Kay Uwe Wagner

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc The two faces of Janus kinases and their respective STATs in mammary gland development and cancer
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, DRC2, Rm 5033, Omaha, NE, USA
    J Carcinog 10:32. 2011
  2. pmc A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death
    Chantey R Morris
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e34308. 2012
  3. pmc Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
    K Sakamoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Oncogene 29:5359-69. 2010
  4. pmc Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells
    Jeffrey W Schmidt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198 5950, U, S, A
    BMC Cancer 14:195. 2014
  5. ncbi request reprint Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Mammary Gland Biol Neoplasia 13:93-103. 2008
  6. ncbi request reprint Pregnancy and stem cell behavior
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Mammary Gland Biol Neoplasia 10:25-36. 2005
  7. pmc Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases and Department of Pathology, University of Nebraska Medical Center, Omaha, 68198 6805, USA
    Mol Cell Biol 24:5510-20. 2004
  8. ncbi request reprint Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly
    K U Wagner
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bldg 8, Rm 107, Bethesda, MD 20892 0822, USA
    Development 127:4949-58. 2000
  9. pmc Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Mol Cell Biol 23:150-62. 2003
  10. ncbi request reprint Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice
    K U Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Transgenic Res 10:545-53. 2001

Collaborators

Detail Information

Publications52

  1. pmc The two faces of Janus kinases and their respective STATs in mammary gland development and cancer
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, DRC2, Rm 5033, Omaha, NE, USA
    J Carcinog 10:32. 2011
    ....
  2. pmc A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death
    Chantey R Morris
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e34308. 2012
    ..These multifaceted alterations need to be recognized as they have an impact on defining particular functions for Tsg101 in processes such as signal transduction and lysosomal/endosomal trafficking...
  3. pmc Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer
    K Sakamoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Oncogene 29:5359-69. 2010
    ..PRL-induced mammary cancers exhibited an upregulation of ErbB2 and other ErbB receptor tyrosine kinases that may supersede the functionality of PRLR signaling through Jak2...
  4. pmc Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells
    Jeffrey W Schmidt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198 5950, U, S, A
    BMC Cancer 14:195. 2014
    ..The purpose of this study was to examine whether normal and neoplastic human breast epithelial cells express an orthologous AKT1m transcript and whether its expression is deregulated in cancer cells...
  5. ncbi request reprint Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Mammary Gland Biol Neoplasia 13:93-103. 2008
    ..Future studies to further test the concept of contrasting effects of Jak2/Stat5 pathway on breast cancer initiation and metastatic progression are proposed...
  6. ncbi request reprint Pregnancy and stem cell behavior
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Mammary Gland Biol Neoplasia 10:25-36. 2005
    ..Using appropriate animal models, we further demonstrate that PI-MECs are cellular targets for pregnancy-enhanced mammary tumorigenesis...
  7. pmc Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases and Department of Pathology, University of Nebraska Medical Center, Omaha, 68198 6805, USA
    Mol Cell Biol 24:5510-20. 2004
    ....
  8. ncbi request reprint Conditional deletion of the Bcl-x gene from erythroid cells results in hemolytic anemia and profound splenomegaly
    K U Wagner
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bldg 8, Rm 107, Bethesda, MD 20892 0822, USA
    Development 127:4949-58. 2000
    ..Mice conditionally deficient in Bcl-x permitted us for the first time to study the effects of Bcl-x deficiency on cell proliferation, maturation and survival under physiological conditions in an adult animal...
  9. pmc Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Mol Cell Biol 23:150-62. 2003
    ..In summary, our results suggest that Tsg101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumor suppressor for sporadic forms of breast cancer...
  10. ncbi request reprint Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice
    K U Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68198 6805, USA
    Transgenic Res 10:545-53. 2001
    ..Information provided by this study will guide the researcher to those cell types and developmental stages at which a phenotype can be expected upon deletion of relevant genes...
  11. pmc Models of breast cancer: quo vadis, animal modeling?
    Kay Uwe Wagner
    University of Nebraska Medical Center, Omaha, Nebraska, USA
    Breast Cancer Res 6:31-8. 2004
    ....
  12. ncbi request reprint An adjunct mammary epithelial cell population in parous females: its role in functional adaptation and tissue renewal
    Kay Uwe Wagner
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm 8009, Omaha, NE 68198 6805, USA
    Development 129:1377-86. 2002
    ..e. ductal morphogenesis and lobulogenesis). We propose that this parity-induced population contributes importantly to the biological differences between the mammary glands of parous and nulliparous females...
  13. ncbi request reprint Bcl-x is not required for maintenance of follicles and corpus luteum in the postnatal mouse ovary
    Gregory Riedlinger
    Laboratory of Genetics and Physiology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Reprod 66:438-44. 2002
    ..Whereas luteal cells underwent apoptosis in the absence of the PrlR, no changes were observed in the absence of Stat5 or Bcl-x...
  14. pmc Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells
    Marissa J Carstens
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Biol Chem 279:35984-94. 2004
    ....
  15. pmc Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1
    Bradley A Creamer
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Mol Cell Biol 30:2957-70. 2010
    ..Collectively, the results of the present study elucidate an underlying mechanism by which active Stat5 mediates evasion from apoptosis and self-sufficiency in growth signals...
  16. pmc Targeted deletion of the Tsg101 gene results in cell cycle arrest at G1/S and p53-independent cell death
    Andrea Krempler
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Biol Chem 277:43216-23. 2002
    ..Our results clearly demonstrate that Tsg101 is not a primary tumor suppressor in mouse embryonic fibroblasts. However, the protein is crucial for cell proliferation and cell survival...
  17. pmc Temporally and spatially controlled expression of transgenes in embryonic and adult tissues
    Qian Zhang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, DRCII, Rm 5033, Omaha, NE 68198 5950, USA
    Transgenic Res 19:499-509. 2010
    ....
  18. ncbi request reprint Basal activation of transcription factor signal transducer and activator of transcription (Stat5) in nonpregnant mouse and human breast epithelium
    Marja T Nevalainen
    United States Military Cancer Institute and Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20852, USA
    Mol Endocrinol 16:1108-24. 2002
    ..Continuous activation of Stat5 indicates a role of this transcription factor in normal, nonpregnant breast epithelial cells, and may shed new light on Stat5 involvement in breast tumor promotion...
  19. ncbi request reprint Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation
    Brian Bierie
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 22:3875-87. 2003
    ..This suggests that the transdifferentiation into squamous metaplasias is an early response of endoderm-derived cells to beta-catenin, and that the development of intra-acinous hyperplasias or neoplastic foci is a later event...
  20. ncbi request reprint Parity-induced mammary epithelial cells facilitate tumorigenesis in MMTV-neu transgenic mice
    MaLinda D Henry
    Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncogene 23:6980-5. 2004
    ....
  21. ncbi request reprint Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice
    Andrea Krempler
    Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Genesis 40:52-7. 2004
    ....
  22. ncbi request reprint Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression
    Corinne A Boulanger
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    Oncogene 24:552-60. 2005
    ....
  23. ncbi request reprint Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells
    Aleata A Triplett
    Eppley Institute for Research in Cancer and Allied Diseases and the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Genesis 43:1-11. 2005
    ..Important implications of these findings for the use of Wap as a marker for advanced differentiation of mammary epithelial cells and the biology of pluripotent progenitors are discussed in the final section...
  24. pmc Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression
    Qian Zhang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Cancer Res 71:7513-24. 2011
    ..Collectively, the results of this study suggest that only the combined inhibition of Cyclin D1 and D3 might be a suitable strategy for breast cancer prevention and therapy...
  25. pmc Targeting janus kinase 2 in Her2/neu-expressing mammary cancer: Implications for cancer prevention and therapy
    Kazuhito Sakamoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, 68198 5950, USA
    Cancer Res 69:6642-50. 2009
    ..This might be a compensatory mechanism that explains why Jak2 is a relevant target for preventing the initiation but not the progression of ErbB2-associated mammary cancer...
  26. ncbi request reprint Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells
    Laurice A Matulka
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Rm 8009, Omaha, NE 68198 6805, USA
    Dev Biol 303:29-44. 2007
    ..These observations suggest that PI-MECs contain multipotent progenitors that are able to self renew and generate diverse epithelial lineages present in the murine mammary gland...
  27. pmc Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging
    Bradley A Creamer
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Genesis 47:234-45. 2009
    ..The study shows that, unlike their progeny in mammary epithelial transplants as reported previously, PI-MECs themselves may not belong to the long-term label-retaining epithelial subtype...
  28. pmc Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer
    Wan chi Lin
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Cancer Res 73:1821-30. 2013
    ....
  29. ncbi request reprint The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells
    Kazuhito Sakamoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Mol Endocrinol 21:1877-92. 2007
    ....
  30. pmc Generation of a novel MMTV-tTA transgenic mouse strain for the targeted expression of genes in the embryonic and postnatal mammary gland
    Kazuhito Sakamoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e43778. 2012
    ....
  31. ncbi request reprint Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility
    Yongzhi Cui
    Laboratory of Genetics and Physiology, NIDDK, the Laboratory of Immunoregulation, Immune Activation Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:17830-5. 2002
    ..These mice have normal populations of follicles, they ovulate and develop corpora lutea. Although progesterone levels are decreased and implantation rates are reduced, the exact cause of the impaired fertility remains to be determined...
  32. pmc Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling
    Yrina Rochman
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Proc Natl Acad Sci U S A 107:19455-60. 2010
    ..These findings clarify the basis for TSLP-mediated signaling and provide an example wherein a cytokine uses JAK1 and JAK2 to mediate the activation of STAT5...
  33. ncbi request reprint Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS
    Magdalene K Sgagias
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cell Cycle 3:1451-6. 2004
    ..These studies support the role of BRCA1 in the CDDP-induced and MMS-induced DNA damage and repair by p53-independent pathways...
  34. pmc Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung
    Wan chi Lin
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA
    PLoS ONE 8:e60902. 2013
    ....
  35. pmc A mammary-specific, long-range deletion on mouse chromosome 11 accelerates Brca1-associated mammary tumorigenesis
    Aleata A Triplett
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Neoplasia 10:1325-34. 2008
    ..The analysis of the coding sequence and expression pattern of p53 and p21 suggests that loss-of-heterozygosity of Trp53 caused by somatic mutations contributes to accelerated mammary tumorigenesis in this model...
  36. pmc Cancer cell dormancy in novel mouse models for reversible pancreatic cancer: a lingering challenge in the development of targeted therapies
    Wan chi Lin
    Authors Affiliations Eppley Institute for Research in Cancer and Allied Diseases and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska
    Cancer Res 74:2138-43. 2014
    ....
  37. pmc Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis
    Jeffrey W Schmidt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Mol Cell Biol 34:1363-77. 2014
    ..Therefore, targeting the Jak2/Stat5 pathway might be a suitable strategy to prevent breast cancer in patients that carry a mutant PTEN allele. ..
  38. pmc Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions
    Chun Tu
    Eppley Institute for Research in Cancer and Allied Diseases and University of Nebraska Medical Center Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Proc Natl Acad Sci U S A 107:16107-12. 2010
    ..These results reveal a critical role for an ESCRT pathway-dependent LE/LY trafficking step in Src function by promoting localization of active Src to FAs...
  39. pmc D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells
    Qian Zhang
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, NE 68198 5950, USA
    Mol Cell Endocrinol 382:583-92. 2014
    ....
  40. pmc Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis
    Ryan A Hlady
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 5950, USA
    J Clin Invest 122:163-77. 2012
    ..Our findings identify Ment as an enhancer of lymphomagenesis that contributes to the tumor suppressor function of Dnmt3b and suggest it could be a potential target for anticancer therapies...
  41. pmc IRF4 is a suppressor of c-Myc induced B cell leukemia
    Simanta Pathak
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e22628. 2011
    ..Thus, IRF4 functions as a classical tumor suppressor to inhibit c-Myc induced B cell leukemia in EμMyc mice...
  42. pmc Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: potential implications for diagnosis and therapy
    Satyanarayana Rachagani
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    J Hematol Oncol 5:68. 2012
    ..However, the initiation of MUC expression during PC remains unknown because of lack of early stage tumor tissues from PC patients...
  43. ncbi request reprint Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland
    Gang Li
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 650 Circle Drive South, 90095 1735, USA
    Development 129:4159-70. 2002
    ....
  44. pmc Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice
    Yuxin Feng
    Department of Cell and Cancer Biology, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 104:14718-23. 2007
    ..These observations suggest that ERalpha expression in the mammary epithelium is essential for normal ductal morphogenesis during puberty and alveologenesis during pregnancy and lactation...
  45. ncbi request reprint Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development
    Aimee V Loladze
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 147:5412-23. 2006
    ..Taken together, our results support distinct roles for IGF-I expressed in epithelial and stromal compartments in mediating growth of the postnatal mammary gland...
  46. doi request reprint Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment
    Brian Bierie
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6838, USA
    Cancer Res 68:1809-19. 2008
    ....
  47. ncbi request reprint Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development
    Eleanor Y M Sum
    The Walter and Eliza Hall Institute of Medical Research and Bone Marrow Research Laboratories, 1G Royal Parade, Parkville, VIC 3050, Australia
    Oncogene 24:4820-8. 2005
    ..Thus, the use of a conditional targeting strategy has revealed that Lmo4 is required for proper development of the mammary gland during pregnancy and indicated that Lmo4 acts as a positive regulator of alveolar epithelial proliferation...
  48. ncbi request reprint Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice
    Alison M Y Cheung
    Advanced Medical Discovery Institute, University Health Network, 620 University Avenue, Suite 706, Toronto, Ontario M5G 2C1, Canada
    Cancer Res 64:1959-65. 2004
    ..Our data indicate that Brca2 is not essential for mammary epithelium development but that Brca2 deficiency and down-regulated p53 expression can work jointly to promote mammary tumorigenesis...
  49. pmc Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
    Stephanie A Backman
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute and University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Proc Natl Acad Sci U S A 101:1725-30. 2004
    ..Consistent with high PTEN mutation rates in human prostate tumors, these data indicate that PTEN is a critical tumor suppressor in this organ...
  50. ncbi request reprint HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland
    Tiffany N Seagroves
    Division of Biological Sciences, Molecular Biology Section, University of California San Diego, La Jolla, CA 92093, USA
    Development 130:1713-24. 2003
    ..Transplantation experiments confirmed that these developmental defects were mammary epithelial cell autonomous. These data make clear that HIF1alpha plays a critical role in the differentiation and function of the mammary epithelium...
  51. ncbi request reprint Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5
    Weiwen Long
    Department of Structural and Cellular Biology, Tulane Cancer Center, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, Louisiana 70112 2699, USA
    Development 130:5257-68. 2003
    ....
  52. ncbi request reprint Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways
    Lynn M Neilson
    Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Mol Endocrinol 21:2218-32. 2007
    ....

Research Grants15

  1. Tumor Susceptibility Gene 101 Deficiency and Neoplasia
    Kay Uwe Wagner; Fiscal Year: 2002
    ..abstract_text> ..
  2. Tsg101 - a Modulator of ErbB2 Signaling in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2010
    ..The genetic and molecular studies outlined in this application will help to predict the potential value of Tsg101 as a therapeutic target before a drug will be developed and tested in preclinical trials. ..
  3. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2010
    ..Furthermore, they might reveal whether a combinatorial therapy of pan-ErbB tyrosine kinase inhibitors and Jak2 inhibitors would be beneficial for the treatment of ErbB2-positive breast cancers. ..
  4. Tsg101 - a Modulator of ErbB2 Signaling in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2009
    ..The genetic and molecular studies outlined in this application will help to predict the potential value of Tsg101 as a therapeutic target before a drug will be developed and tested in preclinical trials. ..
  5. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2009
    ..Furthermore, they might reveal whether a combinatorial therapy of pan-ErbB tyrosine kinase inhibitors and Jak2 inhibitors would be beneficial for the treatment of ErbB2-positive breast cancers. ..
  6. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2007
    ..Furthermore, they might reveal whether a combinatorial therapy of pan-ErbB tyrosine kinase inhibitors and Jak2 inhibitors would be beneficial for the treatment of ErbB2-positive breast cancers. ..
  7. Tsg101 - a Modulator of ErbB2 Signaling in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2009
    ..The genetic and molecular studies outlined in this application will help to predict the potential value of Tsg101 as a therapeutic target before a drug will be developed and tested in preclinical trials. ..
  8. Tumor Susceptibility Gene 101 Deficiency and Neoplasia
    Kay Uwe Wagner; Fiscal Year: 2006
    ..abstract_text> ..
  9. Tumor Susceptibility Gene 101 Deficiency and Neoplasia
    Kay Uwe Wagner; Fiscal Year: 2005
    ..abstract_text> ..
  10. Tumor Susceptibility Gene 101 Deficiency and Neoplasia
    Kay Uwe Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  11. Tumor Susceptibility Gene 101 Deficiency and Neoplasia
    Kay Uwe Wagner; Fiscal Year: 2003
    ..abstract_text> ..
  12. Tumor Susceptibility Gene 101 Deficiency and Neoplasia
    Kay Uwe Wagner; Fiscal Year: 2005
    ..abstract_text> ..
  13. Tumor Susceptibility Gene 101 Deficiency and Neoplasia
    Kay Uwe Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  14. Growth-Regulatory Signaling Networks in Breast Cancer
    Kay Uwe Wagner; Fiscal Year: 2006
    ..Furthermore, they might reveal whether a combinatorial therapy of pan-ErbB tyrosine kinase inhibitors and Jak2 inhibitors would be beneficial for the treatment of ErbB2-positive breast cancers. ..