Thor A Wagner

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low resource settings
    Thor A Wagner
    Seattle Children s, Seattle, Washington, USA Department of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USA
    J Glob Health 1:210-23. 2011
  2. pmc An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells
    Thor A Wagner
    Seattle Children s Research Institute, Seattle, Washington, USA
    J Virol 87:1770-8. 2013
  3. pmc Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay
    Thor A Wagner
    University of Washington, Seattle Children s Hospital Research Institute, 1900 Ninth Ave, 8th Floor, Seattle, WA 98101, USA
    J Clin Microbiol 48:1555-61. 2010
  4. pmc HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
    Thor A Wagner
    Seattle Children s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA University of Washington, Seattle, WA, USA
    Science 345:570-3. 2014
  5. pmc Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses
    Thor A Wagner
    University of Washington, Seattle, Washington, USA
    AIDS 23:923-8. 2009
  6. pmc Quantification of mitochondrial toxicity in HIV-infected individuals by quantitative PCR compared to flow cytometry
    Thor A Wagner
    Seattle Children s Research Institute, Seattle, Washington 98101, USA
    Cytometry B Clin Cytom 84:55-8. 2013
  7. pmc Potential limitation of CCR5 antagonists: drug resistance more often linked to CXCR4-utilizing than to CCR5-utilizing HIV-1
    Thor A Wagner
    University of Washington, Seattle, Washington, USA
    AIDS 22:2393-5. 2008

Research Grants

Detail Information

Publications8

  1. pmc Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low resource settings
    Thor A Wagner
    Seattle Children s, Seattle, Washington, USA Department of Pediatrics at University of Washington School of Medicine, Seattle, Washington, USA
    J Glob Health 1:210-23. 2011
    ..Future clinical trials comparing these biomarkers with more traditional biomarkers seem warranted...
  2. pmc An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cells
    Thor A Wagner
    Seattle Children s Research Institute, Seattle, Washington, USA
    J Virol 87:1770-8. 2013
    ..Our findings suggest that proliferation of cells with proviruses is a likely mechanism of HIV-1 DNA persistence, which should be considered when designing strategies to eradicate HIV-1 infection...
  3. pmc Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay
    Thor A Wagner
    University of Washington, Seattle Children s Hospital Research Institute, 1900 Ninth Ave, 8th Floor, Seattle, WA 98101, USA
    J Clin Microbiol 48:1555-61. 2010
    ....
  4. pmc HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
    Thor A Wagner
    Seattle Children s Research Institute, 1900 9th Avenue, Seattle, WA 98101, USA University of Washington, Seattle, WA, USA
    Science 345:570-3. 2014
    ..Over time on ART, a greater proportion of persisting proviruses were in proliferating cells. HIV integration into specific genes may promote proliferation of HIV-infected cells, slowing viral decay during ART. ..
  5. pmc Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses
    Thor A Wagner
    University of Washington, Seattle, Washington, USA
    AIDS 23:923-8. 2009
    ..Our objective was to examine sputum, which is rich in macrophages, for evidence of increased HIV-1 replication compared with that in the blood during suppressive ART...
  6. pmc Quantification of mitochondrial toxicity in HIV-infected individuals by quantitative PCR compared to flow cytometry
    Thor A Wagner
    Seattle Children s Research Institute, Seattle, Washington 98101, USA
    Cytometry B Clin Cytom 84:55-8. 2013
    ..Non-invasive diagnostic assays to evaluate mitochondrial toxicity could have significant clinical utility for HIV-infected individuals on antiretroviral therapy (ART)...
  7. pmc Potential limitation of CCR5 antagonists: drug resistance more often linked to CXCR4-utilizing than to CCR5-utilizing HIV-1
    Thor A Wagner
    University of Washington, Seattle, Washington, USA
    AIDS 22:2393-5. 2008
    ..Analysis of 117 individual viruses found that 69% of CXCR4-utilizing viruses versus 48% of R5 viruses had drug resistance mutations (P = 0.025). Linkage of X4 and drug resistance may limit the effectiveness of CCR5 antagonists...

Research Grants1

  1. Persistent HIV-1 Replication in the Respiratory Tract Despite ART
    Thor Wagner; Fiscal Year: 2008
    ..Our studies will provide insight into persistent HIV-1 replication during antiretroviral therapy and whether specific drugs are more effective in suppressing viral replication in macrophages. ..