Research Topics
Genomes and Genes | Nobunao WakabayashiSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Regulation of notch1 signaling by nrf2: implications for tissue regenerationNobunao Wakabayashi
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Sci Signal 3:ra52. 2010..We report a functional role for this cross talk between the two pathways and show that disruption of Nrf2 impeded liver regeneration after partial hepatectomy and was rescued by reestablishment of Notch1 signaling...- Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducersNobunao Wakabayashi
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 101:2040-5. 2004.... - Antioxidants enhance mammalian proteasome expression through the Keap1-Nrf2 signaling pathwayMi Kyoung Kwak
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Mol Cell Biol 23:8786-94. 2003..We propose that induction of the 26S proteasome through the Nrf2 pathway represents an important indirect action of these antioxidants that can contribute to their protective effects against chronic diseases... - NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesisSoona Shin
Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
Mol Cell Biol 27:7188-97. 2007..Ectopic expression of Ahr and dominant-positive Nrf2 in Nrf2-/- MEFs also substantially delayed differentiation. Thus, NRF2 directly modulates AHR signaling, highlighting bidirectional interactions of these pathways... 
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survivalMi Kyoung Kwak
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
J Biol Chem 278:8135-45. 2003....- Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damageYusuke Kageyama
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Cell Biol 197:535-51. 2012..Our findings suggest that mitochondrial division serves as a quality control mechanism to suppress oxidative damage and thus promote neuronal survival... - Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloproteinAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Biochemistry 44:6889-99. 2005..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity... - Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayThomas W Kensler
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Annu Rev Pharmacol Toxicol 47:89-116. 2007..This review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses... - The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cellsZhongyan Zhang
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Mol Biol Cell 22:2235-45. 2011..Consequently, mice lacking Opa1 in beta cells develop hyperglycemia. The data suggest that the function of Opa1 in the maintenance of the electron transport chain is physiologically relevant in beta cells... - Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysisDeepti Malhotra
Department of Environmental Health Sciences Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Nucleic Acids Res 38:5718-34. 2010..Results were confirmed in an in vivo stress model of cigarette smoke-exposed mice. This study reveals global circuitry of the Nrf2 stress response emphasizing Nrf2 as a central node in cell survival response... - Chemoprevention by 1,2-dithiole-3-thiones through induction of NQO1 and other phase 2 enzymesMi-Kyoung Kwak
Department of Environmental Health Sciences, School of Public Health Sciences, Johns Hopkins University Bloomberg, Baltimore, Maryland 21205, USA
Methods Enzymol 382:414-23. 2004 - Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducersMi-Kyoung Kwak
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD 21205, USA
Mutat Res 555:133-48. 2004..Rapidly accumulating data on this pathway is providing insight into the coordinated mammalian defense systems against electrophiles and oxidative stresses and the means by which it may be targeted by small molecules... - Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anionWilliam O Osburn
Johns Hopkins University Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD, USA
Arch Biochem Biophys 454:7-15. 2006..Thus the enhanced sensitivity of N0 cells does not reflect basal differences in antioxidative capacity, but rather an impaired ability to mount an adaptive response to sustained oxidative stress... - Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolideSoona Shin
Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
Eur J Pharmacol 620:138-44. 2009..The results indicate that CDDO-Im is an exceedingly potent agent for preventing obesity, and identify the Nrf2 pathway as a novel target for management of obesogenesis... - Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistanceAnju Singh
Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland, USA
Antioxid Redox Signal 13:1627-37. 2010..Thus, targeting Nrf2 activity in radioresistant tumors could be a promising strategy to circumvent radioresistance... - The dynamin-related GTPase Drp1 is required for embryonic and brain development in miceJunko Wakabayashi
Department of Cell Biology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
J Cell Biol 186:805-16. 2009..These findings clearly demonstrate the physiological importance of Drp1-mediated organelle division in mice... - Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 99:11908-13. 2002..These residues are located in the intervening region between BTB and Kelch repeat domains of Keap1 and probably are the direct sensors of inducers of the phase 2 system... - Nrf2: friend or foe for chemoprevention?Thomas W Kensler
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA
Carcinogenesis 31:90-9. 2010..This review provides a synopsis of KEAP1-NRF2 signaling, compares the impact of genetic versus pharmacologic activation and considers both the attributes and concerns of targeting the pathway in chemoprevention...