Ken Waites

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc New insights into the pathogenesis and detection of Mycoplasma pneumoniae infections
    Ken B Waites
    University of Alabama at Birmingham, WP 230, 619 19th Street South, Birmingham, AL 35249, USA
    Future Microbiol 3:635-48. 2008
  2. doi request reprint Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Semin Fetal Neonatal Med 14:190-9. 2009
  3. pmc Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains
    Vanya Paralanov
    J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    BMC Microbiol 12:88. 2012
  4. pmc Standardized methods and quality control limits for agar and broth microdilution susceptibility testing of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Clin Microbiol 50:3542-7. 2012
  5. pmc Molecular methods for the detection of Mycoplasma and ureaplasma infections in humans: a paper from the 2011 William Beaumont Hospital Symposium on molecular pathology
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35226, USA
    J Mol Diagn 14:437-50. 2012
  6. pmc Chromosomal mutations responsible for fluoroquinolone resistance in Ureaplasma species in the United States
    Li Xiao
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Antimicrob Agents Chemother 56:2780-3. 2012
  7. pmc Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101
    Ken B Waites
    Department of Pathology, 619 19th Street South, WP 230, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Antimicrob Agents Chemother 53:2139-41. 2009
  8. ncbi request reprint The role of Mycoplasma in upper respiratory infections
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, WP 230, 619 19th Street South, Birmingham, AL 35249, USA
    Curr Infect Dis Rep 11:198-206. 2009
  9. pmc Genetic relatedness of levofloxacin-nonsusceptible Streptococcus pneumoniae isolates from North America
    Crystal N Johnson
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    J Clin Microbiol 41:2458-64. 2003
  10. doi request reprint Emerging macrolide resistance in Mycoplasma pneumoniae in children: detection and characterization of resistant isolates
    Xiao Li
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Pediatr Infect Dis J 28:693-6. 2009

Collaborators

Detail Information

Publications51

  1. pmc New insights into the pathogenesis and detection of Mycoplasma pneumoniae infections
    Ken B Waites
    University of Alabama at Birmingham, WP 230, 619 19th Street South, Birmingham, AL 35249, USA
    Future Microbiol 3:635-48. 2008
    ....
  2. doi request reprint Congenital and opportunistic infections: Ureaplasma species and Mycoplasma hominis
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Semin Fetal Neonatal Med 14:190-9. 2009
    ....
  3. pmc Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains
    Vanya Paralanov
    J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    BMC Microbiol 12:88. 2012
    ....
  4. pmc Standardized methods and quality control limits for agar and broth microdilution susceptibility testing of Mycoplasma pneumoniae, Mycoplasma hominis, and Ureaplasma urealyticum
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Clin Microbiol 50:3542-7. 2012
    ....
  5. pmc Molecular methods for the detection of Mycoplasma and ureaplasma infections in humans: a paper from the 2011 William Beaumont Hospital Symposium on molecular pathology
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35226, USA
    J Mol Diagn 14:437-50. 2012
    ..This review provides a summary and critical review of methods suitable for detection and characterization of mycoplasmas and ureaplasmas of humans, with emphasis on molecular genotypic techniques...
  6. pmc Chromosomal mutations responsible for fluoroquinolone resistance in Ureaplasma species in the United States
    Li Xiao
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Antimicrob Agents Chemother 56:2780-3. 2012
    ..Mutations were detected in all resistant isolates but in none of the susceptible isolates. The most prevalent mutation was the S83L substitution in the ParC protein. No plasmid-mediated fluoroquinolone resistance genes were detected...
  7. pmc Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101
    Ken B Waites
    Department of Pathology, 619 19th Street South, WP 230, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Antimicrob Agents Chemother 53:2139-41. 2009
    ..All isolates, including two macrolide-resistant M. pneumoniae isolates, were inhibited by CEM-101 at < or = 0.5 microg/ml, making CEM-101 the most potent compound tested...
  8. ncbi request reprint The role of Mycoplasma in upper respiratory infections
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, WP 230, 619 19th Street South, Birmingham, AL 35249, USA
    Curr Infect Dis Rep 11:198-206. 2009
    ..pneumoniae in upper respiratory tract infections; a brief discussion of its cell biology, pathogenic mechanisms, and epidemiology; and recommendations for laboratory diagnosis and management...
  9. pmc Genetic relatedness of levofloxacin-nonsusceptible Streptococcus pneumoniae isolates from North America
    Crystal N Johnson
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    J Clin Microbiol 41:2458-64. 2003
    ..However, seven LNSP were found to be related to three international clones by PFGE...
  10. doi request reprint Emerging macrolide resistance in Mycoplasma pneumoniae in children: detection and characterization of resistant isolates
    Xiao Li
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Pediatr Infect Dis J 28:693-6. 2009
    ..A rapid technique to identify macrolide-resistant M. pneumoniae is needed to guide management of patients with community-acquired respiratory infections...
  11. pmc Characterization of ureaplasmas isolated from preterm infants with and without bronchopulmonary dysplasia
    Brenda Katz
    Department of Pathology, University of Alabama at Birmingham, 35249 7331, USA
    J Clin Microbiol 43:4852-4. 2005
    ..urealyticum. U. parvum was detected more often than U. urealyticum. There was no significant difference or trend in the prevalence of either species between infants with or without bronchopulmonary dysplasia when isolated alone...
  12. pmc In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Antimicrob Agents Chemother 47:161-5. 2003
    ..hominis by measurement of minimal bactericidal activities and by time-kill studies. Further study of garenoxacin is required, as it has great potential for use in the treatment of infections due to mycoplasmas and ureaplasmas...
  13. doi request reprint Stevens-Johnson syndrome in a boy with macrolide-resistant Mycoplasma pneumoniae pneumonia
    T Prescott Atkinson
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Pediatrics 127:e1605-9. 2011
    ..We describe here the case of a child with a prolonged febrile illness associated with Stevens-Johnson-like mucocutaneous involvement who was found to have a respiratory infection with macrolide-resistant M pneumoniae...
  14. doi request reprint The use of a biodegradable, load-bearing scaffold as a carrier for antibiotics in an infected open fracture model
    Rena L Stewart
    Division of Orthopaedics, University of Alabama at Birmingham, Birmingham, AL 35233 3409, USA
    J Orthop Trauma 24:587-91. 2010
    ..This study investigates the use of such scaffolds with gentamicin (along with bone morphogenetic protein) in an infected rat open fracture model to decrease osteomyelitis and promote fracture healing...
  15. pmc Antimicrobial susceptibility among pathogens collected from hospitalized patients in the United States and in vitro activity of tigecycline, a new glycylcycline antimicrobial
    Ken B Waites
    Section of Clinical Microbiology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Antimicrob Agents Chemother 50:3479-84. 2006
    ....
  16. ncbi request reprint Ureaplasma infection and neonatal lung disease
    Robert L Schelonka
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    Semin Perinatol 31:2-9. 2007
    ....
  17. pmc USA300 genotype community-associated methicillin-resistant Staphylococcus aureus as a cause of surgical site infections
    Mukesh Patel
    Department of Medicine, University of Alabama at Birmingham, THT 229, 1530 3rd Avenue South, Birmingham, AL 35294 0006, USA
    J Clin Microbiol 45:3431-3. 2007
    ..CA-MRSA has become a prominent cause of SSI at our institution...
  18. ncbi request reprint New concepts of Mycoplasma pneumoniae infections in children
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, P230 West Pavilion, Birmingham, AL 35233, USA
    Pediatr Pulmonol 36:267-78. 2003
  19. doi request reprint Dissemination of community-associated methicillin-resistant Staphylococcus aureus in a tertiary care hospital
    Mukesh Patel
    Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, 35294 0006, USA
    South Med J 101:40-5. 2008
    ..The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) was investigated at a tertiary care hospital, and relationship was made between the clinical and genetic definitions of community- and healthcare-associated MRSA...
  20. doi request reprint Active surveillance to determine the impact of methicillin-resistant Staphylococcus aureus colonization on patients in intensive care units of a Veterans Affairs Medical Center
    Mukesh Patel
    Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA
    Infect Control Hosp Epidemiol 29:503-9. 2008
    ..We sought to describe the impact of MRSA colonization on patients admitted to intensive care units (ICUs) in the Birmingham Veterans Affairs Medical Center (VAMC)...
  21. pmc Revaccination of adults with spinal cord injury using the 23-valent pneumococcal polysaccharide vaccine
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    J Spinal Cord Med 31:53-9. 2008
    ..This study was undertaken to determine the effect of revaccination with the pneumococcal vaccine on the immune response and the frequency of adverse reactions in this population...
  22. pmc Comparative in vitro activities of the investigational fluoroquinolone DC-159a and other antimicrobial agents against human mycoplasmas and ureaplasmas
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Antimicrob Agents Chemother 52:3776-8. 2008
    ..9% of the inoculum at 24 h for 2 isolates. The excellent in vitro activity of DC-159a demonstrates its potential for use in the treatment of infections due to mycoplasmas and ureaplasmas...
  23. doi request reprint Fusobacterium necrophorum bacteremic tonsillitis: 2 Cases and a review of the literature
    Robert M Centor
    Department of Internal Medicine, University of Alabama at Birmingham, Huntsville, 35801, USA
    Anaerobe 16:626-8. 2010
    ..necrophorum. Recognition of such patients might prevent Lemierre syndrome...
  24. pmc Evaluation of 3 methods of bladder irrigation to treat bacteriuria in persons with neurogenic bladder
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Spinal Cord Med 29:217-26. 2006
    ....
  25. pmc Prevalence of inducible clindamycin resistance among community- and hospital-associated Staphylococcus aureus isolates
    Mukesh Patel
    Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, THT 229, 1530 3rd Avenue South, Birmingham, AL 35294 0006, USA
    J Clin Microbiol 44:2481-4. 2006
    ..Due to the low prevalence of MLSBi among CA-MRSA isolates, clindamycin remains a useful option for outpatient therapy...
  26. pmc Mycoplasma pneumoniae and its role as a human pathogen
    Ken B Waites
    Department of Pathology, WP 230, University of Alabama at Birmingham, 619 19th St South, Birmingham, AL 35249, USA
    Clin Microbiol Rev 17:697-728, table of contents. 2004
    ..As more is learned about the pathogenesis and immune response elicited by M. pneumoniae, improvement in methods for diagnosis and prevention of disease due to this organism may occur...
  27. ncbi request reprint Effect of cranberry extract on bacteriuria and pyuria in persons with neurogenic bladder secondary to spinal cord injury
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7331, USA
    J Spinal Cord Med 27:35-40. 2004
    ..To determine whether antibacterial effects of cranberry extract will reduce or eliminate bacteriuria and pyuria in persons with spinal cord injury (SCI)...
  28. ncbi request reprint Microbiology of the urethra and perineum and its relationship to bacteriuria in community-residing men with spinal cord injury
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    J Spinal Cord Med 27:448-52. 2004
    ..We performed a prospective study of bacterial flora of the urethra and perineum in men with and without bacteriuria to understand more completely the relationship between bacterial colonization and invasion of the urinary tract...
  29. pmc Dissemination of macrolide-resistant Streptococcus pneumoniae isolates containing both erm(B) and mef(A) in South Korea
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    J Clin Microbiol 41:5787-91. 2003
    ..1%) contained mef(A) and erm(B). Nineteen isolates containing mef(A) and erm(B) belonged to serotype 19F, and seven isolates were identical to the Taiwan(19F)-14 clone...
  30. pmc Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas
    Ken B Waites
    Department of Pathology, WP 230, 619 19th Street South, Birmingham, AL 35249, USA
    Antimicrob Agents Chemother 49:2541-2. 2005
    ..LBM-415 was active against M. pneumoniae (MICs, <or=0.008 microg/ml). It showed no activity against M. hominis and M. fermentans and modest activity against Ureaplasma spp...
  31. pmc Relative fitness of fluoroquinolone-resistant Streptococcus pneumoniae
    Crystal N Johnson
    University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Emerg Infect Dis 11:814-20. 2005
    ..However, the strain was equally able to cause competitive or noncompetitive lung infections as well as EF3030...
  32. pmc Comparative in vitro susceptibilities and bactericidal activities of investigational fluoroquinolone ABT-492 and other antimicrobial agents against human mycoplasmas and ureaplasmas
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Antimicrob Agents Chemother 47:3973-5. 2003
    ..ABT-492 MICs were < or =1 microg/ml, and the agent was bactericidal against selected isolates of M. pneumoniae and M. hominis. ABT-492 has potential for treatment of infections due to these microorganisms...
  33. pmc Mycoplasmas and ureaplasmas as neonatal pathogens
    Ken B Waites
    Department of Pathology, University of Alabama, Birmingham, Alabama 35249, USA
    Clin Microbiol Rev 18:757-89. 2005
    ....
  34. ncbi request reprint Critical appraisal of the role of Ureaplasma in the development of bronchopulmonary dysplasia with metaanalytic techniques
    Robert L Schelonka
    Department of Pediatrics University of Alabama at Birmingham, Birmingham, AL, USA
    Pediatr Infect Dis J 24:1033-9. 2005
    ....
  35. ncbi request reprint Inhibitory and bactericidal activities of gemifloxacin and other antimicrobials against Mycoplasma pneumoniae
    Ken B Waites
    Department of Pathology, WP 230, University of Alabama at Birmingham, 619n 19th Street South, Birmingham, AL 35249, USA
    Int J Antimicrob Agents 21:574-7. 2003
    ..MBCs for gemifloxacin were predominantly within 2-4 times the corresponding MIC values, indicating a bactericidal effect...
  36. pmc In vitro activities of ABT-773 and other antimicrobials against human mycoplasmas
    Ken B Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Antimicrob Agents Chemother 47:39-42. 2003
    ..pneumoniae and 0.25 microg/ml for M. fermentans, but they were several dilutions higher for M. hominis and Ureaplasma spp. ABT-773 has great potential for further study for the treatment of infections due to mycoplasmas and ureaplasmas...
  37. pmc Fluoroquinolone resistance in Ureaplasma parvum in the United States
    Lynn Duffy
    Department of Pathology, WP 230, 619 19th St South, University of Alabama at Birmingham, Birmingham, AL 35226, USA
    J Clin Microbiol 44:1590-1. 2006
    ..from the United States. Resistance in this case probably developed as a result of mutations in the gyrA and parC genes of the DNA gyrase/topoisomerase IV complex that occurred in the presence of antimicrobial selective pressure...
  38. ncbi request reprint In vitro comparison of agar and microbroth dilution methods for determination of MICs for Mycoplasma hominis
    Nicholaus J Hilliard
    Department of Pathology, University of Alabama at Birmingham, WP 230, 619 19th St S Birmingham, AL 35249, USA
    J Microbiol Methods 60:285-8. 2005
    ..Both methods provide reproducible results. Agar dilution tends to yield higher MIC values for some drugs...
  39. pmc Nosocomial spread of Enterococcus faecium resistant to vancomycin and linezolid in a tertiary care medical center
    Thomas E Dobbs
    Department of Medicine, University of Alabama at Birmingham, 619 South 19th St, 35249, USA
    J Clin Microbiol 44:3368-70. 2006
    ..Epidemiologic investigation and pulsed-field gel electrophoresis patterns indicated a clonal outbreak related to nosocomial spread...
  40. ncbi request reprint Antimicrobial resistance among isolates of respiratory tract infection pathogens from the southern United States: data from the PROTEKT US surveillance program 2000/2001
    Ken Waites
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233 7331, USA
    South Med J 96:974-85. 2003
    ....
  41. doi request reprint Genital tract methicillin-resistant Staphylococcus aureus: risk of vertical transmission in pregnant women
    William W Andrews
    Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249 7333, USA
    Obstet Gynecol 111:113-8. 2008
    ..To estimate the frequency of genital tract colonization by methicillin-resistant Staphylococcus aureus (MRSA) among pregnant women and evaluate the association of such colonization with infant outcome...
  42. pmc Detection and characterization of human Ureaplasma species and serovars by real-time PCR
    Li Xiao
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    J Clin Microbiol 48:2715-23. 2010
    ..These assays provide quick and reliable means for investigating the epidemiology and pathogenicity of ureaplasmas at the serovar level...
  43. pmc Rapid multiplex assay for serotyping pneumococci with monoclonal and polyclonal antibodies
    Jigui Yu
    Department of Pathology, University of Alabama at Birmingham, AL, USA
    J Clin Microbiol 43:156-62. 2005
    ..This system should be very useful in serotyping clinical isolates for evaluating pneumococcal vaccine efficacy...
  44. ncbi request reprint In vitro activity of ertapenem (MK-0826) against multi-drug resistant Streptococcus pneumoniae compared with 13 other antimicrobials
    Nicholaus J Hilliard
    Department of Pathology, University of Alabama at Birmingham, WP P230N, 619 19th Street South, 35249 7331, USA
    Int J Antimicrob Agents 20:136-40. 2002
    ..pneumoniae, including infections caused by organisms with reduced susceptibilities to other antimicrobial agents...
  45. doi request reprint Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections
    THOMAS PRESCOTT ATKINSON
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    FEMS Microbiol Rev 32:956-73. 2008
    ....
  46. ncbi request reprint Emerging intracellular bacterial infections
    Brenda Katz
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Clin Lab Med 24:627-49, vi. 2004
    ..Emerging evidence suggesting a possible intracellular existence for another organism, Mycoplasma pneumoniae, may explain how this organism interacts with the host to induce chronic inflammatory conditions of the respiratory tract...
  47. pmc Bacillus cereus bacteremia in a preterm neonate
    Nicholaus J Hilliard
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    J Clin Microbiol 41:3441-4. 2003
    ....
  48. pmc Genotypic characterization of ureaplasma serovars from clinical isolates by pulsed-field gel electrophoresis
    Li Xiao
    Department of Pathology, University of Alabama at Birmingham, WP 230, 619 19th Street South, Birmingham, AL 35249, USA
    J Clin Microbiol 49:3325-8. 2011
    ..The organisms were geographically widespread. No unique patterns were associated with invasive disease...
  49. pmc Extensive horizontal gene transfer in ureaplasmas from humans questions the utility of serotyping for diagnostic purposes
    Li Xiao
    University of Alabama at Birmingham, Department of Pathology, WP 230, 619 19th Street South, Birmingham, AL 35249, USA
    J Clin Microbiol 49:2818-26. 2011
    ..This explains the extensive cross-reactivity based upon serotyping and the lack of consistent association of given serotypes with disease...
  50. ncbi request reprint Effective communication of antimicrobial susceptibility data by pathologists to clinicians
    Ken B Waites
    Department of Pathology, University of Alabama, Birmingham, AL, USA
    Adv Exp Med Biol 563:165-77. 2005
    ....
  51. ncbi request reprint Nosocomial ventriculitis due to Roseomonas gilardii complicating subarachnoid haemorrhage
    Jason S Nolan
    Department of Pathology, University of Alabama at Birmingham, WP 230, 619 19th Street South, Birmingham, AL 35249, USA
    J Infect 50:244-51. 2005
    ....