- Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β speciesSteven L Wagner
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, United States
Biochemistry 53:702-13. 2014....
- Potential use of γ-secretase modulators in the treatment of Alzheimer diseaseSteven L Wagner
Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA 92063, USA
Arch Neurol 69:1255-8. 2012..We also discuss certain genetic- and biomarker-based translational and clinical trial paradigms that may assist in developing a useful therapeutic agent...