K B Wallace

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors
    Kaleb C Lund
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota Medical School Duluth, 1035 University Drive, Duluth, MN 55812, USA
    Toxicol Appl Pharmacol 226:94-106. 2008
  2. doi request reprint Mitochondrial off targets of drug therapy
    Kendall B Wallace
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN 55812, USA
    Trends Pharmacol Sci 29:361-6. 2008
  3. pmc Structure-activity relationships for perfluoroalkane-induced in vitro interference with rat liver mitochondrial respiration
    K B Wallace
    University of Minnesota Medical School, Department of Biochemistry and Molecular Biology, Duluth, MN 55812, United States Electronic address
    Toxicol Lett 222:257-64. 2013
  4. pmc Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death
    Vilma A Sardao
    Center for Neurosciences and Cellular Biology, University of Coimbra, Coimbra, Portugal
    BMC Cell Biol 8:11. 2007
  5. ncbi request reprint Doxorubicin-induced cardiac mitochondrionopathy
    Kendall B Wallace
    Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth, MN 55812, USA
    Pharmacol Toxicol 93:105-15. 2003
  6. ncbi request reprint Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis
    Kendall B Wallace
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth, MN 55812, USA
    Cardiovasc Toxicol 7:101-7. 2007
  7. ncbi request reprint Serum troponins as biomarkers of drug-induced cardiac toxicity
    Kendall B Wallace
    Department of Biochemitry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Toxicol Pathol 32:106-21. 2004
  8. ncbi request reprint Mitochondrial targets of drug toxicity
    K B Wallace
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Annu Rev Pharmacol Toxicol 40:353-88. 2000
  9. ncbi request reprint Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin
    S Zhou
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Cancer Res 61:771-7. 2001
  10. ncbi request reprint Doxorubicin-induced persistent oxidative stress to cardiac myocytes
    S Zhou
    Department of Biochemistry and Molecular Biology, and Toxicology Graduate Program, School of Medicine, University of Minnesota, Duluth, MN 55812, USA
    Toxicol Lett 121:151-7. 2001

Research Grants

  1. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2005
  2. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2004
  3. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2004
  4. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2003
  5. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2003
  6. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2002
  7. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2002
  8. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2001
  9. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 1999
  10. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2006

Collaborators

Detail Information

Publications39

  1. pmc Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors
    Kaleb C Lund
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota Medical School Duluth, 1035 University Drive, Duluth, MN 55812, USA
    Toxicol Appl Pharmacol 226:94-106. 2008
    ....
  2. doi request reprint Mitochondrial off targets of drug therapy
    Kendall B Wallace
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN 55812, USA
    Trends Pharmacol Sci 29:361-6. 2008
    ..The present review article briefly reviews the molecular biology and biophysics of mitochondrial bioenergetics, which then serves as a platform for identifying the various potential off targets for drug-induced mitochondrial toxicity...
  3. pmc Structure-activity relationships for perfluoroalkane-induced in vitro interference with rat liver mitochondrial respiration
    K B Wallace
    University of Minnesota Medical School, Department of Biochemistry and Molecular Biology, Duluth, MN 55812, United States Electronic address
    Toxicol Lett 222:257-64. 2013
    ....
  4. pmc Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide--characterization of morphological features of cell death
    Vilma A Sardao
    Center for Neurosciences and Cellular Biology, University of Coimbra, Coimbra, Portugal
    BMC Cell Biol 8:11. 2007
    ..The objective of this work was to characterize, through vital imaging, morphological alterations and the appearance of apoptotic hallmarks, with a special focus on mitochondrial changes, upon exposure of H9c2 cells to tBHP...
  5. ncbi request reprint Doxorubicin-induced cardiac mitochondrionopathy
    Kendall B Wallace
    Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth, MN 55812, USA
    Pharmacol Toxicol 93:105-15. 2003
    ....
  6. ncbi request reprint Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis
    Kendall B Wallace
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth, MN 55812, USA
    Cardiovasc Toxicol 7:101-7. 2007
    ....
  7. ncbi request reprint Serum troponins as biomarkers of drug-induced cardiac toxicity
    Kendall B Wallace
    Department of Biochemitry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Toxicol Pathol 32:106-21. 2004
  8. ncbi request reprint Mitochondrial targets of drug toxicity
    K B Wallace
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Annu Rev Pharmacol Toxicol 40:353-88. 2000
    ....
  9. ncbi request reprint Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin
    S Zhou
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Cancer Res 61:771-7. 2001
    ....
  10. ncbi request reprint Doxorubicin-induced persistent oxidative stress to cardiac myocytes
    S Zhou
    Department of Biochemistry and Molecular Biology, and Toxicology Graduate Program, School of Medicine, University of Minnesota, Duluth, MN 55812, USA
    Toxicol Lett 121:151-7. 2001
    ..This persistent generation of ROS may contribute to the cumulative and irreversible cardiotoxicity observed clinically with the drug...
  11. ncbi request reprint Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
    J A Bjork
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN, USA
    Toxicology 288:8-17. 2011
    ....
  12. ncbi request reprint Interference with calcium-dependent mitochondrial bioenergetics in cardiac myocytes isolated from doxorubicin-treated rats
    S Zhou
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth, Minnesota 55812, USA
    Toxicol Appl Pharmacol 175:60-7. 2001
    ..This interference with mitochondrial calcium regulation may underlie the pathogenesis of DOX-induced cardiomyopathy...
  13. doi request reprint Perfluorooctanoic acid stimulated mitochondrial biogenesis and gene transcription in rats
    M W Walters
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN 55812, USA
    Toxicology 264:10-5. 2009
    ..Implication of the Pgc-1alpha pathway is consistent with PPARgamma transactivation by PFOA and reveals new understanding and possibly new critical targets for assessing or averting the associated metabolic disease...
  14. ncbi request reprint Induction of the mitochondrial permeability transition in vitro by short-chain carboxylic acids
    C M Palmeira
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, Duluth 55812, USA
    Biochem Biophys Res Commun 272:431-5. 2000
    ..We conclude that induction of the MPT in vitro is a general response to short-chain carboxylic acids having a pK(a) of 4 to 5...
  15. ncbi request reprint Adriamycin-induced oxidative mitochondrial cardiotoxicity
    J M Berthiaume
    Toxicology Graduate Program, Medical School, University of Minnesota, Duluth, Minnesota 55812, USA
    Cell Biol Toxicol 23:15-25. 2007
    ..This compilation of current data may reveal valuable insights for the development of therapeutic strategies better tailored to minimizing the dose-limiting effect of ADR...
  16. ncbi request reprint Dietary vitamin E decreases doxorubicin-induced oxidative stress without preventing mitochondrial dysfunction
    J M Berthiaume
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN 55812, USA
    Cardiovasc Toxicol 5:257-67. 2005
    ....
  17. doi request reprint Urea cycle gene expression is suppressed by PFOA treatment in rats
    M W Walters
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN 55812, United States
    Toxicol Lett 197:46-50. 2010
    ..Our findings provide further evidence of the effect of PFOA on intermediary metabolism in rodents and add valuable information in assessing the potential risks of PFOA exposure...
  18. ncbi request reprint Inhibition of the adenine nucleotide translocator by N-acetyl perfluorooctane sulfonamides in vitro
    Timothy M O'Brien
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota, Medical School, 1035 University Drive, Duluth, MN 55812, USA
    Toxicol Appl Pharmacol 227:184-95. 2008
    ....
  19. pmc Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs
    Kaleb C Lund
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota Medical School Duluth, 1035 University Drive, Duluth, MN 55812, USA
    Antimicrob Agents Chemother 51:2531-9. 2007
    ..Additionally, mtDNA abundance does not necessarily correlate with metabolic disruption, especially in cell culture; careful discernment is recommended in this regard...
  20. ncbi request reprint Esterification prevents induction of the mitochondrial permeability transition by N-acetyl perfluorooctane sulfonamides
    Timothy M O'Brien
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota, Medical School, 1035 University Drive, Duluth, Minnesota 55812, USA
    Chem Res Toxicol 19:1305-12. 2006
    ..Results of this investigation demonstrate that the carboxylic acid moiety of the N-acetates is the active functional group, which triggers the MPT by perfluorinated sulfonamides...
  21. ncbi request reprint Multitrack system for superfusing isolated cardiac myocytes
    Lois Jane Heller
    Department of Physiology, School of Medicine, University of Minnesota Duluth, 1035 University Drive, Duluth, MN 55812, USA
    Am J Physiol Heart Circ Physiol 284:H1872-8. 2003
    ..The primary advantage of this system is the ability to conduct experiments on cardiac myocytes isolated concurrently from multiple experimental groups at the same time and under identical conditions...
  22. ncbi request reprint Direct, DNA pol-gamma-independent effects of nucleoside reverse transcriptase inhibitors on mitochondrial bioenergetics
    Kaleb C Lund
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota School of Medicine, Duluth, MN 55812 3031, USA
    Cardiovasc Toxicol 4:217-28. 2004
    ....
  23. ncbi request reprint Mitochondrial permeability transition as the critical target of N-acetyl perfluorooctane sulfonamide toxicity in vitro
    Timothy M O'Brien
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota School of Medicine, 1035 University Drive, Duluth, MN 55812, USA
    Toxicol Sci 82:333-40. 2004
    ..The toxicity of N-acetyl perfluorooctanyl compounds may therefore reflect the mitochondrial dysfunction, which is compounded by the ensuing oxidative injury...
  24. ncbi request reprint Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis
    Jessica Berthiaume
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota School of Medicine, 10 University Drive, Duluth, MN 55812 2496, USA
    Toxicol Lett 129:23-32. 2002
    ..These data demonstrate that acute administration of PFOS or PFOA causes hepatic peroxisome proliferation in rats. However, stimulation of mt biogenesis is not a characteristic response of all peroxisome proliferators...
  25. ncbi request reprint Persistent alterations to the gene expression profile of the heart subsequent to chronic Doxorubicin treatment
    Jessica M Berthiaume
    Toxicology Graduate Program, Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN, 55812, USA
    Cardiovasc Toxicol 7:178-91. 2007
    ..In conclusion, this comprehensive transcript profile provides important insights into critical targets and molecular adaptations that characterize the persistent cardiomyopathy associated with long-term exposure to DOX...
  26. ncbi request reprint Structural determinants of fluorochemical-induced mitochondrial dysfunction
    A A Starkov
    Department of Biochemistry and Molecular Biology, University of Minnesota School of Medicine, 10 University Drive, Duluth, Minnesota, USA
    Toxicol Sci 66:244-52. 2002
    ....
  27. doi request reprint Structure-activity relationships and human relevance for perfluoroalkyl acid-induced transcriptional activation of peroxisome proliferation in liver cell cultures
    James A Bjork
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, Minnesota 55812, USA
    Toxicol Sci 111:89-99. 2009
    ....
  28. ncbi request reprint Perfluorooctane sulfonate-induced changes in fetal rat liver gene expression
    James A Bjork
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, 1035 University Drive, Duluth, MN 55812, USA
    Toxicology 251:8-20. 2008
    ....
  29. ncbi request reprint Depletion of adenine nucleotide translocator protein in heart mitochondria from doxorubicin-treated rats--relevance for mitochondrial dysfunction
    Paulo J Oliveira
    Center for Neurosciences and Cellular Biology, Department of Zoology, University of Coimbra, P 3004 517 Coimbra, Portugal
    Toxicology 220:160-8. 2006
    ....
  30. ncbi request reprint Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis
    Carlos M Palmeira
    Center for Neurosciences and Cell Biology of Coimbra, Department of Zoology, University of Coimbra, 3004 517 Coimbra, Portugal
    Toxicol Appl Pharmacol 225:214-20. 2007
    ..The decrease of mtDNA content and inhibition of mitochondrial function may be pathogenic hallmarks in the altered metabolic status associated with diabetes...
  31. ncbi request reprint Scientific significance on the basis of the quality of mitochondrial preparations with which the experiments were performed
    Kendall B Wallace
    Toxicol Appl Pharmacol 180:64; author reply 65-6. 2002
  32. ncbi request reprint Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity
    Paulo J Oliveira
    Centre of Neurosciences and Cellular Biology of Coimbra, Department of Zoology, University of Coimbra, Portugal
    Toxicol Appl Pharmacol 200:159-68. 2004
    ..We therefore conclude that the cardioprotective effects of carvedilol against DOX-induced mitochondrial cardiotoxicity are due to its inherent antioxidant activity and not to its beta-adrenergic receptor antagonism...
  33. ncbi request reprint Calcium oxalate monohydrate, a metabolite of ethylene glycol, is toxic for rat renal mitochondrial function
    Kenneth E McMartin
    Department of Pharmacology and Therapeutics, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, Louisiana 71130 3932, USA
    Toxicol Sci 84:195-200. 2005
    ..Since COM is transported intracellularly by kidney cells, the renal toxicity of ethylene glycol may result from inhibition of mitochondrial respiratory function in proximal tubular cells by COM crystals...
  34. ncbi request reprint Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action
    Melvin E Andersen
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 102:3-14. 2008
    ..This report summarizes the discourse that occurred during the symposium...
  35. ncbi request reprint Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism
    Anabela P Rolo
    Department of Zoology, Center for Neurosciences and Cell Biology of Coimbra, University of Coimbra, 3004 517 Coimbra, Portugal
    Toxicol Lett 126:197-203. 2002
    ..Therefore, any therapeutic effect of UDCA must be secondary to some other process, such as altered membrane transport or nonparenchymal cell function...
  36. ncbi request reprint Mitochondrially mediated synergistic cell killing by bile acids
    Anabela P Rolo
    Center for Neurosciences and Cell Biology of Coimbra, Department of Zoology, University of Coimbra, 3004 517, Coimbra, Portugal
    Biochim Biophys Acta 1637:127-32. 2003
    ..Our results demonstrate that the synergistic cytotoxicity by UDCA plus CDCA is mediated by impairment of mitochondrial function, an event that is expressed via induction of the MPT...
  37. ncbi request reprint Negative bias from analog methods used in the analysis of free thyroxine in rat serum containing perfluorooctanesulfonate (PFOS)
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Toxicology 234:21-33. 2007
    ..A reference method such as ED-RIA should be used for determination of serum FT4 in the presence of PFOS...
  38. ncbi request reprint Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, MN 55144, United States
    Toxicology 243:330-9. 2008
    ..We undertook this study to investigate the causes for the PFOS-induced reduction of serum total thyroxine (TT4) in rats...
  39. ncbi request reprint Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis
    Anabela P Rolo
    Center for Neurosciences and Cell Biology of Coimbra, Department of Zoology, University of Coimbra, 3004 517 Coimbra, Portugal
    Toxicol Sci 79:196-204. 2004
    ..Consequently, as suggested by the lack of the main hallmarks of the apoptotic pathway, in the presence of UDCA, CDCA-induced apoptosis is not properly executed but degenerates into necrosis...

Research Grants12

  1. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2005
    ..abstract_text> ..
  2. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2004
    ..abstract_text> ..
  3. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2004
    ....
  4. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2003
    ..abstract_text> ..
  5. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2003
    ....
  6. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2002
    ..abstract_text> ..
  7. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2002
    ....
  8. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2001
    ....
  9. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 1999
    ....
  10. NRTI-induced Mitochondrial Cardiomyopathy
    Kendall Wallace; Fiscal Year: 2006
    ..abstract_text> ..