, United Kingdom
J Biomol Screen 10:573-80. 2005..This uncoupling of normally interconnected processes provides time and compound savings, avoids repeated freeze-thaw cycles of compound solutions, and removes the problems associated with the DMSO sensitivity of certain assays types... - Pharmacologic management of neuropathic pain: evidence-based recommendationsRobert H Dworkin
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Pain 132:237-51. 2007..Long-term studies, head-to-head comparisons between medications, studies involving combinations of medications, and RCTs examining treatment of central NP are lacking and should be a priority for future research...