Research Topics
Genomes and GenesSpecies | Suramya WaidyanathaSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone in Swiss Webster miceSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, United States
Chem Biol Interact 172:105-14. 2008..This suggests that mice could be more susceptible than rats to the toxic effects of naphthalene due to more pronounced depletion of glutathione at a given dose...
Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workersYu Sheng Lin
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
Environ Health Perspect 115:28-34. 2007..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...
Modeling human metabolism of benzene following occupational and environmental exposuresSungkyoon Kim
School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...- Comparing urinary biomarkers of airborne and dermal exposure to polycyclic aromatic compounds in asphalt-exposed workersJon R Sobus
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
Ann Occup Hyg 53:561-71. 2009.... - Protein adducts as biomarkers of human benzene metabolismStephen M Rappaport
School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
Chem Biol Interact 153:103-9. 2005..Thus, the biologically effective dose of BO and 1,4-BQ should be proportionally greater in persons exposed to low rather than high levels of benzene... - Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrationsSungkyoon Kim
School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Pharmacogenet Genomics 17:789-801. 2007.... - Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbonsStephen M Rappaport
Department of Environmental Sciences and Engineering, School of Public Health, CB 7431, University of North Carolina, Chapel Hill, NC 27599 7431, USA
J Environ Monit 6:413-6. 2004..Since naphthalene has also been shown to be a respiratory carcinogen in several animal studies, it is also argued that naphthalene exposures should be monitored per se in industries with high levels of PAH... - Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometryRenan Wu
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7431, USA
J Chromatogr B Analyt Technol Biomed Life Sci 826:206-13. 2005..Since the DHNs are precursors of the naphthoquinones, which have been implicated as toxic products of naphthalene metabolism, measurements of urinary DHNs may have toxicological significance... - Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolismSungkyoon Kim
School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute (NCI, National Institutes of Health (NIH, Department of Health and Human Services (DHHS, Bethesda, MD 20892, USA
Carcinogenesis 27:772-81. 2006..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures... - Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbonsSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Epidemiol Biomarkers Prev 13:117-24. 2004..A negative relationship between 1,2-NPQ-Alb and age was observed, suggesting that cytochrome P450 c metabolism diminished with age at approximately 3%/year of life... - Using liquid chromatography-tandem mass spectrometry to quantify monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urineFrank Onyemauwa
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:1117-25. 2009..628), presumably due to confounding by smoking. Metabolites of phenanthrene, an abundant PAH and the smallest to possess a bay region, are promising OHPAHs for characterizing both exposures to PAHs and the various metabolic pathways... - Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 ratsSuramya Waidyanatha
Department of Environmental Sciences and Engineering, CB 7400, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7400, USA
Chem Biol Interact 141:189-210. 2002..Low background levels of 1,2-NPQ-Hb and -Alb and 1,4-NPQ-Hb and -Alb were detected in control animals without known exposure to naphthalene. However, the corresponding NPO-Hb and -Alb adducts were not detected in control animals... - Investigation of PAH biomarkers in the urine of workers exposed to hot asphaltJon R Sobus
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
Ann Occup Hyg 53:551-60. 2009..These results support the use of U-Nap, U-Phe, OH-Phe, and OH-Pyr, but probably not OH-Nap, as short-term biomarkers of exposure to PAHs emanating from hot asphalt... - Investigation of cysteinyl protein adducts of benzene diolepoxideSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7400, USA. suramya.unc.edu
Chem Biol Interact 153:261-6. 2005..Reaction products between these and L-cysteine, and GSH were identified and characterized by mass spectrometry in an attempt to develop an assay to quantify these adducts in serum albumin... - Urinary biomarkers of exposure to jet fuel (JP-8)Berrin Serdar
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Environ Health Perspect 111:1760-4. 2003..We conclude that urinary naphthalene and the naphthols can serve as biomarkers of exposure to jet fuel. Of these, the naphthols are probably more useful because of their greater abundance and slower elimination kinetics... - Characterization and quantification of cysteinyl adducts of benzene diol epoxideSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7431, USA
Chem Res Toxicol 18:1178-85. 2005.... - Simultaneous determination of urinary 1- and 2-naphthols, 3- and 9-phenanthrols, and 1-pyrenol in coke oven workersBerrin Serdar
Department of Environmental Sciences and Engineering, School of Public Health University of North Carolina, Chapel Hill, NC 27599-7431, USA
Biomarkers 8:93-109. 2003.... - Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjectsSuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7431, USA
Anal Biochem 327:184-99. 2004..Since all metabolites were detected in all control subjects, the method can be applied to persons exposed to environmental levels of benzene... - Evidence for the formation of Michael adducts from reactions of (E,E)-muconaldehyde with glutathione and other thiolsAlistair P Henderson
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
Bioorg Chem 33:363-73. 2005..These experiments suggest that (Z,Z)-muconaldehyde, a putative metabolite of benzene, could lead to the long established urinary metabolite of benzene, (E,E)-muconic acid, via glutathione-mediated isomerization to (E,E)-muconaldehyde... - Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spotsWilliam E Funk
Department of Environmental Sciences and Engineering, School of Public Health, University of California at Chapel Hill, Chapel Hill, NC, USA
Cancer Epidemiol Biomarkers Prev 17:1896-901. 2008..Based upon the estimated variance of the benzene oxide-Hb levels, we had 80% power to detect a 1.7-fold difference in geometric mean levels of benzene oxide-Hb in our sample of nine subjects... - Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolismStephen M Rappaport
School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
Cancer Res 62:1330-7. 2002..This study illustrates that Alb adducts can be used to investigate the dispositions of reactive metabolites of procarcinogens in humans, provided that exposures are adequately characterized in the month preceding blood collection... - Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometrySuramya Waidyanatha
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7431, USA
Chem Biol Interact 145:165-74. 2003..Our results indicate that unmetabolized 2-, 3- and 4-ring PAHs can be measured in urine by HS-SPME. Such measurements can be used to investigate the uptake and metabolism of complex PAH mixtures in humans... - Fractionation of protein adducts in rats and mice dosed with [14C]pentachlorophenolChin-Hsiang Tsai
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599-7400, USA
Arch Toxicol 76:628-33. 2002..However, the sum of all quantified adducts accounted for only 7-8% of total cysteinyl binding to Np and 2% to Cp, suggesting that other uncharacterized binding species may be important to the toxicity of PCP... - Stability of hemoglobin and albumin adducts of naphthalene oxide, 1,2-naphthoquinone, and 1,4-naphthoquinoneMelissa A Troester
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA
Toxicol Sci 68:314-21. 2002..In addition, some limitations of current methods for estimating adduct instability were identified... - Hematotoxicity in workers exposed to low levels of benzeneQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI, National Institutes of Health (NIH, Department of Health and Human Services (DHHS, Bethesda, MD 20892, USA
Science 306:1774-6. 2004..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations... - Hematological changes among Chinese workers with a broad range of benzene exposuresQingshan Qu
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
Am J Ind Med 42:275-85. 2002..We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China... - Reactions of benzene oxide with thiols including glutathioneAlistair P Henderson
School of Natural Sciences Chemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle upon Tyne, NEI 7RU, United Kingdom
Chem Res Toxicol 18:265-70. 2005..The pathway leading to S-phenylmercapturic acid is necessarily minor on account of the low efficiency of benzene oxide capture by glutathione at pH 7 vs spontaneous rearrangement to phenol... - Physiologically-based pharmacokinetic modeling of benzene in humans: a Bayesian approachKaren Yokley
Department of Mathematics and Center for Research in Scientific Computation, North Carolina State University, Raleigh, USA
Risk Anal 26:925-43. 2006.... - Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzeneQing Lan
Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
Cancer Res 65:9574-81. 2005..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...