Thor A Wagner

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low resource settings
    Thor A Wagner
    Seattle Children s, Seattle, Washington, USA Department of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USA
    J Glob Health 1:210-23. 2011
  2. pmc An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells
    Thor A Wagner
    Seattle Children s Research Institute, Seattle, Washington, USA
    J Virol 87:1770-8. 2013
  3. pmc Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay
    Thor A Wagner
    University of Washington, Seattle Children s Hospital Research Institute, 1900 Ninth Ave, 8th Floor, Seattle, WA 98101, USA
    J Clin Microbiol 48:1555-61. 2010
  4. pmc Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses
    Thor A Wagner
    University of Washington, Seattle, Washington, USA
    AIDS 23:923-8. 2009
  5. pmc Quantification of mitochondrial toxicity in HIV-infected individuals by quantitative PCR compared to flow cytometry
    Thor A Wagner
    Seattle Children s Research Institute, Seattle, Washington 98101, USA
    Cytometry B Clin Cytom 84:55-8. 2013
  6. pmc Potential limitation of CCR5 antagonists: drug resistance more often linked to CXCR4-utilizing than to CCR5-utilizing HIV-1
    Thor A Wagner
    University of Washington, Seattle, Washington, USA
    AIDS 22:2393-5. 2008
  7. ncbi request reprint HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
    Thor A Wagner
    Seattle Children s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA University of Washington, Seattle, WA, USA
    Science 345:570-3. 2014

Detail Information

Publications8

  1. pmc Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low resource settings
    Thor A Wagner
    Seattle Children s, Seattle, Washington, USA Department of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USA
    J Glob Health 1:210-23. 2011
    ..Future clinical trials comparing these biomarkers with more traditional biomarkers seem warranted...
  2. pmc An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells
    Thor A Wagner
    Seattle Children s Research Institute, Seattle, Washington, USA
    J Virol 87:1770-8. 2013
    ..Our findings suggest that proliferation of cells with proviruses is a likely mechanism of HIV-1 DNA persistence, which should be considered when designing strategies to eradicate HIV-1 infection...
  3. pmc Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay
    Thor A Wagner
    University of Washington, Seattle Children s Hospital Research Institute, 1900 Ninth Ave, 8th Floor, Seattle, WA 98101, USA
    J Clin Microbiol 48:1555-61. 2010
    ....
  4. pmc Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses
    Thor A Wagner
    University of Washington, Seattle, Washington, USA
    AIDS 23:923-8. 2009
    ..Our objective was to examine sputum, which is rich in macrophages, for evidence of increased HIV-1 replication compared with that in the blood during suppressive ART...
  5. pmc Quantification of mitochondrial toxicity in HIV-infected individuals by quantitative PCR compared to flow cytometry
    Thor A Wagner
    Seattle Children s Research Institute, Seattle, Washington 98101, USA
    Cytometry B Clin Cytom 84:55-8. 2013
    ..Non-invasive diagnostic assays to evaluate mitochondrial toxicity could have significant clinical utility for HIV-infected individuals on antiretroviral therapy (ART)...
  6. pmc Potential limitation of CCR5 antagonists: drug resistance more often linked to CXCR4-utilizing than to CCR5-utilizing HIV-1
    Thor A Wagner
    University of Washington, Seattle, Washington, USA
    AIDS 22:2393-5. 2008
    ..Analysis of 117 individual viruses found that 69% of CXCR4-utilizing viruses versus 48% of R5 viruses had drug resistance mutations (P = 0.025). Linkage of X4 and drug resistance may limit the effectiveness of CCR5 antagonists...
  7. ncbi request reprint HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
    Thor A Wagner
    Seattle Children s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA University of Washington, Seattle, WA, USA
    Science 345:570-3. 2014
    ..Over time on ART, a greater proportion of persisting proviruses were in proliferating cells. HIV integration into specific genes may promote proliferation of HIV-infected cells, slowing viral decay during ART. ..