THOMAS WILLIAM contact WAKEFIELD

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint American Venous Forum: The future is now!
    Thomas W Wakefield
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 44:216-8. 2006
  2. ncbi request reprint What is the optimal duration of treatment for DVT? An update on evidence-based medicine of treatment for DVT
    Andrea T East
    Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109 5432, USA
    Semin Vasc Surg 23:182-91. 2010
  3. ncbi request reprint The role of inflammation in early and late venous thrombosis: Are there clinical implications?
    Thomas W Wakefield
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    Semin Vasc Surg 18:118-29. 2005
  4. ncbi request reprint Mechanisms of venous thrombosis and resolution
    Thomas W Wakefield
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Arterioscler Thromb Vasc Biol 28:387-91. 2008
  5. doi request reprint Role of selectins and fibrinolysis in VTE
    Thomas W Wakefield
    Department of Surgery, Ann Arbor, MI, USA
    Thromb Res 123:S35-40. 2009
  6. ncbi request reprint Call to action to prevent venous thromboembolism
    Thomas W Wakefield
    Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
    J Vasc Surg 49:1620-3. 2009
  7. ncbi request reprint Outcome of surgical and endoluminal intervention for infrainguinal bypass anastomotic strictures
    Matthew J Eagleton
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
    Vasc Endovascular Surg 40:11-22. 2006
  8. pmc Vein wall re-endothelialization after deep vein thrombosis is improved with low-molecular-weight heparin
    Daria K Moaveni
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor 48109, USA
    J Vasc Surg 47:616-24. 2008
  9. ncbi request reprint P-selectin inhibition decreases post-thrombotic vein wall fibrosis in a rat model
    Porama Thanaporn
    Section of Vascular Surgery, Department of Surgery, Jobst Vascular Laboratory and Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Surgery 134:365-71. 2003
  10. pmc Vein wall remodeling after deep vein thrombosis: differential effects of low molecular weight heparin and doxycycline
    Vikram Sood
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Ann Vasc Surg 24:233-41. 2010

Research Grants

Collaborators

Detail Information

Publications80

  1. ncbi request reprint American Venous Forum: The future is now!
    Thomas W Wakefield
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 44:216-8. 2006
  2. ncbi request reprint What is the optimal duration of treatment for DVT? An update on evidence-based medicine of treatment for DVT
    Andrea T East
    Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109 5432, USA
    Semin Vasc Surg 23:182-91. 2010
    ..Monitoring with d-dimer and serial ultrasounds may offer an individualized approach to therapy...
  3. ncbi request reprint The role of inflammation in early and late venous thrombosis: Are there clinical implications?
    Thomas W Wakefield
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    Semin Vasc Surg 18:118-29. 2005
    ....
  4. ncbi request reprint Mechanisms of venous thrombosis and resolution
    Thomas W Wakefield
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Arterioscler Thromb Vasc Biol 28:387-91. 2008
    ..Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies...
  5. doi request reprint Role of selectins and fibrinolysis in VTE
    Thomas W Wakefield
    Department of Surgery, Ann Arbor, MI, USA
    Thromb Res 123:S35-40. 2009
    ..In this review, we will address the role of selectins and fibrinolysis in the process of venous thrombogenesis...
  6. ncbi request reprint Call to action to prevent venous thromboembolism
    Thomas W Wakefield
    Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
    J Vasc Surg 49:1620-3. 2009
    ..The Surgeon General's Call to Action represents one of the most important advances in the field of venous thromboembolism and sets the stage for multidisciplinary efforts to combat this serious national health problem...
  7. ncbi request reprint Outcome of surgical and endoluminal intervention for infrainguinal bypass anastomotic strictures
    Matthew J Eagleton
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
    Vasc Endovascular Surg 40:11-22. 2006
    ..Open surgical repair, compared to PTA, provides improved graft function as evident by fewer subsequent interventions required to maintain graft patency...
  8. pmc Vein wall re-endothelialization after deep vein thrombosis is improved with low-molecular-weight heparin
    Daria K Moaveni
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor 48109, USA
    J Vasc Surg 47:616-24. 2008
    ..The purpose of this study was to quantify re-endothelialization after DVT and determine if low-molecular-weight heparin (LMWH) therapy affects this process...
  9. ncbi request reprint P-selectin inhibition decreases post-thrombotic vein wall fibrosis in a rat model
    Porama Thanaporn
    Section of Vascular Surgery, Department of Surgery, Jobst Vascular Laboratory and Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Surgery 134:365-71. 2003
    ..This study tested the hypothesis that P-selectin inhibition would decrease post-thrombotic vein wall fibrosis and associated profibrotic mediators...
  10. pmc Vein wall remodeling after deep vein thrombosis: differential effects of low molecular weight heparin and doxycycline
    Vikram Sood
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Ann Vasc Surg 24:233-41. 2010
    ..This study sought to determine the effect of exogenous MMP inhibition and its potential attenuation of early vein wall injury...
  11. ncbi request reprint Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse model
    Kristopher B Deatrick
    Jobst Vascular Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Vasc Surg 42:140-8. 2005
    ..This study investigated the expression of proteases and collagen involved in early vein wall remodeling...
  12. ncbi request reprint Risk factors and clinical impact of postoperative symptomatic venous thromboembolism
    Chethan Gangireddy
    University of Michigan School of Medicine Section of Vascular Surgery, Ann Arbor, MI, USA
    J Vasc Surg 45:335-341; discussion 341-2. 2007
    ..This study evaluated prospective perioperative demographic and clinical variables associated with occurrence of postoperative symptomatic VTE...
  13. doi request reprint Aging is associated with impaired thrombus resolution in a mouse model of stasis induced thrombosis
    April P McDonald
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0654 USA
    Thromb Res 125:72-8. 2010
    ..To evaluate the effects of aging on venous thrombosis...
  14. ncbi request reprint Southern Association for Vascular Surgery William J. von Leibig Award. Inflammation and intimal hyperplasia associated with experimental pulmonary embolism
    Matthew J Eagleton
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan Health System
    J Vasc Surg 36:581-8. 2002
    ....
  15. ncbi request reprint Neutropenia impairs venous thrombosis resolution in the rat
    Manu R Varma
    Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Vasc Surg 38:1090-8. 2003
    ..This study tests the hypothesis that neutrophils (PMN) are active participants in DVT resolution...
  16. ncbi request reprint Deep vein thrombosis resolution is not accelerated with increased neovascularization
    Manu R Varma
    Department of Surgery, University of Michigan Medical School, Ann Arbor, USA
    J Vasc Surg 40:536-42. 2004
    ..Deep venous thrombosis (DVT) resolution involves fibrinolysis, neovascularization, and fibrosis. We hypothesized that promoting neovascularization would accelerate DVT resolution...
  17. pmc Plasmin inhibition increases MMP-9 activity and decreases vein wall stiffness during venous thrombosis resolution
    Nicholas A Dewyer
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Surg Res 142:357-63. 2007
    ..This study tested the hypothesis that pharmacological inhibition of the plasmin system would impair DVT resolution and worsen vein wall damage...
  18. ncbi request reprint Endovascular treatment of abdominal aortic aneurysm is associated with a low incidence of deep venous thrombosis
    Matthew J Eagleton
    Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor 48109, USA
    J Vasc Surg 36:912-6. 2002
    ..Because aortic endograft placement requires prolonged femoral vessel instrumentation, it may be hypothesized that these patients are at increased risk for development of an acute DVT...
  19. ncbi request reprint Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation
    Daniel D Myers
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, 2Unit for Laboratory Animal Medicine and 3Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0654, USA
    Thromb Haemost 97:400-7. 2007
    ..01). This study is the first to demonstrate the effectiveness of oral P-selectin inhibition to modify venous thrombogenesis, increase vein lumen opening, and decrease inflammation in a large animal model...
  20. ncbi request reprint Pediatric renovascular hypertension: 132 primary and 30 secondary operations in 97 children
    James C Stanley
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 44:1219-28; discussion 1228-9. 2006
    ..This study was undertaken to characterize the contemporary surgical treatment of pediatric renovascular hypertension...
  21. pmc Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution
    Peter K Henke
    CVC 5463, Ann Arbor, MI 48109, USA
    Arterioscler Thromb Vasc Biol 31:43-9. 2011
    ..Toll-like receptors (TLR) bridge innate immunity and host responses, including inflammation. Sterile inflammation such as a venous thrombus (Vt) may involve TLR signaling, including TLR9...
  22. ncbi request reprint Acute limb ischemia associated with type B aortic dissection: clinical relevance and therapy
    Peter K Henke
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich, USA
    Surgery 140:532-9; discussion 539-40. 2006
    ..The goal of the current study is to characterize the presentation, therapy, and outcomes of acute limb ischemia (ALI) associated with type B aortic dissection (AoD)...
  23. ncbi request reprint Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis
    Daniel D Myers
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, 48109 0654, USA
    J Vasc Surg 44:625-32. 2006
    ....
  24. ncbi request reprint Sonographic elasticity imaging of acute and chronic deep venous thrombosis in humans
    Jonathan M Rubin
    Department of Radiology, University of Michigan Hospitals, 1500 E Medical Center Dr, Ann Arbor, 48109, USA
    J Ultrasound Med 25:1179-86. 2006
    ..The purpose of this study was to assess the ability of sonographic elasticity imaging to distinguish acute from chronic deep venous thrombosis (DVT)...
  25. ncbi request reprint Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model
    Peter K Henke
    University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 177:3388-97. 2006
    ..We conclude that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-gamma...
  26. ncbi request reprint Venous thromboembolic events in the rehabilitation setting
    Brian M Kelly
    Department of Physical Medicine and Rehabilitation, University of Michigan Health System, 325 Eisenhower, Suite 200, Ann Arbor, MI 48108, USA
    PM R 2:647-63. 2010
    ..At times, information about acute care protocols is included in our discussion because these situations are encountered during the consultation process that identifies patients for rehabilitation needs...
  27. ncbi request reprint D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot study
    John E Rectenwald
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Thromb Haemost 94:1312-7. 2005
    ..However for clinical applicability, the sensitivity/specificity will need to be improved. These studies also suggest the importance of soluble P-selectin in assessing DVT in humans...
  28. ncbi request reprint Factors associated with outcome after interventional treatment of symptomatic iliac vein compression syndrome
    Brian S Knipp
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Vasc Surg 46:743-749. 2007
    ..Although therapy is often initially successful, factors associated with long-term outcome have been poorly defined. The purpose of this study was to identify factors associated with stent patency...
  29. pmc Do galectins play a role in venous thrombosis? a review
    Jose A Diaz
    Department of Surgery, University of Michigan, Jobst Vascular Research Laboratories, Section of Vascular Surgery, Cardiovascular Center, Ann Arbor, MI, USA
    Thromb Res 125:373-6. 2010
    ..The function of galectins, their role in inflammation and thrombosis as well as their potential implications as a new pharmacological target for DVT management are reviewed in this manuscript...
  30. pmc Proteomics of microparticles after deep venous thrombosis
    Eduardo Ramacciotti
    Jobst Vascular Research Laboratory, Section of Vascular Surgery, Cardiovascular Center, Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Thromb Res 125:e269-74. 2010
    ..MP present diverse biological expressions that may be linked to a unique subset of proteins derived from their origin cells...
  31. pmc Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis
    Eduardo Ramacciotti
    Conrad Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical School Center, Ann Arbor, MI, USA
    Thromb Haemost 101:748-54. 2009
    ..Finally, TF bearing MPs showed a significant correlation to MP concentrations (R = 0.99). In conclusion, MPs appear to be an important element in venous thrombogenesis...
  32. ncbi request reprint Chronic venous insufficiency: current management of varicose vein disease
    Kristopher B Deatrick
    University of Michigan Health System, Section of Vascular Surgery, Ann Arbor, Michigan, USA
    Am Surg 76:125-32. 2010
    ..This review encompasses the basic pathophysiology, diagnosis, and current therapies for superficial venous insufficiency...
  33. doi request reprint Metabolic consequences of acute limb ischemia and their clinical implications
    Jonathan L Eliason
    Section of Vascular Surgery, University of Michigan Health System, Ann Arbor, MI 48109 5867, USA
    Semin Vasc Surg 22:29-33. 2009
    ..A better understanding of these processes may result in improved patient outcomes and decreased mortality...
  34. doi request reprint Endovenous laser ablation: venous outcomes and thrombotic complications are independent of the presence of deep venous insufficiency
    Brian S Knipp
    Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Vasc Surg 48:1538-45. 2008
    ..We hypothesize that endovenous laser ablation (EVA) therapy is equally successful in improving venous insufficiency symptoms in patients with or without deep venous insufficiency (DVI)...
  35. pmc Thrombogenesis with continuous blood flow in the inferior vena cava. A novel mouse model
    Jose A Diaz
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan 48109 0654, USA
    Thromb Haemost 104:366-75. 2010
    ..This EIM closely mimics clinical venous disease and can be used to study endothelial cell activation, leukocyte migration, thrombogenesis and therapeutic applications in the presence of blood flow...
  36. ncbi request reprint Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesis
    Peter K Henke
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Thromb Haemost 98:1045-55. 2007
    ..Limited stasis, non-stasis thrombosis and non-thrombotic IVC occlusion showed a lesser inflammatory response. These data suggest both a static component and the thrombus directs vein wall injury via multiple mechanisms...
  37. pmc P-selectin/ PSGL-1 inhibitors versus enoxaparin in the resolution of venous thrombosis: a meta-analysis
    Eduardo Ramacciotti
    Jobst Vascular Surgery Research Laboratory, Section of Vascular Surgery, Cardiovascular Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Thromb Res 125:e138-42. 2010
    ..P-selectin antagonism has been shown to decrease thrombogenesis and inflammation in animal models of deep venous thrombosis (DVT)...
  38. pmc Microparticle surface protein are associated with experimental venous thrombosis: a preliminary study
    Newaj M Abdullah
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Appl Thromb Hemost 15:201-8. 2009
    ..Further studies are needed to confirm the mechanistic role of these proteins in the pathogenesis of venous thrombosis...
  39. pmc Osteomyelitis of the foot and toe in adults is a surgical disease: conservative management worsens lower extremity salvage
    Peter K Henke
    Section of Vascular Surgery, Department of Surgery, University of Michigan, School of Medicine, Ann Arbor, Michigan, USA
    Ann Surg 241:885-92; discussion 892-4. 2005
    ....
  40. ncbi request reprint Decreased venous thrombosis with an oral inhibitor of P selectin
    Daniel D Myers
    Section of Vascular Surgery, Jobst Vascular Research Laboratories, Ann Arbor, Mich, USA
    J Vasc Surg 42:329-36. 2005
    ..This study evaluated the effects on thrombosis and circulating microparticle populations in this murine venous thrombosis model...
  41. ncbi request reprint Cellular IL-10 is more effective than viral IL-10 in decreasing venous thrombosis
    Daniel D Myers
    Department of Surgery, Section of Vascular Surgery, Jobst Vascular Laboratory, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Surg Res 112:168-74. 2003
    ..Only cIL-10, despite sharing an 84% amino acid sequence homology with vIL-10, decreases thrombosis through mechanisms yet to be determined...
  42. ncbi request reprint A validation study of a retrospective venous thromboembolism risk scoring method
    Vinita Bahl
    Department of Clinical Information and Decision Support Services, Office of Clinical Affairs, University of Michigan, Ann Arbor, MI 48109 5485, USA
    Ann Surg 251:344-50. 2010
    ....
  43. ncbi request reprint P-selectin and leukocyte microparticles are associated with venous thrombogenesis
    Daniel D Myers
    Department of Surgery, University of Michigan, Ann Arbor, 48109 0654, USA
    J Vasc Surg 38:1075-89. 2003
    ..P-selectin inhibition has been found to limit venous thrombosis. We hypothesize that elevated levels of P-selectin will amplify thrombosis, mediated by procoagulant microparticles (MPs)...
  44. ncbi request reprint Gender differences in deep venous thrombosis in a rat model: a preliminary study
    Leslie A VanLangevelde
    Jobst Research Laboratories, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Comp Med 55:55-60. 2005
    ..We conclude that although female rats had greater thrombus mass, the male rats demonstrated more inflammatory cells in circulation and in their vein walls. This finding suggests that inflammation plays a role in thrombus resolution...
  45. ncbi request reprint P-selectin inhibition enhances thrombus resolution and decreases vein wall fibrosis in a rat model
    Daniel D Myers
    Section of Vascular Surgery, Department of Surgery, Jobst Vascular Laboratory, Ann Arbor, MI 48109, USA
    J Vasc Surg 36:928-38. 2002
    ..The purpose of this study was to compare the efficacy of P-selectin inhibition with standard anticoagulant and thrombolytic therapy in a rodent model of established deep vein thrombosis (DVT)...
  46. ncbi request reprint Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model
    Peter K Henke
    Section of Vascular Surgery, Jobst Vascular Research Laboratory, University of Michigan Medical School, Ann Arbor, Mich, USA
    Arterioscler Thromb Vasc Biol 24:1130-7. 2004
    ..To determine the role of CXCR2, the receptor for cysteine-X-cysteine (CXC) chemokines, and its primary effector cell, the neutrophil (PMN), on deep venous thrombosis (DVT) resolution...
  47. ncbi request reprint Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall
    Sharlene M Day
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Blood 105:192-8. 2005
    ..Therefore, our results suggest that thrombus formation in the arterial and venous macrovasculature is driven primarily by TF derived from the blood vessel wall as opposed to leukocytes...
  48. ncbi request reprint Venous thromboembolism: regional differences in the nationwide inpatient sample, 1993 to 2000
    Mary C Proctor
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Vascular 12:374-80. 2004
    ..Regional diagnostic, treatment, and economic differences exist. The data are useful for the purposes of public health care planning and stimulating clinical trial questions...
  49. ncbi request reprint Clinical application of sonographic elasticity imaging for aging of deep venous thrombosis: preliminary findings
    Jonathan M Rubin
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Ultrasound Med 22:443-8. 2003
    ..Because it is known that thrombi harden as they mature, we have preliminarily tested sonographic elasticity imaging, a technique that estimates tissue hardness, to age venous thrombi...
  50. ncbi request reprint Tissue loss, early primary graft occlusion, female gender, and a prohibitive failure rate of secondary infrainguinal arterial reconstruction
    Peter K Henke
    Department of Vascular Surgery, University of Michigan Medical School, 2210 Taubman Health Care Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 35:902-9. 2002
    ..This study tested the hypothesis that a subset of secondary infrainguinal arterial reconstructions show prohibitive failure rates...
  51. ncbi request reprint Risk factors associated with venous thromboembolic events in patients with malignancy
    Jules Lin
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, 48109 0329, USA
    Blood Coagul Fibrinolysis 17:265-70. 2006
    ..02; 1.0-1.04; P = 0.01) were associated with decreased survival. Patients with malignancy who have solid tumors, advanced age, infection, and leukopenia have a significantly increased risk of venous thromboembolic events...
  52. ncbi request reprint Experimental pulmonary embolism: effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparin
    John E Rectenwald
    Department of Surgery, Jobst Vascular Research Laboratory, Section of Vascular Surgery, University of Michigan, Ann Arbor, USA
    J Vasc Surg 43:800-8. 2006
    ..This study evaluated the effect of the thrombus and tested the hypothesis that thrombolytic, antiplatelet, and anticoagulant agents would decrease pulmonary injury...
  53. ncbi request reprint Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization
    Peter K Henke
    University of Michigan Health System, 1500 E Medical Center Drive, 2210 Taubman Health Care Center, Ann Arbor, MI 48109 0329 USA
    Thromb Haemost 95:272-81. 2006
    ..4-fold larger thrombi (P < .05). These data suggest a critical early role for PMN in post DVT vein wall remodeling...
  54. ncbi request reprint A role for interleukin-10 in the assessment of venous thromboembolism risk in injured patients
    Mary C Proctor
    Section of Vascular Surgery, University of Michigan Medical Center, A Alfred Taubman Health Care Center, 1500 E Meedical Center Drive, Ann Arbor, MI 48109, USA
    J Trauma 60:147-51. 2006
    ..Currently, there is no effective strategy for risk assessment. The purpose of this study is to investigate the relationship of serum P-selectin and interleuken-10 (IL-10) with VTE as a possible physiologic marker...
  55. ncbi request reprint Inflammation-dependent thrombosis
    Daniel D Myers
    Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, MI 48109 0654, USA
    Front Biosci 10:2750-7. 2005
    ..Understanding how natural inflammatory mechanisms promote a procoagulant state, may lead to the development of new pharmacological interventions targeted at thrombosis...
  56. ncbi request reprint Cost of routine screening for carotid and lower extremity occlusive disease in patients with abdominal aortic aneurysms
    David A Axelrod
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, 48109 0604, USA
    J Vasc Surg 35:754-8. 2002
    ..Furthermore, the cost-effectiveness of routine versus selective preoperative noninvasive examination of the carotid and lower extremity arterial beds has not been established in patients who undergo elective AAA repair...
  57. ncbi request reprint A negative carotid plaque area test is superior to other noninvasive atherosclerosis studies for reducing the likelihood of having underlying significant coronary artery disease
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
    Arterioscler Thromb Vasc Biol 26:656-62. 2006
    ..Although each test may enhance risk stratification, their comparative abilities to screen for underlying coronary stenoses in individual patients is less established...
  58. ncbi request reprint Pediatric splanchnic arterial occlusive disease: clinical relevance and operative treatment
    Gilbert R Upchurch
    Section of Vascular Surgery, Department of Surgery, University of Michigan Hospital, 1500 E Medical Center Drive, 2210THCC, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 35:860-7. 2002
    ..Splanchnic arterial occlusive disease is rare in childhood. The purpose of this study was to review the clinical relevance and operative treatment of these lesions in a unique experience from a single institution...
  59. doi request reprint Urokinase plasminogen activator independent early experimental thrombus resolution: MMP2 as an alternative mechanism
    Vikram Sood
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Thromb Haemost 104:1174-83. 2010
    ..MMP2-dependent thrombolysis is an important compensatory mechanism of venous thrombus resolution, possibly by collagen type IV metabolism, and may represent an exploitable therapeutic avenue...
  60. ncbi request reprint L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation
    Kevin K Hannawa
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Mich, USA
    Circulation 112:241-7. 2005
    ..This investigation tested the hypothesis that L-selectin is important in experimental abdominal aortic aneurysm (AAA) formation in rodents...
  61. pmc Variation in death rate after abdominal aortic aneurysmectomy in the United States: impact of hospital volume, gender, and age
    Justin B Dimick
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, and Division of Vascular Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA
    Ann Surg 235:579-85. 2002
    ..To determine whether high-volume hospitals (HVHs) have lower in-hospital death rates after abdominal aortic aneurysm (AAA) repair compared with low-volume hospitals (LVHs)...
  62. ncbi request reprint Iliorenal bypass: indications and outcomes following 41 reconstructions
    Vladimir Grigoryants
    Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Ann Vasc Surg 21:1-9. 2007
    ..Iliorenal bypass is an effective means of renal revascularization in patients not amenable to more conventional open or transluminal procedures...
  63. ncbi request reprint Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms
    Brian S Knipp
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, Division of Cardiology, University of Michigan Medical Center, Ann Arbor 48109 0329, USA
    J Vasc Surg 35:363-7. 2002
    ....
  64. ncbi request reprint Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II Investigators
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, 44405 Woodward Ave, Pontiac, MI 48341 5023, and Department of Medicine, Wayne State University, Detroit, MI, USA
    Radiology 242:15-21. 2007
  65. ncbi request reprint Results of the national pilot screening program for venous disease by the American Venous Forum
    Robert B McLafferty
    Southern Illinois University, Springfield, IL 62794 0741, USA
    J Vasc Surg 45:142-148. 2007
    ..This report describes the pilot of a free comprehensive national screening program for venous disease...
  66. pmc Correspondence of ultrasound elasticity imaging to direct mechanical measurement in aging DVT in rats
    Hua Xie
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
    Ultrasound Med Biol 31:1351-9. 2005
    ....
  67. ncbi request reprint Multidetector computed tomography for acute pulmonary embolism
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich, USA
    N Engl J Med 354:2317-27. 2006
    ..The accuracy of multidetector computed tomographic angiography (CTA) for the diagnosis of acute pulmonary embolism has not been determined conclusively...
  68. ncbi request reprint Venous thromboembolism and cancer
    David Bergqvist
    Uppsala University Hospital, Department of Surgical Sciences, Uppsala, Sweden
    Curr Probl Surg 44:157-216. 2007
  69. ncbi request reprint CT venography for deep venous thrombosis: continuous images versus reformatted discontinuous images using PIOPED II data
    Lawrence R Goodman
    Department of Radiology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226 3596, USA
    AJR Am J Roentgenol 189:409-12. 2007
    ....
  70. ncbi request reprint Severe chronic venous insufficiency: magnitude of the problem and consequences
    Susan Tsai
    Section of Vascular Surgery, Department of Surgery, University of Michigan, School of Medicine, Ann Arbor, MI 48109 0329, USA
    Ann Vasc Surg 19:705-11. 2005
    ..Amputation for CVI-related nonhealing wounds has a reasonable outcome. Future therapy must focus on prevention of CVI sequelae...
  71. doi request reprint Increasing awareness about venous disease: The American Venous Forum expands the National Venous Screening Program
    Robert B McLafferty
    Division of Vascular Surgery, Southern Illinois University, Springfield, Ill, USA
    J Vasc Surg 48:394-9. 2008
    ..To evaluate the results of the expanded National Venous Screening Program (NVSP) as administered by the American Venous Forum...
  72. doi request reprint Acute venous disease: venous thrombosis and venous trauma
    Mark H Meissner
    Department of Surgery, University of Washington School of Medicine, Seattle 98195, USA
    J Vasc Surg 46:25S-53S. 2007
    ..Venous injuries are similarly under-reported and the true incidence is unknown. Current recommendations include repair of injuries to the major proximal veins. If repair not safe or possible, ligation should be performed...
  73. ncbi request reprint Staging deep venous thrombosis using ultrasound elasticity imaging: animal model
    Hua Xie
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Ultrasound Med Biol 30:1385-96. 2004
    ....
  74. doi request reprint Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation
    Thomas R Meier
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Thromb Haemost 99:343-51. 2008
    ..This study is the first to demonstrate a reduction in MPTFA associated with vein reopening and reduced vein inflammation due to oral P-selectin inhibition in a baboon model of DVT...
  75. ncbi request reprint The treatment of deep venous thrombosis, including the newer agents
    John E Rectenwald
    Dis Mon 51:104-11. 2005
  76. doi request reprint Preface: acute and chronic venous disease. Current status and future directions
    Mark H Meissner
    Department of Surgery, University of Washington School of Medicine, Seattle 98195, USA
    J Vasc Surg 46:1S-3S. 2007
  77. doi request reprint Mapping the future: organizational, clinical, and research priorities in venous disease
    Mark H Meissner
    Department of Surgery, University of Washington School of Medicine, Seattle 98195, USA
    J Vasc Surg 46:84S-93S. 2007
  78. ncbi request reprint Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II investigators
    Paul D Stein
    Department of Research, St Joseph Mercy Oakland Hospital, Pontiac, Mich 48341 5023, USA
    Am J Med 119:1048-55. 2006
    ..To formulate comprehensive recommendations for the diagnostic approach to patients with suspected pulmonary embolism, based on randomized trials...
  79. ncbi request reprint Revision of the CEAP classification for chronic venous disorders: consensus statement
    Bo Eklof
    University of Lund, Helsingborg, Sweden
    J Vasc Surg 40:1248-52. 2004
    ..It is important to stress that CEAP is a descriptive classification, whereas venous severity scoring and quality of life scores are instruments for longitudinal research to assess outcomes...
  80. ncbi request reprint CT venography and compression sonography are diagnostically equivalent: data from PIOPED II
    Lawrence R Goodman
    Department of Diagnostic Radiology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Milwaukee, WI 53226 3596, USA
    AJR Am J Roentgenol 189:1071-6. 2007
    ..The Prospective Investigation of Pulmonary Embolism Diagnosis II (PIOPED II) showed that lower extremity imaging detects about 7% more patients requiring anticoagulation than CTA alone...

Research Grants18

  1. CYTOKINE BALANCE IN VENOUS THROMBOSIS
    Thomas Wakefield; Fiscal Year: 1999
    ..abstract_text> ..
  2. Novel Therapeutic Targets for Venous Thromboembolism
    THOMAS WILLIAM contact WAKEFIELD; Fiscal Year: 2010
    ..We will also develop new agents to target these molecules for the prevention and treatment of venous thrombosis. ..
  3. Procoagulant Microparticles: Novel Determinants of Venous Thrombosis
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2010
    ..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..
  4. Novel Therapeutic Targets for Venous Thromboembolism
    Thomas Wakefield; Fiscal Year: 2009
    ..We will also develop new agents to target these molecules for the prevention and treatment of venous thrombosis. ..
  5. Procoagulant Microparticles: Novel Determinants of Venous Thrombosis
    Thomas Wakefield; Fiscal Year: 2009
    ..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..
  6. Vascular Surgery: Research Training in Vascular Biology
    Thomas Wakefield; Fiscal Year: 2007
    ..The common thread in this program is the emphasis on the basic study of vessel wall biology and vascular pathology with the ultimate goal to produce the next generation of leaders in academic vascular sciences. ..
  7. Procoagulant Microparticles: Novel Determinants of Venous Thrombosis
    Thomas Wakefield; Fiscal Year: 2007
    ..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..
  8. P-selectin is Central to Venous Thrombosis Pathogenesis
    Thomas Wakefield; Fiscal Year: 2005
    ..These studies will define the role of P-selectin in VT pathogenesis, treatment and thrombolysis. ..
  9. P-selectin is Central to Venous Thrombosis Pathogenesis
    Thomas Wakefield; Fiscal Year: 2004
    ..These studies will define the role of P-selectin in VT pathogenesis, treatment and thrombolysis. ..
  10. P-selectin is Central to Venous Thrombosis Pathogenesis
    Thomas Wakefield; Fiscal Year: 2003
    ..These studies will define the role of P-selectin in VT pathogenesis, treatment and thrombolysis. ..
  11. CYTOKINE BALANCE IN VENOUS THROMBOSIS
    Thomas Wakefield; Fiscal Year: 2002
    ..abstract_text> ..
  12. P-selectin is Central to Venous Thrombosis Pathogenesis
    Thomas Wakefield; Fiscal Year: 2002
    ..These studies will define the role of P-selectin in VT pathogenesis, treatment and thrombolysis. ..
  13. CYTOKINE BALANCE IN VENOUS THROMBOSIS
    Thomas Wakefield; Fiscal Year: 2001
    ..abstract_text> ..
  14. CYTOKINE BALANCE IN VENOUS THROMBOSIS
    Thomas Wakefield; Fiscal Year: 2000
    ..abstract_text> ..
  15. Procoagulant Microparticles: Novel Determinants of Venous Thrombosis
    THOMAS WILLIAM WAKEFIELD; Fiscal Year: 2011
    ..Lay Summary: This proposal will determine the role of procoagulant elements termed microparticles in the etiology of venous thrombosis and their use as a diagnostic tool. ..