Lori A Walker

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice
    Lori A Walker
    University of Colorado Health Sciences Center, Department of Medicine Cardiology, Aurora, CO 80045, USA
    J Mol Cell Cardiol 48:1180-6. 2010
  2. pmc Contractile protein phosphorylation predicts human heart disease phenotypes
    Lori A Walker
    Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Heart Circ Physiol 304:H1644-50. 2013
  3. doi request reprint Tissue procurement strategies affect the protein biochemistry of human heart samples
    Lori A Walker
    Department of Medicine, Division of Cardiology, University of Colorado Denver, B139, 12700 E 19th Ave, Aurora, CO 80045, USA
    J Muscle Res Cell Motil 31:309-14. 2011
  4. pmc Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension
    Lori A Walker
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Am J Physiol Heart Circ Physiol 301:H832-40. 2011
  5. ncbi request reprint Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation
    Stephen F Thoemmes
    University of Colorado Denver, Dept of Medicine Cardiology, Aurora, CO 80045, United States
    J Immunol Methods 403:66-71. 2014
  6. pmc Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support
    Amrut V Ambardekar
    Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA
    Circ Heart Fail 4:425-32. 2011
  7. ncbi request reprint The effect of myosin regulatory light chain phosphorylation on the frequency-dependent regulation of cardiac function
    Fernando A L Dias
    Center for Cardiovascular Research, Department of Medicine, Section of Cardiology, University of Illinois at Chicago, 60612, USA
    J Mol Cell Cardiol 41:330-9. 2006
  8. pmc Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism
    Maria A Cavasin
    Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    Circ Res 110:739-48. 2012
  9. pmc Serendipitous discovery of a novel protein signaling mechanism in heart failure
    Andrea M Vitello
    University of Colorado, Department of Medicine, Division of Cardiology, Aurora, CO 80045, USA
    Biochem Biophys Res Commun 421:431-5. 2012
  10. pmc Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Nat Med 18:774-82. 2012

Collaborators

Detail Information

Publications14

  1. doi request reprint Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice
    Lori A Walker
    University of Colorado Health Sciences Center, Department of Medicine Cardiology, Aurora, CO 80045, USA
    J Mol Cell Cardiol 48:1180-6. 2010
    ..These data suggest that temporal changes in myofilament protein phosphorylation contribute both to the initial compensatory hyperdynamic response to myocardial infarction and subsequently to the gradual progression to myocardial failure...
  2. pmc Contractile protein phosphorylation predicts human heart disease phenotypes
    Lori A Walker
    Division of Cardiology, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Am J Physiol Heart Circ Physiol 304:H1644-50. 2013
    ..Defining these changes in progressive heart disease may provide important diagnostic and treatment information...
  3. doi request reprint Tissue procurement strategies affect the protein biochemistry of human heart samples
    Lori A Walker
    Department of Medicine, Division of Cardiology, University of Colorado Denver, B139, 12700 E 19th Ave, Aurora, CO 80045, USA
    J Muscle Res Cell Motil 31:309-14. 2011
    ..Overall, procurement strategies that involved maintenance of tissue in cardioplegia solution deviated most dramatically from prompt and rapid tissue immersion in liquid nitrogen...
  4. pmc Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension
    Lori A Walker
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Am J Physiol Heart Circ Physiol 301:H832-40. 2011
    ..No changes in total force or cooperativity were seen. Taken together, these results suggest that RV failure is mechanistically unique from left ventricular failure...
  5. ncbi request reprint Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation
    Stephen F Thoemmes
    University of Colorado Denver, Dept of Medicine Cardiology, Aurora, CO 80045, United States
    J Immunol Methods 403:66-71. 2014
    ..These new tools should allow a more accurate assessment and a better understanding of the role of TnI phosphorylation in the response of the heart to pathologic stress...
  6. pmc Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support
    Amrut V Ambardekar
    Division of Cardiology, University of Colorado Denver, Aurora, CO 80045, USA
    Circ Heart Fail 4:425-32. 2011
    ..We hypothesized that evaluation of myocyte contractility and biochemistry at the sarcomere level before and after LVAD may explain organ-level changes...
  7. ncbi request reprint The effect of myosin regulatory light chain phosphorylation on the frequency-dependent regulation of cardiac function
    Fernando A L Dias
    Center for Cardiovascular Research, Department of Medicine, Section of Cardiology, University of Illinois at Chicago, 60612, USA
    J Mol Cell Cardiol 41:330-9. 2006
    ....
  8. pmc Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism
    Maria A Cavasin
    Department of Medicine, Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    Circ Res 110:739-48. 2012
    ..The consequences of HDAC inhibition in the context of pulmonary hypertension with associated right ventricular cardiac remodeling are poorly understood...
  9. pmc Serendipitous discovery of a novel protein signaling mechanism in heart failure
    Andrea M Vitello
    University of Colorado, Department of Medicine, Division of Cardiology, Aurora, CO 80045, USA
    Biochem Biophys Res Commun 421:431-5. 2012
    ..Further studies are needed to elucidate the role that PDIA3 may play in the progression of heart failure...
  10. pmc Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
    Tobias Eckle
    Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado Denver, Aurora, USA
    Nat Med 18:774-82. 2012
    ....
  11. pmc Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction
    J David Port
    Division of Cardiology, Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Physiol Genomics 43:1087-95. 2011
    ....
  12. pmc The right ventricle: biologic insights and response to disease: updated
    Lori A Walker
    University of Colorado Denver, CO, USA
    Curr Cardiol Rev 9:73-81. 2013
    ..The updated version of this review now acknowledges recent advances in the understanding of metabolic, inflammatory and gender-specific influences on the right ventricle...
  13. pmc Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils
    John S Walker
    Division of Cardiology, Dept of Medicine, Univ of Colorado, Denver, Aurora CO 80045, USA
    Am J Physiol Heart Circ Physiol 301:H138-46. 2011
    ....
  14. pmc The right ventricle: biologic insights and response to disease
    Lori A Walker
    University of Colorado Denver, USA
    Curr Cardiol Rev 5:22-8. 2009
    ..This review highlights some of these features and underscores the fact that rational therapy in RV failure should acknowledge this physiology and ought to be chamber specific...