A Wald

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
    A Wald
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Clin Invest 99:1092-7. 1997
  2. ncbi Genital shedding of herpes simplex virus among men
    Anna Wald
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 186:S34-9. 2002
  3. ncbi Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture
    Anna Wald
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 188:1345-51. 2003
  4. ncbi Oral shedding of herpes simplex virus type 2
    A Wald
    University of Washington Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122, USA
    Sex Transm Infect 80:272-6. 2004
  5. ncbi Herpes simplex virus type 2 transmission: risk factors and virus shedding
    Anna Wald
    University of Washington, Virology Research Clinic, Seattle, WA 98122, USA
    Herpes 11:130A-137A. 2004
  6. ncbi Synergistic interactions between herpes simplex virus type-2 and human immunodeficiency virus epidemics
    Anna Wald
    Department of Medicine, Epidemiology and Laboratory Medicine, University of Washington, Seattle, WA, USA
    Herpes 11:70-6. 2004
  7. ncbi Two-day regimen of acyclovir for treatment of recurrent genital herpes simplex virus type 2 infection
    Anna Wald
    Departments of Medicine, Epidemiology, and Laboratory Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:944-8. 2002
  8. ncbi The relationship between condom use and herpes simplex virus acquisition
    Anna Wald
    University of Washington, Virology Research Clinic, Seattle, Washington 98122, USA
    Ann Intern Med 143:707-13. 2005
  9. ncbi Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis
    Anna Wald
    Department of Medicine, Epidemiology, and Laboratory Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 185:45-52. 2002
  10. ncbi Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women
    A Wald
    University of Washington, Virology Research Clinic, 1001 Broadway, Suite 320, Seattle, WA 98122, USA
    JAMA 285:3100-6. 2001

Research Grants

  1. Treatment of Acute Hepatitis C in Injection Drug Users
    Anna Wald; Fiscal Year: 2005
  2. Clinical Research in HSV Infections
    Anna Wald; Fiscal Year: 2007

Detail Information

Publications124 found, 100 shown here

  1. ncbi Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
    A Wald
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Clin Invest 99:1092-7. 1997
    ..HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide...
  2. ncbi Genital shedding of herpes simplex virus among men
    Anna Wald
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 186:S34-9. 2002
    ..4; 95% confidence interval, 1.2-15.3). The frequency of viral shedding in men with genital herpes appears comparable with that in women...
  3. ncbi Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture
    Anna Wald
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 188:1345-51. 2003
    ..In home-collected specimens, the ratio of PCR positivity to viral-culture positivity rose from 3.8:1 in the winter to 8.8:1 in the summer months, reflecting the lability of viral-culture specimens transported during warm weather...
  4. ncbi Oral shedding of herpes simplex virus type 2
    A Wald
    University of Washington Virology Research Clinic, 600 Broadway, Suite 400, Seattle, WA 98122, USA
    Sex Transm Infect 80:272-6. 2004
    ..Herpes simplex virus (HSV) 1 and HSV-2 reactivate preferentially in the oral and genital area, respectively. We aimed to define frequency and characteristics associated with oral shedding of HSV-2...
  5. ncbi Herpes simplex virus type 2 transmission: risk factors and virus shedding
    Anna Wald
    University of Washington, Virology Research Clinic, Seattle, WA 98122, USA
    Herpes 11:130A-137A. 2004
    ..Clinical history is a poor predictor of HSV-2 infection and type-specific serological testing is recommended to detect HSV-2 seropositivity...
  6. ncbi Synergistic interactions between herpes simplex virus type-2 and human immunodeficiency virus epidemics
    Anna Wald
    Department of Medicine, Epidemiology and Laboratory Medicine, University of Washington, Seattle, WA, USA
    Herpes 11:70-6. 2004
    ....
  7. ncbi Two-day regimen of acyclovir for treatment of recurrent genital herpes simplex virus type 2 infection
    Anna Wald
    Departments of Medicine, Epidemiology, and Laboratory Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 34:944-8. 2002
    ..001), and viral shedding (25 hours versus 58.5 hours; P=.04), and it increased the proportion of aborted episodes (P=.029). A 2-day course of acyclovir is a convenient alternative for treatment of recurrent genital herpes...
  8. ncbi The relationship between condom use and herpes simplex virus acquisition
    Anna Wald
    University of Washington, Virology Research Clinic, Seattle, Washington 98122, USA
    Ann Intern Med 143:707-13. 2005
    ..Few studies have evaluated the relationship between condom use and herpes simplex virus type 2 (HSV-2) and HSV type 1 (HSV-1) acquisition...
  9. ncbi Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis
    Anna Wald
    Department of Medicine, Epidemiology, and Laboratory Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 185:45-52. 2002
    ..1-5.1), but the temporal sequence of the 2 infections cannot be documented. Control strategies for HSV-2 need to be incorporated into control of sexually transmitted infections as a strategy for HIV prevention...
  10. ncbi Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women
    A Wald
    University of Washington, Virology Research Clinic, 1001 Broadway, Suite 320, Seattle, WA 98122, USA
    JAMA 285:3100-6. 2001
    ..Herpes simplex virus type 2 (HSV-2) is one of the most common sexually transmitted infections in the United States. No prospective study has shown the ability of condoms to reduce transmission of HSV-2...
  11. ncbi Comparative efficacy of famciclovir and valacyclovir for suppression of recurrent genital herpes and viral shedding
    Anna Wald
    Department of Medicine, School of Medicine and School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 33:529-33. 2006
    ..However, few comparative studies between the 2 antivirals have been performed...
  12. ncbi Knowledge of partners' genital herpes protects against herpes simplex virus type 2 acquisition
    Anna Wald
    Department of Medicine, University of Washington Virology Research Clinic, Seattle, Washington, USA
    J Infect Dis 194:42-52. 2006
    ..However, unlike partners with genital herpes in prospectively monitored couples, most persons who transmit genital herpes are not aware of having the infection...
  13. ncbi Safety and immunogenicity of long HSV-2 peptides complexed with rhHsc70 in HSV-2 seropositive persons
    Anna Wald
    Department of Medicine, University of Washington, Seattle, WA, USA
    Vaccine 29:8520-9. 2011
    ....
  14. ncbi Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons
    A Wald
    Department of Medicine, University of Washington, Seattle 98122, USA
    N Engl J Med 342:844-50. 2000
    ..Historically, it has been assumed that these persons have less frequent viral reactivation than those with symptomatic infection...
  15. ncbi New therapies and prevention strategies for genital herpes
    A Wald
    Department of Medicine and Epidemiology, University of Washington, Seattle 98122, USA
    Clin Infect Dis 28:S4-13. 1999
    ..Further research is needed to define strategies to prevent the spread of this epidemic infection...
  16. ncbi Serological testing for herpes simplex virus (HSV)-1 and HSV-2 infection
    Anna Wald
    Department of Medicine, University of Washington, Virology Research Clinic, Seattle, WA, USA
    Clin Infect Dis 35:S173-82. 2002
    ..Potential settings for use of these tests include sexually transmitted disease clinics, prenatal clinics, and clinics that care for patients with human immunodeficiency virus. Patient interest in HSV serological tests appears high...
  17. ncbi Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
    C Celum
    Department of Global Health, University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359927, Seattle, WA 98104, USA
    N Engl J Med 362:427-39. 2010
    ..Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1...
  18. ncbi Oral mucosal reactivation rates of herpesviruses among HIV-1 seropositive persons
    Elizabeth Griffin
    University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98122, USA
    J Med Virol 80:1153-9. 2008
    ..These data suggest that separate factors influence mucosal shedding of each of the three classes of herpesviruses but that virological interactions between the pathogens also exist...
  19. ncbi High risk of human immunodeficiency virus in men who have sex with men with herpes simplex virus type 2 in the EXPLORE study
    E L Brown
    Department of Epidemiology, University of Washington, Seattle, 98104, USA
    Am J Epidemiol 164:733-41. 2006
    ..5, 95% CI: 1.1, 2.1) infection compared with HSV-2 seronegative participants. HIV intervention strategies targeting HSV-2 prevention and suppression among men who have sex with men should be evaluated...
  20. ncbi Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5272. 2009
    ..We describe the baseline characteristics of this cohort...
  21. ncbi Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    Jia Zhu
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 15:886-92. 2009
    ..The persistence and enrichment of HIV receptor-positive inflammatory cells in the genitalia help explain the inability of anti-HSV-2 therapy to reduce HIV acquisition...
  22. ncbi Famciclovir reduces viral mucosal shedding in HSV-seropositive persons
    Peter Leone
    University of North Carolina, Chapel Hill, NC 27599 7030, USA
    Sex Transm Dis 34:900-7. 2007
    ..This study explores whether famciclovir reduces HSV shedding in HSV-2 seropositive persons with or without a history of symptomatic genital herpes...
  23. ncbi Demographic rather than behavioral risk factors predict herpes simplex virus type 2 infection in sexually active adolescents
    G Sucato
    Department of Pediatrics, Robert Wood Johnson Clinical Scholars Program, University of Washington, Seattle, USA
    Pediatr Infect Dis J 20:422-6. 2001
    ..These data suggest that type-specific serologic testing for HSV-2 infection should be considered in sexually active adolescents. Prevention efforts should target children before initiation of sexual activity...
  24. ncbi Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
    Jairam R Lingappa
    Department of Global Health, Seattle, WA, USA
    Lancet 375:824-33. 2010
    ..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression...
  25. ncbi Testing for genital herpes: how, who, and why
    Anna Wald
    University of Washington School of Medicine, Virology Research Clinic, Seattle, Washington, USA
    Curr Clin Top Infect Dis 22:166-80. 2002
  26. ncbi Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
    ..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity...
  27. ncbi Effect of acyclovir on HIV-1 set point among herpes simplex virus type 2-seropositive persons during early HIV-1 infection
    H Nina Kim
    Department of Medicine, Schools of Medicine and Public Health, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Infect Dis 202:734-8. 2010
    ..In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point...
  28. ncbi One-day regimen of valacyclovir for treatment of recurrent genital herpes simplex virus 2 infection
    Joseph B Bavaro
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 35:383-6. 2008
    ..To evaluate the efficacy of a 1-day course of valacyclovir in reducing the duration and severity of genital herpes recurrences and to measure the frequency of viral shedding episodes subsequent to antiviral therapy...
  29. ncbi Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 54:482-8. 2010
    ..To determine whether rapidly cleared episodes of herpes simplex virus (HSV) reactivation occur in HIV-infected adults...
  30. ncbi Effect of maternal herpes simplex virus (HSV) serostatus and HSV type on risk of neonatal herpes
    Elizabeth L Brown
    Department of Epidemiology, University of Washington, Seattle, WA 98122, USA, and Department of Pediatrics, Karolinska University Hospital, Stockholm, Sweden
    Acta Obstet Gynecol Scand 86:523-9. 2007
    ..We have conducted pooled analyses of data from 3 cohorts to evaluate the effects of maternal HSV serostatus and HSV type on risk of neonatal HSV acquisition and severity...
  31. ncbi Valacyclovir for the suppression of recurrent genital herpes in human immunodeficiency virus-infected subjects
    Edwin DeJesus
    Infectious Disease Consultants, Altamonte Springs, Florida 32701, USA
    J Infect Dis 188:1009-16. 2003
    ..There were no episodes of thrombotic microangiopathy. Valacyclovir was safe and effective for the suppression of recurrent genital herpes infection in HIV-infected individuals...
  32. ncbi Herpes simplex virus type 1 as a cause of genital herpes: impact on surveillance and prevention
    W E Lafferty
    Dept of Health Services, University of Washington, Seattle, WA 98195 7660, USA
    J Infect Dis 181:1454-7. 2000
    ..Genital HSV-1 may often be acquired through contact with a partner's mouth. These data suggest that seroprevalence studies based solely on HSV-2 type-specific assays underestimate overall prevalence of genital HSV infection...
  33. ncbi Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
    Joshua T Schiffer
    Department of Medicine, Laboratory Medicine, Global Health Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:18973-8. 2010
    ..The model suggests that the rate of containment of infected cells by the peripheral mucosal immune system is the major driver of duration and severity of HSV-2 reactivation in the immunocompetent host...
  34. ncbi Development and use of a type-specific antibody avidity test based on herpes simplex virus type 2 glycoprotein G
    Rhoda Ashley Morrow
    Department of Laboratory Medicine, The University of Washington, Seattle, Washington, USA
    Sex Transm Dis 31:508-15. 2004
    ..It is difficult to discriminate between lesions resulting from recently acquired versus established genital herpes simplex virus type 2 (HSV-2) infection. Methods not based on history or serum IgM status are needed...
  35. ncbi Healthcare seeking and sexual behavior among patients with symptomatic newly acquired genital herpes
    Julie Richards
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 35:1015-21. 2008
    ..An improved understanding of this relationship provides insight into the experience of having genital herpes and has implications for counseling...
  36. ncbi Clinical correlates of herpes simplex virus viremia among hospitalized adults
    William R Berrington
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Clin Infect Dis 49:1295-301. 2009
    ..Quantification of herpes simplex virus (HSV) DNA in the peripheral blood is often used to evaluate patients suspected of having disseminated HSV infection. Few studies have examined the clinical correlates of HSV viremia among adults...
  37. ncbi Transferred herpes simplex virus immunity after stem-cell transplantation: clinical implications
    W Garrett Nichols
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue N, D3 100, Seattle, WA 98109 4417, USA
    J Infect Dis 187:801-8. 2003
    ..Serological testing of donors can identify patients who are at highest risk for HSV-related morbidity, for whom prolonged prophylaxis or donor vaccination (once available) could be considered...
  38. ncbi Time course of seroconversion by HerpeSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2
    Rhoda Ashley-Morrow
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 30:310-4. 2003
    ..HerpeSelect HSV-1 and HSV-2 ELISAs are glycoprotein G-based, type-specific antibody detection tests that are approved by the US Food and Drug Administration for diagnosis of genital herpes...
  39. ncbi Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
    ..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
  40. ncbi The psychosocial impact of serological herpes simplex type 2 testing in an urban HIV clinic
    J L Meyer
    University of Washington, Department of Epidemiology, USA
    Sex Transm Infect 81:309-15. 2005
    ..Concerns about psychosocial burden should not deter serological testing for HSV-2. Given the epidemiological and clinical interaction between HSV-2 and HIV, these data support routine HSV-2 testing of HIV infected people...
  41. ncbi Use of the designation "shedder" in mucosal detection of herpes simplex virus DNA involving repeated sampling
    A S Magaret
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    Sex Transm Infect 85:270-5. 2009
    ..We evaluated two methods to describe detection of herpes simplex virus (HSV) from the genital mucosa...
  42. ncbi Herpes simplex virus: the importance of asymptomatic shedding
    D M Koelle
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Antimicrob Chemother 45:1-8. 2000
    ..However, some shedding episodes remain truly asymptomatic even after patient education. Antiviral therapy dramatically reduces asymptomatic shedding, and trials to evaluate its effect on HSV transmission are underway...
  43. ncbi Persistent Kaposi sarcoma in the era of highly active antiretroviral therapy: characterizing the predictors of clinical response
    Huong Q Nguyen
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    AIDS 22:937-45. 2008
    ..To evaluate the role of highly active antiretroviral therapy and chemotherapy on tumor response among persons with AIDS-related Kaposi sarcoma and identify factors associated with response in a clinic setting...
  44. ncbi Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan children
    Soren Gantt
    Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Blood Cancer 54:670-4. 2010
    ..Kaposi sarcoma (KS) is one of the most common pediatric cancers in sub-Saharan Africa. Few data are available about the clinical presentation or response to treatment of children with epidemic (HIV-associated) KS...
  45. ncbi Genital herpes
    Rachna Gupta
    Department of Medicine, University of Washington, Seattle, USA
    Lancet 370:2127-37. 2007
    ..Antiviral treatment of the infected partners and condom use reduce the risk of sexual transmission of HSV-2...
  46. ncbi Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa
    Sunitha Tata
    Vaccine and Infectious Disease Institute, University of Washington, Seattle, USA
    J Infect Dis 201:499-504. 2010
    ..Genital shedding of herpes simplex virus (HSV) type 2 occurs frequently. Anatomic patterns of genital HSV-2 reactivation have not been intensively studied...
  47. ncbi Longitudinal study of herpes simplex virus type 2 infection using viral dynamic modelling
    Catherine M Crespi
    Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA 90095 1772, USA
    Sex Transm Infect 83:359-64. 2007
    ..We conducted a longitudinal study of HSV-2 infection to quantify rates of change in HSV-2 reactivation, mucosal shedding and recurrences of genital lesions, using a newly available model of HSV within-host dynamics...
  48. ncbi HIV prevalence, previous HIV testing, and condom use with clients and regular partners among Senegalese commercial sex workers
    C Wang
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98103, USA
    Sex Transm Infect 83:534-40. 2007
    ....
  49. ncbi HIV serodiscordant sex partners and the prevalence of human herpesvirus 8 infection among HIV negative men who have sex with men: baseline data from the EXPLORE Study
    C Casper
    Department of Medicine, The University of Washington, Seattle, WA, USA
    Sex Transm Infect 82:229-35. 2006
    ..We sought to determine whether oral or anogenital contact with HIV discordant, or unknown serostatus sexual partners is associated with HHV-8 seroprevalence among HIV negative MSM...
  50. ncbi Genital herpes: antiviral therapy for symptom relief and prevention of transmission
    Rachna Gupta
    Department of Medicine, University of Washington, Virology Research Clinic, Seattle, WA 98122, USA
    Expert Opin Pharmacother 7:665-75. 2006
    ..The factors influencing the choice of therapy, such as cost, ease of dosing and acyclovir resistance are also discussed...
  51. ncbi Maternal herpes simplex virus antibody avidity and risk of neonatal herpes
    Elizabeth L Brown
    Department of Epidemiology, University of Washington, Seattle, WA 98122, USA
    Am J Obstet Gynecol 195:115-20. 2006
    ..Among women with herpes simplex virus antibody at delivery, low antibody avidity was associated with herpes simplex virus transmission to the neonate and may be a useful marker for recent seroconversion...
  52. ncbi Isolation of herpes simplex virus from the genital tract during symptomatic recurrence on the buttocks
    Katrina Kerkering
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Obstet Gynecol 108:947-52. 2006
    ..Patients with buttock herpes recurrences should be instructed about the risk of genital shedding during such recurrences. LEVEL OF EVIDENCE: II-2...
  53. ncbi Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
    Jia Zhu
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:595-603. 2007
    ..These findings indicate that the frequency and clinical course of HSV-2 reactivation in humans is influenced by virus-specific CD8(+) T cells that persist in peripheral mucosa and genital skin after resolution of herpes lesions...
  54. ncbi HSV-2 serologic testing in an HMO population: uptake and psychosocial sequelae
    Julie Richards
    Department of Medicine, University of Washington, Seattle, WA, USA
    Sex Transm Dis 34:718-25. 2007
    ..To prospectively measure the uptake of Herpes simplex virus Type 2 (HSV-2) testing and psychosocial response to a new serologic diagnosis of HSV-2 in a health maintenance organization (HMO) population...
  55. ncbi Use of long-term suppressive acyclovir after hematopoietic stem-cell transplantation: impact on herpes simplex virus (HSV) disease and drug-resistant HSV disease
    Veronique Erard
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Infect Dis 196:266-70. 2007
    ..2% [95% CI, 0%-0.8%]; P=.006), and in 0 patients in cohort 3 (cohort 2 vs. cohort 3, P=.3). Long-term use of suppressive prophylactic ACV appears to prevent the emergence of drug-resistant HSV disease in HCT...
  56. ncbi Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA
    J Infect Dis 196:505-9. 2007
    ..02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection...
  57. ncbi Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system
    Ashok Cattamanchi
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Clin Vaccine Immunol 15:1638-43. 2008
    ..A DNA-based vaccination strategy against HSV-2 appears to be safe and may generate a vaccine-specific cellular immune response, but high vaccine doses are likely needed to elicit an immune response in most vaccinees...
  58. ncbi A randomized controlled trial of a replication defective (gH deletion) herpes simplex virus vaccine for the treatment of recurrent genital herpes among immunocompetent subjects
    Guy de Bruyn
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Vaccine 24:914-20. 2006
    ..4%, respectively). CONCLUSION: This replication incompetent HSV-2 vaccine lacking the glycoprotein H gene was safe but had no clinical or virologic benefit in the amelioration of genital HSV-2 disease among immunocompetent men and women...
  59. ncbi Genital herpes and human immunodeficiency virus: double trouble
    Connie Celum
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA
    Bull World Health Organ 82:447-53. 2004
    ....
  60. ncbi Acyclovir sensitivity of sequential herpes simplex virus type 2 isolates from the genital mucosa of immunocompetent women
    Rachna Gupta
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 192:1102-7. 2005
    ..To understand the frequency and clinical significance of acyclovir-resistant isolates, we evaluated the in vitro acyclovir sensitivities of sequential isolates from 34 immunocompetent women...
  61. ncbi Clinical correlates of index values in the focus HerpeSelect ELISA for antibodies to herpes simplex virus type 2 (HSV-2)
    Rhoda Ashley Morrow
    University of Washington, Department of Laboratory Medicine, USA
    J Clin Virol 36:141-5. 2006
    ..Clinical correlates of HerpeSelect ELISA index values are poorly understood...
  62. ncbi Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus
    David M Koelle
    Department of Medicine, Department of Laboratory Medicine, and Department of Pathobiology, University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 110:537-48. 2002
    ..The evaluation of vaccines for skin and mucosal pathogens should include study of the induction of appropriate tissue-specific homing molecules...
  63. ncbi HHV-8 infection: a model for reactivation and transmission
    Lawrence Corey
    Department of Medicine, Laboratory Medicine and Epidemiology, University of Washington, Seattle, WA, USA
    Rev Med Virol 12:47-63. 2002
    ..Hopefully continued study will address many of the critical questions that exist today regarding how this infection is transmitted and acquired...
  64. ncbi Correlates of human herpesvirus-8 seropositivity among U.S. military members recently infected with human immunodeficiency virus
    Nancy F Crum
    Department of Medicine, Infectious Diseases Division, Naval Medical Center San Diego, San Diego, California 92134 1005, USA
    Sex Transm Dis 30:713-8. 2003
    ..Human herpesvirus 8 (HHV-8), the cause of Kaposi's sarcoma, is common among HIV-infected persons. The exact route of transmission of HHV-8 in various populations is still debated...
  65. ncbi Genital herpes: review of the epidemic and potential use of type-specific serology
    R L Ashley
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    Clin Microbiol Rev 12:1-8. 1999
    ....
  66. ncbi Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:12899-904. 2003
    ..We conclude that among circulating cells expressing a homing-associated receptor, during chronic herpes type 2 infection, the CD8 T cell response becomes quite focused despite the presence of many potential antigenic peptides...
  67. ncbi Rapid polymerase chain reaction assay to detect herpes simplex virus in the genital tract of women in labor
    Carolyn Gardella
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195, USA
    Obstet Gynecol 115:1209-16. 2010
    ..To develop a rapid quantitative real-time polymerase chain reaction (PCR) to detect herpes simplex virus (HSV) in the genital secretions of women that may be used in labor...
  68. ncbi Correlates of prevalent and incident Kaposi's sarcoma-associated herpesvirus infection in men who have sex with men
    Corey Casper
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Infect Dis 185:990-3. 2002
    ..Reporting > or =1 HIV-positive partner (OR, 5.9; 95% CI, 1.8-19.3), amyl nitrite use (OR, 7.0; 95% CI, 2.1-23.0), and lymphadenopathy in the past 6 months (OR, 7.7; 95% CI, 1.9-31.0) correlated with KSHV seroconversion...
  69. ncbi Prenatal herpes simplex virus serologic screening beliefs and practices among obstetricians
    Carolyn Gardella
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98119, USA
    Obstet Gynecol 110:1364-70. 2007
    ..To describe the beliefs and practices of obstetricians related to prenatal serologic testing for HSV infection...
  70. ncbi Internet and email use among STD clinic patients
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    Sex Transm Dis 35:960-5. 2008
    ..Little data exist on Internet and email use among STD clinic patients for research and clinical care communication...
  71. ncbi Type-specific testing for herpes simplex virus
    Lara Strick
    Seattle HIV Prevention Trials Unit, 901 Boren Ave, Suite 1300, Seattle, WA 98104, USA
    Expert Rev Mol Diagn 4:443-53. 2004
    ..Populations appropriate for type-specific serologic testing for HSV include people with an uncertain clinical diagnosis, high-risk patients, partners of an HSV-infected individual, HIV-infected individuals and pregnant women...
  72. ncbi The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics
    Lawrence Corey
    Department of Medicine, University of Washington Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 35:435-45. 2004
    ....
  73. ncbi Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial
    Connie Celum
    Department of Global Health, University of Washington, Seattle, WA, USA
    Lancet 371:2109-19. 2008
    ..We investigated whether HSV-2 suppression with aciclovir would reduce the risk of HIV-1 acquisition...
  74. ncbi Impact of HIV infection and Kaposi sarcoma on human herpesvirus-8 mucosal replication and dissemination in Uganda
    Christine Johnston
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e4222. 2009
    ..Human herpesvirus-8 (HHV-8) replication is important both in transmission of HHV-8 and progression to KS. We characterized the sites and frequency of HHV-8 detection in Ugandans with and without HIV and KS...
  75. ncbi Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples
    Jared M Baeten
    University of Washington, WA, USA
    AIDS 24:737-44. 2010
    ....
  76. ncbi A pooled analysis of the effect of condoms in preventing HSV-2 acquisition
    Emily T Martin
    Departments of Epidemiology, University of Washington, Seattle, USA
    Arch Intern Med 169:1233-40. 2009
    ..The degree of effectiveness of condom use in preventing the transmission of herpes simplex virus 2 (HSV-2) is uncertain. To address this issue, we performed a large pooled analysis...
  77. ncbi Prevalence and risk factors for infection with herpes simplex virus type-1 and -2 among lesbians
    Jeanne M Marrazzo
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 30:890-5. 2003
    ..Sexual transmission of bacterial and viral sexually transmitted disease has been reported between women. No data are available on seroprevalence of herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) among lesbians...
  78. ncbi Case report: symptomatic oral herpes simplex virus type 2 and asymptomatic genital shedding
    Laura Olin
    Department of Medicine, University of Washington, Seattle, WA 98122, USA
    Herpes 13:25-6. 2006
    ..During a symptomatic oral recurrence, HSV-2 was found in a perioral lesion as well as in the genital area...
  79. ncbi Influenza-associated cystic fibrosis pulmonary exacerbations
    Justin R Ortiz
    Division of Pulmonary and Critical Care Medicine, University of Washington Medical Center, Box 356522, 1959 NE Pacific St, Seattle, WA 98195 6522, USA
    Chest 137:852-60. 2010
    ..Although cystic fibrosis (CF) is the most common inherited respiratory disease, the burden of influenza among individuals with CF is not well characterized...
  80. ncbi Poor correlation between genital lesions and detection of herpes simplex virus in women in labor
    Carolyn Gardella
    Department of Obstetrics and Gynecology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98195 6460, USA
    Obstet Gynecol 106:268-74. 2005
    ..To estimate the accuracy of clinical diagnosis of genital herpes for herpes simplex virus (HSV) detection among women in labor...
  81. ncbi Assessment of a combined testing strategy for detection of antibodies to human herpesvirus 8 (HHV-8) in persons with Kaposi's sarcoma, persons with asymptomatic HHV-8 infection, and persons at low risk for HHV-8 infection
    Corey Casper
    Department of Medicine, Virology Research Clinic, University of Washington School of Medicine, Box 359928, Seattle, WA 98195, USA
    J Clin Microbiol 40:3822-5. 2002
    ..15 to 0.35) where there was considerable overlap between HHV-8-infected and uninfected individuals. The sensitivity of the testing strategy was 88%, with a specificity of 97%...
  82. ncbi Valganciclovir for suppression of human herpesvirus-8 replication: a randomized, double-blind, placebo-controlled, crossover trial
    Corey Casper
    Department of Medicine, University of Washington, Washington, USA
    J Infect Dis 198:23-30. 2008
    ..In vitro and observational studies suggest that ganciclovir inhibits HHV-8 replication, but no randomized clinical trials have been conducted...
  83. ncbi The acceptance of HSV-testing partners of HSV-2 seronegative pregnant women
    Carolyn Gardella
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
    Sex Transm Dis 36:211-5. 2009
    ..To estimate the acceptance of HSV testing partners of HSV seronegative pregnant women and identify associated factors...
  84. ncbi Remission of HHV-8 and HIV-associated multicentric Castleman disease with ganciclovir treatment
    Corey Casper
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Blood 103:1632-4. 2004
    ..These data provide in vivo evidence for the utility of antiviral agents against HHV-8 in the management of MCD...
  85. ncbi Management of herpes simplex virus type 2 infection in HIV type 1-infected persons
    Lara B Strick
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98104, USA
    Clin Infect Dis 43:347-56. 2006
    ..Studies to quantify the potential clinical and public health benefits of treating individuals who have HIV-1 and HSV-2 coinfection with anti-HSV therapy are underway...
  86. ncbi Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial
    Jared M Baeten
    Department of Global Health, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 198:1804-8. 2008
    ..001]), as was cervical HIV-1 level (-0.35 log10 copies/swab, a 55% decrease [P < .001]). Suppressive HSV-2 therapy has the potential to reduce HIV-1 infectiousness and slow HIV-1 disease progression...
  87. ncbi Genital herpes complicating pregnancy
    Zane A Brown
    Department of Obstetrics and Gynecology, Laboratory Medicine, Medicine and Epidemiology, University of Washington, Seattle, 98195 6460, USA
    Obstet Gynecol 106:845-56. 2005
    ....
  88. ncbi Differentiation of herpes simplex virus types 1 and 2 in clinical samples by a real-time taqman PCR assay
    Lawrence Corey
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109, USA
    J Med Virol 76:350-5. 2005
    ..6% of clinical samples using the new typing assay. This assay, when used in combination with the type common assay, can now accurately type almost all mucosal and visceral HSV isolates by molecular techniques...
  89. ncbi Hepatitis C virus is infrequently evaluated and treated in an urban HIV clinic population
    John D Scott
    Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
    AIDS Patient Care STDS 23:925-9. 2009
    ..Further efforts to identify and to overcome barriers to HCV treatment are warranted...
  90. ncbi Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant
    Zane A Brown
    Department of Obstetrics and Gynecology, University of Washington, Box 356460, Seattle, WA 98195 6460, USA
    JAMA 289:203-9. 2003
    ..Furthermore, no data exist on whether cesarean delivery, the standard of care for women with genital herpes lesions at the time of delivery, reduces HSV transmission...
  91. ncbi T cell immunity to herpes simplex viruses in seronegative subjects: silent infection or acquired immunity?
    Christine M Posavad
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98104, USA
    J Immunol 170:4380-8. 2003
    ..Understanding the basis of these acquired immune responses may be critical in developing effective vaccines for genital herpes...
  92. ncbi Risk factors for herpes simplex virus transmission to pregnant women: a couples study
    Carolyn Gardella
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Am J Obstet Gynecol 193:1891-9. 2005
    ..This study was undertaken to determine risk factors for herpes simplex virus (HSV) acquisition among at risk pregnant women...
  93. ncbi APOE genotype is associated with oral herpetic lesions but not genital or oral herpes simplex virus shedding
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98102, USA
    Sex Transm Infect 86:202-6. 2010
    ..Apolipoprotein E is polymorphic in the human population. APOE4 has previously been reported to correlate with symptomatic oral and genital herpes disease...
  94. ncbi Targeted prenatal herpes simplex virus testing: can we identify women at risk of transmission to the neonate?
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 194:408-14. 2006
    ..The cost-effectiveness of these interventions would be improved if high-risk pregnancies could be easily identified for targeted testing...
  95. ncbi Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 37:838-40. 2003
    ..This case illustrates the potential for infectious complications related to the use of cytotoxic immunosuppressants and anticytokine agents, such as TNF-alpha antagonists...
  96. ncbi Herpes simplex virus type 2 (HSV-2) Western blot confirmatory testing among men testing positive for HSV-2 using the focus enzyme-linked immunosorbent assay in a sexually transmitted disease clinic
    Matthew R Golden
    Department of Medicine, University of Washington, Seattle, USA
    Sex Transm Dis 32:771-7. 2005
    ....
  97. ncbi Diagnostics for herpes simplex virus: is PCR the new gold standard?
    Lara B Strick
    University of Washington, Seattle, Washington, USA
    Mol Diagn Ther 10:17-28. 2006
    ....
  98. ncbi Unusual appendicitis
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, Harborview Medical Center, University of Washington, Seattle 98195, USA
    Clin Infect Dis 37:1334, 1378-9. 2003
  99. ncbi Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, Washington 98122, USA
    J Infect Dis 198:1141-9. 2008
    ..Recent in situ data show the localization of HSV-specific CD8(+) T cells at the dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivation may occur more frequently than previously appreciated...
  100. ncbi Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boost CD8 T-cell responses in HSV-naïve and HSV-2-infected subjects
    David M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Vaccine Immunol 15:773-82. 2008
    ..Modifications of the dose, adjuvant, route, schedule, or HSV antigen may be required to improve responses...
  101. ncbi Condom use and the prevention of genital herpes acquisition
    Corey Casper
    Department of Medicine, University of Washington, Seattle 98122, USA
    Herpes 9:10-4. 2002
    ....

Research Grants3

  1. Treatment of Acute Hepatitis C in Injection Drug Users
    Anna Wald; Fiscal Year: 2005
    ..abstract_text> ..
  2. Clinical Research in HSV Infections
    Anna Wald; Fiscal Year: 2007
    ..Training in ethics of conduct of research is also provided, as is access to seminars, collaborators and classes in related fields. ..