Suramya Waidyanatha

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone in Swiss Webster mice
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, United States
    Chem Biol Interact 172:105-14. 2008
  2. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
  3. ncbi request reprint Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
  4. pmc Comparing urinary biomarkers of airborne and dermal exposure to polycyclic aromatic compounds in asphalt-exposed workers
    Jon R Sobus
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Ann Occup Hyg 53:561-71. 2009
  5. ncbi request reprint Protein adducts as biomarkers of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 153:103-9. 2005
  6. ncbi request reprint Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacogenet Genomics 17:789-801. 2007
  7. ncbi request reprint Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, CB 7431, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Environ Monit 6:413-6. 2004
  8. ncbi request reprint Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometry
    Renan Wu
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 826:206-13. 2005
  9. ncbi request reprint Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006
  10. ncbi request reprint Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 13:117-24. 2004

Collaborators

Detail Information

Publications29

  1. doi request reprint Hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone in Swiss Webster mice
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, United States
    Chem Biol Interact 172:105-14. 2008
    ..This suggests that mice could be more susceptible than rats to the toxic effects of naphthalene due to more pronounced depletion of glutathione at a given dose...
  2. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
    ..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...
  3. ncbi request reprint Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
    ..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...
  4. pmc Comparing urinary biomarkers of airborne and dermal exposure to polycyclic aromatic compounds in asphalt-exposed workers
    Jon R Sobus
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Ann Occup Hyg 53:561-71. 2009
    ....
  5. ncbi request reprint Protein adducts as biomarkers of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 153:103-9. 2005
    ..Thus, the biologically effective dose of BO and 1,4-BQ should be proportionally greater in persons exposed to low rather than high levels of benzene...
  6. ncbi request reprint Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacogenet Genomics 17:789-801. 2007
    ....
  7. ncbi request reprint Naphthalene and its biomarkers as measures of occupational exposure to polycyclic aromatic hydrocarbons
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, CB 7431, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Environ Monit 6:413-6. 2004
    ..Since naphthalene has also been shown to be a respiratory carcinogen in several animal studies, it is also argued that naphthalene exposures should be monitored per se in industries with high levels of PAH...
  8. ncbi request reprint Determination of dihydroxynaphthalenes in human urine by gas chromatography-mass spectrometry
    Renan Wu
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 826:206-13. 2005
    ..Since the DHNs are precursors of the naphthoquinones, which have been implicated as toxic products of naphthalene metabolism, measurements of urinary DHNs may have toxicological significance...
  9. ncbi request reprint Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006
    ..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures...
  10. ncbi request reprint Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 13:117-24. 2004
    ..A negative relationship between 1,2-NPQ-Alb and age was observed, suggesting that cytochrome P450 c metabolism diminished with age at approximately 3%/year of life...
  11. doi request reprint Using liquid chromatography-tandem mass spectrometry to quantify monohydroxylated metabolites of polycyclic aromatic hydrocarbons in urine
    Frank Onyemauwa
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:1117-25. 2009
    ..628), presumably due to confounding by smoking. Metabolites of phenanthrene, an abundant PAH and the smallest to possess a bay region, are promising OHPAHs for characterizing both exposures to PAHs and the various metabolic pathways...
  12. ncbi request reprint Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 rats
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, CB 7400, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
    Chem Biol Interact 141:189-210. 2002
    ..Low background levels of 1,2-NPQ-Hb and -Alb and 1,4-NPQ-Hb and -Alb were detected in control animals without known exposure to naphthalene. However, the corresponding NPO-Hb and -Alb adducts were not detected in control animals...
  13. pmc Investigation of PAH biomarkers in the urine of workers exposed to hot asphalt
    Jon R Sobus
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Ann Occup Hyg 53:551-60. 2009
    ..These results support the use of U-Nap, U-Phe, OH-Phe, and OH-Pyr, but probably not OH-Nap, as short-term biomarkers of exposure to PAHs emanating from hot asphalt...
  14. ncbi request reprint Investigation of cysteinyl protein adducts of benzene diolepoxide
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA suramya unc edu
    Chem Biol Interact 153:261-6. 2005
    ..Reaction products between these and L-cysteine, and GSH were identified and characterized by mass spectrometry in an attempt to develop an assay to quantify these adducts in serum albumin...
  15. pmc Urinary biomarkers of exposure to jet fuel (JP-8)
    Berrin Serdar
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 111:1760-4. 2003
    ..We conclude that urinary naphthalene and the naphthols can serve as biomarkers of exposure to jet fuel. Of these, the naphthols are probably more useful because of their greater abundance and slower elimination kinetics...
  16. ncbi request reprint Characterization and quantification of cysteinyl adducts of benzene diol epoxide
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7431, USA
    Chem Res Toxicol 18:1178-85. 2005
    ....
  17. ncbi request reprint Simultaneous determination of urinary 1- and 2-naphthols, 3- and 9-phenanthrols, and 1-pyrenol in coke oven workers
    Berrin Serdar
    Department of Environmental Sciences and Engineering, School of Public Health University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Biomarkers 8:93-109. 2003
    ....
  18. ncbi request reprint Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjects
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    Anal Biochem 327:184-99. 2004
    ..Since all metabolites were detected in all control subjects, the method can be applied to persons exposed to environmental levels of benzene...
  19. ncbi request reprint Evidence for the formation of Michael adducts from reactions of (E,E)-muconaldehyde with glutathione and other thiols
    Alistair P Henderson
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    Bioorg Chem 33:363-73. 2005
    ..These experiments suggest that (Z,Z)-muconaldehyde, a putative metabolite of benzene, could lead to the long established urinary metabolite of benzene, (E,E)-muconic acid, via glutathione-mediated isomerization to (E,E)-muconaldehyde...
  20. pmc Hemoglobin adducts of benzene oxide in neonatal and adult dried blood spots
    William E Funk
    Department of Environmental Sciences and Engineering, School of Public Health, University of California at Chapel Hill, Chapel Hill, NC, USA
    Cancer Epidemiol Biomarkers Prev 17:1896-901. 2008
    ..Based upon the estimated variance of the benzene oxide-Hb levels, we had 80% power to detect a 1.7-fold difference in geometric mean levels of benzene oxide-Hb in our sample of nine subjects...
  21. ncbi request reprint Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
    Cancer Res 62:1330-7. 2002
    ..This study illustrates that Alb adducts can be used to investigate the dispositions of reactive metabolites of procarcinogens in humans, provided that exposures are adequately characterized in the month preceding blood collection...
  22. ncbi request reprint Determination of polycyclic aromatic hydrocarbons in urine of coke oven workers by headspace solid phase microextraction and gas chromatography-mass spectrometry
    Suramya Waidyanatha
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 145:165-74. 2003
    ..Our results indicate that unmetabolized 2-, 3- and 4-ring PAHs can be measured in urine by HS-SPME. Such measurements can be used to investigate the uptake and metabolism of complex PAH mixtures in humans...
  23. ncbi request reprint Fractionation of protein adducts in rats and mice dosed with [14C]pentachlorophenol
    Chin Hsiang Tsai
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    Arch Toxicol 76:628-33. 2002
    ..However, the sum of all quantified adducts accounted for only 7-8% of total cysteinyl binding to Np and 2% to Cp, suggesting that other uncharacterized binding species may be important to the toxicity of PCP...
  24. ncbi request reprint Stability of hemoglobin and albumin adducts of naphthalene oxide, 1,2-naphthoquinone, and 1,4-naphthoquinone
    Melissa A Troester
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7400, USA
    Toxicol Sci 68:314-21. 2002
    ..In addition, some limitations of current methods for estimating adduct instability were identified...
  25. pmc Hematotoxicity in workers exposed to low levels of benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Science 306:1774-6. 2004
    ..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations...
  26. ncbi request reprint Hematological changes among Chinese workers with a broad range of benzene exposures
    Qingshan Qu
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Am J Ind Med 42:275-85. 2002
    ..We examine hematological findings and their possible relations with exposure markers validated in a recent biomarker project conducted in Tianjin, China...
  27. ncbi request reprint Reactions of benzene oxide with thiols including glutathione
    Alistair P Henderson
    School of Natural Sciences Chemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle upon Tyne, NEI 7RU, United Kingdom
    Chem Res Toxicol 18:265-70. 2005
    ..The pathway leading to S-phenylmercapturic acid is necessarily minor on account of the low efficiency of benzene oxide capture by glutathione at pH 7 vs spontaneous rearrangement to phenol...
  28. ncbi request reprint Physiologically-based pharmacokinetic modeling of benzene in humans: a Bayesian approach
    Karen Yokley
    Department of Mathematics and Center for Research in Scientific Computation, North Carolina State University, Raleigh, USA
    Risk Anal 26:925-43. 2006
    ....
  29. ncbi request reprint Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...