Richard T Waldron

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D
    Richard T Waldron
    Division of Digestive Diseases, Department of Medicine, UCLA David Geffen School of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, UCLA, Los Angeles, California 90095 1786, USA
    J Biol Chem 279:27482-93. 2004
  2. pmc Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D
    Richard T Waldron
    Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
    Biochem Biophys Res Commun 356:361-7. 2007
  3. ncbi request reprint The nuclear import of protein kinase D3 requires its catalytic activity
    Osvaldo Rey
    Division of Digestive Diseases, Department of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1786, USA
    J Biol Chem 281:5149-57. 2006
  4. pmc Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation
    James Sinnett-Smith
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:13434-45. 2009
  5. pmc Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq
    Richard T Waldron
    David Geffen School of Medicine, Department of Medicine, Division of Digestive Diseases, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, USA
    Cell Signal 24:914-21. 2012
  6. pmc Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation
    Rodrigo Jacamo
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:12877-87. 2008
  7. ncbi request reprint Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus
    Cliff Hurd
    Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, School of Medicine and Molecular Biology Institute, University of California, Los Angeles, California, CA 90095 1786, USA
    Oncogene 21:2154-60. 2002
  8. ncbi request reprint Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain
    Richard T Waldron
    Division of Digestive Diseases, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1786, USA
    J Biol Chem 278:154-63. 2003
  9. doi request reprint Protein kinase D isozymes activation and localization during mitosis
    Romeo Papazyan
    Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 90095 1786, USA
    Exp Cell Res 314:3057-68. 2008
  10. pmc CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway
    Eugenia Torres-Marquez
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE, Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095 1786, USA
    Biochem Biophys Res Commun 391:63-8. 2010

Research Grants

  1. OXIDATIVE SIGNALING THROUGH PROTEIN KINASE D
    Richard Waldron; Fiscal Year: 2003
  2. Oxidation Signaling via Protein Kinase D/Jun in GI Cells
    Richard Waldron; Fiscal Year: 2007

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Oxidative stress induces protein kinase C-mediated activation loop phosphorylation and nuclear redistribution of protein kinase D
    Richard T Waldron
    Division of Digestive Diseases, Department of Medicine, UCLA David Geffen School of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, UCLA, Los Angeles, California 90095 1786, USA
    J Biol Chem 279:27482-93. 2004
    ..Taken together, these results indicate that PKC-mediated PKD Ser(744) and Ser(748) phosphorylation induced by oxidative stress integrates PKD activation with redistribution to the nucleus...
  2. pmc Identification of a novel phosphorylation site in c-jun directly targeted in vitro by protein kinase D
    Richard T Waldron
    Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
    Biochem Biophys Res Commun 356:361-7. 2007
    ..These data were further supported by kinase reactions using truncations or point-mutations of GST-c-jun. Together, these data suggest that PKD-mediated phosphorylation modulates c-jun at the level of its N-terminal functional domains...
  3. ncbi request reprint The nuclear import of protein kinase D3 requires its catalytic activity
    Osvaldo Rey
    Division of Digestive Diseases, Department of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1786, USA
    J Biol Chem 281:5149-57. 2006
    ....
  4. pmc Protein kinase D mediates mitogenic signaling by Gq-coupled receptors through protein kinase C-independent regulation of activation loop Ser744 and Ser748 phosphorylation
    James Sinnett-Smith
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:13434-45. 2009
    ..Thus, our results identify a novel mechanism of G(q)-coupled receptor-induced mitogenesis mediated by sustained PKD activation through a PKC-independent pathway...
  5. pmc Differential PKC-dependent and -independent PKD activation by G protein α subunits of the Gq family: selective stimulation of PKD Ser⁷⁴⁸ autophosphorylation by Gαq
    Richard T Waldron
    David Geffen School of Medicine, Department of Medicine, Division of Digestive Diseases, CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, USA
    Cell Signal 24:914-21. 2012
    ..Taken together, our results suggest that Gαq, but not the closely related Gα11, promotes PKD activation in response to GPCR ligands in a unique manner leading to PKD autophosphorylation at Ser⁷⁴⁸...
  6. pmc Sequential protein kinase C (PKC)-dependent and PKC-independent protein kinase D catalytic activation via Gq-coupled receptors: differential regulation of activation loop Ser(744) and Ser(748) phosphorylation
    Rodrigo Jacamo
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:12877-87. 2008
    ..The present studies identify a novel mechanism induced by GPCR activation that leads to late, PKC-independent PKD activation...
  7. ncbi request reprint Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminus
    Cliff Hurd
    Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, School of Medicine and Molecular Biology Institute, University of California, Los Angeles, California, CA 90095 1786, USA
    Oncogene 21:2154-60. 2002
    ....
  8. ncbi request reprint Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain
    Richard T Waldron
    Division of Digestive Diseases, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1786, USA
    J Biol Chem 278:154-63. 2003
    ..These studies provide evidence of a direct PKCepsilon-PKD phosphorylation cascade and provide additional insight into the activation mechanism...
  9. doi request reprint Protein kinase D isozymes activation and localization during mitosis
    Romeo Papazyan
    Unit of Signal Transduction and Gastrointestinal Cancer, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 90095 1786, USA
    Exp Cell Res 314:3057-68. 2008
    ..Thus, this study reveals a connection between the PKD isozymes and cell division, suggesting a novel role for this family of serine/threonine kinases...
  10. pmc CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway
    Eugenia Torres-Marquez
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, CURE, Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095 1786, USA
    Biochem Biophys Res Commun 391:63-8. 2010
    ....
  11. ncbi request reprint Protein kinase D signaling
    Enrique Rozengurt
    Department of Medicine, UCLA CURE Digestive Diseases Research Center and Molecular Biology Institute, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 280:13205-8. 2005
  12. pmc The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins
    Ying Wang
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095, USA
    Mol Cell Biol 22:916-26. 2002
    ..These data suggest that the normal localization and function of RIN1, as well as its ability to compete with RAF, are regulated in part by 14-3-3 binding, which in turn is controlled by PKD phosphorylation...
  13. pmc Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis
    Natalia Shalbueva
    Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California at Los Angeles, Southern California Research Center for Alcoholic Liver and Pancreatic Disease and Cirrhosis, Los Angeles, California 90073, USA
    Gastroenterology 144:437-446.e6. 2013
    ..We investigated the effects of ethanol on the pancreatic MPTP, the mechanisms of these effects, and their role in pancreatitis...

Research Grants3

  1. OXIDATIVE SIGNALING THROUGH PROTEIN KINASE D
    Richard Waldron; Fiscal Year: 2003
    ..abstract_text> ..
  2. Oxidation Signaling via Protein Kinase D/Jun in GI Cells
    Richard Waldron; Fiscal Year: 2007
    ..Successful completion of these aims will improve our understanding of normal and pathological signaling mechanisms in the Gl tract, allowing us to pinpoint new targets for therapy. ..